Polypeptides derived from retinoic acid-related orphan receptor(ror) and their applications

ABSTRACT

The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat RORβ, α, or γ, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of the other mammals. The invention also relates to the use of these polypeptides, or of the molecular complexes or the crystals containing them, for carrying out:—a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor,—or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.

FIELD OF INVENTION

[0001] An aspect of this invention is to obtain crystal structure from orphan receptors by using a heterologous expression system, which will not only produce high amount of the desired protein but may also furnish a pseudo-ligand. The presence of this fortuitous molecule is important to stabilize an active agonist conformation by adding concomitantly a co-activator peptide. These two elements avoid any other non-active alternative conformations.

[0002] This method is illustrated by crystals of brain specific retinoic acid-related orphan receptor ligand binding domain (RORβ-LBD) in complex with a co-activator peptide and a fortuitous fatty acid ligand. This invention also relates to methods of using DNA sequence or derived constructions to produce proteins in order either to find out the physiological ligand or to screen for synthetic analogues. This invention, also relates to methods for designing and selecting ligands that bind to the RORβ and methods of using such ligands. It refers also to the use of DNA sequences of RORβ or derived sequences thereof in order to identify other proteins which interact with RORβ. Obviously the object of this invention is also the usage of the structure of similar or homologous proteins or protein complexes, particularly all these claims are applied to the two isotypes RORα and γ.

BACKGROUND OF THIS INVENTION

[0003] The orphan retinoic acid-related orphan receptor β (RORβ), also called retinoid Z receptor β (RZRβ) (NR1F2) belongs to the nuclear receptor (NR) superfamily and is expressed in areas of the central nervous system. The ligand-dependent activity of the nuclear receptor makes them obvious targets for drug design in many therapeutic areas. However in the case of orphan receptors, the ligand is not known and even the existence of a ligand is not proven. RORβ was never shown to bind retinoic acid. RORβ regulates genes whose products play a role in the context of sensory input integration as well as in the context of the biological clock. A behavioral phenotype of RORβ −/− mice was observed and seems to be similar to the phenotype described >40 years ago for a spontaneous mouse mutation called vacillans (Sirlin, 1956). These mice display a duck-like gait, transient male incapability to sexually reproduce and a severely disorganised retina that suffer from post-natal degeneration.

[0004] Two other closely nuclear receptors are RORα and RORγ. RORα presents 61% identity and 74% similarity with RORβ. RORα is rather ubiquitously expressed (Becker-André et al., 1993) and has been demonstrated to play important roles in cerebellum development and immune response (Matysiak-Scholze and Nehls, 1997; Koibuchi and Chin., 1998). Staggerer mice were found to carry a deletion within the RORα gene that prevents translation of the ligand-binding domain. They present a severe cerebellar ataxia related to a defect in developpement of Purkinje cells. Certain functions of the immune system are also affected (Hamilton & al., 1996).

[0005] Certain functions of the immune system are also affected (Hamilton & al., 1996). RORα is also constitutively expressed during myogenesis (Lau et al. , 1999).

[0006] The expression of RORγ is found mainly in skeletal muscle (Hirose et al., 1994) and is induced in the middle stage of adipocyte differentiation (Kurebayashi S., and Hirose T, 1998).

[0007] As with the other members of the nuclear receptor family, RORβ has several functional domains including a DNA binding domain (DBD), and a 250 residue ligand-binding domain (LBD) which contains the ligand-binding site, and is responsible for switching on the ligand-binding function.

[0008] It would be advantageous to devise methods and compositions for reducing the time required to discover ligands to the RORβ, synthesize such compounds and administer such compounds to organisms to modulate physiological processes regulated by the RORβ receptor or any of its isotypes α or β.

[0009] There have been no crystals reported so far of any orphan receptor in the agonist bound conformation. The structure of USP, the insect ortholog of RXR, has been published recently. Though RXRs bind 9c-RA, USP fail to bind this ligand and must still be considered as an orphan receptor. Juvenile hormones have been proposed to be the natural ligands of USP but matter is still controversial. Nevertheless, the USP LBD structure is in an antagonist-like conformation. We report discovered the first crystal structure of the orphan receptor ligand-binding domain (RORβ-LBD) in the agonist bound conformation, which represents the transcriptionally active form of nuclear receptor.

SUMMARY OF THE INVENTION

[0010] The invention relates to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they comprise at least the amino-acid sequence delimited in its N-terminal extremity by the first amino acid of the H1 helix, and in its C-terminal extremity by the last amino acid of the H12 helix.

[0011] The invention relates more particularly to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals.

[0012] The invention relates more particularly to polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209 of the human or rat nuclear receptor RORβ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes, such as RORα, and RORγ, as represented on FIG. 3, and/or of other mammals, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the human or rat nuclear receptor RORβ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes, such as RORα, and RORγ, and/or of other mammals.

[0013] The invention also concerns polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by the methionine in position 209 of the human or rat nuclear receptor RORβ, as represented on FIG. 3, or by the methionine or another amino-acid such as leucine located at a corresponding position in nuclear receptor ROR of other subtypes, such as RORα, and RORγ, and/or of other mammals, and in its C-terminal extremity by the phenylalanine in position 450 of the human or rat nuclear receptor RORβ, as represented on FIG. 3, or by the phenylalanine or another amino-acid located at a corresponding position in nuclear receptor ROR of other subtypes, such as RORα, and RORγ, and/or of other mammals.

[0014] Advantageously, polypeptides as defined above according to the invention, are characterized in that at least the approximately 100 to 200 first amino-acids of the N-terminal part of the sequence of said receptor is deleted.

[0015] Polypeptides according to the invention defined above are more particularly characterized, in that they are polypeptides derived from the nuclear receptor ROR, wherein the binding properties of the ligand-binding domain, or LBD, of said receptor, are maintained.

[0016] The invention relates more particularly to polypeptides derived from the nuclear receptor RORβ, of mammals, such as human or rat, these derived polypeptides comprising a polypeptide as defined above, such as the polypeptides delimited by the amino-acids located in positions 201 to 459 of the sequences of rat or human RORβ represented on FIG. 3, said polypeptides being characterized in that at least one of the cysteine in position 454 or in position 458 of the amino-acid sequence of said nuclear receptor RORβ, as represented on FIG. 3, is deleted or substituted by another amino-acid, natural or not, such as alanine or serine.

[0017] The invention relates more particularly to polypeptides as defined above, characterized in that:

[0018] the N-terminal sequence delimited by the amino-acids in position 1 to 200 of the receptor, is deleted,

[0019] and the C-terminal sequence starting from the amino-acid in position 450 of the human or rat nuclear receptor RORβ represented on FIG. 3, or from the amino-acid located at a corresponding position in nuclear receptor ROR of other subtypes, such as RORα, and RORγ, as represented on FIG. 3, and/or of other mammals, and more preferably from the amino-acid in position 451, 452, or 453, is deleted.

[0020] The invention relates more particularly to polypeptides as defined above, characterized in that they correspond to the fragments of mammals ROR, and more particularly of rat, human, or murine RORβ, α, or γ, delimited in their N-terminal extremity by the amino acid located in one of the positions 201 to 209 of the ROR sequences represented on FIG. 3, and in their C-terminal extremity by the amino acid located in one of the positions 451 or 452, of the ROR sequences represented on FIG. 3.

[0021] The invention concerns more particularly polypeptides as defined above, chosen among:

[0022] the fragment delimited by the amino acids located in positions 209 to 452 of:

[0023] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 2,

[0024] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 3,

[0025] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 4,

[0026] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 5,

[0027] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 6,

[0028] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 7,

[0029] the fragment delimited by the amino acids located in positions 208 to 452 of:

[0030] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 8,

[0031] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 9,

[0032] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 10,

[0033] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 11,

[0034] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 12,

[0035] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 13,

[0036] the fragment delimited by the amino acids located in positions 208 to 451 of:

[0037] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 14,

[0038] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 15,

[0039] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 16,

[0040] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 17,

[0041] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 18,

[0042] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 19,

[0043] the fragment delimited by the amino acids located in positions 209 to 451 of:

[0044] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 20,

[0045] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 21,

[0046] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 22,

[0047] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 23,

[0048] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 24,

[0049] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 25,

[0050] the fragment delimited by the amino acids located in positions 201 to 451 of:

[0051] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 26,

[0052] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 97,

[0053] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 28,

[0054] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 29,

[0055] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 30,

[0056] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 31,

[0057] the fragment delimited by the amino acids located in positions 201 to 452 of:

[0058] the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 32,

[0059] the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 33,

[0060] the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 34,

[0061] the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 35,

[0062] the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 36,

[0063] the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 37.

[0064] Polypeptides as defined above according to the invention, are more particularly characterized by the following characteristics:

[0065] they have the properties of binding a ligand and of transactivation of the LBD of the receptor ROR,

[0066] they are soluble in aqueous solvants,

[0067] they are crystallisable in aqueous solvents, especially by the hanging drop vapour diffusion method, more particularly at approximately 4° C.,

[0068] or polypeptides or peptide sequences derived of those above mentioned, for example by suppression, addition or substitution of one or several amino acids, these polypeptides or peptide sequences having the characteristics above mentioned.

[0069] The invention also concerns molecular complexes comprising a polypeptide as defined above, said polypeptide being in association with:

[0070] a ROR-LBD ligand which is an agonist, such as stearic acid, or an antagonist of the ROR-LBD, such as retinoic acid,

[0071] and/or with a co-peptide having a sequence of approximately 15-20 amino-acids and comprising the co-activator motif LXXLL or a co-repressor motif (I/L)XX(V/I)I or LXX(H/I)IXXX(I/L) wherein X represents-any amino acid, natural or not, such as co-peptides chosen among fragments of co-activators of transcription, especially those of the p160 family, and more particularly among fragments of the co-activators SRC1, such as the fragment 686-700 of SRC1, or among fragments of co-repressors of transcription.

[0072] The invention also relates to nucleotide sequence coding for a polypeptide as defined above.

[0073] The invention also relates to nucleotide sequence as defined above, associated to elements necessary for the transcription of this sequence, particularly a promoter and a terminator of transcription.

[0074] The invention also concerns vector, particularly plasmid, comprising a nucleotide sequence as defined above.

[0075] The invention also relates to host cells, such as E.coli, transformed with a vector as defined above.

[0076] The invention also relates to a process for obtaining a polypeptide, or a molecular complex, as defined above, characterized in that it comprises:

[0077] a step of transforming host cells with a nucleotide sequence as defined above, using a vector as defined above,

[0078] a step of cultivating the transformed host cell as defined above thus obtained, in an appropriate culture medium,

[0079] and the recovery, and if necessary, the purification of the recombinant polypeptide or molecular complex obtained.

[0080] The invention also relates to a crystal comprising a polypeptide according, or a molecular complex, as defined above.

[0081] Advantageously, a crystal as defined above, is characterized in that it diffracts to at least 3 angstrom resolution and has a crystal stability within 5% of its unit cell dimensions.

[0082] Preferred crystal as defined above, is such that the ROR-LBD has the following unit cell dimensions in angstroms: a=52.302 Å, b=58.490 Å and c=106.036 Å, α=β=χ=90°, and an orthorhombic space group P212121.

[0083] The invention also relates to a crystal as defined above, such as obtained by carrying out a process mentioned above, and comprising a step of crystallisation in aqueous solvents of the polypeptides, or the molecular complexes, as defined above, especially at 4° C. by the hanging drop vapour diffusion method.

[0084] The invention also relates to the use of the polypeptides, or of the molecular complexes, or of the crystals, as defined above, for carrying out:

[0085] a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor, or for the screening of ligands that perturb the structure of the receptor and having an effect on the recruitment of cofactors (co-activators and co-repressors) and hence on gene regulation,

[0086] or a process for the analysis of the tridimensional structure of the complexes formed with said polypeptides, molecular complexes or crystals and a particular compound.

[0087] The invention relates more particularly to the use mentioned above, for the screening of compounds acting as agonists or antagonists of ROR, said compounds being useful in the frame of the treatment of pathologies related to the central nervous system, the retinal organisation, the sensorial signal integration, the motricity, and sterility.

[0088] The invention also relates to a process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor, said process comprising the following steps:

[0089] contacting a polypeptide, or a molecular complex, or a crystal according, as defined above, advantageously linked to a solid support, with the particular compound susceptible to be a ROR-LBD ligand, preferably one of the said polypeptide, or molecular complex, or crystal, or tested ligand, being labelled, such as with a fluorescent, radioactive or enzymatic label,

[0090] detection of the possible association between the said polypeptide, or molecular complex, or crystal, and the tested ligand, by measuring the used label, especially after rinsing the support used in the preceding step, or by mass spectrometry under non denaturing conditions.

[0091] The invention also relates to a process for the analysis of the tridimensional structure of the complexes formed with a polypeptide, or a molecular complex, or a crystal, as defined above, and a particular compound susceptible to be a ROR-LBD ligand, said process comprising the following steps:

[0092] contacting the said polypeptide, or molecular complex, or crystal, with said particular compound,

[0093] crystallisation of the complex formed between the said polypeptide, or molecular complex, or crystal, and the tested ligand, especially with the vapour diffusion method, and tridimensional analysis of said complex, especially with the molecular replacement method,

[0094] or tridimensional analysis of said complex in soluble state, by using an appropriate method such as NMR.

[0095] The present invention provides crystals of an RORβ-LBD bound to a ligand and to a coactivator peptide, i. e. an RORβ-LBD/ligand/peptide complex. The ligand is stearic acid.

[0096] The crystal diffracts to 1.9 Å resolution. The crystal of RORβ-LBD preferably has at least 243 amino acid and preferably comprises amino acid sequence 208 to 451 of rat RORβ. The present invention also provides the structure coordinates of the RORβ-LBD/ligand/peptide complex. The complete coordinates are listed in Table A.

[0097] The complete coordinates of crystals of an RORβ-LBD bound to a ligand and to a coactivator peptide, i. e. an RORβ-LBD/ligand/peptide complex, wherein the ligand is retinoic acid are listed in Table B.

[0098] The present invention also provides a method for determining at least a portion of the three-dimensional structure of molecules or molecular complexes which contain at least some structurally similar features to the RORβ-LBD. It is preferred that these molecules or molecular complexes comprise at least a part of the ligand-binding site defined by structure coordinates of RORβ-LBD amino-acids Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339,_A342, F343, V419, C420, H423, and Y446 according to Table A or a mutant or homologue thereof.

[0099] The present invention also provides a computer comprising a computer readable form to the coordinates contained in Table A.

[0100] The present invention further provides a binding site in RORβ-LBD for_an RORβ-LBD agonist or antagonist ligand as well as methods for designing or selecting agonists, antagonist and/or a selective RORβ receptor modulator (SRORM) of ROR using information about the crystal structures disclosed herein.

[0101] The present invention also provides a method in order to crystallize orphan receptors, which permits the determination of the ligand-binding pocket, important for the discovery of agonists and antagonists.

BRIEF DESCRIPTION OF THE DRAWING

[0102]FIG. 1—Stearate

[0103]FIG. 2—Nucleotide and polypeptide sequences of rat RORβ LBD.

[0104]FIG. 3—Sequence of the rat RORβ LBD as cloned, with the secondary structural elements boxed (α helices) or drawn with an arrow (β strands). Sequences of human RORβ LBD, mouse RORα LBD, human RORα LBD, mouse RORγ LBD and human RORγ LBD are also given.

[0105] For comparison, the aligned sequence of human RARγ LBD, which was used in order to solve the crystallographic structure is given. Residues involved in stearate binding in the case of RORβ or in trans retinoic acid in the case of human RARγ binding are in bold. Residues within a 4 Å cut-off are surrounded by a cercle.

[0106]FIG. 4—Ribbon style drawing of the RORβ LBD and the co-activator peptide. The ligand stearate is shown as a ball-and-stick figure

[0107]FIG. 5—Difference (2Fo-Fc) electron density (1σ).

[0108]FIG. 6: Detail of the hydrogen bond network formed with the ATRA carboxylate group.

[0109]FIG. 7: Superposition of stearate and ATRA in the RORβ LBD pocket.

[0110]FIG. 8: binding and transactivation assays for all-trans retinoic acid

DETAILED DESCRIPTION OF THE INVENTION

[0111] The first crystal structure of the RORβ ligand-binding domain (RORβ-LBD) has been determined to 1.9 Å resolution. Crystals of rat RORβ-LBD were grown from crystallizing solutions containing 0.1 M TrisHCl pH=8.0 and PEG 6000 15%. X-ray diffraction patterns from the crystals have the symmetry and systematic absences of the orthorhombic space group P212121 with unit cell dimensions a=52.302 Å b=58.490 Å and c=106.036 Å and one molecule per asymmetric unit (Mathews Volume=2,57 Å³Da⁻¹). The structure was determined by the method of molecular replacement using the structure of the retinoic acid (RARγ-LBD) as the search model.

[0112] The complex of RORβ-LBD with sterarate and the co-activator peptide shows the mode of binding of the ligand to the orphan receptor in the agonist conformation.

[0113] The following abbreviations are used throughout the application:

[0114] A=Ala=Alanine

[0115] V=Val=Valine

[0116] L=Leu=Leucine

[0117] I=Ile=Isoleucine

[0118] P=Pro=Proline

[0119] F=Phe=Phenylalanine

[0120] W=Trp=Tryptophane

[0121] M=Met=Methionine

[0122] G=Gly=Glycine

[0123] S=Ser=Serine

[0124] T=Thr=Threonine

[0125] C=Cys=Cysteine

[0126] Y=Tyr=Tyrosine

[0127] N=Asn=Asparagine

[0128] Q=Gln=Glutamine

[0129] D=Asp=Aspartic acid

[0130] E=Glu=Glutamic acid

[0131] K=Lys=Lysine

[0132] R=Arg=Arginine

[0133] H=His=Histidine

[0134] “Atom type” refers to the element whose coordinates have been determined. Elements are defined by the first letter in the column.

[0135] “X, Y, Z” crystallographically define the atomic position determined for each atom.

[0136] “B” is a thermal factor that measures movement of the atom around its atomic center.

[0137] “Occ” is an occupancy factor that refers to the fraction of the molecules in which each atom occupies the position specified by the coordinates. A value of “1” indicates that each atom has the same conformation, i.e., the same position, in all molecules of the crystal.

[0138] Additional definitions are set forth in the specification where necessary.

[0139] The RORβ receptor described herein is intended to include any polypeptide which has the activity of the naturally occuring RORβ. The RORβ and RORβ-LBD contemplated herein includes all vertebrate and mammalian forms such as rat, mouse, pig, goat, horse, guinea pig, rabbit, monkey, orangutan and human. Such terms also include polypeptides that differ from naturally occuring forms of RORβ and RORβ-LBD by having amino acid deletions, substitutions, and additions, but which retain the activity of RORβ and RORβ-LBD, respectively. The crystal structure of the invention preferably contains at least 25%, more preferably at least 50%, more preferably at least 75%, more preferably at least 90%, more preferably at least 95%, more preferably at least 99%, and more preferably all of the coordinates listed in Table A. The crystal of the RORβ-LBD/RORβ-LBD-ligand/RORβ-LBD-ligand-peptide of the invention preferably has the following unit cell dimensions in angstroms: a=52.302 Å b=58.490 Å and c=106.036 Å and an orthorhombic space group P212121.

[0140] This includes both agonists or activators and antagonist or inhibitors of the RORβ-LBD.

[0141] The peptides referred to herein (e.g., RORβ, RORβ-LBD, and the like) may be produced by any well-known method, including synthetic method, such as solid phase, liquid phase and combination solid/liquid phase syntheses; recombinant DNA methods, including cDNA cloning, optionally combined with site directed mutagenesis; and/or purification of the natural products, optionally combined with enzymatic cleavage methods to produce fragments of naturally occuring proteins.

[0142] Advantageously, the crystallizable compositions provided by this invention are amenable to x-ray crystallography. Thus, this invention also provides the three-dimensional structure of the RORβ-LBD/RORβ-LBD ligand peptide complex, particularly the complex of rat RORβ-LBD with stearic acid.

[0143] The three-dimensional structure of the RORβ-LBD/ligand complex of this invention is defined by a set of structure coordinates as set forth in Table A. The term “structure coordinates” refers to Cartesian coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of a RORβ/stearate/peptide complex in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are then used to establish the positions of the individual atoms of the complex.

[0144] Those of skill in the art will understand that a set of structure coordinates for a receptor or receptor/ligand, or receptor/ligand/peptide complex or a portion thereof, is a relative set of points that define a shape in three dimensions. Thus, it is possible that an entirely different set of coordinates could define a similar or identical shape. Moreover, slight variations in the individual coordinates will have little effect on overall shape.

[0145] The variations in coordinates discussed above may be generated because of mathematical manipulations of the structure coordinates. For example, the structure coordinates set forth in Table A could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates; integer additions or substractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above.

[0146] Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal could also account for variations in structure coordinates. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be the same.

[0147] Various computational analyses are therefore necessary to determine whether a molecule or molecular complex or a portion thereof is sufficiently similar to all or parts of the RORβ receptor/stearate described above as to be considered the same. Such analyses may be carried out in current software applications, such as the Molecular Similarity application of Quanta (Molecular Simulations Inc., San Diego, Calif.) version 4.1, and as described in the accompanying User's Guide.

[0148] The Molecular Similarity application permits comparisons between different structures, different conformations of the same structure, and different parts of the same structure. The procedure used in Molecular Similarity to compare structures is divided into four steps: 1) load the structures to be compared.; 2) define the atom equivalences in these structures; 3) perform a fitting operation; and 4) analyze the results.

[0149] Each structure is identified by a name. One structure is identified as the target (i.e., the fixed structure); all remaining structures are working structures (i.e., moving structures). Since atom equivalency within QUANTA is defined by user input, for the purpose of this invention we will define equivalent atoms as protein backbone atoms (N, Cα, C and O) for all conserved residues between the two structures being compared. We will also consider only rigid fitting operations.

[0150] When a rigid fitting method is used, the working structure is translated and rotated to obtain an optimum fit with the target structure. The fitting operation uses an algorithm that computes the optimum translation and rotation to be applied to the moving structure, such that the root mean square difference of the fit over the specified pairs of equivalent atom is an absolute minimum. This number, given in angstroms, is reported by QUANTA.

[0151] For the purpose of this invention, any molecule or molecular complex that has a root mean square deviation of conserved residue backbone atoms (N, Cα, C, O) of less than 1.5 Å when superimposed on the relevant backbone atoms described by structure coordinates listed in Table A are considered identical. More preferably, the root mean square deviation is less than 1 Å. In a preferred embodiment of the present invention, the molecule or molecular complex comprises at least a portion of the ligand binding site defined by structure coordinates of RORβ-LBD amino acids Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, and Y446 according to Table A, or a mutant or homologue of said molecule or molecular complex. For purposes of the present invention, by “at least a portion of it” it is meant all or any parts of the ligand-binding site defined by these structure coordinates. More preferred are molecules or molecular complexes comprising all or any parts of the ligand-binding site defined by structure coordinates of RORβ-LBD amino acids Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, and Y446 according to Table A, or a mutant or homologue of said molecule or molecular complex. By mutant or homologue of the molecule or molecular complex it is meant a molecule or molecular complex having a binding pocket that has a root mean square deviation from the backbone atoms of said RORβ-LBD amino acids of not more than 1.5 Angstroms.

[0152] The term “root mean square deviation” means the square root of the arithmetic mean of the squares of deviations from the mean. It is a way to express the deviation or variation from a trend or object. For purposes of this invention, the “root mean square deviation” defines the variation in the backbone of a protein or protein complex from the relevant portion of the backbone of the RORβ portion of the complex as defined by the structure coordinates described herein. Once the structure coordinates of a protein crystal have been determined they are useful in solving the structures of other crystals or in modelling by homology other proteins particularly the two isotypes RORα and γ.

[0153] Thus, in accordance with the present invention, the structure coordinates of a RORβ/stearate/peptide complex, and in particular a complex, and portions thereof is stored in a machine-readable storage medium. Such data may be used for a variety of purposes, such as drug discovery and x-ray crystallographic analysis or protein crystal.

[0154] Accordingly, in one embodiment of this invention is provided a machine-readable data storage medium comprising a data storage material encoded with the structure coordinates set forth in Table A.

[0155] For the first time, the present invention permits the use of structure-based or rational drug design techniques to design, select, and synthesize chemical entities, including inhibitory and stimulatory compounds that are capable of binding to RORβ-LBD, or any portion thereof.

[0156] One particularly useful drug design technique enabled by this invention is iterative drug design. Iterative drug design is a method for optimizing associations between a protein and a compound by determining and evaluating the three-dimensional structures of successive sets of protein/compound complexes.

[0157] Those of skill in the art will realize that association of natural ligands or substrates with the binding pockets of their corresponding receptors or enzymes in the basis of many biological mechanisms of action. The term “binding pocket” as used herein, refers to a region of a molecule or molecular complex, that, as a result of its shape, favorably associates with another chemical entity or compound. Similarly, many drugs exert their biological effects through association with the binding pockets of receptors and enzymes. Such associations may occur with all or any parts of the binding pockets. An understanding of such associations will help lead to the design of drugs having more favorable associations with their target receptor, and thus, improved biological effects. Therefore, this information is valuable in designing potential ligands or inhibitors of receptors, such as inhibitors of RORβ.

[0158] The term “associating with” refers to a condition of proximity between chemical entities or compounds or portions thereof. The association may be non-covalent—wherein the juxtaposition is energetically favored by hydrogen bonding or van der Waals or electrostatic interactions—or it may be covalent.

[0159] In iterative drug design, crystals of a series of protein/compound complexes are obtained and then the three-dimensional structures of each complex is solved. Such an approach provides insight into the association between the proteins and compounds of each complex. This is accomplished by selecting compounds with inhibitory activity, obtaining crystals of this new protein/compound complex, solving the three dimensional structure of the complex, and comparing the associations between the new protein/compound complex and previously solved protein/compound complexes. By observing how changes in the compound affected the protein/compound associations, these associations may be optimized.

[0160] In some cases, iterative drug design is carried out by forming successive protein-compound complexes and then crystallizing each new complex. Alternatively, a preformed protein crystal is soaked in the presence of an inhibitor, thereby forming a protein/compound complex and obviating the need to crystallize each individual protein/compound complex.

[0161] As used herein, the term “soaked” refers to a process in which the crystal is transferred to a solution containing the compound of interest.

[0162] The structure coordinates set forth in Table A can also be used to aid in obtaining structural information about another crystallized molecule or molecular complex. This may be achieved by any of a number of well-known techniques, including molecular replacement.

[0163] The structure coordinates set forth in Table A can also be used for determining at least a portion of the three-dimensional structure of molecules or molecular complexes which contain at least some structurally similar features to RORβ. In particular, structural information about another crystallized molecule or molecular complex may be obtained. This may be achieved by any of a number of well-known techniques, including molecular replacement.

[0164] Therefore, in another embodiment this invention provides a method of utilizing molecular replacement to obtain structural information about a crystallized molecule or molecular complex whose structure is unknown comprising the steps of:

[0165] a) generating an X-ray diffraction pattern from said crystallized molecule or molecular complex,

[0166] b) applying at least a portion of the structure coordinates set forth in Table A to the X-ray diffraction pattern to generate a three-dimensional electron density map of the molecule or molecular complex whose structure is unknown; and

[0167] c) using all or a portion of the structure coordinates set forth in Table A to generate homology models of RORβ-LBD or any other nuclear orphan or hormone receptor ligand-binding domain.

[0168] By using molecular replacement, all or part of the structure coordinates of the RORβ-LBD/RORβ-LBD-ligand/RORβ-LBD-ligand-peptide complex provided by this invention or molecular complex whose structure is unknown more quickly and efficiently than attempting to determine such information ab initio.

[0169] Molecular replacement provides an accurate estimation of the phases for an unknown structure. Phases are factors in equations used to solve crystal structures that cannot be determined directly. Obtaining accurate values for the phases, by methods other than molecular replacement, is a time-consuming process that involves iterative cycles of approximations and refinements and greatly hinders the solution of crystal structures. However, when the crystal structure of a protein containing at least a homologous portion has been solved, the phases from the known structure provide a satisfactory estimate of the phases for the unknown structure.

[0170] Thus, this method involves generating a preliminary model of a molecule or molecular complex whose structure coordinates are unknown, by orienting and positioning the relevant portion of the RORβ-LBD/RORβ-LBD ligand complex according to Table A within the unit cell of the crystal of the unknown molecule or molecular complex so as best to account for the observed X-ray diffraction pattern of the crystal of the molecule or molecular complex whose structure is unknown. Phases can then be calculated from this model and combined with the observed X-ray diffraction pattern amplitudes to generate an electron density map of the structure whose coordinates are unknown. This, in turn, can be subjected to any well-known model building and structure refinement techniques to provide a final, accurate structure of the unknown crystallized molecule or molecular complex [E. Lattman, “Use of the Rotation and Translation Functions”, in Meth. Enzymol., 115, pp55-77 (1985); M. G. Rossmann, ed., “The Molecular Replacement Method”, Int. Sci. Rev. Set., No 13, Gordon & Breach, New York (1972)].

[0171] The structure of any portion of any crystallized molecule or molecular complex that is sufficiently homologous to any portion of the RORβ-LBD/RORβ-LBD ligand complex can be solved by this method.

[0172] The structure coordinates are also particularly useful to solve the structure of crystals of RORβ-LBD/RORβ-LBD ligand or RORβ-LBD ligand peptide co-complexed with a variety of chemical entities. This approach enables the determination of the optimal sites for interaction between chemical entities, including interaction of candidate RORβ inhibitors with the complex. For example, high resolution X-ray diffraction data collected from crystals exposed to different types of solvent allows the determination of where each type of solvent molecule resides. Small molecules that bind tightly to theses sites can then be designed and synthesized and tested for their RORβ inhibition activity.

[0173] All of the complexes referred to above may be studied using well-known X-ray difraction techniques and may be refined versus 1.5-3 Å resolution X-ray data to an R-value of about 0.20 or less using computer software, such as X-PLOR [Yale University, 1992, distributed by Molecular Simulations, Inc.; see, e.g., Blundell & Johnson, supra; Meth. Enzymol., vol. 114 & 115, H. W. Wyckoff et al., eds., Academic Press (1985)]. This information may thus be used to optimize known RORβ agonists/antagonists, and more importantly, to design new RORβ agonists/antagonists.

[0174] Accordingly, the present invention is also directed to a binding site in RORβ-LBD agonist or antagonist ligand in which a portion of RORβ-LBD ligand is in van der Waals contact or hydrogen bonding contact with at least one of the following residues: Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, and Y446 of RORβ-LBD. For purposes of this invention, by RORβ-LBD binding site it is also meant to include mutants or homologues thereof. In a preferred embodiment, the mutants or homologues have at least 25% identity, more preferably 50% identity, more preferably 75% identity, and most preferably 95% identity to residues Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, and Y446 of RORβ-LBD binding sites.

[0175] The present invention is also directed to a machine readable data storage medium, comprising a data storage material encoded with machine readable data, wherein the data is defined by the structure coordinates of an RORβ-LBD/RORβ-LBD ligand according to Table A or a homologue of said complex, wherein said homologue comprises backbone atom that have a root mean square deviation from the backbone atoms of the complex of not more than 3.0 Å. Preferably, the machine readable data storage medium, according to the invention, is wherein said molecule or molecular complex is defined by the set of structure coordinates for RORβ-LBD/RORβ-LBD ligand according to Table A, or a homologue of said molecule or molecular complex, said homologue having a root mean square deviation from the backbone atoms of said aminoacids of not more than 2.0 Å. In a preferred embodiment the machine readable data storage medium comprises a data storage medium comprising a data storage material encoded with a first set of machine readable data comprising a Fourier transform of at least a portion of the structural coordinates for a RORβ-LBD/RORβ-LBD ligand/RORβ-LBD ligand peptide according to Table A; which, when combined with a second set of machine readable data comprising an X-ray diffraction-pattern of a molecule or molecular complex of unknown structure, using a machine programmed with instructions for using said first set of data and said second set of data, can determine at least a portion of the structure coordinates corresponding to the second set of machine readable data, said first set of data and said second set of data.

[0176] The present invention also provides for computational methods using three dimensional models of the RORβ receptor that are based on crystals of RORβ-LBD/RORβ-LBD ligand complex. Generally the computational method of designing an RORβ ligand determines which amino acid or amino acids of the RORβ-LBD interact with a chemical moiety (at least one) of the ligand using a three dimensional model of a crystallized protein comprising the RORβ-LBD with a bound ligand, and selecting a chemical modification (at least one) of the chemical moiety to produce a second chemical moiety with a structure that either decreases or increases an interaction between the interacting amino acid and the second chemical moiety compared to the interaction between the interacting amino acid and the corresponding chemical moiety on the natural hormone.

[0177] The computational methods of the present invention are for designing RORβ synthetic ligands using such crystal and three dimensional structural information to generate synthetic ligands that modulate the conformational changes of the RORβ LBD. These computational methods are particularly useful in designing an antagonist or partial agonist to the RORβ, wherein the antagonist or partial agonist has an extended moiety that prevents any one of a number of ligand-induced molecular events that alter the receptor's influence on the regulation of gene expression, such as preventing the normal coordination of the activation domain observed for a naturally occuring ligand or other ligands that mimic the naturally occuring ligand, such as an agonist. As described herein, synthetic ligands of the RORβ receptor will be useful in modulating RORβ activity in a variety of medical conditions.

[0178] RORβ is known to comprise various domains as follows:

[0179] 1) a variable amino-terminal domain;

[0180] 2) a highly conserved DNA-binding domain (DBD); and

[0181] 3) a less conserved carboxyl-terminal ligand-binding domain (LBD).

[0182] This modularity permits different domains of each protein to separately accomplish different functions, although the domains can influence each other. The separate function of a domain is usually preserved when a particular domain is isolated from the remainder of the protein. Using conventional protein chemistry techniques a modular domain can sometimes be separated from the parent protein. Using conventional molecular biology techniques each domain can usually be separately expressed with its original function intact or chimeraes of two different nuclear receptors can be constructed, wherein the chimerae retain the properties of the individual functional domains of the respective nuclear receptors from which the chimerae were generated.

[0183] Amino-Terminal Domain

[0184] The amino-terminal domain is the least conserved of the three domains. This domain is involved in transcriptional activation and in some cases its uniqueness may dictate selective receptor-DNA binding and activation of target genes by specific receptors isoforms. This domain can display synergistic and antagonistic interactions with the domains of the LBD. For example, studies with mutated and/or deleted receptors show positive cooperativity of the amino and carboxy terminal domains.

[0185] In some cases, deletion of either of these domains will abolish the receptor's transcriptional activation functions.

[0186] DNA-Binding Domain

[0187] The DBD is the most conserved domain. The DBD contains two perpendicularly oriented α-helices that extend from the base of the first and second zinc fingers. The two zinc fingers function in concert along with non-zinc finger residues to direct nuclear receptors to specific target sites on DNA and to align receptor homodimer to heterodimer interfaces. Various amino acids in DBD influence spacing between two half sites for receptor dimer binding.

[0188] Ligand-Binding Domain

[0189] The LBD is the second most highly conserved domain. Whereas integrity of several different LBD sub-domains is important for ligand binding, truncated molecules containing only the LBD retain normal ligand-binding activity. This domain also participates in other functions, including dimerization, nuclear translocation and transcriptional activation. Importantly, this domain binds the ligand and undergoes ligand-induced conformational changes as detailed herein.

[0190] As described herein, the LBD of RORβ can be expressed, crystallized, its three dimensional structure determined with a ligand bound (either using crystal data from the same receptor or a different receptor, or a combination thereof), and computational methods used to design ligands to its LBD, particularly ligands that contain an extension moiety that coordinates the activation domain of RORβ.

[0191] Once a computationaly designed ligand (CDL) is synthesized, it can be tested using assays to establish its activity as an agonist, partial agonist or antagonist, and affinity, as described herein. After such testing, the CDLs can be further refined by generating LBD crystals with a CDL bound to the LBD. The structure of the CDL can then be further refined using the chemical modification methods described herein for three dimensional models to improve the activity or affinity of the CDL and make a second generation CDLs with improved properties, such as that of a super agonist or antagonist.

[0192] Typically RORβ-LBD is purified to homogeneity for crystallisation. Purity of RORβ-LBD is measured with SDS-PAGE and mass spectrometry. The purified RORβ for crystallization should be at least 97.5% pure or 97.5% pure, preferably at least 99.0% pure or 99.0% pure, more preferably at least 99.5% pure or 99.5% pure.

[0193] Initially purification of the receptor can be obtained by conventional techniques, such as affinity chromatography and gel filtration chromatography.

[0194] To achieve higher purification for improved crystals of RORβ, it will be desirable to ligand shift purify the nuclear receptor using a column that separates the receptor according to charge, such as an ion exchange or hydrophobic interaction column, and then bind the eluted receptor with a ligand, especially an agonist. The ligand induces a change in the receptor's surface charge such that when rechromatographed on the same column, the receptor then elutes at the position of the liganded receptor and is removed by the original column run with the unliganded receptor. Usually saturating concentrations of ligand are used in the column and the protein can be preincubated with the ligand prior to passing it over the column.

[0195] Some developed methods involve engineering a “tag” such as with histidine placed on the end of the protein, such as on the amino terminus, and then using a cobalt chelation column for purification, Chaga, G., Biotech. Appl. Biochem. 29: 13811-13814 (1991) incorporated by reference.

[0196] To determine the three dimensional structure of a RORβ-LBD, it is desirable to co-crystallize the LBD with a corresponding LBD ligand.

[0197] Typically purified RORβ-LBD is equilibrated at a saturating concentration of ligand at a temperature that preserves the integrity of the protein. Ligand equilibration can be established between 2 and 37° C., although the receptor tends to be more stable in the 2-20° C. range.

[0198] However if the ligand is unknown it is possible to co-crystallize the RORβ-LBD with a fortuitous ligand coming from the heterologous expression system i.e. Escherichia coli and by adding concomitantly a co-activator peptide.

[0199] Preferably crystals are made with the hanging drop methods. Regulated temperature control is desirable to improve crystal stability and quality. Temperatures between 4 and 25° C. are generally used and it is often preferable to test crystallization over a range of temperatures. It is preferable to use crystallization temperatures from 18° C. to 25° C., more preferably 20 to 23° C., and most preferably 22° C.

[0200] Ligands that interact with RORβ can act as agonists, antagonists and partial agonists based on what ligand-induced conformational changes take place.

[0201] Agonists induce changes in receptors that place them in an active conformation that allows them to influence transcription, either positively or negatively. There may be several different ligand induced changes in the receptor's conformation.

[0202] Antagonists, bind to receptors, but fail to induce conformational changes that leads to the receptor's transcriptionally active form or physiologically relevant conformations. Binding of an antagonist can also block the binding and therefore the actions of an agonist.

[0203] Partial agonists bind to receptors and induce only part of the changes in the receptors that are induced by agonists. The differences can be qualitative or quantitative. Thus, a partial agonist may induce some of the conformation changes induced by agonists, but not others, or it may only induce certain changes to a limited extent.

[0204] As described herein, the unliganded receptor is in a configuration that is either inactive, has some activity or has repressor activity. Binding of agonist ligands induces conformational changes in the receptor such that the receptor becomes more active, either to stimulate or repress the expression of the genes. The receptors may also have non-genomic actions, some of the known types of changes and/or the sequences of these are listed herein.

[0205] Ligand binding by the receptor is a dynamic process, which regulates receptor function by inducing an altered conformation.

[0206] The three-dimensional structure of the liganded RORβ receptor will greatly aid in the development of new RORβ synthetic ligands. In addition, RORβ is overall well suited to modern methods including three dimensional structure elucidation and combinatorial chemistry such as those disclosed in EP 335 628, U.S. Pat. No. 5,463,564, which are incorporated herein by reference. Computer programs that use crystallographic data when practising the present invention will enable the rational design of ligand to RORβ.

[0207] Programs such as RASMOL can be used with the atomic coordinates from crystals generated by practicing the invention or used to practice the invention by generating three dimensional models and/or determining the structures involved in ligand binding. Computer program such as INSIGHT and GRASP allow further manipulation and the ability to introduce new structures. In addition, high throughput binding and bioactivity assays can be devised using purified recombinant protein and modern reporter gene transcription assays described herein and known in the art in order to refine the activity of a CDL.

[0208] Generally, the computational method of designing a RORβ synthetic ligand comprises two steps:

[0209] 1) determining which amino acid or amino acids of RORβ-LBD interacts with a first chemical moiety (at least one) of the ligand using a three dimensional model of a crystallized protein comprising an RORβ-LBD with a bound ligand; and

[0210] 2) selecting a chemical modifications (at least one) of the first chemical moiety to produce a second chemical moiety with a structure to either increase or decrease an interaction between the interacting amino acid and the second chemical moiety compared to the interaction between the interacting amino acid and the first chemical moiety.

[0211] Preferably the method is carried out wherein said three dimensional model is generated by comparing isomorphous ligand derivatives to produce improved phasing. Also preferred is wherein said selecting uses said first chemical moiety that interacts with at least one of the interacting amino acids_Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423 or Y446.

[0212] As shown herein, interacting amino acids form contacts with the ligand and the center of the atoms of the interacting amino acids are usually 2 to 4 angstroms away from the center of the atoms of the ligand. Generally these distances are determined by computer as discussed herein and in Mc Ree 1993, however distances can be determined manually once the three dimensional model is made. See also Renaud et al., Nature 378, 681-689 (1995) for stereochemical figures of three dimensional models.

[0213] More commonly, the atoms of the ligand and the atoms of interacting amino acids are 3 to 4 angstroms apart. The invention can be practiced by repeating step 1 and 2 to refine the fit of the ligand to the LBD and to determine a better ligand, such as an agonist. The three dimensional model of RORβ can be represented in two dimensions to determine which amino acids contact the ligand and to select a position on the ligand for chemical modification and changing the interaction with a particular amino acid compared to that before chemical modification. The chemical modification may be made using a computer, manually using a two dimensional representation of the three dimensional model or by chemically synthesizing the ligand. The ligand can also interact with distant amino acids after chemical modification of the ligand to create a new ligand. Distant amino acids are generally not in contact with the ligand before chemical modification. A chemical modification can change the structure of the ligand to make a new ligand that interacts with a distant amino acid usually at least 4.5 angstroms away from the ligand, preferably wherein said first chemical moiety is 6 to 12 angstroms away from a distant amino acid. Often distant amino acids will not line the surface of the binding activity for the ligand, they are too far away from the ligand to be part of a pocket or binding cavity. The interaction between a LBD amino acid and an atom of an LBD ligand can be made by any force or attraction described in nature. Usually the interaction between the atom of the amino acid and the ligand will be the result of a hydrogen bonding interaction, charge interaction, hydrophobic interaction, van der Waals interaction or dipole interaction. In the case of the hydrophobic interaction it is recognized that is not a per se interaction between the amino acid and ligand, but rather the usual result, in part, of the repulsion of water or other hydrophilic group from a hydrophobic surface. Reducing or enhancing the interaction of the LBD and a ligand can be measured by calculating or testing binding energies, computationally or using thermodynamic or kinetic methods as known in the art.

[0214] Chemical modifications will often enhance or reduce interactions of an atom of a LBD amino acid and an atom of an LBD ligand. Steric hindrance will be a common means of changing the interaction of the LBD cavity with the activation domain.

[0215] The present invention also provides methods for identifying compounds that modulates RORβ activity. Various methods or combination thereof can be used to identify these compounds. For example, test compounds can be modeled that fit spatially into the RORβ-LBD as defined by structure coordinates according to Table A, or using a three-dimensional structural model of RORβ-LBD, mutant RORβ-LBD, or RORβ-LBD homolog or portion thereof. Structure coordinates of the ligand binding site, in particular amino acids Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, or Y446 can also be used to identify structural and chemical features. Identified structural or chemical features can then be employed to design or select compounds as potential RORβ modulators. By structural and chemical features it is meant to include, but is not limited to, van der Waals interactions, hydrogen bonding interactions, charge interaction, hydrophobic bonding interaction, charge interaction, hydrophobic interaction and dipole interaction. Alternatively, or in conjunction, the three-dimensional structural model or the ligand binding site can be employed to design or select compounds as potential RORβ modulators. Compounds identified as potential RORβ modulators can then be synthesized and screened in an assay characterized by binding of a test compound to the RORβ-LBD. Examples of assays useful in screening of potential ROR modulators include, but are not limited to screening in silico, in vitro assays and high throughput assays. Finally, these methods may also involve modifying or replacing one or more amino acids from RORβ-LBD such as Q228, Y229, L234, W259, Q261, C262, A263, Q265, I266, H268, A269, L299, V303, L304, R306, M307, R309, A310, V318, L319, F320, E321, M329, F330, L333, L338, I339, A342, F343, V419, C420, H423, or Y446 of RORβ-LBD according to Table A.

[0216] A preferred method of the invention can be described as a computational method of designing an ROR antagonist from an ROR receptor agonist comprising:

[0217] 1) determining a structure of a molecular recognition domain of said agonist using a three dimensional model of a crystallized protein comprising an RORLBD, and

[0218] 2) selecting at least one chemical modification of said agonist that provides a ligand structure that extends beyond a binding site for said agonist and in the direction of at least one protein domain important in RORβ biological function.

[0219] Another preferred method of the invention can be described as a computational method of designing a selective RORβ receptor modulator such as a ROR receptor super agonist or antagonist comprising:

[0220] 1) determining at least one interacting amino acid of an RORβ-LBD that interacts with at least one first chemical moiety of said ligand using a three dimensional model of a crystallized protein comprising RORβ-LBD with a bound ligand, and

[0221] 2) selecting at least one chemical modification of said first chemical moiety to produce a second chemical moiety with a structure to reduce or enhance an interaction between said interacting amino acid and said second chemical moiety compared to said interaction between said interacting amino acid and said first chemical moiety.

[0222] However, as will be understood by those of skill in the art upon this disclosure, other structure based design methods can be used. Various computational structure based design methods have been disclosed in the art.

[0223] For example, a number computer modeling systems are available in which the sequence of the RORβ-LBD and the RORβ-LBD structure (i.e., atomic coordinates of RORβ-LBD and/or the atomic coordinates of the ligand binding site, the bond and dihedral angles, and distances between atoms in the active site such as provided in Table A) can be input. This computer system then generates the structural details of the site in which a potential RORβ modulator binds so that complementary structural details of the potential modulators can be determined. Design in these modeling systems is generally based upon the compound being capable of physically and structurally associating with RORβ-LBD. In addition, the compound must be able to assume a conformation that allows it to associate with RORβ-LBD. Some modeling systems estimate the potential inhibitory or binding effect of a potential ROR modulator prior to actual synthesis and testing.

[0224] Methods for screening chemical entities or fragments for their ability to associate with RORβ-LBD are also well known. Often these methods begin by visual inspection of the active site on the computer screen. Selected fragments or chemical entities are then positioned with the RORβ-LBD. Docking is accomplished using software such as QUANTA and SYBYL, following by energy minimization and molecular dynamics with standard molecular mechanic forcefields such as CHARMM and AMBER. Examples of computer programs which assist in the selection of chemical fragment or chemical entities useful in the present invention include, but are not limited to, GRID (Goodford, P. J. J. Med. Chem. 1985 28: 849-857), AUTODOCK (Goodsell, D. S. and Olsen, A. J. Proteins, Structure, Functions, and Genetics 1990 8: 195-202), and DOCK (Kunts et al. J. Mol. Biol. 1982 161:269-288).

[0225] Upon selection of preferred chemical entities or fragments, their relationship to each other and RORβ-LBD can be visualized and then assembled into a single potential modulator. Programs useful in assembing the individual chemical entities include, but are not limited to CAVEAT (Bartlett et al. Molecular Recognition in Chemical and Biological Problems Special Publication, Royal Chem. Soc. 78, 00. 182-196 (1989) and 3D Database systems (Martin, Y. C. J. Med. Chem. 1992 35:2145-2154).

[0226] Alternatively, compounds may be designed de novo using either an empty active site or optionaly including some portion of a known inhibitor. Methods of this type of design include, but are not limited to LUDI (Bohm H-J, J. Comp. Aid. Molec. Design 1992 6:61-78) and LeapFrog (Tripos Associates, St. Louis Mo.).

[0227] The present invention is also directed to a RORβ-LBD selective RORβ modulator (SRORM), in particular an agonist or antagonist, identified by a computational process of the invention.

[0228] The present invention is further directed to a method for treating a ROR related disease comprising administering an effective amount of an antagonist identified by a computational process of the invention.

[0229] The present invention is also direct to a method for treating a ROR related disease comprising administering an effective amount of an agonist identified by a computational process of the invention.

[0230] Compounds identified as agonists, antagonists or SRORMs by the methods disclosed herein which are active when given orally can be formulated as liquids for example syrups, suspensions or emulsions, tablets, capsules and lozenges. A liquid composition will generally consist of a suspension or solution of the compound in a suitable liquid carrier(s), for example ethanol, glycerin, sorbitol, non-aqueous solvent such as polyethlene glycol, oils or water, with a suspending agent, preservative, surfactant, wetting agent, flavoring or coloring agent.

[0231] Alternatively, a liquid formulation can be prepared from a reconstitutable powder. For example a powder containing active compound, suspending agent, sucrose and a sweetener can be reconstituted with water to form a suspension; a syrup can be prepared from a powder containing active ingredient, sucrose and a sweetener. A composition in the form of a tablet can be prepared from a powder containing active ingredient, sucrose and a sweetener. A composition in the form of a tablet can be prepared using any suitable pharmaceutical carrier(s) routinely used for preparing solid compositions. Examples of such carriers include magnesium stearate, starch, lactose, sucrose, microcrystalline cellulose, binders, for example polyvinylpyrrolidone. The tablet can also be provided with a color film coating, or color included as part of the carrier(s). In addition, active compound can be formulated in a controlled release dosage form as a tablet comprising a hydrophilic or hydrophobic matrix. A composition in the form of a capsule can be prepared using routine encapsulation procedures, for example by incorporation of active compound and excipients into a hard gelatin capsule. Alternatively, a semi-solid matrix of active compound and high molecular weight polyethylene glycol can be prepared and filled into a hard gelatin capsule; or a solution of active compound in polyethylene glycol or a suspension in edible oil, for example liquid paraffin or fractionated coconut oil can be prepared and filled into a soft gelatin capsule. Compounds identified by the processes described herein which are active when given parenterally can be formulated for intramuscular or intravenous administration. A typical composition for intra-muscular administration will consist of a suspension or solution of active ingredient in an oil, for example arachis oil or sesame oil. A typical composition for intravenous administration will consist of a sterile isotonic aqueous solution containing, for example active ingredient, dextrose, sodium chloride, a co-solvent, for example polyethylene glycol and, optionally, a chelating agent, for example, sodium metabisulphite.

[0232] Alternatively, the solution can be freeze dried and then reconstituted with a suitable solvent just prior to administration. Identified compounds which are active on rectal administration can be formulated as suppositories. A typical suppository formulation will generally consist of active ingredient with a binding and/or lubricating agent such as a gelatin or cocoa butter or other low melting vegetable or synthetic wax or fat. Identified compounds which are active on topical administration can be formulated as transdermal compositions. Such compositions include, for example, a backing, active compound reservoir, a control membrane, liner and contact adhesive. The typical daily dose of a varies according to individual needs, the condition to be treated and with the route of administration. Suitable doses are in the general range of 0.001 to 10 mg/kg bodyweight of the recipient per day.

[0233] The following examples are to illustrate the invention, but should not be interpreted as a limitation thereon.

EXAMPLES Cloning, Expression and Purification of the RORβ Ligand-Binding Domain

[0234] A cDNA for expression of the ligand-binding domain of the rat RORβ-LBD (RORβ-LBD) was constructed using the pet15b vector (Novagen) to include an N-terminal polyhistidine tag and a thrombin cleavage site. E. coli BL21 (DE3) cells were grown in LBM at 37° C. to an OD 0.6 and induced with 0.8 mM IPTG. The incubation was maintained at 16° C. overnight. Cells were harvested and stored at −20° C. A total of 6-9 mg of recombinant RORβ-LBD was isolated from a 6 gram cell pellet following sonication and chromatography on a cobalt-chelate resin. Polyhistidine-tagged RORβ-LBD of approximately 90% purity eluted in a gradient of 0 to 1M imidazole. Gel filtration was performed with a Superdex S-200 Hiload 16:60 from Pharmacia. Polyhistidine-tagged rRORβ-LBD of more than 95% purity and homogeneity as checked by SDS-PAGE was concentrated to 5.8 mg/ml in 20 mM TrisHCl pH=8.5, 5 mMDTT, 2 mM Chaps and 100 mM NaCl.

[0235] Crystallization

[0236] The RORβ-LBD stearate complex was crystallized at 22° C. by vapor diffusion in the hanging-drop mode. In the crystallisation trials, the protein was used without further purification and co-crystallized with a 3-molar excess of SRC-1⁶⁸⁶⁻⁷⁰⁰(RHKILHRLLQEGSPS) NR-interacting peptide co-activator sequence. Addition of the peptide was crucial to obtain crystals. In the initial trial to obtain crystallization conditions, a sparse matrix crystallization screen was done with a home screen. For each crystallization trial, a 4 μl drop was prepared by mixing 2 μl of purified protein (5.8 mg/ml) with an equal volume of reservoir solution. The reservoir contained 500 μl of the precipitating solution. A crystal measuring 110×60×30 mm at 22° C. in PEG 6000 15% and 100 mM Tris HCl at pH=8.0 grew within about 2 weeks. This crystal was used in a first data collection run (as described below).

[0237] Data Collection and Reduction

[0238] The crystals were cryoprotected by equilibration in 15% PEG 6000 at pH 8.0 containing 15% glycerol and then flash frozen in liquid ethane at liquid nitrogen temperature. X-ray diffraction data were collected at liquid nitrogen temperature from a single frozen crystal at the ID14-3 beamline at the ESRF Grenoble, France. Crystals diffracted Xrays to a resolution limit of 1.9 Å. All data were integrated and scaled using DENZO and SCALEPACK (Otwinowski and Minor, 1997). The data set between 30 and 3.4 Å shows a completeness of 88.9% resolution with an Rsym (I) of 2.5. The completeness on high resolution (between 3.4 and 1.9) was 99.8% with an Rsym (I) of 3.3. The unit cell parameters were a=52.302 Å b=58.490 Å and c=106.036 Å, a=b=c=90°. The crystal was composed by one monomer per asymetric unit, has a solvent content of 52%, and one molecule per asymmetric unit (Mathews Volume=2.57 Å³ Da⁻¹) The estimated B factor by Wilson plot is 29. Inspection of systematic absences along each axis indicated that the space group was orthorhombic P212121. TABLE 1 Data Collection and Processing Source Grenoble ID14-3 No of crytals 1 Wavelength 0.93100 Å Frames 331 ΔΦ 1° Crystal to plate distance 260 mm Time/frame 5 sec(low res); 20 sec (high res) Number of Observations 28846 Data Reduction Program HKL Unique reflections 26336 Reflections Used 26331 Resolution 30.0-1.9 Completeness 100 Multiplicity 1 Mosaicity 0.5 ^(a)Rsym 3.6% (15%) Space group P212121 a 52.302 Å b 58.490 Å c 106.036 Å Wilson B-value 28.78 Å²

[0239] In the data collection, the last shell values are presented between parentheses.

[0240] Structure Determination (Molecular Replacement)

[0241] The structure of the complex was solved by molecular replacement using the program AmoRe (Navaza, 1994) and the RARγ holo-LBD (Protein Data Bank accession code, 21bd) as a search model. The top solution had a correlation coefficient of 27.8 (next highest solution 26.2) and an R factor of 52.7 after AMoRe rigid-body refinement. A solution could also be found with RAR anta as a search model according to the following values: correlation coefficient of 21.4 (next highest solution 19.8) and an R factor of 55.9. TABLE 2 Molecular Replacement Statistics holo-RARγ Search Model: (PDB file 2LBD) Program used AMoRe Resolution Range 15-3.0 Å Number of Reflections 4338 Number of Atoms 2011 RF Correlation (first solution) 18.8 TF Correlation (first solution) 24.3 TF R-factor (first solution) 57.0 Rigid Body Correlation 26.0 Rigid Body R-factor 56.7

[0242] Structure Refinement

[0243] The automated model building Arp/wARP (Perrakis A. et al., 1999) combined with iterative structure refinement was used and permit us to obtain 3 chains constructed which correspond to 243 residues and a connectivity index of 0.98. The calculated electron density maps 3Fo-2Fc delivered Rcryst=0.2703 and a Rfree=0.2644.

[0244] A partial model of the monomer was build using the graphic program O (Jones et al., 1991) and subjected to alternating rounds of rigid body refinement with X-PLOR (Brünger, 1996) and manual building. The final steps, using cycles of positional refinement, manual rebuilding, the torsion slow-cool procedure from the program X-PLOR, and individual isotropic B factor refinement delivered Rcryst=0.2238 and a Rfree=0.2494. The final model refined at 1.9 Å, comprises 244 residues, one ligand, a peptide of 10 amino-acid residues, and 146 water molecules. According to Procheck (Laskowski et al., 1993) 93.2% of all residues in the model are in the most favoured main chain torsion angles Ramachandran regions, 5.9% in additional allowed regions, 0.4% in generously allowed regions and 0.4% are in disallowed regions. These last percentages corresponds to two residues (D403 and E404) situated in the loop 9-10, which did not present a well defined density. TABLE 3 Final Refinement Parameters Resolution Range 30.0-1.9 Reflections 26331 R-factor 22.4% R-free 24.9% # residues 201-452 (207) # atoms 1977 RMS deviations bond lengths 0.008 bond angles 1.282 Average B-factors Protein 29.5 Å² Stearate 47.9 Å² Water 39.8 Å²

[0245] Description of the Molecule

[0246] The structure of RORβ-LBD is complete from residues 208 through 451.

[0247] Analysis of the structure with program Procheck showed only minor exceptions to the allowed geometry. In the structure, the first seven residues of the chain (201-207) are not seen in the electron density map and are probably disordered. This leaves only one residue before the initial residue of the first α-helix (H1) in the wild-type structure. On the C-terminal end, only the last residue (452) is not seen in the electron density map. The loop between helices H9 and H10 (residues N399 and E405) is not well defined.

[0248] Folding and Packing

[0249] As expected, the RORβ-LBD has the same overall three-dimensional structure as those of the other nuclear hormone receptor LBDs. The molecule is folded into a “helical sandwich” consisting of 10 α-helices. There are two small pieces of beta strand, forming a short beta sheet located in the core of the molecule between helices 5 and 6 near the ligand binding site. Helix 12 is folded toward the ligand binding domain core. Its last turn comes in close contact to H4, H11 and the co-activator peptide. An interaction surface comprising residues from the H3-H4 region and H12 allows the co-activator peptide to bind.

[0250] The following sequence of the peptide is seen in the crystal structure: HKILHRLLQE. The LXXLL motif also called the NR-box is included in an amphipathic α-helix interacting with a hydrophobic cleft on the LBD surface. In particularly, the side-chains of Leu 693 and Leu 694 are part of an hydrophobic cluster composed also by Val 274 (H3), Ile 292 (H4), and Leu 295 (H4).

[0251] The γ carboxylate of E448 (H12) forms hydrogen bonds with the backbone amides of Leu 697 and Leu 698, residues of N-terminal turn of the peptide helix. This N-capping interaction was already described (Nolte & al., 1998, Shiau et al., 1998). This highly conserved glutamate residue is known to be important for transactivation. Another hydrogen bond requires Gln 288 (H4) OE2 with NE2 of His 695. The side chain of Glu 700 forms a water-mediated hydrogen bond to the carbonyl of residue Arg 696.

[0252] Binding of Stearate

[0253] The volume of the ligand binding pocket is 758 Å³, which is close to that of VDR (660 Å³) (Rochel et al., 2000). A fortuitous ligand, stearic acid, was found in the ligand binding pocket, which was previously characterized by mass spectrometry. Thus, it appears that E. coli-endogeneous stearic acid was co-purified and co-crystallised with the heterologously expressed RORβ LBD. The fatty acid (FA) is buried in a predominantly hydrophobic pocket formed by residues located in H3 (Gln 265, Ile 266, Ala269), H5 (Leu 300, Val303, Leu97), loop H5-H6 (Phe 113), H6 (Phe 320), and H7 (Leu131, Val338). Most of these residues make van der Waals contact with the aliphatic chain of the FA (FIG. 3a). The cavity contains also 11 ordered water molecules. One oxygen atom of the carboxylate group forms hydrogen bond with NE2 of Gln265. This residue varies among RORα and β. The other oxygen atom of the carboxylate group forms hydrogen bond with two ordered water molecules. These two molecules are part of a hydrogen bond network, which connects the carboxylate to other conserved residues among RORα and β of the LBP namely Gln228 and Arg306. Stearate adopts a U-shaped conformation upon binding. TABLE 4 Stearate contacts (3.5 Å) Hydrogen bonds O2 Gln 265 Nε2 2.79 Å O1 Wat 944 2.54 Å O Val 303 3.11 Å Possible Close Contacts O1 Ala 269 Cβ 3.31 Å O2 Gln 265 Cγ 3.33 Å O2 Gln 265 Cδ 3.41 Å O2 Wat 946 3.06 Å C3 Wat 944 3.43 Å C3 Wat 946 3.21 Å C4 Wat 946 3.30 Å C10 Phe 123 CE1 3.43 Å C11 Leu 131 CD2 3.45 Å

[0254] Crystallization and Structure Determination of the RORβ LBD/ATRA (All-trans Retinoic Acid) Complex

[0255] As mentioned above, the RORβ LBD construct where the two C-terminal solvent-exposed cysteines have been removed by truncation of a 7-residue C-terminal segment has proved a valuable tool to get other crystal structures of the RORβ LBD in complex with other ligands. This is illustrated below with the description of the crystallization and the structure determination of the RORβ LBD/ATRA (all-trans retinoic acid) complex. This new structure reveals another mode of binding for the ligand and suggests that natural and synthetic retinoids are candidate ligands for RORβ. This family of compounds may thus be tested for binding to the RORβ LBD, for instance by mass spectrometry, and the crystallization may be tried in the positive cases. From the obtained structures, high-affinity ligands can be designed, synthetized, and tested in vivo, in vitro, as well as for crystallization. Even without the crystal structure of other complexes, filtering for ligand screening and/or design of better ligands can be achieved through docking studies in computo.

[0256] Crystallization of the RORβ LBD/ATRA Complex

[0257] The RORβ LBD/ATRA complex was crystallized by vapor diffusion in the hanging-drop mode. The protein (the RORβ LBD containing stearic acid, purified as previously) was co-crystallised with an excess ATRA and an excess SRC-1 (residues 686-700) under similar conditions as for the RORβ LBD/STE (stearic acid) complex. A 4 μl drop was prepared by mixing 2 μl of purified protein (5.8 mg/ml) with an equal volume of reservoir solution. The reservoir (500 μl) contained 18% PEG 6000 and 100 mM Tris HCl pH=8.0. A crystal measuring 300×160×100 μm grew within 2 weeks at 22° C.

[0258] Data Collection

[0259] The crystals were cryoprotected with a film of viscous paraffin oil and then flash frozen in liquid ethane at liquid nitrogen temperature. X-ray diffraction data were collected at liquid nitrogen temperature from a single frozen crystal at the BM14-CRG beamline at the ESRF Grenoble, France. Crystals diffracted X-rays to a resolution limit of 2.1 Å. All data were integrated and scaled using DENZO and SCALEPACK (Table 5). The data set between 20.0 and 2.1 Å shows a completeness of 100% with an Rsym (I) of 4.5%. The completeness in the highest resolution shell (2.17-2.10 Å) was 100% with an Rsym (I) of 17.5%. The unit cell parameters were a=52.199 Å, b=58.125 Å, and c=106.039 Å, a=b=c=90°. The crystal contains one monomer per asymetric unit and a solvent content of 52%. The estimated B factor by Wilson plot is 32. Inspection of systematic absences along each axis indicated that the space group was P212121.

[0260] Structure Determination and Refinement

[0261] The structure of the complex was solved by molecular replacement using the RORβ LBD/STE complex as a starting model. The all-trans retinoic acid was built using Quanta (MSI). The final model (Rcryst=0.2180 and Rfree=0.2549), refined at 2.1 Å (Table 5), comprises 244 residues from the RORβ LBD, 10 residues from the peptide, one ligand, and 139 water molecules. According to Procheck, 91.2% of all residues in the model are in the most favoured main chain torsion angles Ramachandran regions, 5.9% in additional allowed regions, 2.1% in generously allowed regions and 0.0% in disallowed regions.

[0262] Binding of ATRA (All-Trans Retinoic Acid)

[0263] The protein-ligand contacts within 3.5 Å are listed in Table 6. The present structure reveals the binding site for the carboxylate group of ATRA, which is hydrogen-bonded to Arg 306 and Arg 309 through a water molecule in each case (FIG. 6). The binding mode is different from that of stearate (FIG. 7), which is hydrogen-bonded to Gln 265 directly and to Gln 228 through a water molecule. On the other hand, stearate makes more Van der Waals contacts with pocket residues thanks to its flexible chain which assumes a U shape probably in order to maximize the number of such contacts. ATRA is more rigid, allowing less Van der Waals contacts. Thus, there seems to be a delicate balance between Van der Waals contacts and hydrogen bonds ligand binding to the RORβ LBD. TABLE 5 Data collection and refinement statistics. Source ESRF BM14 Wavelength 0.976205 Å Unique reflections 19431 Resolution range 20.0-2.1 ^(a)Completeness 100% (100%) Multiplicity 6.6 Mosaicity 0.75° ^(a)Rsym 4.5% (17.5%) Space group P212121 a 52.199 Å b 58.125 Å c 106.039 Å Resolution Range 20.0-2.1 Reflections 17679 R-factor 21.8% R-free 25.5% # visible residues 244 (residues 208-451) # atoms 2219 RMS deviations bond lengths 0.007 bond angles 1.129 Average B-factors Protein and peptide 33.6 Å² All-trans retinoic acid 40.3 Å² Water 43.2 Å² Wilson B-factor 31.9 Å²

[0264] TABLE 6 RORβ LBD/ATRA (all-trans retinoic acid) contacts within 3.5 Å Hydrogen bonds O1 N Gln 228 2.97 Å O1 Wat 802 2.72 Å O2 Wat 825 2.59 Å NH1 Arg 306 2.92 Å NH1 Arg 309 2.84 Å Vander Waals contacts O1 Arg 306 Cδ 3.50 Å O2 Tyr 229 N 3.42 Å O2 Gln 228 N 3.42 Å C15 Gln 228 N 3.48 Å C15 Wat 825 3.39 Å C18 Cys 262 Cβ 3.42 Å C18 Cys 262 Sγ 3.44 Å C19 Leu 319 O 3.34 Å C20 Wat 825 3.22 Å

[0265] Cell Culture and Transient Transfection Experiments.

[0266] HT22 were cultured in in Dulbecco's modified Eagle's medium (DMEM). The Medium was supplemented with 5% delipidated fetal calf serum, penicillin, streptomycin and glutamine. Transient transfection assays were carried out in 24-well plates (0.5 10⁵ cells per well) N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammoniummethylsulfate (DOTAP) lipofection (Roche Molecular Biochemicals) according to the manufacturer's protocol. Luciferase activity was assayed as recommended by the manufacturer (Promega) in a Microplate Luminometer (EG & G Berthold). Relative light units were normalized according to (Muller et al., 2002) and protein concentration was determined using the Bradford dye assay (Bio-Rad). All experiments were repeated at least five times.

[0267] Ligands. Purchased ligands include the following: all-trans-[20-methyl-3H]-retinoic acid (65 Ci/mmol) (NEN); all-trans-retinoic acid (Sigma)

[0268] Recombinant plasmids. Reporter plasmids. G5E1BTataLuc

[0269] Expression vectors. CMX-Gal, CMX-Gal-RORβ201-459, pGEX-RORβ201-459 described in (Greiner et al., 1996)

[0270] Ligand binding assays. Scintillation proximity assay were performed with purified bacterial expressed RORβ-LBD (stehlin et al 2001) (250 ng per well) and all-trans-[20-methyl-3H]-retinoic acid (60 Ci/mMol, NEN) in 96-well NiNTA-flash-plates (NEN) in a total volume of 100 μl. Binding buffer: 40 mM HEPES pH 7.6, 40 mM KCl, 0.2% CHAPS, 0.1 mg/ml BSA. Binding was carried out for 1 hour at 4° C. in 100 μl binding buffer. Radioligand was diluted in binding buffer to a final concentration of 5 nM. Unlabelled competing ligands were serially diluted in binding buffer and added at final concentrations ranging from 1 nM to 10 μM. Plates were shaken at 25° C. for 2 hours. Then the radioactivity was measured with a Packard Topcount at 2 min per well. All concentrations were assayed in triplicate and the results were averaged. Values from wells void of competitor represented 100% binding. Saturation-binding experiments used the ligand concentrations indicated in the figure. Nonspecific binding was determined by including unlablled retinoic acid at 10⁻⁴ M and subtracted from total binding. Nonlinear regression analysis for the competition curves, saturation binding and Scratchard analysis to determine the Kd were performed using GRAPHPAD PRISM.

[0271] Greiner, E. F., Kirfel, J., Greschik, H., Dorflinger, U., Becker, P., Mercep, A., and Schule, R. (1996). Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor. Proc Natl Acad Sci U S A 93, 10105-10110.

[0272] Muller, J. M., Metzger, E., Greschik, H., Bosserhoff, A. K., Mercep, L., Buettner, R., and Schule, R. (2002). The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. Embo J 21, 736-748. TABLE A Crystallographic Coordinates of RORbeta LBD/stearic acid/SRC1 peptide complex ATOM 1 CB THR 208 14.051 −0.802 26.838 1.00 36.55 ATOM 2 OG1 THR 208 15.478 −0.898 26.824 1.00 35.48 ATOM 3 CG2 THR 208 13.533 −0.599 25.404 1.00 36.96 ATOM 4 C THR 208 14.780 1.393 27.790 1.00 35.14 ATOM 5 O THR 208 15.234 1.884 26.757 1.00 33.86 ATOM 6 N THR 208 12.302 0.901 27.332 1.00 33.90 ATOM 7 CA THR 208 13.631 0.366 27.747 1.00 34.84 ATOM 8 N MET 209 15.261 1.697 28.997 1.00 35.20 ATOM 9 CA MET 209 16.358 2.647 29.169 1.00 34.91 ATOM 10 CB MET 209 16.717 2.770 30.658 1.00 34.61 ATOM 11 CG MET 209 17.482 4.050 31.032 1.00 35.43 ATOM 12 SD MET 209 16.609 5.601 30.589 1.00 35.84 ATOM 13 CE MET 209 15.558 5.830 32.022 1.00 33.07 ATOM 14 C MET 209 17.598 2.235 28.346 1.00 34.50 ATOM 15 O MET 209 18.313 3.100 27.813 1.00 34.32 ATOM 16 N SER 210 17.846 0.930 28.225 1.00 32.92 ATOM 17 CA SER 210 18.999 0.456 27.461 1.00 33.75 ATOM 18 CB SER 210 19.181 −1.064 27.604 1.00 34.40 ATOM 19 OG SER 210 18.057 −1.784 27.107 1.00 37.86 ATOM 20 C SER 210 18.886 0.821 25.983 1.00 32.54 ATOM 21 O SER 210 19.888 1.145 25.345 1.00 32.59 ATOM 22 N GLU 211 17.684 0.746 25.422 1.00 31.57 ATOM 23 CA GLU 211 17.525 1.121 24.020 1.00 30.40 ATOM 24 CB GLU 211 16.125 0.782 23.484 1.00 30.37 ATOM 25 CG GLU 211 15.813 1.507 22.160 1.00 32.71 ATOM 26 CD GLU 211 14.495 1.097 21.511 1.00 34.29 ATOM 27 OE1 GLU 211 13.563 0.690 22.233 1.00 34.92 ATOM 28 OE2 GLU 211 14.384 1.205 20.267 1.00 34.73 ATOM 29 C GLU 211 17.752 2.625 23.883 1.00 28.59 ATOM 30 O GLU 211 18.351 3.080 22.913 1.00 27.98 ATOM 31 N ILE 212 17.264 3.396 24.848 1.00 27.40 ATOM 32 CA ILE 212 17.424 4.845 24.781 1.00 27.79 ATOM 33 CB ILE 212 16.764 5.571 25.978 1.00 26.35 ATOM 34 CG2 ILE 212 17.010 7.069 25.860 1.00 27.12 ATOM 35 CG1 ILE 212 15.257 5.276 26.029 1.00 26.58 ATOM 36 CD1 ILE 212 14.503 5.643 24.770 1.00 24.95 ATOM 37 C ILE 212 18.895 5.226 24.757 1.00 27.70 ATOM 38 O ILE 212 19.302 6.124 24.021 1.00 26.95 ATOM 39 N ASP 213 19.691 4.530 25.563 1.00 29.11 ATOM 40 CA ASP 213 21.122 4.800 25.653 1.00 29.22 ATOM 41 CB ASP 213 21.699 4.045 26.853 1.00 32.21 ATOM 42 CG ASP 213 23.083 4.517 27.233 1.00 34.57 ATOM 43 OD1 ASP 213 23.255 5.721 27.529 1.00 36.05 ATOM 44 OD2 ASP 213 24.004 3.674 27.248 1.00 37.52 ATOM 45 C ASP 213 21.873 4.430 24.365 1.00 28.75 ATOM 46 O ASP 213 22.804 5.137 23.954 1.00 27.10 ATOM 47 N ARG 214 21.475 3.329 23.732 1.00 28.19 ATOM 48 CA ARG 214 22.108 2.908 22.480 1.00 29.03 ATOM 49 CB ARG 214 21.597 1.535 22.047 1.00 32.44 ATOM 50 CG ARG 214 21.849 0.417 23.050 1.00 38.05 ATOM 51 CD ARG 214 21.039 −0.810 22.667 1.00 41.57 ATOM 52 NE ARG 214 20.958 −1.777 23.759 1.00 46.23 ATOM 53 CZ ARG 214 20.771 −3.082 23.582 1.00 49.23 ATOM 54 NH1 ARG 214 20.644 −3.577 22.346 1.00 50.85 ATOM 55 NH2 ARG 214 20.720 −3.894 24.632 1.00 50.33 ATOM 56 C ARG 214 21.785 3.928 21.383 1.00 27.33 ATOM 57 O ARG 214 22.624 4.236 20.543 1.00 26.60 ATOM 58 N ILE 215 20.559 4.446 21.391 1.00 26.45 ATOM 59 CA ILE 215 20.150 5.432 20.395 1.00 24.84 ATOM 60 CB ILE 215 18.629 5.699 20.472 1.00 26.20 ATOM 61 CG2 ILE 215 18.280 7.043 19.821 1.00 25.14 ATOM 62 CG1 ILE 215 17.881 4.554 19.781 1.00 25.45 ATOM 63 CD1 ILE 215 16.422 4.456 20.176 1.00 25.36 ATOM 64 C ILE 215 20.929 6.723 20.629 1.00 24.62 ATOM 65 O ILE 215 21.426 7.338 19.686 1.00 23.32 ATOM 66 N ALA 216 21.050 7.116 21.893 1.00 24.39 ATOM 67 CA ALA 216 21.782 8.323 22.242 1.00 25.02 ATOM 68 CB ALA 216 21.677 8.589 23.740 1.00 24.99 ATOM 69 C ALA 216 23.249 8.232 21.829 1.00 25.36 ATOM 70 O ALA 216 23.77

9.151 21.193 1.00 25.93 ATOM 71 N GLN 217 23.922 7.137 22.177 1.00 25.23 ATOM 72 CA GLN 217 25.332 6.999 21.819 1.00 26.24 ATOM 73 CB GLN 217 25.917 5.705 22.397 1.00 29.19 ATOM 74 CG GLN 217 26.090 5.734 23.917 1.00 35.04 ATOM 75 CD GLN 217 27.010 4.630 24.420 1.00 38.21 ATOM 76 OE1 GLN 217 26.714 3.443 24.278 1.00 40.35 ATOM 77 NE2 GLN 217 28.140 5.022 25.006 1.00 41.77 ATOM 78 C GLN 217 25.556 7.041 20.305 1.00 25.19 ATOM 79 O GLN 217 26.518 7.651 19.823 1.00 24.32 ATOM 80 N ASN 218 24.659 6.392 19.568 1.00 23.86 ATOM 81 CA ASN 218 24.725 6.341 18.113 1.00 23.77 ATOM 82 CB ASN 218 23.580 5.472 17.591 1.00 23.56 ATOM 83 CG ASN 218 23.554 5.381 16.084 1.00 24.49 ATOM 84 OD1 ASN 218 22.492 5.461 15.480 1.00 24.92 ATOM 85 ND2 ASN 218 24.723 5.194 15.466 1.00 26.45 ATOM 86 C ASN 218 24.632 7.746 17.508 1.00 23.84 ATOM 87 O ASN 218 25.430 8.122 16.642 1.00 23.34 ATOM 88 N ILE 219 23.654 8.518 17.967 1.00 23.13 ATOM 89 CA ILE 219 23.464 9.872 17.462 1.00 22.12 ATOM 90 CB ILE 219 22.116 10.448 17.948 1.00 20.95 ATOM 91 CG2 ILE 219 22.033 11.927 17.630 1.00 18.97 ATOM 92 CG1 ILE 219 20.975 9.653 17.300 1.00 20.42 ATOM 93 CD1 ILE 219 19.602 9.904 17.878 1.00 21.20 ATOM 94 C ILE 219 24.615 10.784 17.874 1.00 22.86 ATOM 95 O ILE 219 25.132 11.552 17.063 1.00 21.51 ATOM 96 N ILE 220 25.020 10.693 19.132 1.00 22.66 ATOM 97 CA ILE 220 26.128 11.503 19.616 1.00 24.02 ATOM 98 CB ILE 220 26.418 11.199 21.098 1.00 23.77 ATOM 99 CG2 ILE 220 27.801 11.712 21.479 1.00 25.51 ATOM 100 CG1 ILE 220 25.323 11.824 21.970 1.00 24.25 ATOM 101 CD1 ILE 220 25.371 11.402 23.442 1.00 25.63 ATOM 102 C ILE 220 27.379 11.217 18.783 1.00 24.51 ATOM 103 O ILE 220 28.070 12.133 18.338 1.00 24.01 ATOM 104 N LYS 221 27.655 9.937 18.563 1.00 25.74 ATOM 105 CA LYS 221 28.826 9.538 17.796 1.00 26.09 ATOM 106 CB LYS 221 28.987 8.017 17.845 1.00 27.05 ATOM 107 CG LYS 221 30.069 7.447 16.940 1.00 30.22 ATOM 108 CD LYS 221 30.218 5.948 17.211 1.00 33.17 ATOM 109 CE LYS 221 30.998 5.233 16.112 1.00 35.08 ATOM 110 NZ LYS 221 32.350 5.814 15.948 1.00 37.04 ATOM 111 C LYS 221 28.724 10.027 16.352 1.00 26.19 ATOM 112 O LYS 221 29.710 10.504 15.783 1.00 26.37 ATOM 113 N SER 222 27.538 9.932 15.765 1.00 24.31 ATOM 114 CA SER 222 27.365 10.388 14.389 1.00 24.58 ATOM 115 CB SER 222 25.947 10.105 13.894 1.00 25.00 ATOM 116 OG SER 222 25.818 10.539 12.544 1.00 27.88 ATOM 117 C SER 222 27.654 11.882 14.278 1.00 23.15 ATOM 118 O SER 222 28.312 12.332 13.340 1.00 20.13 ATOM 119 N HIS 223 27.160 12.640 15.254 1.00 22.79 ATOM 120 CA HIS 223 27.369 14.081 15.292 1.00 23.51 ATOM 121 CB HIS 223 26.694 14.672 16.530 1.00 22.71 ATOM 122 CG HIS 223 27.071 16.095 16.803 1.00 22.35 ATOM 123 CD2 HIS 223 27.948 16.627 17.686 1.00 23.97 ATOM 124 ND1 HIS 223 26.531 17.158 16.114 1.00 23.67 ATOM 125 CE1 HIS 223 27.055 16.284 16.561 1.00 22.61 ATOM 126 NE2 HIS 223 27.918 17.990 17.516 1.00 24.30 ATOM 127 C HIS 223 28.860 14.408 15.334 1.00 24.83 ATOM 128 O HIS 223 29.348 15.233 14.570 1.00 23.29 ATOM 129 N LEU 224 29.581 13.758 16.239 1.00 26.00 ATOM 130 CA LEU 224 31.005 14.012 16.378 1.00 27.42 ATOM 131 CB LEU 224 31.564 13.241 17.579 1.00 28.17 ATOM 132 CG LEU 224 31.065 13.762 18.936 1.00 29.44 ATOM 133 CD1 LEU 224 31.630 12.901 20.062 1.00 30.81 ATOM 134 CD2 LEU 224 31.482 15.226 19.118 1.00 31.36 ATOM 135 C LEU 224 31.791 13.686 15.116 1.00 27.94 ATOM 136 O LEU 224 32.777 14.358 14.823 1.00 28.46 ATOM 137 N GLU 225 31.352 12.676 14.366 1.00 26.53 ATOM 138 CA GLU 225 32.042 12.289 13.138 1.00 28.08 ATOM 139 CB GLU 225 31.897 10.785 12.867 1.00 29.02 ATOM 140 CG GLU 225 31.994 9.881 14.083 1.00 32.55 ATOM 141 CD GLU 225 31.914 8.410 13.714 1.00 34.16 ATOM 142 OE1 GLU 225 31.093 8.046 12.822 1.00 35.71 ATOM 143 OE2 GLU 225 32.666 7.615 14.322 1.00 33.88 ATOM 144 C GLU 225 31.540 13.028 11.897 1.00 26.89 ATOM 145 O GLU 225 32.105 12.862 10.820 1.00 27.36 ATOM 146 N THR 226 30.499 13.845 12.032 1.00 26.42 ATOM 147 CA THR 226 29.959 14.540 10.860 1.00 25.86 ATOM 148 CB THR 226 28.574 13.972 10.486 1.00 24.69 ATOM 149 OG1 THR 226 27.670 14.165 11.579 1.00 21.37 ATOM 150 CG2 THR 226 28.684 12.478 10.162 1.00 25.22 ATOM 151 C THR 226 29.850 16.067 10.890 1.00 26.84 ATOM 152 O THR 226 29.016 16.645 10.196 1.00 25.61 ATOM 153 N CYS 227 30.670 16.719 11.698 1.00 27.47 ATOM 154 CA CYS 227 30.677 18.177 11.733 1.00 29.95 ATOM 155 CB CYS 227 30.725 16.694 13.160 1.00 30.26 ATOM 156 SG CYS 227 29.129 18.666 13.964 1.00 31.37 ATOM 157 C CYS 227 31.927 18.614 10.993 1.00 31.15 ATOM 158 O CYS 227 32.949 17.926 11.044 1.00 32.10 ATOM 159 N GLN 228 31.856 19.737 10.291 1.00 32.99 ATOM 160 CA GLN 228 33.028 20.217 9.559 1.00 34.05 ATOM 161 CB GLN 228 32.700 21.472 8.746 1.00 34.74 ATOM 162 CG GLN 228 33.975 22.087 8.166 1.00 36.23 ATOM 163 CD GLN 228 33.732 23.051 7.040 1.00 36.08 ATOM 164 OE1 GLN 228 34.591 23.216 6.172 1.00 37.80 ATOM 165 NE2 GLN 228 32.579 23.710 7.049 1.00 35.92 ATOM 166 C GLN 228 34.163 20.543 10.527 1.00 34.44 ATOM 167 O GLN 228 35.345 20.276 10.254 1.00 35.97 ATOM 168 N TYR 229 33.794 21.134 11.656 1.00 33.42 ATOM 169 CA TYR 229 34.762 21.508 12.664 1.00 34.12 ATOM 170 CB TYR 229 34.804 23.025 12.814 1.00 34.64 ATOM 171 CG TYR 229 35.252 23.753 11.578 1.00 35.84 ATOM 172 CD1 TYR 229 36.530 23.558 11.052 1.00 37.22 ATOM 173 CE1 TYR 229 36.960 24.278 9.925 1.00 37.82 ATOM 174 CD2 TYR 229 34.412 24.667 10.953 1.00 36.84 ATOM 175 CE2 TYR 229 34.823 25.380 9.841 1.00 37.23 ATOM 176 CZ TYR 229 36.093 25.191 9.333 1.00 38.42 ATOM 177 OH TYR 229 36.496 25.957 8.260 1.00 40.27 ATOM 178 C TYR 229 34.420 20.895 14.004 1.00 34.39 ATOM 179 O TYR 229 33.292 21.045 14.489 1.00 33.47 ATOM 180 N THR 230 35.385 20.202 14.601 1.00 35.45 ATOM 181 CA THR 230 35.151 19.622 15.913 1.00 37.95 ATOM 182 CB THR 230 36.301 18.697 16.373 1.00 38.23 ATOM 183 OG1 THR 230 37.502 19.463 16.518 1.00 40.39 ATOM 184 CG2 THR 230 36.522 17.593 15.370 1.00 39.49 ATOM 185 C THR 230 35.074 20.807 16.851 1.00 38.40 ATOM 186 O THR 230 35.466 21.927 16.488 1.00 37.62 ATOM 187 N MET 231 34.555 20.567 18.049 1.00 40.09 ATOM 188 CA MET 231 34.421 21.614 19.055 1.00 42.13 ATOM 189 CB MET 231 33.812 21.031 20.319 1.00 42.86 ATOM 190 CG MET 231 32.379 21.368 20.493 1.00 44.14 ATOM 191 SD MET 231 32.214 22.979 21.200 1.00 48.47 ATOM 192 CE MET 231 31.477 23.899 19.813 1.00 44.81 ATOM 193 C MET 231 35.761 22.239 19.392 1.00 42.66 ATOM 194 O MET 231 35.833 23.413 19.754 1.00 42.23 ATOM 195 N GLU 232 36.817 21.435 19.287 1.00 44.27 ATOM 196 CA GLU 232 38.176 21.900 19.564 1.00 46.03 ATOM 197 CB GLU 232 39.150 20.718 19.589 1.00 48.16 ATOM 198 CG GLU 232 39.075 19.847 20.834 1.00 52.20 ATOM 199 CD GLU 232 39.978 18.626 20.745 1.00 54.53 ATOM 200 OE1 GLU 232 41.211 18.807 20.581 1.00 55.69 ATOM 201 OE2 GLU 232 39.452 17.483 20.831 1.00 55.83 ATOM 202 C GLU 232 38.629 22.893 18.484 1.00 45.35 ATOM 203 O GLU 232 39.137 23.971 18.785 1.00 45.45 ATOM 204 N GLU 233 38.449 22.506 17.227 1.00 44.58 ATOM 205 CA GLU 233 38.837 23.341 16.099 1.00 43.02 ATOM 206 CB GLU 233 38.530 22.625 14.780 1.00 43.47 ATOM 207 CG GLU 233 39.477 21.486 14.414 1.00 43.69 ATOM 208 CD GLU 233 39.053 20.792 13.134 1.00 44.50 ATOM 209 OE1 GLU 233 37.937 20.228 13.113 1.00 42.94 ATOM 210 OE2 GLU 233 39.826 20.819 12.144 1.00 45.82 ATOM 211 C GLU 233 38.130 24.693 16.128 1.00 42.63 ATOM 212 O GLU 233 38.664 25.689 15.629 1.00 41.56 ATOM 213 N LEU 234 36.927 24.716 16.702 1.00 41.55 ATOM 214 CA LEU 234 36.130 25.929 16.800 1.00 41.68 ATOM 215 CB LEU 234 34.662 25.569 17.081 1.00 38.99 ATOM 216 CG LEU 234 33.595 25.745 15.984 1.00 37.42 ATOM 217 CD1 LEU 234 34.202 25.811 14.598 1.00 36.02 ATOM 218 CD2 LEU 234 32.598 24.602 16.068 1.00 35.04 ATOM 219 C LEU 234 36.659 26.884 17.874 1.00 43.02 ATOM 220 O LEU 234 36.689 28.097 17.665 1.00 42.82 ATOM 221 N HIS 235 37.063 26.347 19.024 1.00 44.76 ATOM 222 CA HIS 235 37.609 27.183 20.100 1.00 46.16 ATOM 223 CB HIS 235 37.997 26.304 21.303 1.00 47.16 ATOM 224 CG HIS 235 36.823 25.826 22.102 1.00 47.88 ATOM 225 CD2 HIS 235 35.624 26.405 22.363 1.00 48.26 ATOM 226 ND1 HIS 235 36.816 24.615 22.765 1.00 48.61 ATOM 227 CE1 HIS 235 35.664 24.465 23.398 1.00 48.18 ATOM 228 NE2 HIS 235 34.922 25.536 23.169 1.00 48.08 ATOM 229 C HIS 235 38.833 27.943 19.580 1.00 46.16 ATOM 230 O HIS 235 39.093 29.086 19.972 1.00 46.99 ATOM 231 N GLN 236 39.570 27.304 18.676 1.00 46.28 ATOM 232 CA GLN 236 40.763 27.888 18.078 1.00 46.35 ATOM 233 CB GLN 236 41.709 26.769 17.647 1.00 48.10 ATOM 234 CG GLN 236 42.314 26.013 18.819 1.00 50.88 ATOM 235 CD GLN 236 43.066 24.776 18.378 1.00 53.03 ATOM 236 OE1 GLN 236 42.483 23.846 17.799 1.00 54.30 ATOM 237 NE2 GLN 236 44.368 24.750 18.651 1.00 53.30 ATOM 238 C GLN 236 40.469 28.804 16.882 1.00 45.38 ATOM 239 O GLN 236 41.358 29.510 16.401 1.00 45.98 ATOM 240 N LEU 237 39.231 28.793 16.396 1.00 43.26 ATOM 241 CA LEU 237 38.864 29.650 15.276 1.00 41.13 ATOM 242 CB LEU 237 38.032 28.877 14.249 1.00 40.63 ATOM 243 CG LEU 237 38.733 27.918 13.291 1.00 40.27 ATOM 244 CD1 LEU 237 37.700 27.272 12.379 1.00 39.92 ATOM 245 CD2 LEU 237 39.777 28.674 12.485 1.00 40.45 ATOM 246 C LEU 237 38.081 30.878 15.727 1.00 39.51 ATOM 247 O LEU 237 38.086 31.903 15.047 1.00 38.80 ATOM 248 N ALA 238 37.427 30.778 16.880 1.00 39.51 ATOM 249 CA ALA 238 36.618 31.871 17.406 1.00 38.91 ATOM 250 CB ALA 238 35.908 31.423 18.694 1.00 39.73 ATOM 251 C ALA 238 37.408 33.152 17.656 1.00 38.89 ATOM 252 O ALA 238 36.832 34.239 17.716 1.00 38.65 ATOM 253 N TRP 239 38.725 33.041 17.794 1.00 39.18 ATOM 254 CA TRP 239 39.524 34.239 18.022 1.00 39.10 ATOM 255 CB TRP 239 40.771 33.912 18.844 1.00 39.97 ATOM 256 CG TRP 239 40.439 33.575 20.265 1.00 41.05 ATOM 257 CD2 TRP 239 40.329 34.502 21.357 1.00 41.89 ATOM 258 CE2 TRP 239 39.925 33.764 22.496 1.00 42.28 ATOM 259 CE3 TRP 239 40.52

35.889 21.481 1.00 42.04 ATOM 260 CD1 TRP 239 40.111 32.345 20.768 1.00 41.20 ATOM 261 NE1 TRP 239 39.800 32.451 22.113 1.00 41.62 ATOM 262 CZ2 TRP 239 39.718 34.369 23.749 1.00 42.42 ATOM 263 CZ3 TRP 239 40.318 36.495 22.734 1.00 41.71 ATOM 264 CH2 TRP 239 39.917 35.732 23.846 1.00 41.59 ATOM 265 C TRP 239 39.904 34.917 16.715 1.00 38.66 ATOM 266 O TRP 239 40.315 36.081 16.708 1.00 39.17 ATOM 267 N GLN 240 39.750 34.191 15.613 1.00 37.88 ATOM 268 CA GLN 240 40.052 34.715 14.281 1.00 38.38 ATOM 269 CB GLN 240 40.402 33.569 13.325 1.00 39.13 ATOM 270 CG GLN 240 41.815 33.009 13.448 1.00 43.03 ATOM 271 CD GLN 240 42.865 33.999 12.962 1.00 45.47 ATOM 272 OE1 GLN 240 42.697 34.640 11.913 1.00 46.02 ATOM 273 NE2 GLN 240 43.962 34.121 13.712 1.00 45.97 ATOM 274 C GLN 240 38.841 35.473 13.726 1.00 38.04 ATOM 275 O GLN 240 37.750 34.900 13.590 1.00 36.35 ATOM 276 N THR 241 39.029 36.752 13.406 1.00 37.28 ATOM 277 CA THR 241 37.938 37.554 12.865 1.00 37.13 ATOM 278 CB THR 241 37.417 38.596 13.901 1.00 38.89 ATOM 279 OG1 THR 241 38.436 39.565 14.186 1.00 40.81 ATOM 280 CG2 THR 241 37.028 37.907 15.208 1.00 39.48 ATOM 281 C THR 241 38.347 38.279 11.580 1.00 36.22 ATOM 282 O THR 241 39.485 38.758 11.451 1.00 36.33 ATOM 283 N HIS 242 37.430 38.324 10.613 1.00 34.05 ATOM 284 CA HIS 242 37.695 39.012 9.354 1.00 31.44 ATOM 285 CB HIS 242 36.472 38.974 8.436 1.00 29.25 ATOM 286 CG HIS 242 36.149 37.615 7.904 1.00 27.92 ATOM 287 CD2 HIS 242 36.71

36.887 6.915 1.00 26.55 ATOM 288 ND1 HIS 242 35.111 36.853 8.393 1.00 27.30 ATOM 289 CE1 HIS 242 35.055 35.715 7.727 1.00 26.17 ATOM 290 NE2 HIS 242 36.020 35.710 6.826 1.00 27.22 ATOM 291 C HIS 242 38.020 40.465 9.668 1.00 30.68 ATOM 292 O HIS 242 37.358 41.096 10.490 1.00 30.78 ATOM 293 N THR 243 39.038 40.991 9.004 1.00 31.03 ATOM 294 CA THR 243 39.460 42.372 9.199 1.00 30.79 ATOM 295 CB THR 243 40.822 42.612 8.543 1.00 30.73 ATOM 296 OG1 THR 243 40.717 42.383 7.126 1.00 31.15 ATOM 297 CG2 THR 243 41.864 41.669 9.140 1.00 29.69 ATOM 298 C THR 243 38.470 43.363 8.595 1.00 31.03 ATOM 299 O THR 243 37.534 42.970 7.901 1.00 29.40 ATOM 300 N TYR 244 38.684 44.648 8.868 1.00 31.19 ATOM 301 CA TYR 244 37.834 45.702 8.324 1.00 31.95 ATOM 302 CB TYR 244 38.297 47.095 6.802 1.00 33.18 ATOM 303 CG TYR 244 37.829 47.457 10.204 1.00 33.91 ATOM 304 CD1 TYR 244 38.719 47.484 11.289 1.00 35.00 ATOM 305 CE1 TYR 244 38.268 47.784 12.599 1.00 35.72 ATOM 306 CD2 TYR 244 36.486 47.736 10.450 1.00 35.64 ATOM 307 CE2 TYR 244 36.025 48.032 11.740 1.00 35.81 ATOM 308 CZ TYR 244 36.915 48.054 12.809 1.00 36.54 ATOM 309 OH TYR 244 36.440 48.350 14.072 1.00 36.95 ATOM 310 C TYR 244 37.894 45.641 6.805 1.00 31.62 ATOM 311 O TYR 244 36.879 45.842 6.123 1.00 31.91 ATOM 312 N GLU 245 39.085 45.363 6.280 1.00 30.27 ATOM 313 CA GLU 245 39.281 45.271 4.641 1.00 30.86 ATOM 314 CB GLU 245 40.764 45.070 4.502 1.00 32.11 ATOM 315 CG GLU 245 41.664 46.274 4.773 1.00 34.64 ATOM 316 CD GLU 245 41.999 46.477 6.248 1.00 36.73 ATOM 317 OE1 GLU 245 42.570 47.546 6.573 1.00 37.44 ATOM 318 OE2 GLU 245 41.710 45.578 7.080 1.00 36.51 ATOM 319 C GLU 245 38.476 44.105 4.283 1.00 29.31 ATOM 320 O GLU 245 37.722 44.262 3.325 1.00 28.06 ATOM 321 N GLU 246 38.632 42.939 4.904 1.00 28.59 ATOM 322 CA GLU 246 37.921 41.740 4.458 1.00 28.73 ATOM 323 CB GLU 246 38.360 40.539 5.298 1.00 28.89 ATOM 324 CG GLU 246 39.841 40.230 5.106 1.00 33.43 ATOM 325 CD GLU 246 40.377 39.192 6.065 1.00 34.90 ATOM 326 OE1 GLU 246 40.008 39.213 7.259 1.00 36.44 ATOM 327 OE2 GLU 246 41.196 38.363 5.625 1.00 37.65 ATOM 328 C GLU 246 36.407 41.941 4.515 1.00 26.90 ATOM 329 O GLU 246 35.690 41.539 3.604 1.00 26.66 ATOM 330 N ILE 247 35.921 42.580 5.575 1.00 27.96 ATOM 331 CA ILE 247 34.488 42.838 5.702 1.00 26.28 ATOM 332 CB ILE 247 34.155 43.539 7.048 1.00 26.69 ATOM 333 CG2 ILE 247 32.729 44.062 7.031 1.00 25.56 ATOM 334 CG1 ILE 247 34.360 42.570 8.222 1.00 25.46 ATOM 335 CD1 ILE 247 33.500 41.318 6.148 1.00 26.47 ATOM 336 C ILE 247 34.043 43.741 4.546 1.00 27.42 ATOM 337 O ILE 247 32.977 43.544 3.954 1.00 25.31 ATOM 338 N LYS 248 34.876 44.723 4.214 1.00 27.71 ATOM 339 CA LYS 248 34.538 45.638 3.135 1.00 28.31 ATOM 340 CB LYS 248 35.547 46.786 3.059 1.00 31.00 ATOM 341 CG LYS 248 34.912 48.072 2.556 1.00 36.20 ATOM 342 CD LYS 248 34.261 48.862 3.708 1.00 37.72 ATOM 343 CE LYS 248 33.507 47.965 4.691 1.00 39.77 ATOM 344 NZ LYS 248 32.922 48.683 5.861 1.00 40.50 ATOM 345 C LYS 248 34.482 44.914 1.602 1.00 27.15 ATOM 346 O LYS 248 33.618 45.191 0.972 1.00 25.35 ATOM 347 N ALA 249 35.404 43.976 1.612 1.00 27.48 ATOM 348 CA ALA 249 35.462 43.197 0.380 1.00 27.44 ATOM 349 CB ALA 249 36.639 42.235 0.423 1.00 28.05 ATOM 350 C ALA 249 34.151 42.427 0.213 1.00 27.33 ATOM 351 O ALA 249 33.576 42.386 −0.882 1.00 26.70 ATOM 352 N TYR 250 33.681 41.820 1.303 1.00 26.77 ATOM 353 CA TYR 250 32.428 41.072 1.272 1.00 26.29 ATOM 354 CB TYR 250 32.131 40.421 2.628 1.00 26.30 ATOM 355 CG TYR 250 32.869 39.129 2.881 1.00 26.73 ATOM 356 CD1 TYR 250 32.749 38.051 2.008 1.00 26.93 ATOM 357 CE1 TYR 250 33.416 36.854 2.252 1.00 27.90 ATOM 358 CD2 TYR 250 33.674 36.961 4.007 1.00 27.33 ATOM 359 CE2 TYR 250 34.342 37.788 4.262 1.00 27.78 ATOM 360 CZ TYR 250 34.210 36.731 3.385 1.00 27.25 ATOM 361 OH TYR 250 34.878 35.555 3.650 1.00 28.52 ATOM 362 C TYR 250 31.276 41.997 0.932 1.00 25.31 ATOM 363 O TYR 250 30.352 41.612 0.230 1.00 24.79 ATOM 364 N GLN 251 31.324 43.213 1.456 1.00 26.05 ATOM 365 CA GLN 251 30.261 44.169 1.198 1.00 27.36 ATOM 366 CB GLN 251 30.311 45.309 2.208 1.00 28.26 ATOM 367 CG GLN 251 30.146 44.860 3.644 1.00 29.79 ATOM 368 CD GLN 251 30.114 46.024 4.597 1.00 32.00 ATOM 369 OE1 GLN 251 30.908 46.963 4.465 1.00 33.43 ATOM 370 NE2 GLN 251 29.208 45.972 5.577 1.00 30.11 ATOM 371 C GLN 251 30.333 44.739 −0.207 1.00 28.15 ATOM 372 O GLN 251 29.348 45.278 −0.714 1.00 28.35 ATOM 373 N SER 252 31.498 44.629 −0.835 1.00 28.46 ATOM 374 CA SER 252 31.670 45.138 −2.195 1.00 29.58 ATOM 375 CB SER 252 33.115 45.586 −2.408 1.00 29.66 ATOM 376 OG SER 252 33.399 46.707 −1.587 1.00 33.07 ATOM 377 C SER 252 31.287 44.087 −3.225 1.00 30.02 ATOM 378 O SER 252 31.319 44.333 −4.432 1.00 30.26 ATOM 379 N LYS 253 30.917 42.908 −2.742 1.00 29.52 ATOM 380 CA LYS 253 30.512 41.827 −3.630 1.00 30.07 ATOM 381 CB LYS 253 30.421 40.509 −2.854 1.00 30.99 ATOM 382 CG LYS 253 31.759 39.923 −2.457 1.00 33.63 ATOM 383 CD LYS 253 32.609 39.683 −3.697 1.00 35.38 ATOM 384 CE LYS 253 33.918 38.993 −3.352 1.00 38.01 ATOM 385 NZ LYS 253 33.690 37.648 −2.761 1.00 36.66 ATOM 386 C LYS 253 29.156 42.120 −4.250 1.00 29.23 ATOM 387 O LYS 253 28.333 42.815 −3.663 1.00 29.23 ATOM 388 N SER 254 28.922 41.596 −5.446 1.00 29.17 ATOM 389 CA SER 254 27.631 41.786 −6.080 1.00 29.19 ATOM 390 CB SER 254 27.667 41.371 −7.545 1.00 29.22 ATOM 391 OG SER 254 27.816 39.968 −7.640 1.00 25.88 ATOM 392 C SER 254 26.710 40.830 −5.341 1.00 29.60 ATOM 393 O SER 254 27.171 39.862 −4.739 1.00 29.62 ATOM 394 N ARG 255 25.416 41.097 −5.404 1.00 28.75 ATOM 395 CA ARG 255 24.430 40.257 −4.749 1.00 29.78 ATOM 396 CB ARG 255 23.034 40.853 −4.969 1.00 31.17 ATOM 397 CG ARG 255 21.941 40.222 −4.139 1.00 34.14 ATOM 398 CD ARG 255 20.773 41.191 −3.965 1.00 37.49 ATOM 399 NE ARG 255 19.500 40.485 −3.868 1.00 40.31 ATOM 400 CZ ARG 255 19.100 39.578 −4.755 1.00 41.60 ATOM 401 NH1 ARG 255 19.890 39.287 −5.782 1.00 44.13 ATOM 402 NH2 ARG 255 17.924 38.971 −4.631 1.00 39.96 ATOM 403 C ARG 255 24.508 38.809 −5.255 1.00 27.97 ATOM 404 O ARG 255 24.376 37.867 −4.473 1.00 27.13 ATOM 405 N GLU 256 24.748 38.628 −6.549 1.00 27.81 ATOM 406 CA GLU 256 24.854 37.284 −7.115 1.00 28.27 ATOM 407 CB GLU 256 24.876 37.331 −8.647 1.00 29.71 ATOM 408 CG GLU 256 24.028 38.425 −9.243 1.00 34.67 ATOM 409 CD GLU 256 24.701 39.784 −9.149 1.00 34.34 ATOM 410 OE1 GLU 256 25.746 39.971 −9.808 1.00 37.48 ATOM 411 OE2 GLU 256 24.193 40.652 −8.417 1.00 34.93 ATOM 412 C GLU 256 26.121 36.577 −6.639 1.00 27.13 ATOM 413 O GLU 256 26.106 35.379 −6.379 1.00 26.34 ATOM 414 N ALA 257 27.221 37.322 −6.543 1.00 26.59 ATOM 415 CA ALA 257 28.497 36.747 −6.108 1.00 24.46 ATOM 416 CB ALA 257 29.593 37.789 −6.190 1.00 23.06 ATOM 417 C ALA 257 28.406 36.210 −4.685 1.00 23.27 ATOM 418 O ALA 257 28.828 35.084 −4.413 1.00 22.83 ATOM 419 N LEU 258 27.855 37.015 −3.780 1.00 22.28 ATOM 420 CA LEU 258 27.743 36.602 −2.386 1.00 22.36 ATOM 421 CB LEU 258 27.382 37.788 −1.480 1.00 21.42 ATOM 422 CG LEU 258 27.623 37.516 0.012 1.00 21.16 ATOM 423 CD1 LEU 258 29.104 37.335 0.264 1.00 22.80 ATOM 424 CD2 LEU 258 27.098 38.656 0.857 1.00 22.10 ATOM 425 C LEU 258 26.712 35.487 −2.253 1.00 22.29 ATOM 426 O LEU 258 26.921 34.537 −1.498 1.00 21.82 ATOM 427 N TRP 259 25.608 35.580 −2.990 1.00 21.90 ATOM 428 CA TRP 259 24.617 34.514 −2.921 1.00 23.48 ATOM 429 CB TRP 259 23.405 34.801 −3.823 1.00 24.84 ATOM 430 CG TRP 259 22.260 35.370 −3.052 1.00 28.57 ATOM 431 CD2 TRP 259 21.325 34.637 −2.259 1.00 30.31 ATOM 432 CE2 TRP 259 20.509 35.580 −1.594 1.00 31.88 ATOM 433 CE3 TRP 259 21.101 33.269 −2.039 1.00 31.88 ATOM 434 CD1 TRP 259 21.974 36.692 −2.853 1.00 29.73 ATOM 435 NE1 TRP 259 20.926 36.826 −1.977 1.00 31.45 ATOM 436 CZ2 TRP 259 19.484 35.202 −0.721 1.00 33.37 ATOM 437 CZ3 TRP 259 20.084 32.893 −1.171 1.00 32.58 ATOM 438 CH2 TRP 259 19.288 33.858 −0.520 1.00 33.41 ATOM 439 C TRP 259 25.279 33.203 −3.328 1.00 23.16 ATOM 440 O TRP 259 25.066 32.176 −2.695 1.00 23.39 ATOM 441 N GLN 260 26.094 33.238 −4.378 1.00 24.68 ATOM 442 CA GLN 260 26.793 32.037 −4.824 1.00 24.94 ATOM 443 CB GLN 260 27.666 32.352 −6.046 1.00 28.06 ATOM 444 CG GLN 260 28.451 31.142 −6.568 1.00 34.11 ATOM 445 CD GLN 260 29.968 31.291 −6.467 1.00 38.33 ATOM 446 OE1 GLN 260 30.524 31.565 −5.390 1.00 39.00 ATOM 447 NE2 GLN 260 30.650 31.084 −7.594 1.00 40.25 ATOM 448 C GLN 260 27.671 31.473 −3.695 1.00 24.10 ATOM 449 O GLN 260 27.671 30.269 −3.435 1.00 23.36 ATOM 450 N GLN 261 28.429 32.342 −3.037 1.00 22.77 ATOM 451 CA GLN 261 29.302 31.926 −1.940 1.00 23.59 ATOM 452 CB GLN 261 30.089 33.124 −1.395 1.00 25.53 ATOM 453 CG GLN 261 31.165 33.672 −2.321 1.00 31.43 ATOM 454 CD GLN 261 31.847 34.924 −1.754 1.00 35.45 ATOM 455 OE1 GLN 261 31.616 36.053 −2.226 1.00 38.71 ATOM 456 NE2 GLN 261 32.678 34.732 −0.733 1.00 33.46 ATOM 457 C GLN 261 28.508 31.295 −0.796 1.00 22.79 ATOM 458 O GLN 261 28.893 30.254 −0.255 1.00 21.63 ATOM 459 N CYS 262 27.404 31.940 −0.425 1.00 21.36 ATOM 460 CA CYS 262 26.558 31.437 0.651 1.00 21.18 ATOM 461 CB CYS 262 25.483 32.453 1.003 1.00 20.56 ATOM 462 SG CYS 262 26.149 33.886 1.830 1.00 23.42 ATOM 463 C CYS 262 25.907 30.110 0.287 1.00 20.19 ATOM 464 O CYS 262 25.800 29.216 1.128 1.00 20.82 ATOM 465 N ALA 263 25.475 29.977 −0.962 1.00 19.51 ATOM 466 CA ALA 263 24.855 28.731 −1.391 1.00 20.19 ATOM 467 CB ALA 263 24.323 28.875 −2.790 1.00 19.19 ATOM 468 C ALA 263 25.871 27.582 −1.319 1.00 20.32 ATOM 469 O ALA 263 25.530 26.455 −0.946 1.00 20.47 ATOM 470 N ILE 264 27.120 27.869 −1.666 1.00 19.64 ATOM 471 CA ILE 264 28.163 26.844 −1.613 1.00 20.56 ATOM 472 CB ILE 264 29.479 27.352 −2.233 1.00 21.64 ATOM 473 CG2 ILE 264 30.599 26.336 −2.003 1.00 24.40 ATOM 474 CG1 ILE 264 29.276 27.584 −3.733 1.00 22.79 ATOM 475 CD1 ILE 264 30.506 28.182 −4.453 1.00 23.68 ATOM 476 C ILE 264 28.411 26.426 −0.169 1.00 19.92 ATOM 477 O ILE 264 28.490 25.235 0.142 1.00 20.57 ATOM 478 N GLN 265 28.518 27.408 0.720 1.00 20.33 ATOM 479 CA GLN 265 28.749 27.108 2.122 1.00 20.30 ATOM 480 CB GLN 265 28.961 28.392 2.919 1.00 22.53 ATOM 481 CG GLN 265 29.345 28.128 4.349 1.00 27.06 ATOM 482 CD GLN 265 30.391 27.024 4.480 1.00 30.59 ATOM 483 OE1 GLN 265 31.470 27.086 3.866 1.00 31.46 ATOM 484 NE2 GLN 265 30.075 26.003 5.286 1.00 31.02 ATOM 485 C GLN 265 27.584 26.313 2.722 1.00 19.48 ATOM 486 O GLN 265 27.800 25.335 3.435 1.00 18.61 ATOM 487 N ILE 266 26.357 26.734 2.427 1.00 18.19 ATOM 488 CA ILE 266 25.167 26.049 2.933 1.00 19.33 ATOM 489 CB ILE 266 23.877 26.775 2.494 1.00 19.84 ATOM 490 CG2 ILE 266 22.652 25.925 2.813 1.00 17.56 ATOM 491 CG1 ILE 266 23.797 28.134 3.179 1.00 20.35 ATOM 492 CD1 ILE 266 22.643 28.987 2.693 1.00 21.92 ATOM 493 C ILE 266 25.137 24.619 2.406 1.00 19.49 ATOM 494 O ILE 266 24.860 23.681 3.151 1.00 19.71 ATOM 495 N THR 267 25.427 24.452 1.120 1.00 19.07 ATOM 496 CA THR 267 25.426 23.117 0.529 1.00 20.39 ATOM 497 CB THR 267 25.732 23.173 −0.973 1.00 19.62 ATOM 498 OG1 THR 267 24.727 23.949 −1.624 1.00 18.77 ATOM 499 CG2 THR 267 25.747 21.767 −1.577 1.00 19.77 ATOM 500 C THR 267 26.476 22.239 1.204 1.00 19.70 ATOM 501 O THR 267 26.240 21.063 1.484 1.00 19.00 ATOM 502 N HIS 268 27.642 22.823 1.449 1.00 18.99 ATOM 503 CA HIS 268 28.734 22.113 2.098 1.00 19.17 ATOM 504 CB HIS 268 29.926 23.063 2.248 1.00 20.12 ATOM 505 CG HIS 268 31.167 22.409 2.764 1.00 22.30 ATOM 506 CD2 HIS 268 32.052 22.803 3.707 1.00 24.34 ATOM 507 ND1 HIS 268 31.634 21.207 2.279 1.00 24.49 ATOM 508 CE1 HIS 268 32.752 20.887 2.903 1.00 23.24 ATOM 509 NE2 HIS 268 33.029 21.838 3.775 1.00 23.14 ATOM 510 C HIS 268 28.237 21.616 3.462 1.00 19.37 ATOM 511 O HIS 268 28.415 20.449 3.811 1.00 19.15 ATOM 512 N ALA 269 27.587 22.501 4.215 1.00 17.47 ATOM 513 CA ALA 269 27.050 22.139 5.525 1.00 18.95 ATOM 514 CB ALA 269 26.522 23.380 6.237 1.00 18.60 ATOM 515 C ALA 269 25.938 21.090 5.406 1.00 18.49 ATOM 516 O ALA 269 25.838 20.181 6.229 1.00 19.32 ATOM 517 N ILE 270 25.104 21.221 4.377 1.00 17.85 ATOM 518 CA ILE 270 24.017 20.277 4.165 1.00 17.94 ATOM 519 CB ILE 270 23.113 20.735 2.999 1.00 17.72 ATOM 520 CG2 ILE 270 22.238 19.569 2.502 1.00 15.68 ATOM 521 CG1 ILE 270 22.256 21.914 3.476 1.00 17.69 ATOM 522 CD1 ILE 270 21.442 22.593 2.381 1.00 19.17 ATOM 523 C ILE 270 24.571 18.883 3.889 1.00 19.48 ATOM 524 O ILE 270 24.049 17.881 4.377 1.00 17.18 ATOM 525 N GLN 271 25.644 18.815 3.114 1.00 19.72 ATOM 526 CA GLN 271 26.229 17.519 2.826 1.00 20.49 ATOM 527 CB GLN 271 27.376 17.687 1.827 1.00 21.65 ATOM 528 CG GLN 271 26.832 18.047 0.439 1.00 22.49 ATOM 529 CD GLN 271 27.895 18.166 −0.646 1.00 23.92 ATOM 530 OE1 GLN 271 27.588 18.037 −1.831 1.00 26.25 ATOM 531 NE2 GLN 271 29.129 18.429 −0.252 1.00 23.47 ATOM 532 C GLN 271 26.663 16.804 4.118 1.00 20.60 ATOM 533 O GLN 271 26.516 15.586 4.236 1.00 20.59 ATOM 534 N TYR 272 27.159 17.552 5.098 1.00 20.89 ATOM 535 CA TYR 272 27.547 16.940 6.368 1.00 21.15 ATOM 536 CB TYR 272 28.329 17.933 7.231 1.00 23.11 ATOM 537 CG TYR 272 29.801 18.001 6.871 1.00 26.45 ATOM 538 CD1 TYR 272 30.637 16.898 7.065 1.00 29.06 ATOM 539 CE1 TYR 272 31.989 16.937 6.702 1.00 31.21 ATOM 540 CD2 TYR 272 30.351 19.153 6.306 1.00 28.01 ATOM 541 CE2 TYR 272 31.705 19.203 5.938 1.00 30.00 ATOM 542 CZ TYR 272 32.513 18.091 6.140 1.00 31.38 ATOM 543 OH TYR 272 33.846 18.137 5.786 1.00 34.21 ATOM 544 C TYR 272 26.312 16.426 7.120 1.00 21.57 ATOM 545 O TYR 272 26.378 15.401 7.810 1.00 20.19 ATOM 546 N VAL 273 25.185 17.122 6.973 1.00 18.53 ATOM 547 CA VAL 273 23.950 16.687 7.623 1.00 18.96 ATOM 546 CB VAL 273 22.832 17.740 7.496 1.00 18.38 ATOM 549 CG1 VAL 273 21.529 17.186 8.052 1.00 15.65 ATOM 550 CG2 VAL 273 23.229 19.004 8.247 1.00 17.10 ATOM 551 C VAL 273 23.474 15.365 7.007 1.00 19.57 ATOM 552 O VAL 273 22.881 14.526 7.687 1.00 20.30 ATOM 553 N VAL 274 23.731 15.181 5.718 1.00 19.26 ATOM 554 CA VAL 274 23.352 13.934 5.065 1.00 21.47 ATOM 555 CB VAL 274 23.595 13.997 3.538 1.00 19.96 ATOM 556 CG1 VAL 274 23.323 12.640 2.914 1.00 22.18 ATOM 557 CG2 VAL 274 22.678 15.052 2.905 1.00 20.72 ATOM 558 C VAL 274 24.191 12.808 5.685 1.00 21.11 ATOM 559 O VAL 274 23.668 11.746 6.021 1.00 22.06 ATOM 560 N GLU 275 25.487 13.062 5.854 1.00 22.26 ATOM 561 CA GLU 275 26.401 12.088 6.446 1.00 23.73 ATOM 562 CB GLU 275 27.836 12.632 6.449 1.00 26.76 ATOM 563 CG GLU 275 28.446 12.827 5.058 1.00 30.97 ATOM 564 CD GLU 275 29.000 11.534 4.446 1.00 34.75 ATOM 565 OE1 GLU 275 28.264 10.512 4.404 1.00 34.78 ATOM 566 OE2 GLU 275 30.180 11.553 3.995 1.00 37.39 ATOM 567 C GLU 275 25.954 11.803 7.875 1.00 22.91 ATOM 566 O GLU 275 26.046 10.674 8.354 1.00 21.80 ATOM 569 N PHE 276 25.468 12.842 8.547 1.00 21.94 ATOM 570 CA PHE 276 24.978 12.725 9.915 1.00 21.89 ATOM 571 CB PHE 276 24.512 14.101 10.412 1.00 20.02 ATOM 572 CG PHE 276 23.891 14.091 11.790 1.00 20.99 ATOM 573 CD1 PHE 276 54.507 13.431 12.850 1.00 20.22 ATOM 574 CD2 PHE 276 22.722 14.817 12.040 1.00 20.12 ATOM 575 CE1 PHE 276 23.975 13.502 14.144 1.00 21.36 ATOM 576 CE2 PHE 276 22.182 14.895 13.325 1.00 20.21 ATOM 577 CZ PHE 276 22.808 14.239 14.381 1.00 19.91 ATOM 578 C PHE 276 23.809 11.741 9.935 1.00 21.78 ATOM 579 O PHE 276 23.815 10.771 10.688 1.00 22.96 ATOM 580 N ALA 277 22.813 11.997 9.091 1.00 21.26 ATOM 581 CA ALA 277 21.626 11.148 9.012 1.00 21.02 ATOM 582 CB ALA 277 20.650 11.705 7.979 1.00 19.08 ATOM 583 C ALA 277 21.968 9.700 8.671 1.00 21.78 ATOM 584 O ALA 277 21.450 8.774 9.294 1.00 22.63 ATOM 585 N LYS 278 22.836 9.511 7.683 1.00 23.13 ATOM 586 CA LYS 278 23.240 8.173 7.256 1.00 25.28 ATOM 587 CB LYS 278 24.209 8.275 6.078 1.00 24.01 ATOM 588 CG LYS 278 23.561 8.837 4.803 1.00 26.41 ATOM 589 CD LYS 278 24.575 8.997 3.689 1.00 24.85 ATOM 590 CE LYS 278 25.265 7.676 3.395 1.00 25.80 ATOM 591 NZ LYS 278 26.214 7.801 2.259 1.00 28.08 ATOM 592 C LYS 278 23.862 7.317 8.361 1.00 25.78 ATOM 593 O LYS 278 23.866 6.091 8.271 1.00 26.96 ATOM 594 N ARG 279 24.388 7.950 9.400 1.00 26.39 ATOM 595 CA ARG 279 24.999 7.195 10.482 1.00 27.59 ATOM 596 CB ARG 279 26.266 7.893 10.953 1.00 28.22 ATOM 597 CG ARG 279 27.190 8.219 9.794 1.00 31.75 ATOM 598 CD ARG 279 28.645 8.302 10.202 1.00 33.61 ATOM 599 NE ARG 279 29.490 8.575 9.047 1.00 35.68 ATOM 600 CZ ARG 279 30.818 8.479 9.035 1.00 38.22 ATOM 601 NH1 ARG 279 31.478 8.108 10.128 1.00 38.46 ATOM 602 NH2 ARG 279 31.488 8.760 7.920 1.00 37.61 ATOM 603 C ARG 279 24.053 6.936 11.652 1.00 27.34 ATOM 604 O ARG 279 24.397 6.217 12.589 1.00 28.95 ATOM 605 N ILE 280 22.854 7.503 11.596 1.00 25.28 ATOM 606 CA ILE 280 21.886 7.270 12.661 1.00 24.59 ATOM 607 CB ILE 280 20.922 8.464 12.827 1.00 22.88 ATOM 608 CG2 ILE 280 19.884 8.152 13.912 1.00 21.69 ATOM 609 CG1 ILE 280 21.708 9.722 13.219 1.00 21.57 ATOM 610 CD1 ILE 260 20.835 10.965 13.380 1.00 20.98 ATOM 611 C ILE 280 21.085 6.014 12.315 1.00 24.77 ATOM 612 O ILE 280 20.181 6.051 11.481 1.00 23.84 ATOM 613 N THR 281 21.421 4.902 12.967 1.00 25.98 ATOM 614 CA THR 281 20.754 3.628 12.706 1.00 27.40 ATOM 615 CB THR 281 21.064 2.608 13.805 1.00 28.22 ATOM 616 OG1 THR 281 22.485 2.514 13.970 1.00 32.17 ATOM 617 CG2 THR 281 20.518 1.237 13.422 1.00 30.45 ATOM 618 C THR 281 19.236 3.720 12.547 1.00 26.89 ATOM 619 O THR 261 18.685 3.173 11.596 1.00 27.85 ATOM 620 N GLY 282 18.568 4.405 13.468 1.00 25.97 ATOM 621 CA GLY 262 17.120 4.536 13.395 1.00 24.93 ATOM 622 C GLY 282 16.605 5.255 12.156 1.00 25.15 ATOM 623 O GLY 282 15.502 4.981 11.680 1.00 23.70 ATOM 624 N PHE 283 17.400 6.187 11.639 1.00 24.97 ATOM 625 CA PHE 283 17.035 6.948 10.439 1.00 25.33 ATOM 626 CB PHE 283 17.958 8.169 10.295 1.00 23.28 ATOM 627 CG PHE 283 17.757 8.945 9.017 1.00 23.75 ATOM 628 CD1 PHE 283 18.377 8.548 7.837 1.00 23.86 ATOM 629 CD2 PHE 283 16.940 10.069 8.994 1.00 22.16 ATOM 630 CE1 PHE 283 18.185 9.261 6.654 1.00 23.03 ATOM 631 CE2 PHE 283 16.743 10.784 7.820 1.00 23.21 ATOM 632 CZ PHE 283 17.367 10.382 6.648 1.00 20.80 ATOM 633 C PHE 283 17.141 6.072 9.185 1.00 25.72 ATOM 634 O PHE 283 16.287 6.128 8.295 1.00 26.38 ATOM 635 N MET 284 18.194 5.265 9.115 1.00 26.64 ATOM 636 CA MET 284 18.384 4.398 7.960 1.00 28.17 ATOM 637 CB MET 284 19.825 3.887 7.916 1.00 29.11 ATOM 638 CG MET 284 20.836 4.994 7.618 1.00 30.38 ATOM 639 SD MET 284 20.370 6.064 6.205 1.00 33.12 ATOM 640 CE MET 284 20.937 5.078 4.772 1.00 34.35 ATOM 641 C. MET 284 17.395 3.235 7.917 1.00 29.78 ATOM 642 O MET 284 17.313 2.516 6.917 1.00 28.85 ATOM 643 N GLU 285 16.629 3.068 8.991 1.00 31.01 ATOM 644 CA GLU 285 15.638 1.999 9.060 1.00 31.97 ATOM 645 CB GLU 285 15.439 1.536 10.507 1.00 33.56 ATOM 646 CG GLU 285 16.658 0.814 11.078 1.00 37.02 ATOM 647 CD GLU 285 16.417 0.259 12.469 1.00 38.77 ATOM 646 OE1 GLU 285 15.390 0.617 13.090 1.00 39.52 ATOM 649 OE2 GLU 285 17.265 −0.529 12.942 1.00 40.58 ATOM 650 C GLU 285 14.306 2.444 8.479 1.00 31.93 ATOM 651 O GLU 285 13.430 1.619 8.211 1.00 32.23 ATOM 652 N LEU 286 14.153 3.754 8.289 1.00 30.77 ATOM 653 CA LEU 286 12.935 4.315 7.715 1.00 30.76 ATOM 654 CB LEU 286 12.890 5.835 7.931 1.00 29.72 ATOM 655 CG LEU 286 13.009 6.367 9.364 1.00 29.96 ATOM 656 CD1 LEU 286 12.937 7.884 9.339 1.00 28.70 ATOM 657 CD2 LEU 286 11.890 5.805 10.235 1.00 29.71 ATOM 656 C LEU 286 13.960 4.011 6.220 1.00 29.96 ATOM 659 O LEU 286 14.021 3.715 5.666 1.00 30.54 ATOM 660 N CYS 287 11.814 4.075 5.555 1.00 30.89 ATOM 661 CA CYS 287 11.821 3.791 4.123 1.00 31.57 ATOM 662 CB CYS 287 10.400 3.677 3.555 1.00 32.51 ATOM 663 SG CYS 287 9.395 5.168 3.569 1.00 35.47 ATOM 664 C CYS 287 12.579 4.921 3.457 1.00 31.76 ATOM 665 O CYS 287 12.504 6.071 3.891 1.00 30.50 ATOM 666 N GLN 288 13.327 4.591 2.411 1.00 32.56 ATOM 667 CA GLN 288 14.134 5.591 1.723 1.00 32.18 ATOM 668 CB GLN 288 14.818 4.960 0.519 1.00 34.37 ATOM 669 CG GLN 288 16.070 5.697 0.077 1.00 37.44 ATOM 670 CD GLN 288 16.766 4.982 −1.045 1.00 38.80 ATOM 671 OE1 GLN 288 16.178 4.741 −2.095 1.00 40.25 ATOM 672 NE2 GLN 288 18.023 4.626 −0.832 1.00 41.12 ATOM 673 C GLN 288 13.304 6.800 1.305 1.00 31.30 ATOM 674 O GLN 288 13.809 7.918 1.213 1.00 29.76 ATOM 675 N ASN 289 12.019 6.586 1.063 1.00 29.60 ATOM 676 CA ASN 289 11.180 7.701 0.685 1.00 30.09 ATOM 677 CB ASN 289 9.789 7.222 0.320 1.00 32.43 ATOM 678 CG ASN 289 8.831 8.363 0.186 1.00 34.94 ATOM 679 OD1 ASN 289 8.262 8.837 1.177 1.00 37.17 ATOM 680 ND2 ASN 289 8.670 8.850 −1.038 1.00 37.46 ATOM 681 C ASN 289 11.065 8.737 1.803 1.00 28.55 ATOM 682 O ASN 289 11.120 9.954 1.561 1.00 28.23 ATOM 683 N ASP 290 10.880 8.253 3.027 1.00 27.44 ATOM 684 CA ASP 290 10.75

9.146 4.166 1.00 25.42 ATOM 685 CB ASP 290 10.100 8.423 5.351 1.00 25.58 ATOM 686 CG ASP 290 8.593 8.245 5.159 1.00 25.63 ATOM 687 OD1 ASP 290 8.033 8.887 4.247 1.00 25.74 ATOM 688 OD2 ASP 290 7.966 7.479 5.918 1.00 24.50 ATOM 689 C ASP 290 12.116 9.712 4.541 1.00 24.26 ATOM 690 O ASP 290 12.205 10.793 5.113 1.00 23.09 ATOM 691 N GLN 291 13.176 8.984 4.203 1.00 24.37 ATOM 692 CA GLN 291 14.525 9.453 4.482 1.00 23.42 ATOM 693 CB GLN 291 15.562 8.400 4.092 1.00 23.59 ATOM 694 CG GLN 291 15.608 7.164 4.965 1.00 22.66 ATOM 695 CD GLN 291 16.639 6.173 4.464 1.00 22.68 ATOM 696 OE1 GLN 291 17.532 6.527 3.694 1.00 24.72 ATOM 697 NE2 GLN 291 16.532 4.930 4.908 1.00 24.25 ATOM 698 C GLN 291 14.773 10.704 3.649 1.00 23.72 ATOM 699 O GLN 291 15.328 11.688 4.134 1.00 21.67 ATOM 700 N ILE 292 14.358 10.648 2.384 1.00 23.54 ATOM 701 CA ILE 292 14.541 11.765 1.462 1.00 23.40 ATOM 702 CB ILE 292 14.166 11.363 −0.003 1.00 24.40 ATOM 703 CG2 ILE 292 14.176 12.592 −0.913 1.00 24.00 ATOM 704 CG1 ILE 292 15.160 10.326 −0.535 1.00 25.84 ATOM 705 CD1 ILE 292 16.582 10.825 −0.654 1.00 28.34 ATOM 706 C ILE 292 13.681 12.938 1.903 1.00 22.88 ATOM 707 O ILE 292 14.148 14.078 1.952 1.00 22.08 ATOM 708 N LEU 293 12.430 12.649 2.245 1.00 21.21 ATOM 709 CA LEU 293 11.513 13.679 2.684 1.00 22.20 ATOM 710 CB LEU 293 10.128 13.077 2.945 1.00 22.87 ATOM 711 CG LEU 293 9.337 12.783 1.668 1.00 26.65 ATOM 712 CD1 LEU 293 8.100 11.943 1.981 1.00 27.63 ATOM 713 CD2 LEU 293 8.947 14.115 1.009 1.00 27.30 ATOM 714 C LEU 293 12.041 14.366 3.936 1.00 21.47 ATOM 715 O LEU 293 12.013 15.588 4.034 1.00 20.74 ATOM 716 N LEU 294 12.532 13.578 4.887 1.00 22.09 ATOM 717 CA LEU 294 13.053 14.158 6.111 1.00 21.85 ATOM 718 CB LEU 294 13.410 13.062 7.120 1.00 22.49 ATOM 719 CG LEU 294 12.210 12.367 7.770 1.00 23.61 ATOM 720 CD1 LEU 294 12.693 11.448 8.877 1.00 23.93 ATOM 721 CD2 LEU 294 11.254 13.400 8.339 1.00 23.56 ATOM 722 C LEU 294 14.262 15.034 5.818 1.00 20.92 ATOM 723 O LEU 294 14.371 16.138 6.335 1.00 20.70 ATOM 724 N LEU 295 15.170 14.549 4.979 1.00 21.44 ATOM 725 CA LEU 295 16.352 15.334 4.636 1.00 21.46 ATOM 726 CB LEU 295 17.325 14.481 3.836 1.00 21.73 ATOM 727 CG LEU 295 18.087 13.499 4.725 1.00 24.02 ATOM 728 CD1 LEU 295 18.824 12.477 3.879 1.00 23.40 ATOM 729 CD2 LEU 295 19.053 14.292 5.602 1.00 25.66 ATOM 730 C LEU 295 16.020 16.605 3.857 1.00 21.70 ATOM 731 O LEU 295 16.537 17.682 4.158 1.00 19.82 ATOM 732 N LYS 296 15.158 16.473 2.855 1.00 21.79 ATOM 733 CA LYS 296 14.769 17.605 2.029 1.00 25.11 ATOM 734 CB LYS 296 13.821 17.139 0.919 1.00 27.17 ATOM 735 CG LYS 296 13.241 18.257 0.084 1.00 30.32 ATOM 736 CD LYS 296 12.261 17.694 −0.938 1.00 33.40 ATOM 737 CE LYS 296 11.800 18.766 −1.903 1.00 35.42 ATOM 738 NZ LYS 296 12.910 19.218 −2.791 1.00 37.44 ATOM 739 C LYS 296 14.109 18.714 2.831 1.00 23.87 ATOM 740 O LYS 296 14.348 19.902 2.582 1.00 23.29 ATOM 741 N SER 297 13.287 18.326 3.798 1.00 23.52 ATOM 742 CA SER 297 12.587 19.294 4.628 1.00 24.66 ATOM 743 CB SER 297 11.243 18.707 5.086 1.00 25.85 ATOM 744 OG SER 297 11.426 17.494 5.798 1.00 25.78 ATOM 745 C SER 297 13.374 19.791 5.652 1.00 24.52 ATOM 746 O SER 297 13.123 20.898 6.338 1.00 25.12 ATOM 747 N GLY 298 14.333 19.002 6.328 1.00 22.15 ATOM 748 CA GLY 298 15.068 19.406 7.511 1.00 22.02 ATOM 749 C GLY 298 16.570 19.616 7.445 1.00 20.47 ATOM 750 O GLY 298 17.160 20.017 8.437 1.00 20.04 ATOM 751 N CYS 299 17.203 19.363 6.306 1.00 20.94 ATOM 752 CA CYS 299 18.649 19.543 6.237 1.00 21.39 ATOM 753 CB CYS 299 19.182 19.250 4.827 1.00 23.06 ATOM 754 SG CYS 299 18.429 20.203 3.482 1.00 29.00 ATOM 755 C CYS 299 19.039 20.951 6.658 1.00 20.07 ATOM 756 O CYS 299 19.907 21.121 7.506 1.00 18.32 ATOM 757 N LEU 300 18.379 21.958 6.097 1.00 18.43 ATOM 758 CA LEU 300 18.704 23.335 6.443 1.00 18.89 ATOM 759 CB LEU 300 17.942 24.303 5.540 1.00 17.66 ATOM 760 CG LEU 300 18.466 25.744 5.496 1.00 18.57 ATOM 761 CD1 LEU 300 19.961 25.753 5.152 1.00 18.04 ATOM 762 CD2 LEU 300 17.670 26.535 4.469 1.00 18.71 ATOM 763 C LEU 300 18.424 23.657 7.913 1.00 18.49 ATOM 764 O LEU 300 19.151 24.435 8.535 1.00 18.49 ATOM 765 N GLU 301 17.368 23.061 8.462 1.00 18.69 ATOM 766 CA GLU 301 17.020 23.278 9.858 1.00 18.42 ATOM 767 CB GLU 301 15.680 22.604 10.181 1.00 18.90 ATOM 768 CG GLU 301 14.505 23.235 9.443 1.00 21.00 ATOM 769 CD GLU 301 13.163 22.710 9.897 1.00 22.11 ATOM 770 OE1 GLU 301 13.145 21.861 10.809 1.00 22.99 ATOM 771 OE2 GLU 301 12.128 23.156 9.342 1.00 23.74 ATOM 772 C GLU 301 18.137 22.729 10.744 1.00 18.45 ATOM 773 O GLU 301 18.488 23.327 11.764 1.00 17.98 ATOM 774 N VAL 302 18.705 21.594 10.354 1.00 18.55 ATOM 775 CA VAL 302 19.804 21.013 11.126 1.00 18.30 ATOM 776 CB VAL 302 20.165 19.597 10.631 1.00 17.49 ATOM 777 CG1 VAL 302 21.417 19.094 11.337 1.00 17.23 ATOM 778 CG2 VAL 302 19.004 18.660 10.888 1.00 18.62 ATOM 779 C VAL 302 21.037 21.913 10.991 1.00 18.44 ATOM 780 O VAL 302 21.762 22.142 11.959 1.00 18.67 ATOM 781 N VAL 303 21.274 22.413 9.782 1.00 17.76 ATOM 782 CA VAL 303 22.406 23.296 9.546 1.00 17.41 ATOM 783 CB VAL 303 22.461 23.762 8.074 1.00 17.57 ATOM 784 CG1 VAL 303 23.544 24.829 7.906 1.00 16.57 ATOM 785 CG2 VAL 303 22.737 22.574 7.156 1.00 18.12 ATOM 786 C VAL 303 22.260 24.528 10.435 1.00 18.40 ATOM 787 O VAL 303 23.219 24.985 11.051 1.00 18.46 ATOM 788 N LEU 304 21.043 25.057 10.495 1.00 17.81 ATOM 789 CA LEU 304 20.771 26.237 11.296 1.00 18.40 ATOM 790 CB LEU 304 19.310 26.664 11.145 1.00 18.67 ATOM 791 CG LEU 304 18.905 27.901 11.954 1.00 18.74 ATOM 792 CD1 LEU 304 19.798 29.072 11.572 1.00 19.24 ATOM 793 CD2 LEU 304 17.439 28.224 11.690 1.00 19.46 ATOM 794 C LEU 304 21.089 25.994 12.762 1.00 19.34 ATOM 795 O LEU 304 21.642 26.873 13.422 1.00 18.80 ATOM 796 N VAL 305 20.720 24.811 13.265 1.00 19.25 ATOM 797 CA VAL 305 20.984 24.439 14.655 1.00 19.61 ATOM 798 CB VAL 305 20.342 23.072 15.031 1.00 20.39 ATOM 799 CG1 VAL 305 20.877 22.596 16.381 1.00 18.01 ATOM 800 CG2 VAL 305 18.819 23.192 15.081 1.00 18.19 ATOM 801 C VAL 305 22.495 24.320 14.828 1.00 20.18 ATOM 802 O VAL 305 23.059 24.849 15.779 1.00 20.30 ATOM 803 N ARG 306 23.142 23.628 13.896 1.00 19.99 ATOM 804 CA ARG 306 24.587 23.456 13.957 1.00 21.89 ATOM 805 CB ARG 306 25.063 22.541 12.836 1.00 21.78 ATOM 806 CG ARG 306 24.838 21.076 13.112 1.00 19.29 ATOM 807 CD ARG 306 25.401 20.245 11.990 1.00 20.34 ATOM 808 NE ARG 306 25.516 18.853 12.393 1.00 22.00 ATOM 809 CZ ARG 306 26.166 17.928 11.702 1.00 22.25 ATOM 810 NH1 ARG 306 26.760 18.247 10.558 1.00 20.55 ATOM 811 NH2 ARG 306 26.241 16.692 12.173 1.00 22.86 ATOM 812 C ARG 306 25.373 24.763 13.908 1.00 22.45 ATOM 813 O ARG 306 26.474 24.840 14.445 1.00 22.73 ATOM 814 N MET 307 24.805 25.785 13.277 1.00 24.18 ATOM 815 CA MET 307 25.470 27.084 13.169 1.00 26.27 ATOM 816 CB MET 307 24.608 28.046 12.353 1.00 27.38 ATOM 817 CG MET 307 25.231 29.412 12.170 1.00 28.81 ATOM 818 SD MET 307 24.099 30.460 11.288 1.00 30.68 ATOM 819 CE MET 307 23.147 31.073 12.604 1.00 27.74 ATOM 820 C MET 307 25.763 27.708 14.532 1.00 25.58 ATOM 821 O MET 307 26.731 28.453 14.701 1.00 25.50 ATOM 822 N CYS 308 24.921 27.400 15.505 1.00 26.62 ATOM 823 CA CYS 308 25.087 27.935 16.842 1.00 25.94 ATOM 824 CB CYS 308 23.901 27.512 17.693 1.00 27.50 ATOM 825 SG CYS 308 22.349 27.999 16.879 1.00 32.50 ATOM 826 C CYS 308 26.411 27.483 17.451 1.00 25.08 ATOM 827 O CYS 308 26.951 28.139 18.337 1.00 26.40 ATOM 828 N ARG 309 26.932 26.367 16.958 1.00 24.15 ATOM 829 CA ARG 309 28.212 25.836 17.426 1.00 23.77 ATOM 830 CB ARG 309 28.514 24.490 16.763 1.00 22.37 ATOM 831 CG ARG 309 27.526 23.377 17.070 1.00 23.23 ATOM 832 CD ARG 309 27.900 22.123 16.296 1.00 22.66 ATOM 833 NE ARG 309 29.133 21.499 16.778 1.00 23.68 ATOM 834 CZ ARG 309 30.260 21.397 16.079 1.00 22.00 ATOM 835 NH1 ARG 309 30.337 21.884 14.850 1.00 20.45 ATOM 836 NH2 ARG 309 31.309 20.777 16.612 1.00 21.98 ATOM 837 C ARG 309 29.337 26.792 17.043 1.00 23.79 ATOM 838 O ARG 309 30.334 26.918 17.758 1.00 23.81 ATOM 839 N ALA 310 29.167 27.438 15.892 1.00 23.32 ATOM 840 CA ALA 310 30.163 28.354 15.344 1.00 22.67 ATOM 841 CB ALA 310 30.501 27.953 13.903 1.00 23.22 ATOM 842 C ALA 310 29.690 29.796 15.376 1.00 22.59 ATOM 643 O ALA 310 29.895 30.549 14.424 1.00 22.73 ATOM 844 N PHE 311 29.047 30.170 16.471 1.00 22.48 ATOM 845 CA PHE 311 28.552 31.524 16.639 1.00 23.10 ATOM 846 CB PHE 311 27.025 31.516 16.677 1.00 22.61 ATOM 847 CG PHE 311 26.419 32.879 16.811 1.00 24.45 ATOM 848 CD1 PHE 311 26.166 33.422 18.066 1.00 25.03 ATOM 849 CD2 PHE 311 26.111 33.625 15.677 1.00 24.86 ATOM 850 CE1 PHE 311 25.610 34.697 18.189 1.00 26.19 ATOM 851 CE2 PHE 311 25.555 34.904 15.787 1.00 25.65 ATOM 852 CZ PHE 311 25.303 35.440 17.044 1.00 25.60 ATOM 853 C PHE 311 29.118 32.064 17.950 1.00 23.95 ATOM 854 O PHE 311 29.225 31.332 18.926 1.00 24.13 ATOM 855 N ASN 312 29.496 33.336 17.965 1.00 23.37 ATOM 856 CA ASN 312 30.041 33.928 19.170 1.00 23.53 ATOM 857 CB ASN 312 31.413 34.524 18.884 1.00 24.46 ATOM 858 CG ASN 312 32.066 35.059 20.125 1.00 25.90 ATOM 859 OD1 ASN 312 31.439 35.112 21.187 1.00 28.29 ATOM 860 ND2 ASN 312 33.326 35.465 20.009 1.00 25.97 ATOM 861 C ASN 312 29.091 35.015 19.670 1.00 23.70 ATOM 862 O ASN 312 29.051 36.121 19.127 1.00 22.70 ATOM 863 N PRO 313 28.309 34.707 20.715 1.00 23.93 ATOM 864 CD PRO 313 28.291 33.413 21.415 1.00 24.49 ATOM 865 CA PRO 313 27.340 35.635 21.307 1.00 25.73 ATOM 866 CB PRO 313 26.561 34.748 22.283 1.00 25.50 ATOM 867 CG PRO 313 27.557 33.738 22.691 1.00 25.23 ATOM 868 C PRO 313 27.955 36.856 21.976 1.00 26.34 ATOM 869 O PRO 313 27.271 37.852 22.209 1.00 27.02 ATOM 870 N LEU 314 29.243 36.782 22.283 1.00 27.08 ATOM 871 CA LEU 314 29.933 37.908 22.900 1.00 28.42 ATOM 872 CB LEU 314 31.384 37.525 23.202 1.00 29.58 ATOM 873 CG LEU 314 31.588 36.580 24.390 1.00 30.01 ATOM 874 CD1 LEU 314 32.985 35.966 24.353 1.00 30.50 ATOM 875 CD2 LEU 314 31.366 37.344 25.685 1.00 31.31 ATOM 876 C LEU 314 29.881 39.134 21.980 1.00 29.42 ATOM 877 O LEU 314 29.618 40.247 22.438 1.00 29.09 ATOM 878 N ASN 315 30.119 38.918 20.685 1.00 28.55 ATOM 879 CA ASN 315 30.104 39.995 19.699 1.00 28.31 ATOM 880 CB ASN 315 31.520 40.220 19.135 1.00 28.09 ATOM 881 CG ASN 315 32.114 38.966 18.488 1.00 28.61 ATOM 882 OD1 ASN 315 31.459 37.935 18.375 1.00 27.11 ATOM 883 ND2 ASN 315 33.368 39.065 18.053 1.00 29.33 ATOM 884 C ASN 315 29.123 39.771 18.536 1.00 28.16 ATOM 885 O ASN 315 29.115 40.534 17.566 1.00 28.31 ATOM 886 N ASN 316 28.289 38.742 18.637 1.00 27.03 ATOM 887 CA ASN 316 27.322 38.430 17.582 1.00 26.93 ATOM 888 CB ASN 316 26.246 39.522 17.467 1.00 27.40 ATOM 889 CG ASN 316 25.247 39.491 18.621 1.00 29.23 ATOM 890 OD1 ASN 316 24.845 38.423 19.079 1.00 29.19 ATOM 891 ND2 ASN 316 24.828 40.673 19.081 1.00 29.80 ATOM 892 C ASN 316 28.002 38.253 16.226 1.00 25.60 ATOM 893 O ASN 316 27.688 38.956 15.264 1.00 25.51 ATOM 894 N THR 317 28.947 37.322 16.162 1.00 24.54 ATOM 895 CA THR 317 29.635 37.031 14.917 1.00 24.24 ATOM 896 CB THR 317 31.124 37.428 14.970 1.00 24.58 ATOM 897 OG1 THR 317 31.780 36.721 16.029 1.00 25.19 ATOM 898 CG2 THR 317 31.255 38.924 15.194 1.00 24.84 ATOM 899 C THR 317 29.516 35.532 14.648 1.00 22.99 ATOM 900 O THR 317 29.262 34.741 15.559 1.00 22.92 ATOM 901 N VAL 318 29.674 35.154 13.388 1.00 22.45 ATOM 902 CA VAL 318 29.577 33.761 13.004 1.00 22.06 ATOM 903 CB VAL 318 28.239 33.460 12.281 1.00 21.83 ATOM 904 CG1 VAL 318 28.127 34.294 11.017 1.00 21.77 ATOM 905 CG2 VAL 318 28.155 31.983 11.950 1.00 23.58 ATOM 906 C VAL 318 30.719 33.402 12.081 1.00 21.76 ATOM 907 O VAL 318 31.245 34.256 11.366 1.00 21.99 ATOM 908 N LEU 319 31.109 32.132 12.122 1.00 21.37 ATOM 909 CA LEU 319 32.177 31.626 11.278 1.00 22.24 ATOM 910 CB LEU 319 32.619 30.243 11.767 1.00 22.86 ATOM 911 CG LEU 319 33.660 29.513 10.921 1.00 23.05 ATOM 912 CD1 LEU 319 34.955 30.318 10.928 1.00 25.19 ATOM 913 CD2 LEU 319 33.896 28.116 11.475 1.00 24.34 ATOM 914 C LEU 319 31.684 31.528 9.833 1.00 23.30 ATOM 915 O LEU 319 30.687 30.870 9.551 1.00 22.87 ATOM 916 N PHE 320 32.389 32.194 8.925 1.00 23.64 ATOM 917 CA PHE 320 32.037 32.176 7.508 1.00 25.23 ATOM 918 CB PHE 320 31.108 33.346 7.172 1.00 24.27 ATOM 919 CG PHE 320 30.699 33.397 5.729 1.00 25.29 ATOM 920 CD1 PHE 320 29.735 32.522 5.229 1.00 25.59 ATOM 921 CD2 PHE 320 31.269 34.325 4.865 1.00 24.72 ATOM 922 CE1 PHE 320 29.347 32.576 3.894 1.00 25.95 ATOM 923 CE2 PHE 320 30.886 34.383 3.525 1.00 25.91 ATOM 924 CZ PHE 320 29.924 33.509 3.040 1.00 25.81 ATOM 925 C PHE 320 33.327 32.290 6.702 1.00 26.25 ATOM 926 O PHE 320 34.045 33.284 6.787 1.00 26.22 ATOM 927 N GLU 321 33.621 31.255 5.929 1.00 28.45 ATOM 928 CA GLU 321 34.831 31.210 5.125 1.00 29.34 ATOM 929 CB GLU 321 34.779 32.272 4.006 1.00 29.96 ATOM 930 CG GLU 321 33.650 32.017 2.999 1.00 31.85 ATOM 931 CD GLU 321 33.659 32.933 1.774 1.00 32.92 ATOM 932 OE1 GLU 321 34.446 33.910 1.724 1.00 35.63 ATOM 933 OE2 GLU 321 32.860 32.667 0.855 1.00 31.62 ATOM 934 C GLU 321 36.114 31.357 5.953 1.00 29.82 ATOM 935 O GLU 321 36.994 32.128 5.602 1.00 29.97 ATOM 936 N GLY 322 36.202 30.635 7.067 1.00 29.47 ATOM 937 CA GLY 322 37.411 30.658 7.880 1.00 28.49 ATOM 938 C GLY 322 37.607 31.596 9.062 1.00 27.90 ATOM 939 O GLY 322 38.501 31.362 9.882 1.00 28.38 ATOM 940 N LYS 323 36.824 32.663 9.160 1.00 26.69 ATOM 941 CA LYS 323 36.979 33.591 10.280 1.00 26.84 ATOM 942 CB LYS 323 37.836 34.801 9.878 1.00 28.64 ATOM 943 CG LYS 323 39.232 34.483 9.329 1.00 31.90 ATOM 944 CD LYS 323 39.949 35.778 8.935 1.00 34.33 ATOM 945 CE LYS 323 41.320 35.534 8.325 1.00 36.36 ATOM 946 NZ LYS 323 42.359 35.109 9.323 1.00 38.14 ATOM 947 C LYS 323 35.608 34.087 10.707 1.00 25.87 ATOM 948 O LYS 323 34.638 33.952 9.961 1.00 23.69 ATOM 949 N TYR 324 35.526 34.672 11.899 1.00 25.68 ATOM 950 CA TYR 324 34.249 35.186 12.378 1.00 25.45 ATOM 951 CB TYR 324 34.205 35.174 13.903 1.00 26.32 ATOM 952 CG TYR 324 33.996 33.794 14.474 1.00 26.94 ATOM 953 CD1 TYR 324 34.918 32.773 14.237 1.00 27.29 ATOM 954 CE1 TYR 324 34.705 31.486 14.722 1.00 28.49 ATOM 955 CD2 TYR 324 32.858 33.491 15.215 1.00 25.92 ATOM 956 CE2 TYR 324 32.640 32.210 15.702 1.00 26.59 ATOM 957 CZ TYR 324 33.564 31.211 15.451 1.00 27.01 ATOM 958 OH TYR 324 33.339 29.930 15.920 1.00 28.62 ATOM 959 C TYR 324 33.965 36.585 11.863 1.00 25.14 ATOM 960 O TYR 324 34.864 37.422 11.781 1.00 25.62 ATOM 961 N GLY 325 32.705 36.829 11.507 1.00 23.90 ATOM 962 CA GLY 325 32.310 38.127 11.001 1.00 23.79 ATOM 963 C GLY 325 30.897 38.461 11.441 1.00 25.33 ATOM 964 O GLY 325 30.079 37.561 11.652 1.00 24.38 ATOM 965 N GLY 326 30.610 39.752 11.589 1.00 24.25 ATOM 966 CA GLY 326 29.282 40.168 12.004 1.00 24.94 ATOM 967 C GLY 326 28.261 40.090 10.883 1.00 25.23 ATOM 968 O GLY 326 28.598 39.728 9.751 1.00 25.79 ATOM 969 N MET 327 27.014 40.445 11.185 1.00 26.02 ATOM 970 CA MET 327 25.953 40.401 10.190 1.00 27.32 ATOM 971 CB MET 327 24.595 40.646 10.864 1.00 29.29 ATOM 972 CG MET 327 24.389 42.052 11.416 1.00 32.37 ATOM 973 SD MET 327 23.965 43.257 10.146 1.00 37.07 ATOM 974 CE MET 327 22.345 42.637 9.596 1.00 35.38 ATOM 975 C MET 327 26.152 41.373 9.017 1.00 27.13 ATOM 976 O MET 327 25.592 41.172 7.950 1.00 25.51 ATOM 977 N GLN 328 26.950 42.423 9.211 1.00 27.79 ATOM 978 CA GLN 328 27.198 43.392 8.138 1.00 29.04 ATOM 979 CB GLN 328 28.025 44.571 8.662 1.00 31.55 ATOM 980 CG GLN 328 29.460 44.204 8.990 1.00 33.92 ATOM 961 CD GLN 328 29.682 43.901 10.462 1.00 36.11 ATOM 982 OE1 GLN 328 28.873 43.216 11.102 1.00 35.48 ATOM 983 NE2 GLN 328 30.802 44.407 11.011 1.00 36.91 ATOM 984 C GLN 328 27.959 42.718 6.993 1.00 28.92 ATOM 985 O GLN 328 27.970 43.193 5.864 1.00 28.52 ATOM 986 N MET 329 28.604 41.604 7.317 1.00 28.72 ATOM 987 CA MET 329 29.368 40.813 6.366 1.00 27.66 ATOM 988 CB MET 329 29.998 39.633 7.124 1.00 29.67 ATOM 989 CG MET 329 30.698 38.584 6.294 1.00 30.31 ATOM 990 SD MET 329 31.675 37.438 7.333 1.00 30.76 ATOM 991 CE MET 329 30.395 36.763 8.395 1.00 27.38 ATOM 992 C MET 329 28.462 40.322 5.228 1.00 27.08 ATOM 993 O MET 329 28.927 40.093 4.115 1.00 25.67 ATOM 994 N PHE 330 27.166 40.197 5.505 1.00 25.56 ATOM 995 CA PHE 330 26.202 39.717 4.510 1.00 25.27 ATOM 996 CB PHE 330 25.258 38.717 5.164 1.00 26.21 ATOM 997 CG PHE 330 25.960 37.546 5.779 1.00 26.31 ATOM 998 CD1 PHE 330 26.573 36.591 4.979 1.00 26.75 ATOM 999 CD2 PHE 330 26.037 37.413 7.160 1.00 27.20 ATOM 1000 CE1 PHE 330 27.263 35.514 5.547 1.00 28.46 ATOM 1001 CE2 PHE 330 26.722 36.342 7.737 1.00 28.83 ATOM 1002 CZ PHE 330 27.337 35.391 6.928 1.00 27.19 ATOM 1003 C PHE 330 25.368 40.812 3.858 1.00 24.55 ATOM 1004 O PHE 330 24.351 40.536 3.226 1.00 24.95 ATOM 1005 N LYS 331 25.803 42.051 4.007 1.00 24.84 ATOM 1006 CA LYS 331 25.081 43.181 3.452 1.00 25.68 ATOM 1007 CB LYS 331 25.923 44.442 3.602 1.00 27.69 ATOM 1008 CG LYS 331 25.100 45.699 3.629 1.00 30.20 ATOM 1009 CD LYS 331 24.105 45.611 4.781 1.00 34.11 ATOM 1010 CE LYS 331 23.238 46.853 4.879 1.00 35.87 ATOM 1011 NZ LYS 331 22.167 46.684 5.903 1.00 37.65 ATOM 1012 C LYS 331 24.679 43.007 1.990 1.00 26.00 ATOM 1013 O LYS 331 23.551 43.317 1.609 1.00 26.68 ATOM 1014 N ALA 332 25.594 42.493 1.182 1.00 26.27 ATOM 1015 CA ALA 332 25.357 42.299 −0.242 1.00 26.94 ATOM 1016 CB ALA 332 26.645 41.847 −0.917 1.00 27.13 ATOM 1017 C ALA 332 24.211 41.348 −0.588 1.00 27.68 ATOM 1018 O ALA 332 23.687 41.398 −1.705 1.00 28.00 ATOM 1019 N LEU 333 23.817 40.492 0.356 1.00 26.04 ATOM 1020 CA LEU 333 22.709 39.566 0.119 1.00 25.55 ATOM 1021 CB LEU 333 22.548 38.586 1.279 1.00 22.80 ATOM 1022 CG LEU 333 23.589 37.495 1.501 1.00 23.44 ATOM 1023 CD1 LEU 333 23.127 36.616 2.659 1.00 21.98 ATOM 1024 CD2 LEU 333 23.766 36.673 0.241 1.00 24.51 ATOM 1025 C LEU 333 21.391 40.318 −0.048 1.00 25.80 ATOM 1026 O LEU 333 20.454 39.807 −0.644 1.00 26.35 ATOM 1027 N GLY 334 21.330 41.533 0.480 1.00 26.06 ATOM 1028 CA GLY 334 20.115 42.307 0.387 1.00 27.61 ATOM 1029 C GLY 334 18.980 41.627 1.127 1.00 28.38 ATOM 1030 O GLY 334 17.821 41.762 0.743 1.00 29.21 ATOM 1031 N SER 335 19.313 40.898 2.191 1.00 28.07 ATOM 1032 CA SER 335 18.310 40.190 2.984 1.00 28.11 ATOM 1033 CB SER 335 18.251 38.723 2.551 1.00 29.24 ATOM 1034 OG SER 335 18.153 38.604 1.143 1.00 31.20 ATOM 1035 C SER 335 18.648 40.266 4.474 1.00 28.25 ATOM 1036 O SER 335 18.816 39.235 5.134 1.00 27.31 ATOM 1037 N ASP 336 18.751 41.482 5.004 1.00 27.15 ATOM 1038 CA ASP 336 19.080 41.661 6.411 1.00 27.95 ATOM 1039 CB ASP 336 19.182 43.146 6.758 1.00 28.40 ATOM 1040 CG ASP 336 20.462 43.776 6.256 1.00 31.17 ATOM 1041 OD1 ASP 336 21.300 43.061 5.671 1.00 30.76 ATOM 1042 OD2 ASP 336 20.630 45.000 6.450 1.00 33.65 ATOM 1043 C ASP 336 18.054 41.000 7.321 1.00 27.32 ATOM 1044 O ASP 336 18.393 40.523 8.406 1.00 27.74 ATOM 1045 N ASP 337 16.799 40.985 6.887 1.00 26.73 ATOM 1046 CA ASP 337 15.748 40.364 7.678 1.00 27.00 ATOM 1047 CB ASP 337 14.383 40.532 6.982 1.00 29.56 ATOM 1048 CG ASP 337 14.362 39.994 5.564 1.00 30.90 ATOM 1049 OD1 ASP 337 15.434 39.888 4.931 1.00 32.90 ATOM 1050 OD2 ASP 337 13.251 39.693 5.066 1.00 32.99 ATOM 1051 C ASP 337 16.082 38.886 7.917 1.00 25.07 ATOM 1052 O ASP 337 15.948 38.375 9.031 1.00 23.90 ATOM 1053 N LEU 338 16.537 38.210 6.873 1.00 23.72 ATOM 1054 CA LEU 338 16.904 36.809 6.997 1.00 23.15 ATOM 1055 CB LEU 338 17.174 36.212 5.618 1.00 21.77 ATOM 1056 CG LEU 338 17.719 34.783 5.629 1.00 22.22 ATOM 1057 CD1 LEU 338 16.705 33.837 6.276 1.00 22.75 ATOM 1058 CD2 LEU 338 18.021 34.355 4.206 1.00 20.63 ATOM 1059 C LEU 338 18.144 36.668 7.880 1.00 22.07 ATOM 1060 O LEU 338 18.176 35.856 8.799 1.00 22.27 ATOM 1061 N VAL 339 19.165 37.474 7.610 1.00 22.77 ATOM 1062 CA VAL 339 20.388 37.406 8.403 1.00 23.12 ATOM 1063 CB VAL 339 21.448 38.408 7.893 1.00 23.99 ATOM 1064 CG1 VAL 339 22.718 38.275 8.717 1.00 23.37 ATOM 1065 CG2 VAL 339 21.732 38.163 6.411 1.00 24.06 ATOM 1066 C VAL 339 20.108 37.690 9.884 1.00 23.24 ATOM 1067 O VAL 339 20.611 36.998 10.770 1.00 22.39 ATOM 1068 N ASN 340 19.296 38.708 10.150 1.00 24.30 ATOM 1069 CA ASN 340 18.973 39.065 11.522 1.00 25.14 ATOM 1070 CB ASN 340 18.205 40.391 11.561 1.00 28.38 ATOM 1071 CG ASN 340 19.134 41.592 11.610 1.00 30.44 ATOM 1072 OD1 ASN 340 18.844 42.649 11.042 1.00 33.87 ATOM 1073 ND2 ASN 340 20.258 41.440 12.303 1.00 31.74 ATOM 1074 C ASN 340 18.189 37.970 12.229 1.00 24.36 ATOM 1075 O ASN 340 18.392 37.737 13.415 1.00 23.30 ATOM 1076 N GLU 341 17.294 37.298 11.514 1.00 24.45 ATOM 1077 CA GLU 341 16.527 36.224 12.139 1.00 24.75 ATOM 1078 CB GLU 341 15.350 35.814 11.254 1.00 26.89 ATOM 1079 CG GLU 341 14.179 36.773 11.358 1.00 31.50 ATOM 1080 CD GLU 341 12.945 36.239 10.681 1.00 34.84 ATOM 1081 OE1 GLU 341 12.720 35.013 10.750 1.00 37.24 ATOM 1082 OE2 GLU 341 12.187 37.038 10.096 1.00 37.28 ATOM 1083 C GLU 341 17.432 35.027 12.417 1.00 23.12 ATOM 1084 O GLU 341 17.290 34.356 13.448 1.00 22.72 ATOM 1085 N ALA 342 18.365 34.766 11.506 1.00 21.14 ATOM 1086 CA ALA 342 19.304 33.664 11.684 1.00 20.58 ATOM 1087 CB ALA 342 20.158 33.498 10.442 1.00 19.08 ATOM 1088 C ALA 342 20.193 33.943 12.906 1.00 21.25 ATOM 1089 O ALA 342 20.386 33.074 13.764 1.00 21.78 ATOM 1090 N PHE 343 20.720 35.164 12.987 1.00 21.28 ATOM 1091 CA PHE 343 21.581 35.548 14.105 1.00 23.79 ATOM 1092 CB PHE 343 22.201 36.933 13.864 1.00 22.95 ATOM 1093 CG PHE 343 23.487 36.906 13.083 1.00 22.10 ATOM 1094 CD1 PHE 343 23.540 36.348 11.814 1.00 21.63 ATOM 1095 CD2 PHE 343 24.644 37.480 13.607 1.00 22.10 ATOM 1096 CE1 PHE 343 24.724 36.366 11.079 1.00 22.66 ATOM 1097 CE2 PHE 343 25.831 37.503 12.880 1.00 20.80 ATOM 1098 CZ PHE 343 25.871 36.945 11.614 1.00 21.73 ATOM 1099 C PHE 343 20.820 35.563 15.437 1.00 24.28 ATOM 1100 O PHE 343 21.348 35.143 16.466 1.00 25.24 ATOM 1101 N ASP 344 19.581 36.042 15.422 1.00 25.30 ATOM 1102 CA ASP 344 18.807 36.088 16.655 1.00 27.20 ATOM 1103 CB ASP 344 17.453 36.754 16.425 1.00 30.33 ATOM 1104 CG ASP 344 17.581 38.215 16.084 1.00 34.37 ATOM 1105 OD1 ASP 344 18.728 38.719 16.068 1.00 36.85 ATOM 1106 OD2 ASP 344 16.529 38.853 15.835 1.00 36.92 ATOM 1107 C ASP 344 18.600 34.674 17.165 1.00 25.45 ATOM 1108 O ASP 344 18.728 34.400 18.364 1.00 25.36 ATOM 1109 N PHE 345 18.274 33.770 16.250 1.00 24.47 ATOM 1110 CA PHE 345 18.072 32.393 16.647 1.00 23.12 ATOM 1111 CB PHE 345 17.703 31.513 15.457 1.00 23.28 ATOM 1112 CG PHE 345 17.733 30.058 15.784 1.00 22.38 ATOM 1113 CD1 PHE 345 16.777 29.512 16.633 1.00 22.93 ATOM 1114 CD2 PHE 345 18.773 29.250 15.329 1.00 22.45 ATOM 1115 CE1 PHE 345 16.856 28.183 17.036 1.00 21.83 ATOM 1116 CE2 PHE 345 18.861 27.919 15.724 1.00 22.15 ATOM 1117 CZ PHE 345 17.901 27.385 16.582 1.00 23.05 ATOM 1118 C PHE 345 19.333 31.825 17.281 1.00 22.93 ATOM 1119 O PHE 345 19.286 31.241 18.360 1.00 22.27 ATOM 1120 N ALA 346 20.459 31.982 16.592 1.00 23.57 ATOM 1121 CA ALA 346 21.712 31.457 17.099 1.00 25.20 ATOM 1122 CB ALA 346 22.839 31.734 16.127 1.00 26.42 ATOM 1123 C ALA 346 22.038 32.040 18.459 1.00 27.60 ATOM 1124 O ALA 346 22.459 31.314 19.349 1.00 25.96 ATOM 1125 N LYS 347 21.843 33.348 18.620 1.00 28.41 ATOM 1126 CA LYS 347 22.127 33.985 19.901 1.00 30.85 ATOM 1127 CB LYS 347 21.838 35.485 19.841 1.00 32.36 ATOM 1128 CG LYS 347 21.860 36.147 21.202 1.00 36.99 ATOM 1129 CD LYS 347 21.431 37.613 21.140 1.00 39.60 ATOM 1130 CE LYS 347 21.227 38.185 22.561 1.00 42.60 ATOM 1131 NZ LYS 347 22.459 38.130 23.428 1.00 42.88 ATOM 1132 C LYS 347 21.298 33.355 21.011 1.00 30.95 ATOM 1133 O LYS 347 21.847 32.949 22.039 1.00 31.24 ATOM 1134 N ASN 348 19.986 33.259 20.807 1.00 30.97 ATOM 1135 CA ASN 348 19.121 32.676 21.826 1.00 32.18 ATOM 1136 CB ASN 348 17.645 32.804 21.435 1.00 34.34 ATOM 1137 CG ASN 348 17.173 34.246 21.450 1.00 38.72 ATOM 1138 OD1 ASN 348 17.656 35.057 22.247 1.00 40.24 ATOM 1139 ND2 ASN 348 16.222 34.579 20.574 1.00 39.22 ATOM 1140 C ASN 348 19.457 31.227 22.149 1.00 30.79 ATOM 1141 O ASN 348 19.442 30.838 23.316 1.00 30.95 ATOM 1142 N LEU 349 19.776 30.425 21.138 1.00 29.90 ATOM 1143 CA LEU 349 20.122 29.033 21.409 1.00 29.04 ATOM 1144 CB LEU 349 20.298 28.238 20.108 1.00 29.41 ATOM 1145 CG LEU 349 20.380 26.738 20.388 1.00 28.84 ATOM 1146 CD1 LEU 349 19.012 26.269 20.904 1.00 29.78 ATOM 1147 CD2 LEU 349 20.756 25.976 19.136 1.00 30.12 ATOM 1148 C LEU 349 21.419 28.977 22.212 1.00 28.27 ATOM 1149 O LEU 349 21.527 28.229 23.181 1.00 28.13 ATOM 1150 N CYS 350 22.405 29.768 21.802 1.00 27.19 ATOM 1151 CA CYS 350 23.689 29.804 22.498 1.00 27.50 ATOM 1152 CB CYS 350 24.618 30.856 21.875 1.00 27.40 ATOM 1153 SG CYS 350 25.370 30.336 20.331 1.00 30.05 ATOM 1154 C CYS 350 23.530 30.112 23.979 1.00 27.44 ATOM 1155 O CYS 350 24.280 29.596 24.806 1.00 25.65 ATOM 1156 N SER 351 22.551 30.944 24.316 1.00 28.30 ATOM 1157 CA SER 351 22.341 31.321 25.716 1.00 29.76 ATOM 1158 CB SER 351 21.239 32.377 25.835 1.00 27.97 ATOM 1159 OG SER 351 19.972 31.819 25.545 1.00 27.29 ATOM 1160 C SER 351 21.998 30.143 26.618 1.00 30.56 ATOM 1161 O SER 351 22.104 30.253 27.835 1.00 30.76 ATOM 1162 N LEU 352 21.582 29.027 26.030 1.00 30.81 ATOM 1163 CA LEU 352 21.232 27.848 26.815 1.00 30.42 ATOM 1164 CB LEU 352 20.275 26.948 26.035 1.00 31.12 ATOM 1165 CG LEU 352 19.035 27.615 25.410 1.00 31.69 ATOM 1166 CD1 LEU 352 18.055 26.553 24.966 1.00 31.69 ATOM 1167 CD2 LEU 352 18.377 28.538 26.411 1.00 33.44 ATOM 1168 C LEU 352 22.479 27.071 27.206 1.00 30.67 ATOM 1169 O LEU 352 22.429 26.195 28.070 1.00 31.08 ATOM 1170 N GLN 353 23.600 27.389 26.565 1.00 30.60 ATOM 1171 CA GLN 353 24.871 26.733 26.869 1.00 31.59 ATOM 1172 CB GLN 353 25.265 27.050 28.315 1.00 34.06 ATOM 1173 CG GLN 353 25.542 28.519 28.575 1.00 37.01 ATOM 1174 CD GLN 353 86.850 28.959 27.955 1.00 39.88 ATOM 1175 OE1 GLN 353 27.890 28.318 28.156 1.00 43.06 ATOM 1176 NE2 GLN 353 26.818 30.061 27.209 1.00 41.20 ATOM 1177 C GLN 353 24.865 25.220 26.661 1.00 30.89 ATOM 1178 O GLN 353 25.382 24.469 27.486 1.00 30.05 ATOM 1179 N LEU 354 24.294 24.772 25.550 1.00 28.93 ATOM 1180 CA LEU 354 24.229 23.349 25.268 1.00 27.99 ATOM 1181 CB LEU 354 23.373 23.082 24.026 1.00 28.43 ATOM 1182 CG LEU 354 21.881 23.406 24.046 1.00 30.02 ATOM 1183 CD1 LEU 354 21.316 23.086 22.659 1.00 30.63 ATOM 1184 CD2 LEU 354 21.15

22.608 25.114 1.00 29.61 ATOM 1185 C LEU 354 25.604 22.736 25.039 1.00 27.41 ATOM 1186 O LEU 354 26.540 23.415 24.604 1.00 27.14 ATOM 1187 N THR 355 25.711 21.452 25.359 1.00 25.55 ATOM 1188 CA THR 355 26.933 20.693 25.147 1.00 24.53 ATOM 1189 CB THR 355 27.121 19.573 26.199 1.00 24.00 ATOM 1190 OG1 THR 355 26.116 18.564 26.015 1.00 23.40 ATOM 1191 CG2 THR 355 27.017 20.136 27.603 1.00 24.13 ATOM 1192 C THR 355 26.750 20.026 23.785 1.00 24.40 ATOM 1193 O THR 355 25.650 20.047 23.226 1.00 23.30 ATOM 1194 N GLU 356 27.816 19.427 23.263 1.00 22.46 ATOM 1195 CA GLU 356 27.754 18.756 21.971 1.00 24.63 ATOM 1196 CB GLU 356 29.141 18.242 21.582 1.00 24.58 ATOM 1197 CG GLU 356 30.075 19.358 21.170 1.00 26.29 ATOM 1198 CD GLU 356 29.831 19.832 19.745 1.00 23.74 ATOM 1199 OE1 GLU 356 30.390 19.223 18.820 1.00 26.81 ATOM 1200 OE2 GLU 356 29.078 20.806 19.548 1.00 25.33 ATOM 1201 C GLU 356 26.752 17.610 21.942 1.00 24.03 ATOM 1202 O GLU 356 26.081 17.400 20.933 1.00 23.02 ATOM 1203 N GLU 357 26.657 16.865 23.042 1.00 25.24 ATOM 1204 CA GLU 357 25.721 15.746 23.122 1.00 25.24 ATOM 1205 CB GLU 357 25.870 15.011 24.460 1.00 25.58 ATOM 1206 CG GLU 357 27.261 14.435 24.698 1.00 28.22 ATOM 1207 CD GLU 357 27.358 13.628 25.991 1.00 29.57 ATOM 1208 OE1 GLU 357 26.600 13.913 26.936 1.00 28.40 ATOM 1209 OE2 GLU 357 28.210 12.712 26.064 1.00 31.71 ATOM 1210 C GLU 357 24.288 16.244 22.979 1.00 24.57 ATOM 1211 O GLU 357 23.472 15.633 22.296 1.00 24.04 ATOM 1212 N GLU 358 23.989 17.359 23.628 1.00 25.23 ATOM 1213 CA GLU 358 22.655 17.933 23.560 1.00 25.61 ATOM 1214 CB GLU 358 22.508 18.998 24.639 1.00 27.12 ATOM 1215 CG GLU 358 22.943 18.437 25.982 1.00 29.78 ATOM 1216 CD GLU 358 22.986 19.447 27.078 1.00 31.57 ATOM 1217 OE1 GLU 358 23.395 20.605 26.822 1.00 32.27 ATOM 1218 OE2 GLU 358 22.632 19.067 28.215 1.00 32.12 ATOM 1219 C GLU 358 22.371 18.491 22.169 1.00 24.96 ATOM 1220 O GLU 358 21.254 18.349 21.668 1.00 24.25 ATOM 1221 N ILE 359 23.371 19.113 21.542 1.00 22.67 ATOM 1222 CA ILE 359 23.188 19.645 20.191 1.00 22.78 ATOM 1223 CB ILE 359 24.404 20.490 19.744 1.00 23.34 ATOM 1224 CG2 ILE 359 24.344 20.740 18.236 1.00 22.93 ATOM 1225 CG1 ILE 359 24.430 21.803 20.538 1.00 25.31 ATOM 1226 CD1 ILE 359 25.711 22.603 20.401 1.00 27.90 ATOM 1227 C ILE 359 23.000 18.481 19.215 1.00 21.51 ATOM 1228 O ILE 359 22.223 18.570 18.272 1.00 21.39 ATOM 1229 N ALA 360 23.725 17.393 19.455 1.00 20.70 ATOM 1230 CA ALA 360 23.629 16.206 18.617 1.00 20.02 ATOM 1231 CB ALA 360 24.617 15.140 19.104 1.00 19.77 ATOM 1232 C ALA 360 22.198 15.675 18.688 1.00 19.38 ATOM 1233 O ALA 360 21.528 15.540 17.665 1.00 18.92 ATOM 1234 N LEU 361 21.736 15.393 19.903 1.00 18.99 ATOM 1235 CA LEU 361 20.388 14.870 20.117 1.00 19.89 ATOM 1236 CB LEU 361 20.184 14.533 21.600 1.00 20.98 ATOM 1237 CG LEU 361 21.138 13.452 22.105 1.00 22.49 ATOM 1238 CD1 LEU 361 20.951 13.265 23.592 1.00 23.19 ATOM 1239 CD2 LEU 361 20.882 12.151 21.358 1.00 22.76 ATOM 1240 C LEU 361 19.285 15.817 19.642 1.00 19.52 ATOM 1241 O LEU 361 18.374 15.402 18.933 1.00 18.57 ATOM 1242 N PHE 362 19.356 17.085 20.030 1.00 19.75 ATOM 1243 CA PHE 362 18.335 18.030 19.595 1.00 20.87 ATOM 1244 CB PHE 362 18.559 19.409 20.212 1.00 19.97 ATOM 1245 CG PHE 362 17.537 20.429 19.788 1.00 20.58 ATOM 1246 CD1 PHE 362 16.186 20.224 20.036 1.00 22.23 ATOM 1247 CD2 PHE 362 17.925 21.590 19.127 1.00 21.76 ATOM 1248 CE1 PHE 362 15.240 21.156 19.634 1.00 21.84 ATOM 1249 CE2 PHE 362 16.984 22.528 18.724 1.00 23.51 ATOM 1250 CZ PHE 362 15.640 22.314 18.974 1.00 21.56 ATOM 1251 C PHE 362 18.306 18.161 18.067 1.00 20.26 ATOM 1252 O PHE 362 17.233 18.189 17.461 1.00 21.41 ATOM 1253 N SER 363 19.476 18.253 17.445 1.00 19.81 ATOM 1254 CA SER 363 19.521 18.371 15.991 1.00 20.02 ATOM 1255 CB SER 363 20.963 18.572 15.498 1.00 18.56 ATOM 1256 OG SER 363 21.728 17.396 15.663 1.00 20.81 ATOM 1257 C SER 363 18.906 17.121 15.353 1.00 20.59 ATOM 1258 O SER 363 18.231 17.217 14.325 1.00 20.37 ATOM 1259 N SER 364 19.124 15.954 15.957 1.00 19.20 ATOM 1260 CA SER 364 18.541 14.729 15.406 1.00 20.84 ATOM 1261 CB SER 364 19.108 13.474 16.099 1.00 20.81 ATOM 1262 OG SER 364 18.644 13.335 17.426 1.00 21.39 ATOM 1263 C SER 364 17.007 14.772 15.538 1.00 20.41 ATOM 1264 O SER 364 16.293 14.283 14.662 1.00 20.80 ATOM 1265 N ALA 365 16.503 15.374 16.614 1.00 20.02 ATOM 1266 CA ALA 365 15.053 15.484 16.813 1.00 20.02 ATOM 1267 CB ALA 365 14.734 15.950 18.227 1.00 20.30 ATOM 1266 C ALA 365 14.450 16.455 15.794 1.00 21.11 ATOM 1269 O ALA 365 13.337 16.252 15.324 1.00 19.92 ATOM 1270 H VAL 366 15.189 17.509 15.458 1.00 20.57 ATOM 1271 CA VAL 366 14.720 18.473 14.468 1.00 19.45 ATOM 1272 CB VAL 366 15.684 19.677 14.360 1.00 19.15 ATOM 1273 CG1 VAL 366 15.369 20.502 13.106 1.00 19.19 ATOM 1274 CG2 VAL 366 15.567 20.542 15.618 1.00 20.02 ATOM 1275 C VAL 366 14.617 17.786 13.107 1.00 19.50 ATOM 1276 O VAL 366 13.686 18.038 12.352 1.00 19.45 ATOM 1277 N LEU 367 15.576 16.911 12.811 1.00 19.31 ATOM 1278 CA LEU 367 15.602 16.176 11.550 1.00 21.04 ATOM 1279 CB LEU 367 16.975 15.534 11.335 1.00 21.11 ATOM 1280 CG LEU 367 17.117 14.679 10.070 1.00 21.76 ATOM 1281 CD1 LEU 367 17.139 15.585 8.841 1.00 24.04 ATOM 1282 CD2 LEU 367 18.395 13.868 10.138 1.00 19.99 ATOM 1283 C LEU 367 14.540 15.073 11.520 1.00 20.91 ATOM 1284 O LEU 367 13.819 14.924 10.541 1.00 19.56 ATOM 1285 N ILE 368 14.472 14.297 12.596 1.00 20.91 ATOM 1286 CA ILE 368 13.521 13.199 12.699 1.00 21.53 ATOM 1287 CB ILE 368 14.047 12.095 13.649 1.00 22.94 ATOM 1288 CG2 ILE 368 13.171 10.867 13.550 1.00 22.23 ATOM 1289 CG1 ILE 368 15.499 11.735 13.308 1.00 24.46 ATOM 1290 CD1 ILE 368 15.719 11.309 11.896 1.00 27.21 ATOM 1291 C ILE 368 12.183 13.722 13.231 1.00 22.51 ATOM 1292 O ILE 368 11.830 13.501 14.393 1.00 21.63 ATOM 1293 N SER 369 11.446 14.424 12.370 1.00 22.24 ATOM 1294 CA SER 369 10.155 14.986 12.750 1.00 24.12 ATOM 1295 CB SER 369 10.063 16.449 12.332 1.00 24.27 ATOM 1296 OG SER 369 8.745 16.929 12.528 1.00 26.59 ATOM 1297 C SER 369 9.011 14.221 12.107 1.00 25.22 ATOM 1298 O SER 369 8.921 14.140 10.884 1.00 23.14 ATOM 1299 N PRO 370 8.117 13.646 12.929 1.00 27.45 ATOM 1300 CD PRO 370 8.169 13.553 14.402 1.00 28.35 ATOM 1301 CA PRO 370 6.981 12.888 12.393 1.00 28.35 ATOM 1302 CB PRO 370 6.488 12.105 13.607 1.00 28.25 ATOM 1303 CG PRO 370 6.765 13.054 14.746 1.00 29.61 ATOM 1304 C PRO 370 5.906 13.791 11.812 1.00 29.35 ATOM 1305 O PRO 370 4.920 13.310 11.254 1.00 29.26 ATOM 1306 N ASP 371 6.107 15.096 11.944 1.00 29.51 ATOM 1307 CA ASP 371 5.151 16.074 11.450 1.00 30.84 ATOM 1308 CB ASP 371 5.132 17.296 12.377 1.00 32.99 ATOM 1309 CG ASP 371 4.616 16.962 13.765 1.00 35.86 ATOM 1310 OD1 ASP 371 3.508 16.390 13.853 1.00 36.71 ATOM 1311 OD2 ASP 371 5.311 17.270 14.763 1.00 37.76 ATOM 1312 C ASP 371 5.355 16.549 10.007 1.00 29.75 ATOM 1313 O ASP 371 4.515 17.276 9.484 1.00 30.14 ATOM 1314 N ARG 372 6.455 16.162 9.364 1.00 28.07 ATOM 1315 CA ARG 372 6.694 16.597 7.988 1.00 26.59 ATOM 1316 CB ARG 372 8.030 16.075 7.458 1.00 25.22 ATOM 1317 CG ARG 372 9.252 16.430 8.291 1.00 23.03 ATOM 1318 CD ARG 372 9.412 17.926 8.486 1.00 22.25 ATOM 1319 ME ARG 372 10.732 18.209 9.049 1.00 21.70 ATOM 1320 CZ ARG 372 11.160 19.412 9.412 1.00 21.40 ATOM 1321 NH1 ARG 372 10.374 20.472 9.278 1.00 19.74 ATOM 1322 NH2 ARG 372 12.378 19.547 9.915 1.00 19.59 ATOM 1323 C ARG 372 5.590 16.079 7.081 1.00 27.64 ATOM 1324 O ARG 372 5.186 14.917 7.172 1.00 26.49 ATOM 1325 N ALA 373 5.120 16.943 6.193 1.00 27.44 ATOM 1326 CA ALA 373 4.074 16.563 5.259 1.00 27.38 ATOM 1327 GB ALA 373 3.603 17.789 4.508 1.00 28.35 ATOM 1328 C ALA 373 4.585 15.504 4.276 1.00 26.33 ATOM 1329 O ALA 373 5.770 15.464 3.945 1.00 26.14 ATOM 1330 N TRP 374 3.681 14.637 3.830 1.00 26.51 ATOM 1331 CA TRP 374 3.987 13.582 2.856 1.00 25.94 ATOM 1332 CB TRP 374 4.795 14.153 1.674 1.00 28.23 ATOM 1333 CG TRP 374 4.231 15.435 1.047 1.00 30.91 ATOM 1334 CD2 TRP 374 3.112 15.543 0.146 1.00 31.01 ATOM 1335 CE2 TRP 374 2.936 16.922 −0.144 1.00 31.51 ATOM 1336 CE3 TRP 374 2.240 14.614 −0.438 1.00 30.75 ATOM 1337 CD1 TRP 374 4.676 16.718 1.252 1.00 31.80 ATOM 1338 NB1 TRP 374 3.903 17.614 0.541 1.00 31.78 ATOM 1339 CZ2 TRP 374 1.920 17.390 −0.998 1.00 31.60 ATOM 1340 CZ3 TRP 374 1.223 15.082 −1.289 1.00 32.14 ATOM 1341 CH2 TRP 374 1.075 16.458 −1.556 1.00 31.37 ATOM 1342 C TRP 374 4.690 12.310 3.365 1.00 24.31 ATOM 1343 O TRP 374 4.926 11.384 2.588 1.00 23.56 ATOM 1344 N LEU 375 5.039 12.258 4.648 1.00 24.62 ATOM 1345 CA LEU 375 5.698 11.070 5.185 1.00 24.04 ATOM 1346 CB LEU 375 6.074 11.282 6.657 1.00 24.87 ATOM 1347 CG LEU 375 7.256 12.194 7.022 1.00 24.99 ATOM 1348 CD1 LEU 375 7.422 12.210 8.542 1.00 25.00 ATOM 1349 CD2 LEU 375 8.543 11.686 6.367 1.00 25.29 ATOM 1350 C LEU 375 4.769 9.853 5.065 1.00 23.50 ATOM 1351 O LEU 375 3.584 9.946 5.366 1.00 23.84 ATOM 1352 N LEU 376 5.318 8.721 4.632 1.00 23.94 ATOM 1353 CA LEU 376 4.540 7.489 4.411 1.00 24.75 ATOM 1354 CB LEU 376 5.202 6.595 3.423 1.00 24.43 ATOM 1355 CG LEU 376 5.268 7.172 2.001 1.00 26.18 ATOM 1356 CD1 LEU 376 6.160 6.296 1.124 1.00 27.91 ATOM 1357 CD2 LEU 376 3.858 7.260 1.415 1.00 26.56 ATOM 1358 C LEU 376 4.355 6.711 5.783 1.00 25.66 ATOM 1359 O LEU 376 3.317 6.079 6.002 1.00 24.55 ATOM 1360 N GLU 377 5.359 6.758 6.654 1.00 26.36 ATOM 1361 CA GLU 377 5.284 6.063 7.938 1.00 27.47 ATOM 1362 CB GLU 377 6.261 4.878 7.947 1.00 29.08 ATOM 1363 CG GLU 377 5.959 3.840 6.875 1.00 30.40 ATOM 1364 CD GLU 377 6.773 2.574 7.010 1.00 32.62 ATOM 1365 OE1 GLU 377 7.981 2.578 6.704 1.00 33.66 ATOM 1366 OE2 GLU 377 6.197 1.556 7.428 1.00 33.92 ATOM 1367 C GLU 377 5.602 7.037 9.077 1.00 27.62 ATOM 1368 O GLU 377 6.619 6.902 9.762 1.00 27.21 ATOM 1369 N PRO 378 4.728 8.035 9.295 1.00 27.83 ATOM 1370 CD PRO 378 3.483 8.329 8.561 1.00 27.90 ATOM 1371 CA PRO 378 4.951 9.020 10.358 1.00 28.17 ATOM 1372 CB PRO 378 3.794 10.004 10.167 1.00 29.14 ATOM 1373 CG PRO 378 2.702 9.143 9.564 1.00 28.27 ATOM 1374 C PRO 378 5.015 8.458 11.776 1.00 29.36 ATOM 1375 O PRO 378 5.655 9.050 12.649 1.00 28.11 ATOM 1376 N ARG 379 4.349 7.328 12.008 1.00 28.75 ATOM 1377 CA ARG 379 4.339 6.714 13.331 1.00 30.40 ATOM 1378 CB ARG 379 3.327 5.551 13.366 1.00 32.82 ATOM 1379 CG ARG 379 2.361 5.554 14.559 1.00 38.05 ATOM 1380 CD ARG 379 3.009 5.102 15.888 1.00 42.49 ATOM 1381 NB ARG 379 3.379 6.216 16.779 1.00 45.57 ATOM 1382 CZ ARG 379 3.867 6.071 18.014 1.00 47.28 ATOM 1383 NH1 ARG 379 4.062 4.858 18.530 1.00 48.40 ATOM 1384 NH2 ARG 379 4.145 7.142 18.752 1.00 48.86 ATOM 1385 C ARG 379 5.741 6.199 13.652 1.00 29.02 ATOM 1386 O ARG 379 6.230 6.334 14.773 1.00 29.03 ATOM 1387 N LYS 380 6.377 5.611 12.647 1.00 28.46 ATOM 1388 CA LYS 380 7.706 5.058 12.791 1.00 29.03 ATOM 1389 CB LYS 380 8.109 4.391 11.481 1.00 30.34 ATOM 1390 CG LYS 380 9.086 3.254 11.621 1.00 33.47 ATOM 1391 CD LYS 380 9.080 2.353 10.379 1.00 34.27 ATOM 1392 CE LYS 380 7.739 1.647 10.196 1.00 35.69 ATOM 1393 HZ LYS 380 7.814 0.565 9.162 1.00 37.30 ATOM 1394 C LYS 380 8.657 6.196 13.137 1.00 29.26 ATOM 1395 O LYS 380 9.528 6.049 13.999 1.00 30.09 ATOM 1396 N VAL 381 8.480 7.330 12.466 1.00 27.49 ATOM 1397 CA VAL 381 9.314 8.501 12.713 1.00 27.12 ATOM 1398 CB VAL 381 9.054 9.617 11.663 1.00 26.02 ATOM 1399 CG1 VAL 381 9.821 10.888 12.038 1.00 25.31 ATOM 1400 CG2 VAL 381 9.494 9.140 10.280 1.00 25.42 ATOM 1401 C VAL 381 9.014 9.047 14.104 1.00 27.48 ATOM 1402 O VAL 381 9.914 9.478 14.830 1.00 26.45 ATOM 1403 N GLN 382 7.743 9.014 14.475 1.00 28.11 ATOM 1404 CA GLN 382 7.324 9.508 15.775 1.00 29.95 ATOM 1405 CB GLN 382 5.803 9.505 15.873 1.00 31.75 ATOM 1406 CG GLN 382 5.302 10.011 17.202 1.00 35.79 ATOM 1407 CD GLN 382 3.886 10.501 17.117 1.00 38.98 ATOM 1408 OE1 GLN 382 2.978 9.761 16.711 1.00 40.59 ATOM 1409 NE2 GLN 382 3.677 11.765 17.487 1.00 40.58 ATOM 1410 C GLN 382 7.907 8.707 16.931 1.00 29.66 ATOM 1411 O GLN 382 8.323 9.278 17.943 1.00 28.76 ATOM 1412 N LYS 383 7.922 7.385 16.776 1.00 29.16 ATOM 1413 CA LYS 383 8.454 6.491 17.799 1.00 29.20 ATOM 1414 CB LYS 383 8.303 5.027 17.369 1.00 30.44 ATOM 1415 CG LYS 383 6.860 4.503 17.326 1.00 33.92 ATOM 1416 CD LYS 383 6.810 3.149 16.627 1.00 37.33 ATOM 1417 CE LYS 383 5.486 2.419 16.837 1.00 39.20 ATOM 1418 NZ LYS 383 5.439 1.665 18.135 1.00 40.75 ATOM 1419 C LYS 383 9.928 6.785 18.055 1.00 28.39 ATOM 1420 O LYS 383 10.370 6.781 19.202 1.00 28.89 ATOM 1421 N LEU 384 10.692 7.019 16.990 1.00 26.11 ATOM 1422 CA LEU 384 12.117 7.324 17.138 1.00 25.71 ATOM 1423 CB LEU 384 12.829 7.235 15.778 1.00 23.95 ATOM 1424 CG LEU 384 14.332 7.536 15.718 1.00 22.17 ATOM 1425 CD1 LEU 384 15.102 6.661 16.719 1.00 24.02 ATOM 1426 CD2 LEU 384 14.833 7.285 14.299 1.00 21.00 ATOM 1427 C LEU 384 12.330 8.711 17.760 1.00 25.43 ATOM 1428 O LEU 384 13.157 8.867 18.663 1.00 25.70 ATOM 1429 N GLN 385 11.591 9.714 17.294 1.00 24.38 ATOM 1430 CA GLN 385 11.748 11.054 17.846 1.00 24.43 ATOM 1431 CB GLN 385 10.819 12.072 17.167 1.00 24.78 ATOM 1432 CG GLN 385 11.260 13.503 17.459 1.00 22.10 ATOM 1433 CD GLN 385 10.221 14.561 17.135 1.00 23.15 ATOM 1434 OE1 GLN 385 10.528 15.569 16.498 1.00 24.07 ATOM 1435 NE2 GLN 385 8.936 14.350 17.592 1.00 19.99 ATOM 1436 C GLN 385 11.449 11.040 19.347 1.00 24.85 ATOM 1437 O GLN 385 12.101 11.731 20.125 1.00 23.88 ATOM 1438 N GLU 386 10.449 10.265 19.745 1.00 25.17 ATOM 1439 CA GLU 386 10.093 10.170 21.159 1.00 27.06 ATOM 1440 CB GLU 386 8.902 9.237 21.355 1.00 30.30 ATOM 1441 CG GLU 386 7.581 9.951 21.578 1.00 36.42 ATOM 1442 CD GLU 386 6.470 8.966 21.878 1.00 40.38 ATOM 1443 OE1 GLU 386 5.997 8.309 20.923 1.00 42.90 ATOM 1444 OE2 GLU 386 6.094 8.828 23.068 1.00 43.27 ATOM 1445 C GLU 386 11.271 9.661 21.978 1.00 25.28 ATOM 1446 O GLU 386 11.563 10.198 23.044 1.00 25.32 ATOM 1447 N LYS 387 11.932 8.619 21.476 1.00 23.39 ATOM 1448 CA LYS 387 13.088 8.038 22.148 1.00 24.19 ATOM 1449 CB LYS 387 13.532 6.769 21.434 1.00 24.48 ATOM 1450 CG LYS 387 12.526 5.645 21.544 1.00 25.85 ATOM 1451 CD LYS 387 12.849 4.512 20.605 1.00 26.31 ATOM 1452 CE LYS 387 11.751 3.477 20.656 1.00 25.95 ATOM 1453 NZ LYS 387 11.950 2.448 19.620 1.00 27.79 ATOM 1454 C LYS 387 14.244 9.031 22.191 1.00 24.21 ATOM 1455 O LYS 387 14.972 9.104 23.175 1.00 21.82 ATOM 1456 N ILE 388 14.410 9.783 21.109 1.00 23.57 ATOM 1457 CA ILE 388 15.465 10.786 21.033 1.00 23.44 ATOM 1458 CB ILE 388 15.484 11.463 19.637 1.00 21.69 ATOM 1459 CG2 ILE 388 16.394 12.678 19.646 1.00 22.46 ATOM 1460 CG1 ILE 388 15.936 10.449 18.588 1.00 23.21 ATOM 1461 CD1 ILE 388 15.987 11.002 17.186 1.00 23.27 ATOM 1462 C ILE 388 15.234 11.840 22.113 1.00 22.84 ATOM 1463 O ILE 388 16.145 12.173 22.872 1.00 22.21 ATOM 1464 N TYR 389 14.009 12.351 22.198 1.00 22.43 ATOM 1465 CA TYR 389 13.695 13.363 23.197 1.00 24.16 ATOM 1466 CB TYR 389 12.268 13.868 23.003 1.00 25.05 ATOM 1467 CG TYR 389 12.164 14.996 22.000 1.00 26.11 ATOM 1468 CD1 TYR 389 11.103 15.057 21.093 1.00 26.57 ATOM 1469 CE1 TYR 389 10.971 16.124 20.203 1.00 25.71 ATOM 1470 CD2 TYR 389 13.101 16.037 21.990 1.00 28.12 ATOM 1471 CE2 TYR 389 12.975 17.115 21.102 1.00 27.45 ATOM 1472 CZ TYR 389 11.906 17.149 20.215 1.00 26.96 ATOM 1473 OH TYR 389 11.754 18.218 19.356 1.00 26.94 ATOM 1474 C TYR 389 13.876 12.802 24.607 1.00 24.83 ATOM 1475 O TYR 389 14.337 13.502 25.503 1.00 24.78 ATOM 1476 N PHE 390 13.514 11.537 24.794 1.00 25.27 ATOM 1477 CA PHE 390 13.672 10.908 26.100 1.00 27.07 ATOM 1478 CB PHE 390 13.150 9.469 26.070 1.00 29.52 ATOM 1479 CG PHE 390 11.710 9.331 26.499 1.00 33.25 ATOM 1480 CD1 PHE 390 10.839 8.482 25.807 1.00 34.80 ATOM 1481 CD2 PHE 390 11.230 10.029 27.609 1.00 34.21 ATOM 1482 CE1 PHE 390 9.499 8.325 26.208 1.00 35.97 ATOM 1483 CE2 PHE 390 9.895 9.882 28.025 1.00 37.03 ATOM 1484 CZ PHE 390 9.027 9.025 27.319 1.00 35.82 ATOM 1485 C PHE 390 15.156 10.929 26.451 1.00 25.45 ATOM 1486 O PHE 390 15.531 11.227 27.584 1.00 23.68 ATOM 1487 N ALA 391 15.991 10.625 25.461 1.00 24.65 ATOM 1488 CA ALA 391 17.432 10.627 25.658 1.00 24.20 ATOM 1489 CB ALA 391 18.141 10.116 24.414 1.00 24.05 ATOM 1490 C ALA 391 17.907 12.036 25.989 1.00 24.18 ATOM 1491 O ALA 391 18.650 12.232 26.951 1.00 25.43 ATOM 1492 N LEU 392 17.465 13.014 25.201 1.00 24.17 ATOM 1493 CA LEU 392 17.857 14.402 25.410 1.00 23.73 ATOM 1494 CB LEU 392 17.178 15.309 24.375 1.00 23.42 ATOM 1495 CG LEU 392 17.432 16.815 24.510 1.00 21.24 ATOM 1496 CD1 LEU 392 18.928 17.097 24.423 1.00 21.69 ATOM 1497 CD2 LEU 392 16.671 17.571 23.423 1.00 22.29 ATOM 1498 C LEU 392 17.506 14.868 26.819 1.00 25.25 ATOM 1499 O LEU 392 18.293 15.549 27.474 1.00 24.27 ATOM 1500 N GLN 393 16.323 14.485 27.288 1.00 25.02 ATOM 1501 CA GLN 393 15.864 14.873 28.614 1.00 26.69 ATOM 1502 CB GLN 393 14.439 14.366 28.818 1.00 29.39 ATOM 1503 CG GLN 393 13.773 14.865 30.074 1.00 34.04 ATOM 1504 CD GLN 393 12.294 14.569 30.079 1.00 36.82 ATOM 1505 OE1 GLN 393 11.880 13.411 29.996 1.00 37.30 ATOM 1506 NE2 GLN 393 11.484 15.617 30.167 1.00 38.82 ATOM 1507 C GLN 393 16.783 14.349 29.724 1.00 26.46 ATOM 1508 O GLN 393 17.019 15.040 30.710 1.00 25.57 ATOM 1509 N HIS 394 17.287 13.128 29.572 1.00 25.89 ATOM 1510 CA HIS 394 18.190 12.559 30.569 1.00 26.72 ATOM 1511 CB HIS 394 18.314 11.049 30.375 1.00 27.82 ATOM 1512 CG HIS 394 17.087 10.289 30.776 1.00 31.60 ATOM 1513 CD2 HIS 394 15.994 9.927 30.065 1.00 31.53 ATOM 1514 ND1 HIS 394 16.873 9.841 32.063 1.00 33.22 ATOM 1515 CE1 HIS 394 15.702 9.238 32.127 1.00 33.60 ATOM 1516 NE2 HIS 394 15.146 9.276 30.929 1.00 34.06 ATOM 1517 C HIS 394 19.567 13.208 30.491 1.00 25.56 ATOM 1518 O HIS 394 20.155 13.552 31.513 1.00 25.72 ATOM 1519 N VAL 395 20.082 13.385 29.274 1.00 25.55 ATOM 1520 CA VAL 395 21.402 13.993 29.094 1.00 24.89 ATOM 1521 CB VAL 395 21.821 13.992 27.599 1.00 25.87 ATOM 1522 CG1 VAL 395 23.094 14.815 27.399 1.00 25.30 ATOM 1523 CG2 VAL 395 22.056 12.554 27.134 1.00 25.17 ATOM 1524 C VAL 395 21.461 15.426 29.633 1.00 25.38 ATOM 1525 O VAL 395 22.476 15.847 30.185 1.00 23.83 ATOM 1526 N ILE 396 20.366 16.162 29.488 1.00 24.76 ATOM 1527 CA ILE 396 20.310 17.542 29.956 1.00 25.56 ATOM 1528 CB ILE 396 18.953 18.180 29.588 1.00 25.31 ATOM 1529 CG2 ILE 396 18.725 19.465 30.382 1.00 24.55 ATOM 1530 CG1 ILE 396 18.910 18.465 28.080 1.00 24.97 ATOM 1531 CD1 ILE 396 17.556 18.989 27.593 1.00 24.29 ATOM 1532 C ILE 396 20.531 17.635 31.471 1.00 28.65 ATOM 1533 O ILE 396 21.134 18.583 31.960 1.00 28.05 ATOM 1534 N GLN 397 20.046 16.639 32.203 1.00 31.32 ATOM 1535 CA GLN 397 20.191 16.609 33.656 1.00 35.38 ATOM 1536 CB GLN 397 19.472 15.393 34.221 1.00 36.34 ATOM 1537 CG GLN 397 18.056 15.243 33.752 1.00 39.24 ATOM 1538 CD GLN 397 17.387 14.038 34.382 1.00 42.16 ATOM 1539 OE1 GLN 397 17.995 12.971 34.522 1.00 42.62 ATOM 1540 NE2 GLN 397 16.125 14.195 34.755 1.00 43.91 ATOM 1541 C GLN 397 21.640 16.577 34.143 1.00 37.04 ATOM 1542 O GLN 397 21.936 17.049 35.240 1.00 37.11 ATOM 1543 N LYS 398 22.533 15.993 33.350 1.00 39.23 ATOM 1544 CA LYS 398 23.945 15.915 33.733 1.00 42.23 ATOM 1545 CB LYS 398 24.742 15.089 32.720 1.00 40.46 ATOM 1546 CG LYS 398 24.193 13.689 32.476 1.00 39.92 ATOM 1547 CD LYS 398 25.170 12.833 31.675 1.00 39.62 ATOM 1548 CE LYS 398 25.430 13.434 30.286 1.00 39.22 ATOM 1549 NZ LYS 398 26.362 12.596 29.484 1.00 37.98 ATOM 1550 C LYS 398 24.557 17.306 33.818 1.00 44.28 ATOM 1551 O LYS 398 25.543 17.535 34.529 1.00 44.44 ATOM 1552 N ASN 399 23.964 18.241 33.091 1.00 45.83 ATOM 1553 CA ASN 399 24.469 19.595 33.063 1.00 47.39 ATOM 1554 CB ASN 399 24.734 19.967 31.604 1.00 47.57 ATOM 1555 CG ASN 399 25.348 18.807 30.803 1.00 47.79 ATOM 1556 OD1 ASN 399 26.505 18.434 31.010 1.00 47.93 ATOM 1557 ND2 ASN 399 24.564 18.226 29.896 1.00 48.24 ATOM 1558 C ASN 399 23.474 20.560 33.710 1.00 49.01 ATOM 1559 O ASN 399 23.431 20.717 34.937 1.00 49.34 ATOM 1560 N HIS 400 22.671 21.186 32.861 1.00 50.43 ATOM 1561 CA HIS 400 21.655 22.160 33.240 1.00 52.29 ATOM 1562 CB HIS 400 20.737 22.349 32.046 1.00 51.08 ATOM 1563 CG HIS 400 21.475 22.344 30.750 1.00 50.35 ATOM 1564 CD2 HIS 400 21.653 21.368 29.832 1.00 50.24 ATOM 1565 ND1 HIS 400 22.219 23.419 30.316 1.00 50.79 ATOM 1566 CE1 HIS 400 22.823 23.102 29.183 1.00 50.91 ATOM 1567 NE2 HIS 400 22.495 21.862 28.871 1.00 49.91 ATOM 1568 C HIS 400 20.839 21.782 34.467 1.00 54.62 ATOM 1569 O HIS 400 19.881 21.006 34.369 1.00 54.65 ATOM 1570 N LEU 401 21.211 22.343 35.618 1.00 56.91 ATOM 1571 CA LEU 401 20.487 22.061 36.854 1.00 59.10 ATOM 1572 CB LEU 401 21.306 22.469 38.081 1.00 59.50 ATOM 1573 CG LEU 401 21.083 21.490 39.244 1.00 60.29 ATOM 1574 CD1 LEU 401 19.671 21.626 39.794 1.00 60.01 ATOM 1575 CD2 LEU 401 21.317 20.062 38.748 1.00 59.79 ATOM 1576 C LEU 401 19.224 22.890 36.729 1.00 60.18 ATOM 1577 O LEU 401 19.275 24.017 36.220 1.00 61.06 ATOM 1578 N ASP 402 18.097 22.341 37.188 1.00 60.81 ATOM 1579 CA ASP 402 16.814 23.001 37.016 1.00 61.03 ATOM 1580 CB ASP 402 16.766 24.371 37.711 1.00 62.09 ATOM 1581 CG ASP 402 16.409 24.256 39.205 1.00 63.42 ATOM 1582 OD1 ASP 402 16.940 23.342 39.883 1.00 63.79 ATOM 1583 OD2 ASP 402 15.609 25.076 39.716 1.00 63.96 ATOM 1584 C ASP 402 16.836 23.099 35.499 1.00 60.63 ATOM 1585 O ASP 402 17.621 22.375 34.864 1.00 61.17 ATOM 1586 N ASP 403 16.035 23.950 34.882 1.00 59.71 ATOM 1587 CA ASP 403 16.083 23.943 33.430 1.00 57.97 ATOM 1588 CB ASP 403 15.969 22.502 32.944 1.00 57.91 ATOM 1589 CG ASP 403 14.749 21.799 33.538 1.00 58.27 ATOM 1590 OD1 ASP 403 13.789 21.500 32.785 1.00 57.61 ATOM 1591 OD2 ASP 403 14.747 21.570 34.774 1.00 57.74 ATOM 1592 C ASP 403 15.025 24.719 32.703 1.00 56.47 ATOM 1593 O ASP 403 15.042 25.947 32.631 1.00 56.67 ATOM 1594 N GLU 404 14.097 23.936 32.157 1.00 54.01 ATOM 1595 CA GLU 404 13.021 24.422 31.319 1.00 50.92 ATOM 1596 CB GLU 404 12.788 25.917 31.554 1.00 52.53 ATOM 1597 CG GLU 404 11.500 26.492 30.994 1.00 55.75 ATOM 1598 CD GLU 404 11.230 27.889 31.537 1.00 57.67 ATOM 1599 OE1 GLU 404 10.211 28.503 31.134 1.00 58.54 ATOM 1600 OE2 GLU 404 12.041 28.371 32.375 1.00 58.20 ATOM 1601 C GLU 404 13.714 24.171 29.977 1.00 47.15 ATOM 1602 O GLU 404 13.121 24.300 28.907 1.00 46.59 ATOM 1603 N THR 405 14.986 23.774 30.070 1.00 43.07 ATOM 1604 CA THR 405 15.815 23.492 28.895 1.00 38.65 ATOM 1605 CB THR 405 17.122 22.735 29.288 1.00 38.43 ATOM 1606 OG1 THR 405 17.950 23.598 30.083 1.00 36.75 ATOM 1607 CG2 THR 405 17.915 22.330 28.036 1.00 37.77 ATOM 1608 C THR 405 15.101 22.712 27.791 1.00 35.86 ATOM 1609 O THR 405 14.859 23.258 26.721 1.00 33.56 ATOM 1610 N LEU 406 14.749 21.449 28.039 1.00 34.04 ATOM 1611 CA LEU 406 14.083 20.668 27.000 1.00 32.51 ATOM 1612 CB LEU 406 13.653 19.290 27.516 1.00 32.98 ATOM 1613 CG LEU 406 13.758 18.137 26.500 1.00 31.34 ATOM 1614 CD1 LEU 406 12.660 17.122 26.773 1.00 32.45 ATOM 1615 CD2 LEU 406 13.645 18.644 25.077 1.00 32.35 ATOM 1616 C LEU 406 12.856 21.395 26.456 1.00 31.91 ATOM 1617 O LEU 406 12.625 21.414 25.253 1.00 30.54 ATOM 1618 N ALA 407 12.070 21.988 27.348 1.00 32.12 ATOM 1619 CA ALA 407 10.879 22.720 26.931 1.00 31.85 ATOM 1620 CB ALA 407 10.078 23.150 28.146 1.00 31.21 ATOM 1621 C ALA 407 11.246 23.942 26.084 1.00 31.46 ATOM 1622 O ALA 407 10.584 24.221 25.093 1.00 31.62 ATOM 1623 N LYS 408 12.296 24.667 26.473 1.00 31.28 ATOM 1624 CA LYS 408 12.723 25.849 25.718 1.00 30.77 ATOM 1625 CB LYS 408 13.794 26.635 26.481 1.00 33.47 ATOM 1626 CG LYS 408 13.279 27.310 27.747 1.00 35.82 ATOM 1627 CD LYS 408 14.332 28.218 28.353 1.00 36.77 ATOM 1628 CE LYS 408 13.747 29.011 29.522 1.00 38.42 ATOM 1629 NZ LYS 408 14.719 29.999 30.088 1.00 39.51 ATOM 1630 C LYS 408 13.263 25.462 24.351 1.00 28.18 ATOM 1631 O LYS 408 13.158 26.229 23.396 1.00 27.16 ATOM 1632 N LEU 409 13.858 24.276 24.265 1.00 27.09 ATOM 1633 CA LEU 409 14.387 23.793 22.994 1.00 26.20 ATOM 1634 CB LEU 409 15.246 22.546 23.210 1.00 24.61 ATOM 1635 CG LEU 409 16.608 22.793 23.844 1.00 25.33 ATOM 1636 CD1 LEU 409 17.347 21.465 24.018 1.00 23.27 ATOM 1637 CD2 LEU 409 17.399 23.757 22.957 1.00 25.46 ATOM 1638 C LEU 409 13.228 23.462 22.057 1.00 26.11 ATOM 1639 O LEU 409 13.184 23.928 20.916 1.00 25.38 ATOM 1640 N ILE 410 12.289 22.657 22.548 1.00 25.80 ATOM 1641 CA ILE 410 11.130 22.263 21.750 1.00 27.11 ATOM 1642 CB ILE 410 10.212 21.309 22.556 1.00 27.55 ATOM 1643 CG2 ILE 410 8.831 21.225 21.915 1.00 29.14 ATOM 1644 CG1 ILE 410 10.862 19.925 22.640 1.00 28.88 ATOM 1645 CD1 ILE 410 10.227 18.999 23.672 1.00 29.04 ATOM 1646 C ILE 410 10.324 23.477 21.271 1.00 26.54 ATOM 1647 O ILE 410 9.801 23.483 20.157 1.00 27.28 ATOM 1648 N ALA 411 10.240 24.504 22.108 1.00 26.52 ATOM 1649 CA ALA 411 9.501 25.716 21.762 1.00 27.27 ATOM 1650 CB ALA 411 9.388 26.618 22.982 1.00 28.31 ATOM 1651 C ALA 411 10.187 26.473 20.618 1.00 28.07 ATOM 1652 O ALA 411 9.600 27.379 20.026 1.00 27.10 ATOM 1653 K LYS 412 11.426 26.095 20.310 1.00 27.07 ATOM 1654 CA LYS 412 12.175 26.751 19.244 1.00 28.19 ATOM 1655 CB LYS 412 13.680 26.756 19.579 1.00 28.62 ATOM 1656 CG LYS 412 14.067 27.694 20.728 1.00 30.34 ATOM 1657 CD LYS 412 15.559 27.615 21.042 1.00 31.67 ATOM 1658 CE LYS 412 15.950 28.514 22.215 1.00 33.03 ATOM 1659 HZ LYS 412 15.797 29.985 21.964 1.00 35.05 ATOM 1660 C LYS 412 11.955 26.117 17.864 1.00 27.51 ATOM 1661 O LYS 412 12.316 26.708 16.847 1.00 27.32 ATOM 1662 N ILE 413 11.363 24.926 17.834 1.00 26.06 ATOM 1663 CA ILE 413 11.105 24.202 16.588 1.00 26.80 ATOM 1664 CB ILE 413 10.220 22.939 16.841 1.00 27.43 ATOM 1665 CG2 ILE 413 9.881 22.247 15.523 1.00 27.29 ATOM 1666 CG1 ILE 413 10.945 21.958 17.770 1.00 28.37 ATOM 1667 CD1 ILE 413 12.121 21.254 17.148 1.00 29.37 ATOM 1668 C ILE 413 10.433 25.057 15.519 1.00 26.56 ATOM 1669 O ILE 413 10.864 25.076 14.372 1.00 26.28 ATOM 1670 N PRO 414 9.359 25.775 15.882 1.00 27.37 ATOM 1671 CD PRO 414 8.700 25.857 17.198 1.00 26.88 ATOM 1672 CA PRO 414 8.669 26.614 14.897 1.00 26.65 ATOM 1673 CB PRO 414 7.427 27.080 15.658 1.00 27.87 ATOM 1674 CG PRO 414 7.903 27.129 17.070 1.00 29.01 ATOM 1675 C PRO 414 9.525 27.771 14.374 1.00 25.68 ATOM 1676 O PRO 414 9.448 28.126 13.201 1.00 27.18 ATOM 1677 N THR 415 10.352 28.342 15.241 1.00 25.08 ATOM 1678 CA THR 415 11.226 29.448 14.850 1.00 25.70 ATOM 1679 CB THR 415 11.944 30.028 16.089 1.00 27.08 ATOM 1680 OG1 THR 415 10.964 30.406 17.060 1.00 27.92 ATOM 1681 CG2 THR 415 12.768 31.250 15.727 1.00 26.93 ATOM 1682 C THR 415 12.260 28.954 13.825 1.00 23.76 ATOM 1683 O THR 415 12.546 29.624 12.839 1.00 23.92 ATOM 1684 N ILE 416 12.801 27.768 14.072 1.00 22.76 ATOM 1685 CA ILE 416 13.780 27.158 13.184 1.00 21.78 ATOM 1686 CB ILE 416 14.175 25.760 13.711 1.00 22.29 ATOM 1687 CG2 ILE 416 14.921 24.976 12.648 1.00 21.98 ATOM 1688 CG1 ILE 416 15.012 25.918 14.979 1.00 20.99 ATOM 1689 CD1 ILE 416 15.190 24.634 15.776 1.00 22.24 ATOM 1690 C ILE 416 13.187 27.041 11.785 1.00 20.31 ATOM 1691 O ILE 416 13.790 27.454 10.797 1.00 19.18 ATOM 1692 N THR 417 11.988 26.480 11.710 1.00 20.67 ATOM 1693 CA THR 417 11.328 26.317 10.432 1.00 20.39 ATOM 1694 CB THR 417 10.048 25.508 10.602 1.00 21.40 ATOM 1695 OG1 THR 417 10.390 24.228 11.147 1.00 20.70 ATOM 1696 CG2 THR 417 9.351 25.313 9.257 1.00 19.07 ATOM 1697 C THR 417 11.025 27.661 9.785 1.00 20.61 ATOM 1698 O THR 417 11.118 27.795 8.570 1.00 21.29 ATOM 1699 N ALA 418 10.674 28.651 10.605 1.00 21.09 ATOM 1700 CA ALA 418 10.367 29.987 10.118 1.00 20.90 ATOM 1701 CB ALA 418 9.956 30.880 11.273 1.00 21.36 ATOM 1702 C ALA 418 11.573 30.592 9.404 1.00 21.24 ATOM 1703 O ALA 418 11.441 31.157 8.321 1.00 19.90 ATOM 1704 N VAL 419 12.747 30.457 10.015 1.00 21.50 ATOM 1705 CA VAL 419 13.975 30.995 9.440 1.00 21.76 ATOM 1706 CB VAL 419 15.170 30.797 10.406 1.00 20.86 ATOM 1707 CG1 VAL 419 16.491 31.146 9.713 1.00 22.17 ATOM 1708 CG2 VAL 419 14.969 31.655 11.648 1.00 23.28 ATOM 1709 C VAL 419 14.282 30.328 8.104 1.00 21.71 ATOM 1710 O VAL 419 14.586 30.997 7.120 1.00 21.28 ATOM 1711 N CYS 420 14.180 29.006 8.065 1.00 20.93 ATOM 1712 CA CYS 420 14.467 28.282 6.840 1.00 22.24 ATOM 1713 CB CYS 420 14.560 26.782 7.137 1.00 20.03 ATOM 1714 SG CYS 420 15.994 26.393 8.177 1.00 21.62 ATOM 1715 C CYS 420 13.462 28.573 5.724 1.00 22.17 ATOM 1716 O CYS 420 13.815 28.560 4.545 1.00 22.39 ATOM 1717 N ASN 421 12.213 28.843 6.090 1.00 22.88 ATOM 1718 CA ASN 421 11.213 29.165 5.083 1.00 23.16 ATOM 1719 CB ASN 421 9.803 29.189 5.686 1.00 24.82 ATOM 1720 CG ASN 421 9.254 27.797 5.945 1.00 26.54 ATOM 1721 OD1 ASN 421 9.691 26.821 5.332 1.00 28.43 ATOM 1722 ND2 ASN 421 8.274 27.703 6.841 1.00 28.17 ATOM 1723 C ASN 421 11.548 30.539 4.507 1.00 22.83 ATOM 1724 O ASN 421 11.372 30.783 3.311 1.00 23.42 ATOM 1725 N LEU 422 12.026 31.438 5.362 1.00 21.51 ATOM 1726 CA LEU 422 12.394 32.773 4.912 1.00 21.12 ATOM 1727 CB LEU 422 12.814 33.657 6.094 1.00 20.93 ATOM 1728 CG LEU 422 13.106 35.117 5.724 1.00 22.12 ATOM 1729 CD1 LEU 422 11.914 35.708 4.998 1.00 23.58 ATOM 1730 CD2 LEU 422 13.420 35.919 6.968 1.00 21.92 ATOM 1731 C LEU 422 13.539 32.651 3.909 1.00 20.79 ATOM 1732 O LEU 422 13.589 33.385 2.924 1.00 20.16 ATOM 1733 N HIS 423 14.457 31.721 4.162 1.00 20.32 ATOM 1734 CA HIS 423 15.569 31.496 3.246 1.00 19.09 ATOM 1735 CB HIS 423 16.480 30.377 3.774 1.00 19.51 ATOM 1736 CG HIS 423 17.357 29.757 2.726 1.00 20.42 ATOM 1737 CD2 HIS 423 18.560 30.132 2.233 1.00 22.15 ATOM 1738 ND1 HIS 423 17.002 28.617 2.037 1.00 19.93 ATOM 1739 CE1 HIS 423 17.945 28.317 1.164 1.00 21.28 ATOM 1740 NE2 HIS 423 18.903 29.221 1.261 1.00 23.18 ATOM 1741 C HIS 423 14.991 31.114 1.887 1.00 20.06 ATOM 1742 O HIS 423 15.406 31.633 0.854 1.00 19.48 ATOM 1743 N GLY 424 14.025 30.202 1.897 1.00 20.89 ATOM 1744 CA GLY 424 13.409 29.779 0.656 1.00 21.77 ATOM 1745 C GLY 424 12.747 30.948 −0.045 1.00 22.46 ATOM 1746 O GLY 424 12.854 31.092 −1.260 1.00 22.28 ATOM 1747 N GLU 425 12.055 31.781 0.723 1.00 23.68 ATOM 1748 CA GLU 425 11.388 32.944 0.156 1.00 26.30 ATOM 1749 CB GLU 425 10.654 33.714 1.254 1.00 29.71 ATOM 1750 CG GLU 425 9.438 32.987 1.807 1.00 34.81 ATOM 1751 CD GLU 425 8.840 33.708 3.000 1.00 39.53 ATOM 1752 OE1 GLU 425 8.732 34.960 2.940 1.00 40.10 ATOM 1753 OE2 GLU 425 8.471 33.026 3.992 1.00 42.79 ATOM 1754 C GLU 425 12.380 33.862 −0.553 1.00 25.74 ATOM 1755 O GLU 425 12.166 34.228 −1.708 1.00 26.36 ATOM 1756 N LYS 426 13.468 34.221 0.125 1.00 25.26 ATOM 1757 CA LYS 426 14.484 35.094 −0.470 1.00 25.80 ATOM 1758 CB LYS 426 15.610 35.376 0.531 1.00 25.12 ATOM 1759 CG LYS 426 15.150 36.115 1.775 1.00 28.49 ATOM 1760 CD LYS 426 14.489 37.445 1.415 1.00 29.27 ATOM 1761 CE LYS 426 13.995 38.148 2.666 1.00 32.12 ATOM 1762 NZ LYS 426 13.235 39.411 2.390 1.00 31.15 ATOM 1763 C LYS 426 15.083 34.497 −1.733 1.00 25.06 ATOM 1764 O LYS 426 15.363 35.209 −2.703 1.00 24.27 ATOM 1765 N LEU 427 15.278 33.183 −1.717 1.00 25.20 ATOM 1766 CA LEU 427 15.848 32.480 −2.857 1.00 26.06 ATOM 1767 CB LEU 427 16.165 31.032 −2.473 1.00 25.95 ATOM 1768 CG LEU 427 16.582 30.058 −3.581 1.00 27.66 ATOM 1769 CD1 LEU 427 17.718 30.638 −4.415 1.00 26.38 ATOM 1770 CD2 LEU 427 17.002 28.740 −2.940 1.00 27.07 ATOM 1771 C LEU 427 14.922 32.523 −4.072 1.00 26.54 ATOM 1772 O LEU 427 15.383 32.716 −5.194 1.00 26.46 ATOM 1773 N GLN 428 13.622 32.369 −3.847 1.00 27.45 ATOM 1774 CA GLN 428 12.653 32.399 −4.942 1.00 29.19 ATOM 1775 CB GLN 428 11.247 32.108 −4.416 1.00 32.05 ATOM 1776 CG GLN 428 11.172 30.852 −3.561 1.00 36.92 ATOM 1777 CD GLN 428 12.009 29.714 −4.139 1.00 39.47 ATOM 1778 OE1 GLN 428 11.946 29.442 −5.345 1.00 41.41 ATOM 1779 NE2 GLN 428 12.788 29.034 −3.281 1.00 37.83 ATOM 1780 C GLN 428 12.654 33.736 −5.675 1.00 28.90 ATOM 1781 O GLN 428 12.466 33.780 −6.889 1.00 28.50 ATOM 1782 N VAL 429 12.844 34.826 −4.938 1.00 28.63 ATOM 1783 CA VAL 429 12.893 36.145 −5.551 1.00 29.18 ATOM 1784 CB VAL 429 12.708 37.272 −4.515 1.00 29.49 ATOM 1785 CG1 VAL 429 12.789 38.632 −5.215 1.00 30.49 ATOM 1786 CG2 VAL 429 11.362 37.126 −3.824 1.00 30.87 ATOM 1787 C VAL 429 14.260 36.297 −6.210 1.00 28.70 ATOM 1788 O VAL 429 14.398 36.924 −7.267 1.00 27.69 ATOM 1789 N PHE 430 15.279 35.723 −5.584 1.00 28.04 ATOM 1790 CA PHE 430 16.601 35.793 −6.177 1.00 28.41 ATOM 1791 CB PHE 430 17.633 35.074 −5.317 1.00 27.09 ATOM 1792 CG PHE 430 19.021 35.157 −5.872 1.00 27.44 ATOM 1793 CD1 PHE 430 19.777 36.314 −5.711 1.00 27.34 ATOM 1794 CD2 PHE 430 19.553 34.096 −6.602 1.00 26.42 ATOM 1795 CE1 PHE 430 21.049 36.415 −6.274 1.00 27.80 ATOM 1796 CE2 PHE 430 20.807 34.182 −7.166 1.00 27.06 ATOM 1797 CZ PHE 430 21.564 35.346 −7.004 1.00 27.26 ATOM 1798 C PHE 430 16.549 35.120 −7.553 1.00 28.91 ATOM 1799 O PHE 430 17.104 35.641 −8.524 1.00 28.87 ATOM 1800 N LYS 431 15.886 33.964 −7.622 1.00 29.85 ATOM 1801 CA LYS 431 15.766 33.212 −8.874 1.00 32.68 ATOM 1802 CB LYS 431 14.976 31.906 −8.670 1.00 33.56 ATOM 1803 CG LYS 431 14.832 31.090 −9.970 1.00 37.44 ATOM 1804 CD LYS 431 13.617 30.145 −9.977 1.00 39.34 ATOM 1805 CE LYS 431 13.997 28.714 −9.618 1.00 41.84 ATOM 1806 NZ LYS 431 14.937 28.127 −10.621 1.00 42.78 ATOM 1807 C LYS 431 15.077 34.053 −9.944 1.00 33.57 ATOM 1808 O LYS 431 15.415 33.958 −11.125 1.00 33.07 ATOM 1809 N GLN 432 14.103 34.865 −9.536 1.00 34.34 ATOM 1810 CA GLN 432 13.392 35.728 −10.484 1.00 35.91 ATOM 1811 CB GLN 432 12.353 36.589 −9.768 1.00 38.08 ATOM 1812 CG GLN 432 11.091 35.901 −9.303 1.00 39.88 ATOM 1813 CD GLN 432 10.123 36.910 −8.684 1.00 41.50 ATOM 1814 OE1 GLN 432 10.388 37.471 −7.617 1.00 40.92 ATOM 1815 NE2 GLN 432 9.011 37.170 −9.372 1.00 42.35 ATOM 1816 C GLN 432 14.362 36.676 −11.182 1.00 35.12 ATOM 1817 O GLN 432 14.358 36.804 −12.408 1.00 35.26 ATOM 1818 N SER 433 15.180 37.347 −10.377 1.00 34.32 ATOM 1819 CA SER 433 16.156 38.313 −10.868 1.00 34.30 ATOM 1820 CB SER 433 16.608 39.220 −9.718 1.00 33.92 ATOM 1821 OG SER 433 15.605 40.165 −9.392 1.00 35.35 ATOM 1822 C SER 433 17.386 37.707 −11.536 1.00 33.58 ATOM 1823 O SER 433 17.948 38.298 −12.458 1.00 33.32 ATOM 1824 N HIS 434 17.809 36.537 −11.071 1.00 33.33 ATOM 1825 CA HIS 434 18.990 35.890 −11.635 1.00 34.01 ATOM 1826 CB HIS 434 20.184 36.077 −10.697 1.00 34.09 ATOM 1827 CG HIS 434 20.418 37.498 −10.299 1.00 34.93 ATOM 1828 CD2 HIS 434 21.195 38.462 −10.849 1.00 35.03 ATOM 1829 ND1 HIS 434 19.776 38.087 −9.232 1.00 35.41 ATOM 1830 CE1 HIS 434 20.147 39.351 −9.140 1.00 35.21 ATOM 1831 NE2 HIS 434 21.007 39.604 −10.110 1.00 36.62 ATOM 1832 C HIS 434 18.771 34.405 −11.883 1.00 34.38 ATOM 1833 O HIS 434 19.341 33.561 −11.193 1.00 33.93 ATOM 1834 N PRO 435 17.938 34.064 −12.876 1.00 34.98 ATOM 1835 CD PRO 435 17.182 34.919 −13.805 1.00 35.01 ATOM 1836 CA PRO 435 17.689 32.650 −13.158 1.00 35.44 ATOM 1837 CB PRO 435 16.607 32.695 −14.237 1.00 35.29 ATOM 1838 CG PRO 435 16.916 33.963 −14.962 1.00 35.40 ATOM 1839 C PRO 435 18.915 31.882 −13.613 1.00 36.20 ATOM 1840 O PRO 435 19.122 30.758 −13.172 1.00 35.55 ATOM 1841 N ASP 436 19.733 32.480 −14.481 1.00 37.54 ATOM 1842 CA ASP 436 20.919 31.785 −14.980 1.00 40.08 ATOM 1843 CB ASP 436 21.634 32.607 −16.058 1.00 42.72 ATOM 1844 CG ASP 436 22.700 31.794 −16.803 1.00 45.95 ATOM 1845 OD1 ASP 436 22.313 30.821 −17.497 1.00 46.29 ATOM 1846 OD2 ASP 436 23.914 32.119 −16.695 1.00 47.67 ATOM 1847 C ASP 436 21.918 31.423 −13.886 1.00 39.77 ATOM 1848 O ASP 436 22.572 30.385 −13.966 1.00 39.96 ATOM 1849 N ILE 437 22.042 32.270 −12.867 1.00 39.31 ATOM 1850 CA ILE 437 22.972 31.999 −11.775 1.00 38.61 ATOM 1851 CB ILE 437 23.096 33.227 −10.806 1.00 39.13 ATOM 1852 CG2 ILE 437 23.864 32.842 −9.547 1.00 39.06 ATOM 1853 CG1 ILE 437 23.848 34.378 −11.491 1.00 39.49 ATOM 1854 CD1 ILE 437 23.124 34.982 −12.681 1.00 41.59 ATOM 1855 C ILE 437 22.538 30.757 −10.995 1.00 38.26 ATOM 1856 O ILE 437 23.350 29.858 −10.745 1.00 37.65 ATOM 1857 N VAL 438 21.255 30.692 −10.641 1.00 37.18 ATOM 1858 CA VAL 438 20.727 29.566 −9.885 1.00 37.56 ATOM 1859 CB VAL 438 19.239 29.785 −9.458 1.00 37.27 ATOM 1860 CG1 VAL 438 18.716 28.546 −8.751 1.00 36.25 ATOM 1861 CG2 VAL 438 19.116 30.983 −8.525 1.00 36.28 ATOM 1362 C VAL 438 20.800 28.261 −10.672 1.00 38.30 ATOM 1863 O VAL 438 21.265 27.246 −10.157 1.00 37.66 ATOM 1864 N ASN 439 20.368 28.287 −11.927 1.00 39.10 ATOM 1865 CA ASN 439 20.370 27.060 −12.716 1.00 39.91 ATOM 1866 CB ASN 439 19.390 27.189 −13.895 1.00 41.62 ATOM 1867 CG ASN 439 17.934 27.190 −13.445 1.00 43.36 ATOM 1868 OD1 ASN 439 17.596 26.609 −12.410 1.00 44.58 ATOM 1869 ND2 ASN 439 17.064 27.827 −14.225 1.00 44.62 ATOM 1870 C ASN 439 21.711 26.555 −13.219 1.00 39.39 ATOM 1871 O ASN 439 21.835 25.377 −13.561 1.00 40.93 ATOM 1872 N THR 440 22.728 27.406 −13.260 1.00 39.19 ATOM 1873 CA THR 440 24.017 26.950 −13.777 1.00 38.65 ATOM 1874 CB THR 440 24.287 27.533 −15.181 1.00 38.77 ATOM 1875 OG1 THR 440 24.895 28.828 −15.057 1.00 40.00 ATOM 1876 CG2 THR 440 22.985 27.670 −15.955 1.00 38.78 ATOM 1877 C THR 440 25.248 27.238 −12.926 1.00 37.59 ATOM 1878 O THR 440 26.353 26.835 −13.290 1.00 38.22 ATOM 1879 N LEU 441 25.079 27.940 −11.811 1.00 35.62 ATOM 1880 CA LEU 441 26.224 28.254 −10.965 1.00 33.88 ATOM 1881 CB LEU 441 26.494 29.762 −10.971 1.00 35.57 ATOM 1882 CG LEU 441 27.001 30.326 −12.304 1.00 37.86 ATOM 1883 CD1 LEU 441 27.177 31.837 −12.174 1.00 38.20 ATOM 1884 CD2 LEU 441 28.321 29.677 −12.683 1.00 38.80 ATOM 1885 C LEU 441 26.071 27.763 −9.533 1.00 31.60 ATOM 1886 O LEU 441 27.064 27.532 −8.839 1.00 32.48 ATOM 1887 N PHE 442 24.831 27.602 −9.086 1.00 28.10 ATOM 1888 CA PHE 442 24.587 27.122 −7.731 1.00 25.29 ATOM 1889 CB PHE 442 23.135 27.405 −7.318 1.00 25.99 ATOM 1890 CG PHE 442 22.909 28.776 −6.747 1.00 27.30 ATOM 1891 CD1 PHE 442 23.833 29.796 −6.937 1.00 26.54 ATOM 1892 CD2 PHE 442 21.748 29.047 −6.026 1.00 27.97 ATOM 1893 CE1 PHE 442 23.604 31.064 −6.416 1.00 29.09 ATOM 1894 CE2 PHE 442 21.508 30.321 −5.499 1.00 28.50 ATOM 1895 CZ PHE 442 22.438 31.326 −5.695 1.00 27.97 ATOM 1896 C PHE 442 24.830 25.615 −7.676 1.00 23.49 ATOM 1897 O PHE 442 24.616 24.907 −8.663 1.00 21.57 ATOM 1898 N PRO 443 25.300 25.107 −6.525 1.00 21.70 ATOM 1899 CD PRO 443 25.758 25.819 −5.316 1.00 21.76 ATOM 1900 CA PRO 443 25.539 23.665 −6.414 1.00 21.30 ATOM 1901 CB PRO 443 25.886 23.488 −4.940 1.00 20.81 ATOM 1902 CG PRO 443 26.615 24.773 −4.619 1.00 20.63 ATOM 1903 C PRO 443 24.263 22.911 −6.795 1.00 22.58 ATOM 1904 O PRO 443 23.179 23.243 −6.326 1.00 21.97 ATOM 1905 N PRO 444 24.377 21.893 −7.662 1.00 24.17 ATOM 1906 CD PRO 444 25.574 21.463 −8.404 1.00 24.11 ATOM 1907 CA PRO 444 23.205 21.117 −8.080 1.00 24.81 ATOM 1908 CB PRO 444 23.825 19.970 −8.867 1.00 25.10 ATOM 1909 CG PRO 444 24.976 20.652 −9.543 1.00 25.51 ATOM 1910 C PRO 444 22.313 20.637 −6.933 1.00 24.27 ATOM 1911 O PRO 444 21.093 20.599 −7.081 1.00 24.40 ATOM 1912 N LEU 445 22.905 20.272 −5.797 1.00 23.78 ATOM 1913 CA LEU 445 22.106 19.807 −4.653 1.00 23.55 ATOM 1914 CB LEU 445 23.001 19.218 −3.563 1.00 22.47 ATOM 1915 CG LEU 445 22.273 18.815 −2.274 1.00 21.23 ATOM 1916 CD1 LEU 445 21.251 17.742 −2.592 1.00 22.32 ATOM 1917 CD2 LEU 445 23.273 18.307 −1.242 1.00 20.86 ATOM 1918 C LEU 445 21.278 20.943 −4.055 1.00 22.92 ATOM 1919 O LEU 445 20.124 20.757 −3.647 1.00 21.21 ATOM 1920 N TYR 446 21.880 22.121 −3.998 1.00 23.10 ATOM 1921 CA TYR 446 21.197 23.284 −3.465 1.00 23.29 ATOM 1922 CB TYR 446 22.171 24.458 −3.418 1.00 23.30 ATOM 1923 CG TYR 446 21.611 25.737 −2.846 1.00 23.78 ATOM 1924 CD1 TYR 446 20.891 26.617 −3.647 1.00 25.71 ATOM 1925 CE1 TYR 446 20.430 27.835 −3.151 1.00 25.93 ATOM 1926 CD2 TYR 446 21.850 26.094 −1.518 1.00 23.35 ATOM 1927 CE2 TYR 446 21.394 27.311 −1.002 1.00 25.61 ATOM 1928 CZ TYR 446 20.688 28.179 −1.829 1.00 26.53 ATOM 1929 OH TYR 446 20.281 29.404 −1.359 1.00 26.63 ATOM 1930 C TYR 446 19.986 23.592 −4.346 1.00 25.01 ATOM 1931 O TYR 446 18.903 23.896 −3.837 1.00 26.28 ATOM 1932 N LYS 447 20.163 23.502 −5.664 1.00 24.54 ATOM 1933 CA LYS 447 19.063 23.753 −6.591 1.00 26.44 ATOM 1934 CB LYS 447 19.566 23.733 −8.042 1.00 28.07 ATOM 1935 CG LYS 447 18.458 23.840 −9.086 1.00 33.16 ATOM 1936 CD LYS 447 19.025 23.787 −10.514 1.00 36.54 ATOM 1937 CE LYS 447 17.920 23.595 −11.542 1.00 39.14 ATOM 1938 NZ LYS 447 18.494 23.447 −12.910 1.00 40.17 ATOM 1939 C LYS 447 17.985 22.680 −6.414 1.00 25.88 ATOM 1940 O LYS 447 16.796 22.980 −6.367 1.00 26.47 ATOM 1941 N GLU 448 18.417 21.430 −6.306 1.00 25.85 ATOM 1942 CA GLU 448 17.498 20.305 −6.147 1.00 26.71 ATOM 1943 CB GLU 448 18.290 18.993 −6.099 1.00 26.95 ATOM 1944 CG GLU 448 17.448 17.775 −5.804 1.00 29.45 ATOM 1945 CD GLU 448 18.239 16.475 −5.861 1.00 29.93 ATOM 1946 OE1 GLU 448 18.785 16.140 −6.935 1.00 30.55 ATOM 1947 OE2 GLU 448 18.301 15.773 −4.832 1.00 30.84 ATOM 1948 C GLU 448 16.637 20.432 −4.894 1.00 26.51 ATOM 1949 O GLU 448 15.430 20.137 −4.323 1.00 26.27 ATOM 1950 N LEU 449 17.268 20.832 −3.798 1.00 25.93 ATOM 1951 CA LEU 449 16.589 20.981 −2.523 1.00 26.71 ATOM 1952 CB LEU 449 17.622 21.017 −1.392 1.00 26.21 ATOM 1953 CG LEU 449 18.502 19.788 −1.172 1.00 26.61 ATOM 1954 CD1 LEU 449 19.610 20.112 −0.154 1.00 25.71 ATOM 1955 CD2 LEU 449 17.633 18.623 −0.697 1.00 26.71 ATOM 1956 C LEU 449 15.674 22.189 −2.364 1.00 28.16 ATOM 1957 O LEU 449 14.593 22.064 −1.782 1.00 28.09 ATOM 1958 N PHE 450 16.098 23.348 −2.876 1.00 29.00 ATOM 1959 CA PHE 450 15.338 24.577 −2.692 1.00 31.20 ATOM 1960 CB PHE 450 16.224 25.609 −1.993 1.00 29.89 ATOM 1961 CG PHE 450 16.886 25.084 −0.757 1.00 27.85 ATOM 1962 CD1 PHE 450 18.263 24.862 −0.729 1.00 27.95 ATOM 1963 CD2 PHE 450 16.127 24.748 0.362 1.00 28.29 ATOM 1964 CE1 PHE 450 18.877 24.305 0.402 1.00 27.72 ATOM 1965 CE2 PHE 450 16.723 24.190 1.498 1.00 27.38 ATOM 1966 CZ PHE 450 18.105 23.966 1.518 1.00 28.09 ATOM 1967 C PHE 450 14.625 25.257 −3.854 1.00 33.41 ATOM 1968 O PHE 450 13.844 26.169 −3.615 1.00 32.89 ATOM 1969 N ASN 451 14.889 24.862 −5.096 1.00 36.22 ATOM 1970 CA ASN 451 14.185 25.493 −6.219 1.00 39.47 ATOM 1971 CB ASN 451 15.168 26.004 −7.281 1.00 41.40 ATOM 1972 CG ASN 451 15.939 27.245 −6.818 1.00 43.69 ATOM 1973 OD1 ASN 451 15.371 28.342 −6.672 1.00 44.14 ATOM 1974 ND2 ASN 451 17.238 27.071 −6.567 1.00 44.76 ATOM 1975 C ASN 451 13.217 24.509 −6.851 1.00 40.32 ATOM 1976 O ASN 451 11.993 24.725 −6.697 1.00 41.43 ATOM 1977 OXT ASN 451 13.696 23.537 −7.475 1.00 40.86 ATOM 1978 CB HIS 691 15.393 13.885 −4.499 1.00 41.85 ATOM 1979 CG HIS 691 13.918 14.001 −4.283 1.00 43.67 ATOM 1980 CD2 HIS 691 13.151 15.051 −3.912 1.00 44.45 ATOM 1981 ND1 HIS 691 13.051 12.954 −4.521 1.00 44.92 ATOM 1982 CE1 HIS 691 11.810 13.358 −4.305 1.00 45.35 ATOM 1983 NE2 HIS 691 11.843 14.625 −3.935 1.00 45.49 ATOM 1984 C HIS 691 16.996 13.164 −6.244 1.00 38.01 ATOM 1985 O HIS 691 17.471 12.469 −5.361 1.00 38.13 ATOM 1986 N HIS 691 14.685 13.691 −6.864 1.00 39.52 ATOM 1987 CA HIS 691 15.813 14.063 −5.956 1.00 39.14 ATOM 1988 N LYS 692 17.475 13.190 −7.484 1.00 36.76 ATOM 1989 CA LYS 692 18.589 12.350 −7.903 1.00 35.59 ATOM 1990 CB LYS 692 18.893 12.623 −9.378 1.00 37.83 ATOM 1991 CG LYS 692 19.742 11.564 −10.051 1.00 40.63 ATOM 1992 CD LYS 692 19.728 11.714 −11.575 1.00 42.76 ATOM 1993 CE LYS 692 20.323 10.472 −12.235 1.00 43.47 ATOM 1994 NZ LYS 692 21.706 10.196 −11.753 1.00 43.90 ATOM 1995 C LYS 692 19.873 12.498 −7.080 1.00 33.87 ATOM 1996 O LYS 692 20.467 11.509 −6.658 1.00 33.35 ATOM 1997 N ILE 693 20.309 13.729 −6.857 1.00 32.23 ATOM 1998 CA ILE 693 21.535 13.950 −6.113 1.00 31.32 ATOM 1999 CB ILE 693 21.930 15.427 −6.149 1.00 30.80 ATOM 2000 CG2 ILE 693 23.269 15.635 −5.440 1.00 29.72 ATOM 2001 CG1 ILE 693 22.033 15.873 −7.608 1.00 31.13 ATOM 2002 CD1 ILE 693 22.234 17.371 −7.780 1.00 31.56 ATOM 2003 C ILE 693 21.432 13.482 −4.678 1.00 30.60 ATOM 2004 O ILE 693 22.298 12.750 −4.201 1.00 30.47 ATOM 2005 N LEU 694 20.373 13.894 −3.988 1.00 30.60 ATOM 2006 CA LEU 694 20.189 13.498 −2.599 1.00 29.95 ATOM 2007 CB LEU 694 18.901 14.127 −2.049 1.00 30.02 ATOM 2008 CG LEU 694 18.575 13.956 −0.565 1.00 30.42 ATOM 2009 CD1 LEU 694 19.761 14.380 0.289 1.00 27.83 ATOM 2010 CD2 LEU 694 17.338 14.782 −0.228 1.00 29.11 ATOM 2011 C LEU 694 20.133 11.973 −2.530 1.00 31.03 ATOM 2012 O LEU 694 20.692 11.347 −1.624 1.00 28.47 ATOM 2013 N HIS 695 19.476 11.365 −3.512 1.00 31.88 ATOM 2014 CA HIS 695 19.374 9.913 −3.529 1.00 33.30 ATOM 2015 CB HIS 695 18.477 9.459 −4.670 1.00 36.30 ATOM 2016 CG HIS 695 17.945 8.080 −4.478 1.00 40.00 ATOM 2017 CD2 HIS 695 16.683 7.629 −4.299 1.00 41.54 ATOM 2018 ND1 HIS 695 18.768 6.980 −4.364 1.00 41.93 ATOM 2019 CE1 HIS 695 18.035 5.910 −4.117 1.00 42.57 ATOM 2020 NE2 HIS 695 16.766 6.277 −4.071 1.00 43.22 ATOM 2021 C HIS 695 20.746 9.260 −3.676 1.00 33.11 ATOM 2022 O HIS 695 21.048 8.249 −3.040 1.00 32.39 ATOM 2023 N ARG 696 21.579 9.849 −4.521 1.00 32.29 ATOM 2024 CA ARG 696 22.909 9.322 −4.743 1.00 30.93 ATOM 2025 CB ARG 696 23.603 10.093 −5.867 1.00 31.23 ATOM 2026 CG ARG 696 24.984 9.543 −6.182 1.00 32.75 ATOM 2027 CD ARG 696 25.804 10.477 −7.050 1.00 33.56 ATOM 2028 NE ARG 696 27.125 9.909 −7.307 1.00 35.72 ATOM 2029 CZ ARG 696 28.099 10.546 −7.950 1.00 35.45 ATOM 2030 NH1 ARG 696 27.901 11.782 −8.398 1.00 35.32 ATOM 2031 HH2 ARG 696 29.268 9.943 −8.151 1.00 36.04 ATOM 2032 C ARG 696 23.772 9.386 −3.480 1.00 29.89 ATOM 2033 O ARG 696 24.475 8.433 −3.161 1.00 29.24 ATOM 2034 N LEU 697 23.716 10.509 −2.768 1.00 29.17 ATOM 2035 CA LEU 697 24.511 10.690 −1.557 1.00 28.52 ATOM 2036 CB LEU 697 24.368 12.124 −1.046 1.00 26.92 ATOM 2037 CG LEU 697 24.699 13.228 −2.053 1.00 27.27 ATOM 2038 CD1 LEU 697 24.463 14.602 −1.417 1.00 25.02 ATOM 2039 CD2 LEU 697 26.142 13.085 −2.505 1.00 26.53 ATOM 2040 C LEU 697 24.140 9.712 −0.448 1.00 29.70 ATOM 2041 O LEU 697 25.004 9.258 0.302 1.00 28.66 ATOM 2042 N LEU 698 22.853 9.397 −0.345 1.00 31.41 ATOM 2043 CA LEU 698 22.375 8.453 0.661 1.00 34.12 ATOM 2044 CB LEU 698 20.846 8.472 0.718 1.00 33.23 ATOM 2045 CG LEU 698 20.134 9.426 1.669 1.00 32.91 ATOM 2046 CD1 LEU 698 18.680 9.463 1.307 1.00 33.90 ATOM 2047 CD2 LEU 698 20.302 8.964 3.107 1.00 31.41 ATOM 2048 C LEU 698 22.848 7.044 0.315 1.00 36.29 ATOM 2049 O LEU 698 23.159 6.242 1.194 1.00 36.31 ATOM 2050 N GLN 699 22.909 6.760 −0.977 1.00 39.15 ATOM 2051 CA GLN 699 23.328 5.450 −1.471 1.00 42.12 ATOM 2052 CB GLN 699 22.802 5.239 −2.896 1.00 43.64 ATOM 2053 CG GLN 699 21.274 5.140 −2.989 1.00 45.98 ATOM 2054 CD GLN 699 20.750 3.781 −2.547 1.00 47.08 ATOM 2055 OE1 GLN 699 21.233 3.204 −1.566 1.00 48.60 ATOM 2056 NE2 GLN 699 19.747 3.269 −3.258 1.00 48.36 ATOM 2057 C GLN 699 24.836 5.245 −1.465 1.00 43.37 ATOM 2058 O GLN 699 25.305 4.126 −1.660 1.00 43.65 ATOM 2059 N GLU 700 25.599 6.312 −1.260 1.00 44.64 ATOM 2060 CA GLU 700 27.052 6.190 −1.250 1.00 47.04 ATOM 2061 CB GLU 700 27.700 7.568 −1.095 1.00 47.40 ATOM 2062 CG GLU 700 29.220 7.519 −1.157 1.00 49.39 ATOM 2063 CD GLU 700 29.791 8.048 −2.461 1.00 49.85 ATOM 2064 OE1 GLU 700 29.288 7.680 −3.554 1.00 49.19 ATOM 2065 OE2 GLU 700 30.763 8.836 −2.382 1.00 51.58 ATOM 2066 C GLU 700 27.540 5.255 −0.132 1.00 48.52 ATOM 2067 O GLU 700 28.449 4.423 −0.386 1.00 48.99 ATOM 2068 OXT GLU 700 27.021 5.379 1.001 1.00 49.57 ATOM 2069 OH2 WAT 801 14.817 26.937 2.587 1.00 20.16 ATOM 2070 OH2 WAT 802 26.733 20.689 8.917 1.00 19.93 ATOM 2071 OH2 WAT 803 26.566 41.076 13.914 1.00 25.96 ATOM 2072 OH2 WAT 804 12.901 16.692 8.722 1.00 19.78 ATOM 2073 OH2 WAT 805 21.441 41.033 3.838 1.00 27.88 ATOM 2074 OH2 WAT 806 11.576 19.809 13.280 1.00 21.67 ATOM 2075 OH2 WAT 807 24.269 17.527 14.566 1.00 22.47 ATOM 2076 OH2 WAT 808 25.329 19.487 −5.550 1.00 38.43 ATOM 2077 OH2 WAT 809 28.090 41.701 1.977 1.00 27.58 ATOM 2078 OH2 WAT 810 1.405 9.268 4.014 1.00 28.13 ATOM 2079 OH2 WAT 811 7.275 28.248 11.748 1.00 33.78 ATOM 2080 OH2 WAT 812 24.068 26.427 23.332 1.00 29.89 ATOM 2081 OH2 WAT 813 14.772 34.264 14.684 1.00 25.08 ATOM 2082 OH2 WAT 814 12.543 3.741 17.005 1.00 29.72 ATOM 2083 OH2 WAT 815 30.580 18.289 2.261 1.00 31.66 ATOM 2084 OH2 WAT 816 36.688 39.061 2.238 1.00 31.61 ATOM 2085 OH2 WAT 817 11.630 23.199 6.840 1.00 31.07 ATOM 2086 OH2 WAT 818 2.742 5.405 10.288 1.00 30.11 ATOM 2087 OH2 WAT 819 1.368 13.915 5.083 1.00 35.24 ATOM 2088 OH2 WAT 820 3.546 13.308 8.739 1.00 32.87 ATOM 2089 OH2 WAT 821 0.197 11.314 7.692 1.00 31.34 ATOM 2090 OH2 WAT 822 −0.265 12.324 3.836 1.00 31.56 ATOM 2091 OH2 WAT 823 32.317 41.732 11.781 1.00 30.31 ATOM 2092 OK2 WAT 824 31.188 22.170 11.656 1.00 30.40 ATOM 2093 OH2 WAT 825 28.708 24.054 13.003 1.00 32.74 ATOM 2094 OH2 WAT 826 30.451 24.872 11.210 1.00 53.39 ATOM 2095 OH2 WAT 832 14.659 19.191 30.954 1.00 33.74 ATOM 2096 OH2 WAT 835 2.458 12.055 6.762 1.00 30.04 ATOM 2097 OH2 WAT 836 8.996 22.689 12.009 1.00 49.90 ATOM 2098 OH2 WAT 837 14.375 24.499 4.186 1.00 30.61 ATOM 2099 OH2 WAT 839 2.130 4.386 7.857 1.00 30.22 ATOM 2100 OH2 WAT 840 26.339 16.316 27.739 1.00 35.01 ATOM 2101 OH2 WAT 841 8.001 21.050 7.844 1.00 25.09 ATOM 2102 OH2 WAT 842 11.218 3.956 14.667 1.00 29.78 ATOM 2103 OH2 WAT 843 13.538 3.582 13.108 1.00 29.55 ATOM 2104 OH2 WAT 844 12.401 22.827 13.222 1.00 30.20 ATOM 2105 OH2 WAT 846 34.979 40.443 11.829 1.00 38.06 ATOM 2106 OH2 WAT 847 9.388 6.952 8.514 1.00 44.86 ATOM 2107 OH2 WAT 848 9.424 32.516 7.968 1.00 34.80 ATOM 2108 OH2 WAT 849 12.152 25.422 5.217 1.00 33.49 ATOM 2109 OH2 WAT 850 38.479 45.718 1.108 1.00 32.54 ATOM 2110 OH2 WAT 851 32.489 27.280 7.768 1.00 52.84 ATOM 2111 OH2 WAT 852 19.651 17.055 −9.301 1.00 37.88 ATOM 2112 OH2 WAT 853 18.746 43.921 3.425 1.00 36.94 ATOM 2113 OH2 WAT 854 25.431 10.057 26.150 1.00 38.06 ATOM 2114 OH2 WAT 855 7.134 18.540 4.931 1.00 63.81 ATOM 2115 OH2 WAT 856 9.614 18.288 18.085 1.00 35.99 ATOM 2116 OH2 WAT 857 9.960 11.674 24.894 1.00 34.82 ATOM 2117 OH2 WAT 858 21.673 44.846 2.726 1.00 29.09 ATOM 2118 OH2 WAT 859 12.420 −0.591 5.172 1.00 56.22 ATOM 2119 OH2 WAT 860 2.112 7.553 21.676 1.00 63.50 ATOM 2120 OH2 WAT 861 32.871 18.504 18.445 1.00 37.53 ATOM 2121 OH2 WAT 862 7.060 24.628 6.457 1.00 41.11 ATOM 2122 OH2 WAT 863 30.339 19.808 24.562 1.00 35.73 ATOM 2123 OH2 WAT 865 31.408 40.456 −6.981 1.00 28.87 ATOM 2124 OH2 WAT 866 16.060 42.941 9.793 1.00 44.24 ATOM 2125 OH2 WAT 867 12.843 26.219 0.918 1.00 35.68 ATOM 2126 OH2 WAT 868 37.364 44.144 −7.616 1.00 64.48 ATOM 2127 OH2 WAT 869 8.875 20.108 12.516 1.00 35.65 ATOM 2128 OH2 WAT 870 15.439 22.492 5.981 1.00 34.94 ATOM 2129 OH2 WAT 871 23.795 42.644 6.558 1.00 37.44 ATOM 2130 OH2 WAT 873 24.777 36.088 21.937 1.00 37.38 ATOM 2131 OH2 WAT 874 19.791 35.055 −15.004 1.00 49.00 ATOM 2132 OH2 WAT 875 4.885 20.278 10.170 1.00 42.95 ATOM 2133 OH2 WAT 876 22.387 24.643 −10.436 1.00 51.01 ATOM 2134 OH2 WAT 877 12.606 26.960 −1.579 1.00 38.28 ATOM 2135 OH2 WAT 878 29.020 8.186 21.464 1.00 34.65 ATOM 2136 OH2 WAT 879 19.154 5.255 15.898 1.00 45.06 ATOM 2137 OH2 WAT 880 23.704 47.324 18.452 1.00 68.34 ATOM 2138 OH2 WAT 881 28.057 9.062 6.603 1.00 44.32 ATOM 2139 OH2 WAT 883 43.023 41.890 5.788 1.00 38.31 ATOM 2140 OH2 WAT 884 7.119 28.891 9.099 1.00 32.09 ATOM 2141 OH2 WAT 885 17.021 2.408 2.764 1.00 45.47 ATOM 2142 OH2 WAT 886 23.215 4.005 10.105 1.00 32.13 ATOM 2143 OH2 WAT 887 15.983 38.039 −2.715 1.00 54.73 ATOM 2144 OH2 WAT 889 4.205 3.441 11.079 1.00 39.06 ATOM 2145 OH2 WAT 890 20.791 9.054 −7.915 1.00 33.22 ATOM 2146 OH2 WAT 891 25.305 7.602 26.964 1.00 51.43 ATOM 2147 OH2 WAT 892 27.413 6.919 14.503 1.00 32.31 ATOM 2148 OH2 WAT 893 33.552 15.908 12.742 1.00 47.40 ATOM 2149 OH2 WAT 894 27.172 23.883 29.442 1.00 51.19 ATOM 2150 OH2 WAT 895 32.219 29.350 18.302 1.00 39.52 ATOM 2151 OH2 WAT 896 20.082 1.162 10.052 1.00 37.15 ATOM 2152 OH2 WAT 898 23.983 4.384 5.989 1.00 35.18 ATOM 2153 OH2 WAT 899 9.782 19.780 0.976 1.00 50.23 ATOM 2154 OH2 WAT 900 36.407 19.082 20.876 1.00 44.97 ATOM 2155 OH2 WAT 901 7.403 19.567 14.815 1.00 37.37 ATOM 2156 OH2 WAT 902 39.710 36.772 1.207 1.00 58.27 ATOM 2157 OH2 WAT 903 10.185 18.360 15.457 1.00 33.56 ATOM 2158 OH2 WAT 904 10.260 38.244 11.664 1.00 51.98 ATOM 2159 OH2 WAT 905 11.584 31.849 −8.614 1.00 37.52 ATOM 2160 OH2 WAT 906 31.638 29.686 −0.266 1.00 32.48 ATOM 2161 OH2 WAT 907 −0.206 4.924 11.081 1.00 36.49 ATOM 2162 OH2 WAT 908 31.665 29.237 6.272 1.00 49.19 ATOM 2163 OH2 WAT 909 −2.417 16.800 9.041 1.00 44.02 ATOM 2164 OH2 WAT 910 10.940 39.261 6.571 1.00 43.92 ATOM 2165 OH2 WAT 911 13.036 1.866 1.304 1.00 40.13 ATOM 2166 OH2 WAT 912 14.565 2.593 15.801 1.00 47.21 ATOM 2167 OH2 WAT 913 15.968 17.289 31.561 1.00 33.25 ATOM 2168 OH2 WAT 914 34.332 36.096 17.436 1.00 48.32 ATOM 2169 OH2 WAT 915 −0.731 12.520 9.973 1.00 49.45 ATOM 2170 OH2 WAT 916 19.666 1.578 18.349 1.00 44.84 ATOM 2171 OH2 WAT 917 22.978 40.125 16.179 1.00 45.10 ATOM 2172 OH2 WAT 918 14.785 33.819 17.497 1.00 38.88 ATOM 2173 OH2 WAT 919 25.871 13.595 −7.644 1.00 45.77 ATOM 2174 OH2 WAT 920 25.570 6.591 −4.596 1.00 38.57 ATOM 2175 OH2 WAT 921 16.974 2.870 16.605 1.00 33.05 ATOM 2176 OH2 WAT 922 33.181 45.831 10.253 1.00 42.64 ATOM 2177 OH2 WAT 923 12.975 32.550 −12.651 1.00 46.09 ATOM 2178 OH2 WAT 924 26.965 45.895 0.183 1.00 55.12 ATOM 2179 OH2 WAT 925 7.626 22.836 18.961 1.00 41.09 ATOM 2180 OH2 WAT 926 23.414 34.472 23.517 1.00 34.89 ATOM 2181 OH2 WAT 927 21.725 53.855 −1.107 1.00 58.84 ATOM 2182 OH2 WAT 928 30.305 48.946 2.286 1.00 45.28 ATOM 2183 OH2 WAT 929 21.547 3.556 1.853 1.00 49.41 ATOM 2184 OH2 WAT 930 18.916 35.911 −17.290 1.00 54.56 ATOM 2185 OH2 WAT 931 7.922 23.555 24.917 1.00 41.77 ATOM 2185 OH2 WAT 932 22.938 41.070 21.176 1.00 38.69 ATOM 2187 OH2 WAT 933 34.983 42.284 −3.078 1.00 35.66 ATOM 2188 OH2 WAT 934 10.445 29.254 25.404 1.00 53.07 ATOM 2189 OH2 WAT 935 13.385 22.747 1.929 1.00 57.68 ATOM 2190 OH2 WAT 936 17.800 1.033 15.037 1.00 43.46 ATOM 2191 OH2 WAT 938 29.919 23.540 7.796 1.00 38.24 ATOM 2192 OH2 WAT 939 26.837 29.236 −6.134 1.00 34.00 ATOM 2193 OH2 WAT 940 4.282 1.689 8.958 1.00 44.18 ATOM 2194 OH2 WAT 941 16.572 41.825 −1.750 1.00 64.20 ATOM 2195 OH2 WAT 942 18.212 46.711 4.803 1.00 54.44 ATOM 2196 OH2 WAT 943 15.478 42.818 4.335 1.00 50.85 ATOM 2197 OH2 WAT 944 26.414 23.899 9.989 1.00 39.22 ATOM 2198 OH2 WAT 945 29.440 21.150 9.611 1.00 32.92 ATOM 2199 OH2 WAT 946 30.822 26.523 9.587 1.00 53.88 ATOM 2200 OH2 WAT 950 8.855 22.869 6.573 1.00 38.42 ATOM 2201 OH2 WAT 951 5.112 26.325 5.735 1.00 61.02 ATOM 2202 OH2 WAT 952 −0.889 10.066 5.523 1.00 36.76 ATOM 2203 OH2 WAT 954 34.805 28.111 7.254 1.00 38.30 ATOM 2204 OH2 WAT 955 19.872 20.234 −9.431 1.00 35.47 ATOM 2205 OH2 WAT 956 22.406 22.660 −11.886 1.00 39.93 ATOM 2206 O2 STE 1001 28.707 27.099 7.452 1.00 49.40 ATOM 2207 O1 STE 1001 27.940 25.317 8.529 1.00 50.77 ATOM 2208 C4 STE 1001 26.850 27.424 8.987 1.00 49.77 ATOM 2209 C1 STE 1001 25.793 30.578 5.434 1.00 50.35 ATOM 2210 C2 STE 1001 24.996 29.501 6.215 1.00 50.21 ATOM 2211 C6 STE 1001 25.841 28.419 6.860 1.00 50.29 ATOM 2212 C9 STE 1001 25.977 28.550 8.389 1.00 50.59 ATOM 2213 C5 STE 1001 23.387 34.488 6.590 1.00 48.06 ATOM 2214 C10 STE 1001 24.488 33.559 6.013 1.00 49.21 ATOM 2215 C13 STE 1001 25.128 32.598 7.006 1.00 49.62 ATOM 2216 C16 STE 1001 26.247 31.729 6.377 1.00 50.27 ATOM 2217 C7 STE 1001 20.503 31.145 6.873 1.00 45.75 ATOM 2218 C11 STE 1001 20.179 32.288 5.920 1.00 45.75 ATOM 2219 C14 STE 1001 21.350 33.208 5.604 1.00 46.43 ATOM 2220 C17 STE 1001 22.034 33.806 6.858 1.00 48.02 ATOM 2221 C8 STE 1001 20.032 29.801 6.378 1.00 44.03 ATOM 2222 C12 STE 1001 20.065 28.778 7.502 1.00 43.90 ATOM 2223 C15 STE 1001 21.407 28.027 7.586 1.00 42.74 ATOM 2224 C18 STE 1001 22.227 28.387 8.831 1.00 43.23 ATOM 2225 C3 STE 1001 27.878 26.507 8.311 1.00 50.33 END

[0273] TABLE B Crystallographic Coordinates of RORbeta LBD/retinoic acid/SRC1 peptide complex ATOM 1 CB THR 1 14.936 −1.893 26.570 1.00 44.08 ATOM 2 OG1 THR 1 16.329 −2.232 26.551 1.00 44.42 ATOM 3 CG2 THR 1 14.475 −1.471 25.180 1.00 44.84 ATOM 4 C THR 1 15.825 0.265 27.508 1.00 44.25 ATOM 5 O THR 1 16.183 0.740 26.428 1.00 42.75 ATOM 6 N THR 1 13.347 −0.138 27.331 1.00 43.63 ATOM 7 CA THR 1 14.685 −0.761 27.580 1.00 44.30 ATOM 8 N MET 2 16.388 0.599 28.670 1.00 44.87 ATOM 9 CA MET 2 17.474 1.576 28.770 1.00 45.02 ATOM 10 CB MET 2 17.914 1.727 30.240 1.00 48.12 ATOM 11 CG MET 2 18.864 2.913 30.535 1.00 52.67 ATOM 12 SD MET 2 18.066 4.488 31.067 1.00 58.78 ATOM 13 CE MET 2 18.185 4.360 32.887 1.00 53.72 ATOM 14 C MET 2 18.669 1.176 27.894 1.00 43.49 ATOM 15 O MET 2 19.405 2.034 27.406 1.00 42.50 ATOM 16 N SER 3 18.854 −0.126 27.690 1.00 41.13 ATOM 17 CA SER 3 19.955 −0.610 26.862 1.00 40.00 ATOM 18 CB SER 3 19.927 −2.135 26.793 1.00 40.28 ATOM 19 OG SER 3 20.891 −2.608 25.874 1.00 41.89 ATOM 20 C SER 3 19.864 −0.031 25.447 1.00 38.47 ATOM 21 O SER 3 20.860 0.429 24.883 1.00 37.74 ATOM 22 N GLU 4 18.666 −0.056 24.876 1.00 36.43 ATOM 23 CA GLU 4 18.464 0.478 23.536 1.00 34.72 ATOM 24 CB GLU 4 17.076 0.100 23.003 1.00 34.35 ATOM 25 CG GLU 4 16.711 0.808 21.697 1.00 35.50 ATOM 26 CD GLU 4 15.384 0.347 21.124 1.00 36.78 ATOM 27 OE1 GLU 4 14.551 −0.177 21.896 1.00 38.95 ATOM 28 OE2 GLU 4 15.164 0.522 19.906 1.00 36.38 ATOM 29 C GLU 4 18.624 1.995 23.536 1.00 33.23 ATOM 30 O GLU 4 19.304 2.552 22.674 1.00 33.90 ATOM 31 N ILE 5 18.010 2.661 24.511 1.00 31.72 ATOM 32 CA ILE 5 18.099 4.112 24.600 1.00 30.77 ATOM 33 CB ILE 5 17.390 4.654 25.856 1.00 31.04 ATOM 34 CG2 ILE 5 17.525 6.169 25.921 1.00 29.17 ATOM 35 CG1 ILE 5 15.907 4.272 25.828 1.00 31.73 ATOM 36 CD1 ILE 5 15.143 4.871 24.668 1.00 32.36 ATOM 37 C ILE 5 19.554 4.547 24.640 1.00 30.75 ATOM 38 O ILE 5 19.947 5.467 23.939 1.00 29.87 ATOM 39 N ASP 6 20.358 3.876 25.458 1.00 31.69 ATOM 40 CA ASP 6 21.769 4.227 25.567 1.00 31.78 ATOM 41 CB ASP 6 22.433 3.437 26.706 1.00 35.48 ATOM 42 CG ASP 6 23.900 3.807 26.898 1.00 37.43 ATOM 43 OD1 ASP 6 24.241 5.002 26.755 1.00 38.83 ATOM 44 OD2 ASP 6 24.711 2.907 27.203 1.00 39.59 ATOM 45 C ASP 6 22.524 3.999 24.256 1.00 31.34 ATOM 46 O ASP 6 23.303 4.855 23.832 1.00 30.34 ATOM 47 N ARG 7 22.298 2.860 23.605 1.00 30.65 ATOM 48 CA ARG 7 22.992 2.594 22.345 1.00 32.17 ATOM 49 CB ARG 7 22.675 1.186 21.847 1.00 34.91 ATOM 50 CG ARG 7 23.169 0.086 22.788 1.00 44.22 ATOM 51 CD ARG 7 22.770 −1.289 22.276 1.00 48.39 ATOM 52 NE ARG 7 21.346 −1.332 21.948 1.00 52.06 ATOM 53 CZ ARG 7 20.751 −2.337 21.317 1.00 52.86 ATOM 54 NH1 ARG 7 21.456 −3.397 20.942 1.00 54.84 ATOM 55 NH2 ARG 7 19.454 −2.277 21.050 1.00 54.02 ATOM 56 C ARG 7 22.620 3.631 21.280 1.00 30.15 ATOM 57 O ARG 7 23.487 4.133 20.566 1.00 29.79 ATOM 58 N ILE 8 21.332 3.954 21.185 1.00 28.75 ATOM 59 CA ILE 8 20.865 4.944 20.220 1.00 27.58 ATOM 60 CB ILE 8 19.330 5.161 20.324 1.00 26.92 ATOM 61 CG2 ILE 8 18.917 6.408 19.534 1.00 24.05 ATOM 62 CG1 ILE 8 18.589 3.924 19.803 1.00 28.50 ATOM 63 CD1 ILE 8 17.065 4.003 19.947 1.00 25.10 ATOM 64 C ILE 8 21.571 6.271 20.494 1.00 28.49 ATOM 65 O ILE 8 22.081 6.908 19.579 1.00 27.22 ATOM 66 N ALA 9 21.600 6.677 21.760 1.00 28.38 ATOM 67 CA ALA 9 22.241 7.929 22.147 1.00 28.28 ATOM 68 CB ALA 9 22.086 8.150 23.648 1.00 26.41 ATOM 69 C ALA 9 23.721 7.956 21.759 1.00 29.29 ATOM 70 O ALA 9 24.176 8.890 21.099 1.00 27.81 ATOM 71 N GLN 10 24.474 6.935 22.167 1.00 30.09 ATOM 72 CA GLN 10 25.897 6.878 21.844 1.00 30.31 ATOM 73 CB GLN 10 26.515 5.581 22.369 1.00 34.96 ATOM 74 CG GLN 10 26.435 5.403 23.873 1.00 41.16 ATOM 75 CD GLN 10 27.020 4.076 24.329 1.00 47.78 ATOM 76 OE1 GLN 10 28.217 3.809 24.162 1.00 48.59 ATOM 77 NE2 GLN 10 26.171 3.229 24.905 1.00 51.11 ATOM 78 C GLN 10 26.141 6.967 20.338 1.00 28.54 ATOM 79 O GLN 10 27.031 7.684 19.887 1.00 29.98 ATOM 80 N ASN 11 25.350 6.228 19.568 1.00 26.39 ATOM 81 CA ASN 11 25.486 6.216 18.115 1.00 25.48 ATOM 82 CB ASN 11 24.439 5.266 17.524 1.00 25.98 ATOM 83 CG ASN 11 24.439 5.251 16.014 1.00 24.40 ATOM 84 OD1 ASN 11 23.422 5.527 15.394 1.00 26.44 ATOM 85 ND2 ASN 11 25.578 4.920 15.413 1.00 24.88 ATOM 86 C ASN 11 25.329 7.627 17.533 1.00 25.80 ATOM 87 O ASN 11 26.106 8.047 16.674 1.00 25.13 ATOM 88 N ILE 12 24.326 8.360 18.008 1.00 25.44 ATOM 89 CA ILE 12 24.092 9.719 17.524 1.00 24.85 ATOM 90 CB ILE 12 22.743 10.255 18.031 1.00 23.12 ATOM 91 CG2 ILE 12 22.617 11.739 17.719 1.00 22.76 ATOM 92 CG1 ILE 12 21.613 9.462 17.363 1.00 23.39 ATOM 93 CD1 ILE 12 20.253 9.769 17.882 1.00 20.56 ATOM 94 C ILE 12 25.214 10.664 17.949 1.00 25.34 ATOM 95 O ILE 12 25.683 11.474 17.158 1.00 25.18 ATOM 96 N ILE 13 25.648 10.556 19.198 1.00 25.76 ATOM 97 CA ILE 13 26.728 11.403 19.686 1.00 26.18 ATOM 98 CB ILE 13 26.993 11.137 21.184 1.00 26.42 ATOM 99 CG2 ILE 13 28.317 11.759 21.605 1.00 27.88 ATOM 100 CG1 ILE 13 25.822 11.683 22.015 1.00 24.88 ATOM 101 CD1 ILE 13 25.887 11.341 23.510 1.00 24.90 ATOM 102 C ILE 13 27.987 11.122 18.855 1.00 26.22 ATOM 103 O ILE 13 28.680 12.045 18.423 1.00 25.36 ATOM 104 N LYS 14 28.266 9.847 18.616 1.00 27.79 ATOM 105 CA LYS 14 29.425 9.453 17.819 1.00 28.58 ATOM 106 CB LYS 14 29.504 7.927 17.734 1.00 31.83 ATOM 107 CG LYS 14 30.610 7.389 16.827 1.00 36.77 ATOM 108 CD LYS 14 30.454 5.879 16.615 1.00 41.46 ATOM 109 CE LYS 14 31.523 5.320 15.681 1.00 42.19 ATOM 110 NZ LYS 14 32.877 5.449 16.278 1.00 44.14 ATOM 111 C LYS 14 29.311 10.039 16.412 1.00 28.52 ATOM 112 O LYS 14 30.268 10.609 15.883 1.00 29.83 ATOM 113 N SER 15 28.136 9.905 15.806 1.00 26.79 ATOM 114 CA SER 15 27.929 10.429 14.459 1.00 26.88 ATOM 115 CB SER 15 26.500 10.132 13.994 1.00 27.05 ATOM 116 OG SER 15 26.280 10.611 12.676 1.00 30.56 ATOM 117 C SER 15 28.193 11.932 14.414 1.00 26.19 ATOM 118 O SER 15 28.895 12.427 13.529 1.00 25.81 ATOM 119 N HIS 16 27.627 12.657 15.373 1.00 25.25 ATOM 120 CA HIS 16 27.807 14.104 15.448 1.00 25.35 ATOM 121 CB HIS 16 27.098 14.652 16.688 1.00 23.98 ATOM 122 CG HIS 16 27.485 16.055 17.035 1.00 22.83 ATOM 123 CD2 HIS 16 28.473 16.533 17.830 1.00 22.89 ATOM 124 ND1 HIS 16 26.831 17.159 16.530 1.00 21.54 ATOM 125 CE1 HIS 16 27.398 18.256 16.999 1.00 23.79 ATOM 126 NE2 HIS 16 28.398 17.904 17.789 1.00 24.95 ATOM 127 C HIS 16 29.296 14.438 15.532 1.00 27.00 ATOM 128 O HIS 16 29.794 15.325 14.832 1.00 25.20 ATOM 129 N LEU 17 29.998 13.723 16.406 1.00 27.86 ATOM 130 CA LEU 17 31.423 13.940 16.591 1.00 28.80 ATOM 131 CB LEU 17 31.996 12.917 17.578 1.00 30.56 ATOM 132 CG LEU 17 33.501 13.008 17.863 1.00 33.43 ATOM 133 CD1 LEU 17 33.784 14.232 18.725 1.00 35.11 ATOM 134 CD2 LEU 17 33.968 11.757 18.578 1.00 35.02 ATOM 135 C LEU 17 32.153 13.809 15.269 1.00 28.50 ATOM 136 O LEU 17 33.060 14.588 14.973 1.00 29.06 ATOM 137 N GLU 18 31.758 12.833 14.466 1.00 27.38 ATOM 138 CA GLU 18 32.430 12.584 13.197 1.00 29.19 ATOM 139 CB GLU 18 32.419 11.080 12.897 1.00 30.86 ATOM 140 CG GLU 18 32.740 10.192 14.093 1.00 35.14 ATOM 141 CD GLU 18 32.508 8.718 13.807 1.00 38.27 ATOM 142 OE1 GLU 18 31.604 8.399 12.997 1.00 40.84 ATOM 143 OE2 GLU 18 33.215 7.877 14.407 1.00 38.21 ATOM 144 C GLU 18 31.884 13.311 11.977 1.00 28.77 ATOM 145 O GLU 18 32.495 13.242 10.909 1.00 29.35 ATOM 146 N THR 19 30.767 14.023 12.109 1.00 26.26 ATOM 147 CA THR 19 30.194 14.656 10.926 1.00 25.75 ATOM 148 CB THR 19 28.916 13.921 10.510 1.00 24.77 ATOM 149 OG1 THR 19 27.906 14.120 11.508 1.00 22.37 ATOM 150 CG2 THR 19 29.194 12.428 10.366 1.00 24.32 ATOM 151 C THR 19 29.888 16.148 10.903 1.00 26.21 ATOM 152 O THR 19 29.143 16.606 10.040 1.00 26.97 ATOM 153 N CYS 20 30.425 16.916 11.839 1.00 28.90 ATOM 154 CA CYS 20 30.190 18.351 11.789 1.00 31.93 ATOM 155 CB CYS 20 30.306 18.979 13.175 1.00 29.90 ATOM 156 SG CYS 20 28.844 18.742 14.175 1.00 30.72 ATOM 157 C CYS 20 31.258 18.930 10.876 1.00 33.01 ATOM 158 O CYS 20 32.368 18.412 10.824 1.00 33.41 ATOM 159 N GLN 21 30.927 19.986 10.143 1.00 34.90 ATOM 160 CA GLN 21 31.911 20.595 9.261 1.00 36.25 ATOM 161 CB GLN 21 31.314 21.782 8.509 1.00 37.23 ATOM 162 CG GLN 21 32.359 22.563 7.731 1.00 39.86 ATOM 163 CD GLN 21 31.797 23.770 7.024 1.00 39.83 ATOM 164 OE1 GLN 21 32.545 24.580 6.476 1.00 43.69 ATOM 165 NE2 GLN 21 30.478 23.900 7.025 1.00 41.69 ATOM 166 C GLN 21 33.090 21.077 10.099 1.00 36.79 ATOM 167 O GLN 21 34.229 21.077 9.636 1.00 36.87 ATOM 168 N TYR 22 32.799 21.489 11.331 1.00 35.98 ATOM 169 CA TYR 22 33.818 21.974 12.262 1.00 37.06 ATOM 170 CB TYR 22 33.608 23.460 12.559 1.00 37.63 ATOM 171 CG TYR 22 34.105 24.384 11.480 1.00 37.76 ATOM 172 CD1 TYR 22 35.467 24.505 11.219 1.00 39.21 ATOM 173 CE1 TYR 22 35.933 25.362 10.231 1.00 41.19 ATOM 174 CD2 TYR 22 33.217 25.142 10.724 1.00 38.25 ATOM 175 CE2 TYR 22 33.671 26.001 9.733 1.00 40.65 ATOM 176 CZ TYR 22 35.029 26.105 9.492 1.00 40.42 ATOM 177 OH TYR 22 35.483 26.946 8.509 1.00 43.37 ATOM 178 C TYR 22 33.786 21.214 13.580 1.00 35.92 ATOM 179 O TYR 22 32.767 21.199 14.268 1.00 35.59 ATOM 180 N THR 23 34.900 20.587 13.935 1.00 36.10 ATOM 181 CA THR 23 34.968 19.861 15.193 1.00 36.94 ATOM 182 CB THR 23 36.179 18.921 15.242 1.00 39.58 ATOM 183 OG1 THR 23 37.380 19.700 15.216 1.00 39.59 ATOM 184 CG2 THR 23 36.169 17.969 14.056 1.00 40.40 ATOM 185 C THR 23 35.128 20.892 16.302 1.00 36.49 ATOM 186 O THR 23 35.459 22.052 16.041 1.00 32.29 ATOM 187 N MET 24 34.895 20.471 17.539 1.00 37.33 ATOM 188 CA MET 24 35.029 21.371 18.674 1.00 38.75 ATOM 189 CB MET 24 34.654 20.648 19.966 1.00 39.75 ATOM 190 CG MET 24 33.161 20.570 20.204 1.00 42.25 ATOM 191 SD MET 24 32.471 22.130 20.821 1.00 43.80 ATOM 192 CE MET 24 32.356 23.099 19.341 1.00 43.48 ATOM 193 C MET 24 36.454 21.889 18.765 1.00 39.58 ATOM 194 O MET 24 36.688 23.054 19.083 1.00 39.75 ATOM 195 N GLU 25 37.409 21.017 18.469 1.00 41.04 ATOM 196 CA GLU 25 38.808 21.397 18.529 1.00 41.50 ATOM 197 CB GLU 25 39.685 20.172 18.242 1.00 45.13 ATOM 198 CG GLU 25 39.356 18.989 19.165 1.00 50.86 ATOM 199 CD GLU 25 40.586 18.370 19.829 1.00 55.72 ATOM 200 OE1 GLU 25 41.444 19.126 20.344 1.00 56.58 ATOM 201 OE2 GLU 25 40.686 17.122 19.851 1.00 57.47 ATOM 202 C GLU 25 39.103 22.536 17.553 1.00 40.38 ATOM 203 O GLU 25 39.708 23.538 17.928 1.00 37.53 ATOM 204 N GLU 26 38.655 22.390 16.310 1.00 38.80 ATOM 205 CA GLU 26 38.885 23.415 15.298 1.00 38.72 ATOM 206 CB GLU 26 38.353 22.948 13.943 1.00 40.80 ATOM 207 CG GLU 26 38.837 21.562 13.555 1.00 45.17 ATOM 208 CD GLU 26 38.289 21.099 12.225 1.00 47.49 ATOM 209 OE1 GLU 26 37.059 21.191 12.023 1.00 50.42 ATOM 210 OE2 GLU 26 39.087 20.633 11.384 1.00 50.96 ATOM 211 C GLU 26 38.205 24.716 15.701 1.00 37.74 ATOM 212 O GLU 26 38.745 25.799 15.478 1.00 35.99 ATOM 213 N LEU 27 37.020 24.604 16.298 1.00 37.47 ATOM 214 CA LEU 27 36.278 25.776 16.744 1.00 37.81 ATOM 215 CB LEU 27 34.894 25.369 17.272 1.00 36.85 ATOM 216 CG LEU 27 33.650 25.542 16.379 1.00 36.21 ATOM 217 CD1 LEU 27 34.023 26.084 15.013 1.00 34.78 ATOM 219 CD2 LEU 27 32.927 24.214 16.248 1.00 34.77 ATOM 219 C LEU 27 37.051 26.512 17.833 1.00 39.23 ATOM 220 O LEU 27 37.145 27.738 17.820 1.00 37.29 ATOM 221 N HIS 28 37.610 25.762 18.776 1.00 42.29 ATOM 222 CA HIS 28 38.369 26.378 19.852 1.00 45.83 ATOM 223 CB HIS 28 38.867 25.311 20.834 1.00 49.02 ATOM 224 CG HIS 28 37.786 24.745 21.707 1.00 53.69 ATOM 225 CD2 HIS 28 36.461 25.024 21.782 1.00 54.33 ATOM 226 ND1 HIS 28 38.025 23.775 22.660 1.00 54.53 ATOM 227 CE1 HIS 28 36.896 23.484 23.283 1.00 53.92 ATOM 228 NE2 HIS 28 35.932 24.228 22.770 1.00 54.66 ATOM 229 C HIS 28 39.533 27.202 19.306 1.00 46.70 ATOM 230 O HIS 28 39.809 28.292 19.806 1.00 46.07 ATOM 231 N GLN 29 40.206 26.695 18.277 1.00 47.88 ATOM 232 CA GLN 29 41.321 27.432 17.686 1.00 49.79 ATOM 233 CB GLN 29 42.205 26.504 16.841 1.00 51.23 ATOM 234 CG GLN 29 43.142 25.629 17.673 1.00 55.35 ATOM 235 CD GLN 29 42.632 24.210 17.843 1.00 57.34 ATOM 236 OE1 GLN 29 42.896 23.556 18.856 1.00 58.45 ATOM 237 NE2 GLN 29 41.913 23.717 16.839 1.00 58.43 ATOM 238 C GLN 29 40.842 28.609 16.835 1.00 49.61 ATOM 239 O GLN 29 41.532 29.621 16.725 1.00 50.02 ATOM 240 N LEU 30 39.659 28.472 16.245 1.00 49.60 ATOM 241 CA LEU 30 39.081 29.519 15.404 1.00 51.37 ATOM 242 CB LEU 30 38.164 26.908 14.346 1.00 51.30 ATOM 243 CG LEU 30 38.817 28.187 13.172 1.00 52.22 ATOM 244 CD1 LEU 30 37.770 27.391 12.407 1.00 51.55 ATOM 245 CD2 LEU 30 39.491 29.212 12.275 1.00 52.87 ATOM 246 C LEU 30 38.266 30.493 16.233 1.00 52.89 ATOM 247 O LEU 30 37.645 31.409 15.694 1.00 53.39 ATOM 248 N ALA 31 38.271 30.283 17.544 1.00 54.40 ATOM 249 CA ALA 31 37.509 31.107 18.474 1.00 54.90 ATOM 250 CB ALA 31 37.875 30.728 19.902 1.00 55.70 ATOM 251 C ALA 31 37.674 32.608 18.284 1.00 54.89 ATOM 252 O ALA 31 36.695 33.339 18.109 1.00 52.72 ATOM 253 N TRP 32 38.925 33.055 18.324 1.00 56.51 ATOM 254 CA TRP 32 39.254 34.468 18.197 1.00 57.22 ATOM 255 CB TRP 32 40.362 34.816 19.192 1.00 59.36 ATOM 256 CG TRP 32 39.979 34.430 20.581 1.00 62.16 ATOM 257 CD2 TRP 32 39.717 35.315 21.678 1.00 63.50 ATOM 258 CE2 TRP 32 39.268 34.519 22.757 1.00 64.21 ATOM 259 CE3 TRP 32 39.814 36.702 21.855 1.00 63.45 ATOM 260 CD1 TRP 32 39.697 33.168 21.031 1.00 62.50 ATOM 261 NE1 TRP 32 39.265 33.215 22.335 1.00 63.94 ATOM 262 CZ2 TRP 32 38.913 35.068 23.995 1.00 63.81 ATOM 263 CZ3 TRP 32 39.461 37.244 23.087 1.00 62.65 ATOM 264 CH2 TRP 32 39.016 36.426 24.137 1.00 62.53 ATOM 265 C TRP 32 39.667 34.850 16.787 1.00 57.28 ATOM 266 O TRP 32 40.826 35.187 16.526 1.00 58.45 ATOM 267 N GLN 33 38.701 34.802 15.879 1.00 54.65 ATOM 268 CA GLN 33 38.954 35.145 14.494 1.00 52.60 ATOM 269 CB GLN 33 39.326 33.892 13.697 1.00 54.99 ATOM 270 CG GLN 33 40.753 33.411 13.884 1.00 59.00 ATOM 271 CD GLN 33 41.772 34.297 13.184 1.00 61.62 ATOM 272 OE1 GLN 33 42.960 33.978 13.148 1.00 63.64 ATOM 273 NE2 GLN 33 41.312 35.415 12.624 1.00 63.55 ATOM 274 C GLN 33 37.737 35.801 13.863 1.00 49.63 ATOM 275 O GLN 33 36.785 35.124 13.489 1.00 47.22 ATOM 276 N THR 34 37.763 37.125 13.771 1.00 47.47 ATOM 277 CA THR 34 36.678 37.863 13.139 1.00 45.87 ATOM 278 CB THR 34 36.159 39.019 14.033 1.00 46.83 ATOM 279 OG1 THR 34 37.237 39.911 14.346 1.00 46.09 ATOM 280 CG2 THR 34 35.556 38.475 15.321 1.00 47.41 ATOM 281 C THR 34 37.260 38.446 11.856 1.00 44.40 ATOM 282 O THR 34 38.469 38.731 11.797 1.00 44.57 ATOM 283 N HIS 35 36.451 38.605 10.822 1.00 41.42 ATOM 284 CA HIS 35 36.964 39.168 9.581 1.00 37.99 ATOM 285 CB HIS 35 35.894 39.157 8.487 1.00 34.94 ATOM 286 CG HIS 35 35.570 37.792 7.967 1.00 32.18 ATOM 287 CD2 HIS 35 36.167 37.037 7.015 1.00 30.88 ATOM 288 ND1 HIS 35 34.510 37.047 8.438 1.00 31.87 ATOM 289 CE1 HIS 35 34.467 35.893 7.797 1.00 30.43 ATOM 290 NE2 HIS 35 35.463 35.862 6.929 1.00 32.44 ATOM 291 C HIS 35 37.414 40.601 9.844 1.00 36.88 ATOM 292 O HIS 35 36.856 41.287 10.697 1.00 35.24 ATOM 293 N THR 36 38.439 41.042 9.124 1.00 38.20 ATOM 294 CA THR 36 38.949 42.402 9.276 1.00 39.26 ATOM 295 CB THR 36 40.319 42.550 8.597 1.00 39.89 ATOM 296 OG1 THR 36 40.181 42.304 7.192 1.00 40.21 ATOM 297 CG2 THR 36 41.312 41.548 9.178 1.00 40.05 ATOM 298 C THR 36 37.959 43.346 8.599 1.00 39.52 ATOM 299 O THR 36 37.070 42.894 7.873 1.00 38.71 ATOM 300 N TYR 37 38.101 44.648 8.824 1.00 40.48 ATOM 301 CA TYR 37 37.186 45.595 8.197 1.00 41.59 ATOM 302 CB TYR 37 37.474 47.026 8.653 1.00 44.12 ATOM 303 CG TYR 37 37.124 47.289 10.099 1.00 46.75 ATOM 304 CD1 TYR 37 38.080 47.149 11.110 1.00 48.09 ATOM 305 CE1 TYR 37 37.754 47.392 12.453 1.00 49.23 ATOM 306 CD2 TYR 37 35.831 47.675 10.460 1.00 47.60 ATOM 307 CE2 TYR 37 35.493 47.916 11.795 1.00 49.16 ATOM 308 CZ TYR 37 36.456 47.775 12.786 1.00 49.69 ATOM 309 OH TYR 37 36.120 48.027 14.100 1.00 48.49 ATOM 310 C TYR 37 37.269 45.515 6.678 1.00 41.21 ATOM 311 O TYR 37 36.265 45.673 5.988 1.00 39.83 ATOM 312 N GLU 38 38.469 45.270 6.158 1.00 40.73 ATOM 313 CA GLU 38 38.652 45.161 4.715 1.00 41.99 ATOM 314 CB GLU 38 40.136 45.020 4.358 1.00 43.80 ATOM 315 CG GLU 38 40.985 46.242 4.668 1.00 46.95 ATOM 316 CD GLU 38 41.266 46.412 6.154 1.00 48.29 ATOM 317 OE1 GLU 38 41.815 47.470 6.528 1.00 50.72 ATOM 318 OE2 GLU 38 40.948 45.493 6.943 1.00 48.78 ATOM 319 C GLU 38 37.896 43.949 4.185 1.00 41.21 ATOM 320 O GLU 38 37.284 44.000 3.122 1.00 39.46 ATOM 321 N GLU 39 37.946 42.854 4.935 1.00 41.37 ATOM 322 CA GLU 39 37.265 41.632 4.527 1.00 41.22 ATOM 323 CB GLU 39 37.693 40.473 5.429 1.00 42.06 ATOM 324 CG GLU 39 39.208 40.289 5.453 1.00 46.35 ATOM 325 CD GLU 39 39.668 39.164 6.363 1.00 48.63 ATOM 326 OE1 GLU 39 39.234 39.126 7.534 1.00 48.96 ATOM 327 OE2 GLU 39 40.476 38.324 5.909 1.00 50.59 ATOM 328 C GLU 39 35.756 41.844 4.581 1.00 39.62 ATOM 329 O GLU 39 35.023 41.339 3.728 1.00 40.20 ATOM 330 N ILE 40 35.296 42.601 5.575 1.00 37.13 ATOM 331 CA ILE 40 33.873 42.885 5.706 1.00 36.49 ATOM 332 CB ILE 40 33.541 43.587 7.058 1.00 35.15 ATOM 333 CG2 ILE 40 32.105 44.100 7.054 1.00 34.00 ATOM 334 CG1 ILE 40 33.715 42.603 8.219 1.00 34.57 ATOM 335 CD1 ILE 40 32.853 41.351 8.102 1.00 32.97 ATOM 336 C ILE 40 33.445 43.784 4.557 1.00 36.47 ATOM 337 O ILE 40 32.386 43.582 3.966 1.00 35.95 ATOM 338 N LYS 41 34.277 44.772 4.233 1.00 37.54 ATOM 339 CA LYS 41 33.955 45.688 3.141 1.00 38.47 ATOM 340 CB LYS 41 35.023 46.774 3.002 1.00 41.50 ATOM 341 CG LYS 41 34.532 48.021 2.277 1.00 45.40 ATOM 342 CD LYS 41 33.917 49.022 3.257 1.00 49.51 ATOM 343 CE LYS 41 32.816 48.394 4.110 1.00 50.14 ATOM 344 NZ LYS 41 32.365 49.280 5.217 1.00 51.19 ATOM 345 C LYS 41 33.876 44.899 1.846 1.00 36.39 ATOM 346 O LYS 41 32.987 45.121 1.023 1.00 34.38 ATOM 347 N ALA 42 34.813 43.972 1.679 1.00 35.77 ATOM 348 CA ALA 42 34.855 43.134 0.492 1.00 36.18 ATOM 349 CB ALA 42 35.999 42.132 0.599 1.00 37.07 ATOM 350 C ALA 42 33.523 42.409 0.345 1.00 35.76 ATOM 351 O ALA 42 32.958 42.355 −0.749 1.00 35.23 ATOM 352 N TYR 43 33.015 41.868 1.451 1.00 34.54 ATOM 353 CA TYR 43 31.740 41.155 1.423 1.00 33.59 ATOM 354 CB TYR 43 31.423 40.539 2.794 1.00 33.00 ATOM 355 CG TYR 43 32.175 39.263 3.093 1.00 31.41 ATOM 356 CD1 TYR 43 32.035 38.138 2.275 1.00 31.79 ATOM 357 CE1 TYR 43 32.734 36.959 2.543 1.00 32.00 ATOM 358 CD2 TYR 43 33.031 39.179 4.190 1.00 32.57 ATOM 359 CE2 TYR 43 33.735 38.006 4.468 1.00 32.13 ATOM 360 CZ TYR 43 33.583 36.902 3.643 1.00 32.91 ATOM 361 OH TYR 43 34.287 35.750 3.922 1.00 32.24 ATOM 362 C TYR 43 30.589 42.061 1.017 1.00 33.94 ATOM 363 O TYR 43 29.697 41.647 0.277 1.00 33.69 ATOM 364 N GLN 44 30.605 43.295 1.510 1.00 34.41 ATOM 365 CA GLN 44 29.540 44.244 1.206 1.00 35.55 ATOM 366 CB GLN 44 29.571 45.405 2.210 1.00 36.41 ATOM 367 CG GLN 44 29.489 44.944 3.665 1.00 38.05 ATOM 368 CD GLN 44 29.509 46.090 4.667 1.00 39.51 ATOM 369 OE1 GLN 44 30.353 46.984 4.592 1.00 40.40 ATOM 370 NE2 GLN 44 28.586 46.056 5.621 1.00 38.09 ATOM 371 C GLN 44 29.635 44.774 −0.220 1.00 35.22 ATOM 372 O GLN 44 28.657 45.279 −0.769 1.00 35.57 ATOM 373 N SER 45 30.813 44.645 −0.821 1.00 36.36 ATOM 374 CA SER 45 31.029 45.115 −2.186 1.00 37.51 ATOM 375 CB SER 45 32.490 45.520 −2.385 1.00 36.45 ATOM 376 OG SER 45 32.830 46.585 −1.519 1.00 37.77 ATOM 377 C SER 45 30.649 44.065 −3.224 1.00 37.52 ATOM 378 O SER 45 30.433 44.390 −4.394 1.00 37.81 ATOM 379 N LYS 46 30.581 42.805 −2.804 1.00 37.01 ATOM 380 CA LYS 46 30.207 41.729 −3.718 1.00 37.49 ATOM 381 CB LYS 46 30.185 40.385 −2.978 1.00 38.89 ATOM 382 CG LYS 46 31.554 39.830 −2.619 1.00 41.39 ATOM 383 CD LYS 46 32.285 39.347 −3.859 1.00 43.62 ATOM 384 CE LYS 46 33.618 38.716 −3.501 1.00 45.39 ATOM 385 NZ LYS 46 33.460 37.587 −2.542 1.00 46.78 ATOM 386 C LYS 46 28.811 42.027 −4.261 1.00 36.47 ATOM 387 O LYS 46 28.024 42.714 −3.616 1.00 34.79 ATOM 388 N SER 47 28.505 41.526 −5.450 1.00 35.94 ATOM 389 CA SER 47 27.181 41.741 −6.011 1.00 36.64 ATOM 390 CB SER 47 27.149 41.341 −7.486 1.00 36.69 ATOM 391 OG SER 47 27.443 39.964 −7.636 1.00 35.57 ATOM 392 C SER 47 26.232 40.843 −5.225 1.00 37.24 ATOM 393 O SER 47 26.672 39.994 −4.452 1.00 36.62 ATOM 394 N ARG 48 24.934 41.026 −5.419 1.00 37.93 ATOM 395 CA ARG 48 23.957 40.202 −4.726 1.00 37.32 ATOM 396 CB ARG 48 22.551 40.762 −4.966 1.00 38.56 ATOM 397 CG ARG 48 21.427 39.977 −4.315 1.00 38.73 ATOM 398 CD ARG 48 20.311 40.908 −3.869 1.00 39.69 ATOM 399 NE ARG 48 19.091 40.181 −3.530 1.00 41.75 ATOM 400 CZ ARG 48 18.294 39.611 −4.429 1.00 43.27 ATOM 401 NH1 ARG 48 18.588 39.688 −5.721 1.00 43.91 ATOM 402 NH2 ARG 48 17.203 38.965 −4.041 1.00 41.76 ATOM 403 C ARG 48 24.073 38.754 −5.220 1.00 36.87 ATOM 404 O ARG 48 23.928 37.806 −4.441 1.00 35.81 ATOM 405 N GLU 49 24.352 38.592 −6.511 1.00 34.76 ATOM 406 CA GLU 49 24.501 37.268 −7.113 1.00 35.71 ATOM 407 CB GLU 49 24.643 37.371 −8.636 1.00 38.45 ATOM 408 CG GLU 49 23.676 38.328 −9.302 1.00 44.94 ATOM 409 CD GLU 49 24.015 39.782 −9.028 1.00 47.01 ATOM 410 OE1 GLU 49 25.099 40.231 −9.460 1.00 49.86 ATOM 411 OE2 GLU 49 23.201 40.476 −8.380 1.00 46.92 ATOM 412 C GLU 49 25.751 36.591 −6.568 1.00 33.86 ATOM 413 O GLU 49 25.731 35.414 −6.213 1.00 33.86 ATOM 414 N ALA 50 26.843 37.344 −6.511 1.00 32.28 ATOM 415 CA ALA 50 28.098 36.804 −6.021 1.00 31.98 ATOM 416 CB ALA 50 29.206 37.849 −6.139 1.00 30.17 ATOM 417 C ALA 50 27.975 36.322 −4.579 1.00 31.48 ATOM 418 O ALA 50 28.373 35.201 −4.263 1.00 29.44 ATOM 419 N LEU 51 27.422 37.159 −3.703 1.00 30.98 ATOM 420 CA LEU 51 27.289 36.762 −2.305 1.00 30.66 ATOM 421 CB LEU 51 26.830 37.940 −1.441 1.00 30.32 ATOM 422 CG LEU 51 26.893 37.675 0.070 1.00 32.08 ATOM 423 CD1 LEU 51 28.267 37.144 0.444 1.00 32.44 ATOM 424 CD2 LEU 51 26.594 38.952 0.842 1.00 32.02 ATOM 425 C LEU 51 26.332 35.582 −2.156 1.00 29.32 ATOM 426 O LEU 51 26.601 34.652 −1.393 1.00 28.16 ATOM 427 N TRP 52 25.220 35.614 −2.886 1.00 28.73 ATOM 428 CA TRP 52 24.261 34.520 −2.835 1.00 28.59 ATOM 429 CB TRP 52 23.076 34.781 −3.770 1.00 30.93 ATOM 430 CG TRP 52 21.878 35.296 −3.050 1.00 35.78 ATOM 431 CD2 TRP 52 20.905 34.513 −2.351 1.00 39.02 ATOM 432 CE2 TRP 52 19.990 35.413 −1.759 1.00 39.44 ATOM 433 CE3 TRP 52 20.720 33.135 −2.161 1.00 40.28 ATOM 434 CD1 TRP 52 21.524 36.602 −2.865 1.00 35.55 ATOM 435 NE1 TRP 52 20.391 36.681 −2.089 1.00 38.68 ATOM 436 CZ2 TRP 52 18.905 34.980 −0.991 1.00 42.34 ATOM 437 CZ3 TRP 52 19.644 32.705 −1.398 1.00 41.70 ATOM 438 CH2 TRP 52 18.749 33.626 −0.821 1.00 42.77 ATOM 439 C TRP 52 24.929 33.213 −3.231 1.00 27.04 ATOM 440 O TRP 52 24.704 32.182 −2.609 1.00 26.75 ATOM 441 N GLN 53 25.742 33.259 −4.279 1.00 26.75 ATOM 442 CA GLN 53 26.446 32.071 −4.740 1.00 27.50 ATOM 443 CB GLN 53 27.209 32.391 −6.031 1.00 31.81 ATOM 444 CG GLN 53 27.894 31.198 −6.678 1.00 36.92 ATOM 445 CD GLN 53 28.277 31.456 −8.137 1.00 42.85 ATOM 446 OE1 GLN 53 28.893 30.609 −8.786 1.00 43.92 ATOM 447 NE2 GLN 53 27.904 32.628 −8.657 1.00 42.90 ATOM 448 C GLN 53 27.403 31.558 −3.655 1.00 26.49 ATOM 449 O GLN 53 27.530 30.354 −3.449 1.00 24.81 ATOM 450 N GLN 54 28.071 32.473 −2.960 1.00 25.88 ATOM 451 CA GLN 54 28.992 32.094 −1.890 1.00 27.32 ATOM 452 CB GLN 54 29.727 33.323 −1.343 1.00 31.35 ATOM 453 CG GLN 54 30.846 33.861 −2.229 1.00 37.27 ATOM 454 CD GLN 54 31.493 35.112 −1.645 1.00 41.33 ATOM 455 OE1 GLN 54 31.105 36.239 −1.969 1.00 44.63 ATOM 456 NE2 GLN 54 32.474 34.916 −0.766 1.00 40.57 ATOM 457 C GLN 54 28.210 31.445 −0.754 1.00 26.99 ATOM 458 O GLN 54 28.621 30.423 −0.201 1.00 25.42 ATOM 459 N CYS 55 27.084 32.060 −0.402 1.00 26.01 ATOM 460 CA CYS 55 26.236 31.550 0.663 1.00 25.09 ATOM 461 CB CYS 55 25.097 32.536 0.935 1.00 26.44 ATOM 462 SG CYS 55 25.637 34.013 1.827 1.00 26.26 ATOM 463 C CYS 55 25.673 30.175 0.304 1.00 24.90 ATOM 464 O CYS 55 25.603 29.284 1.151 1.00 23.90 ATOM 465 N ALA 56 25.287 30.011 −0.958 1.00 22.85 ATOM 466 CA ALA 56 24.733 28.752 −1.438 1.00 22.57 ATOM 467 CB ALA 56 24.310 28.903 −2.878 1.00 18.31 ATOM 468 C ALA 56 25.765 27.625 −1.305 1.00 23.49 ATOM 469 O ALA 56 25.425 26.499 −0.967 1.00 24.70 ATOM 470 N ILE 57 27.027 27.937 −1.575 1.00 24.87 ATOM 471 CA ILE 57 28.094 26.945 −1.471 1.00 26.21 ATOM 472 CB ILE 57 29.390 27.479 −2.104 1.00 27.82 ATOM 473 CG2 ILE 57 30.597 26.671 −1.616 1.00 29.94 ATOM 474 CG1 ILE 57 29.260 27.432 −3.630 1.00 28.92 ATOM 475 CD1 ILE 57 30.484 27.913 −4.374 1.00 31.67 ATOM 476 C ILE 57 28.348 26.554 −0.012 1.00 27.09 ATOM 477 O ILE 57 28.465 25.370 0.306 1.00 27.29 ATOM 478 N GLN 58 28.416 27.547 0.872 1.00 26.96 ATOM 479 CA GLN 58 28.637 27.289 2.291 1.00 28.94 ATOM 480 CB GLN 58 28.761 28.613 3.056 1.00 31.47 ATOM 481 CG GLN 58 28.855 28.471 4.571 1.00 37.58 ATOM 482 CD GLN 58 29.890 27.439 5.012 1.00 43.52 ATOM 483 OE1 GLN 58 31.043 27.458 4.557 1.00 45.14 ATOM 484 NE2 GLN 58 29.482 26.536 5.907 1.00 40.77 ATOM 485 C GLN 58 27.495 26.449 2.866 1.00 25.89 ATOM 486 O GLN 58 27.725 25.506 3.619 1.00 25.53 ATOM 487 N ILE 59 26.264 26.794 2.511 1.00 24.98 ATOM 488 CA ILE 59 25.104 26.049 2.985 1.00 22.92 ATOM 489 CB ILE 59 23.787 26.717 2.531 1.00 23.63 ATOM 490 CG2 ILE 59 22.617 25.752 2.715 1.00 21.17 ATOM 491 CG1 ILE 59 23.570 28.021 3.307 1.00 22.62 ATOM 492 CD1 ILE 59 22.311 28.781 2.879 1.00 23.75 ATOM 493 C ILE 59 25.133 24.618 2.448 1.00 23.06 ATOM 494 O ILE 59 24.867 23.668 3.181 1.00 21.94 ATOM 495 N THR 60 25.445 24.470 1.163 1.00 23.15 ATOM 496 CA THR 60 25.510 23.149 0.552 1.00 23.53 ATOM 497 CB THR 60 25.837 23.243 −0.956 1.00 22.65 ATOM 498 OG1 THR 60 24.787 23.946 −1.631 1.00 24.06 ATOM 499 CG2 THR 60 25.986 21.854 −1.562 1.00 22.93 ATOM 500 C THR 60 26.596 22.333 1.244 1.00 22.48 ATOM 501 O THR 60 26.423 21.148 1.514 1.00 24.18 ATOM 502 N HIS 61 27.715 22.984 1.537 1.00 23.04 ATOM 503 CA HIS 61 28.837 22.324 2.194 1.00 22.43 ATOM 504 CB HIS 61 29.958 23.346 2.401 1.00 23.21 ATOM 505 CG HIS 61 31.257 22.753 2.846 1.00 26.52 ATOM 506 CD2 HIS 61 32.298 23.298 3.520 1.00 28.76 ATOM 507 ND1 HIS 61 31.623 21.455 2.566 1.00 28.62 ATOM 508 CE1 HIS 61 32.830 21.224 3.049 1.00 27.83 ATOM 509 NE2 HIS 61 33.263 22.326 3.634 1.00 29.16 ATOM 510 C HIS 61 28.356 21.753 3.528 1.00 22.71 ATOM 511 O HIS 61 28.583 20.582 3.837 1.00 22.54 ATOM 512 N ALA 62 27.659 22.579 4.297 1.00 21.43 ATOM 513 CA ALA 62 27.141 22.168 5.596 1.00 22.12 ATOM 514 CB ALA 62 26.597 23.392 6.349 1.00 17.66 ATOM 515 C ALA 62 26.059 21.088 5.480 1.00 21.21 ATOM 516 O ALA 62 25.959 20.208 6.340 1.00 22.10 ATOM 517 N ILE 63 25.245 21.157 4.428 1.00 21.36 ATOM 518 CA ILE 63 24.185 20.172 4.221 1.00 21.14 ATOM 519 CB ILE 63 23.239 20.582 3.075 1.00 20.43 ATOM 520 CG2 ILE 63 22.333 19.429 2.711 1.00 20.13 ATOM 521 CG1 ILE 63 22.402 21.795 3.493 1.00 20.25 ATOM 522 CD1 ILE 63 21.416 22.260 2.425 1.00 22.13 ATOM 523 C ILE 63 24.773 18.804 3.901 1.00 22.25 ATOM 524 O ILE 63 24.238 17.779 4.323 1.00 22.39 ATOM 525 N GLN 64 25.875 18.787 3.155 1.00 22.82 ATOM 526 CA GLN 64 26.517 17.528 2.801 1.00 22.75 ATOM 527 CB GLN 64 27.700 17.782 1.846 1.00 21.87 ATOM 528 CG GLN 64 27.200 18.212 0.465 1.00 24.19 ATOM 529 CD GLN 64 28.293 18.402 −0.582 1.00 26.74 ATOM 530 OE1 GLN 64 28.005 18.432 −1.783 1.00 29.29 ATOM 531 NE2 GLN 64 29.536 18.541 −0.140 1.00 22.66 ATOM 532 C GLN 64 26.950 18.798 4.064 1.00 22.10 ATOM 533 O GLN 64 26.872 15.575 4.139 1.00 21.93 ATOM 534 N TYR 65 27.385 17.554 5.064 1.00 22.47 ATOM 535 CA TYR 65 27.791 16.964 6.335 1.00 23.86 ATOM 536 CB TYR 65 28.572 17.980 7.171 1.00 26.62 ATOM 537 CG TYR 65 30.050 18.030 6.823 1.00 30.04 ATOM 538 CD1 TYR 65 30.895 16.963 7.140 1.00 32.17 ATOM 539 CE1 TYR 65 32.252 16.986 6.807 1.00 33.14 ATOM 540 CD2 TYR 65 30.599 19.128 6.160 1.00 30.53 ATOM 541 CE2 TYR 65 31.957 19.161 5.818 1.00 33.67 ATOM 542 CZ TYR 65 32.777 18.086 6.147 1.00 36.28 ATOM 543 OH TYR 65 34.122 18.109 5.821 1.00 40.50 ATOM 544 C TYR 65 26.581 16.449 7.120 1.00 22.30 ATOM 545 O TYR 65 26.702 15.498 7.888 1.00 23.33 ATOM 546 N VAL 66 25.417 17.071 6.938 1.00 20.36 ATOM 547 CA VAL 66 24.222 16.598 7.637 1.00 20.83 ATOM 548 CB VAL 66 23.020 17.574 7.502 1.00 18.86 ATOM 549 CG1 VAL 66 21.784 16.965 8.176 1.00 19.22 ATOM 550 CG2 VAL 66 23.348 18.914 8.159 1.00 16.99 ATOM 551 C VAL 66 23.830 15.246 7.040 1.00 20.81 ATOM 552 O VAL 66 23.338 14.370 7.740 1.00 22.04 ATOM 553 N VAL 67 24.048 15.085 5.739 1.00 22.31 ATOM 554 CA VAL 67 23.740 13.830 5.062 1.00 21.44 ATOM 555 CB VAL 67 23.989 13.943 3.544 1.00 22.66 ATOM 556 CG VAL 67 23.770 12.593 2.872 1.00 22.40 ATOM 557 CG2 VAL 67 23.047 14.992 2.939 1.00 23.72 ATOM 558 C VAL 67 24.624 12.726 5.653 1.00 22.20 ATOM 559 O VAL 67 24.160 11.616 5.913 1.00 22.69 ATOM 560 N GLU 68 25.896 13.040 5.879 1.00 23.93 ATOM 561 CA GLU 68 26.825 12.072 6.463 1.00 25.73 ATOM 562 CB GLU 68 28.241 12.652 6.483 1.00 31.22 ATOM 563 CG GLU 68 28.790 12.972 5.097 1.00 35.81 ATOM 564 CD GLU 68 29.333 11.745 4.375 1.00 42.48 ATOM 565 OE1 GLU 68 28.652 10.692 4.362 1.00 42.24 ATOM 566 OE2 GLU 68 30.449 11.841 3.808 1.00 45.88 ATOM 567 C GLU 68 26.366 11.749 7.882 1.00 25.40 ATOM 568 O GLU 68 26.432 10.597 8.322 1.00 23.68 ATOM 569 N PHE 69 25.896 12.776 8.590 1.00 23.61 ATOM 570 CA PHE 69 25.386 12.633 9.956 1.00 22.83 ATOM 571 CB PHE 69 24.885 14.001 10.448 1.00 21.69 ATOM 572 CG PHE 69 24.252 13.989 11.822 1.00 24.10 ATOM 573 CD1 PHE 69 24.903 13.412 12.912 1.00 21.29 ATOM 574 CD2 PHE 69 23.018 14.613 12.034 1.00 23.32 ATOM 575 CE1 PHE 69 24.341 13.459 14.184 1.00 22.08 ATOM 576 CE2 PHE 69 22.444 14.667 13.308 1.00 20.43 ATOM 577 CZ PHE 69 23.106 14.089 14.386 1.00 22.91 ATOM 578 C PHE 69 24.253 11.598 9.967 1.00 23.85 ATOM 579 O PHE 69 24.265 10.659 10.764 1.00 25.22 ATOM 580 N ALA 70 23.292 11.757 9.058 1.00 23.28 ATOM 581 CA ALA 70 22.151 10.851 8.962 1.00 22.31 ATOM 582 CB ALA 70 21.163 11.382 7.926 1.00 22.02 ATOM 583 C ALA 70 22.538 9.406 8.618 1.00 22.95 ATOM 584 O ALA 70 22.011 8.457 9.205 1.00 21.88 ATOM 585 N LYS 71 23.449 9.241 7.664 1.00 23.24 ATOM 586 CA LYS 71 23.889 7.911 7.249 1.00 26.69 ATOM 587 CB LYS 71 24.853 8.026 6.065 1.00 27.02 ATOM 588 CG LYS 71 24.246 8.701 4.848 1.00 28.09 ATOM 589 CD LYS 71 25.300 9.022 3.802 1.00 29.71 ATOM 590 CE LYS 71 25.970 7.770 3.257 1.00 30.06 ATOM 591 NZ LYS 71 26.968 8.147 2.221 1.00 33.92 ATOM 592 C LYS 71 24.557 7.114 8.379 1.00 26.63 ATOM 593 O LYS 71 24.536 5.880 8.370 1.00 26.95 ATOM 594 N ARG 72 25.144 7.808 9.347 1.00 24.99 ATOM 595 CA ARG 72 25.804 7.120 10.449 1.00 27.31 ATOM 596 CB ARG 72 27.051 7.892 10.880 1.00 28.59 ATOM 597 CG ARG 72 28.031 8.064 9.732 1.00 29.69 ATOM 598 CD ARG 72 29.365 8.593 10.180 1.00 31.03 ATOM 599 NE ARG 72 30.268 8.732 9.044 1.00 33.59 ATOM 600 CZ ARG 72 31.546 9.081 9.145 1.00 38.36 ATOM 601 NH1 ARG 72 32.076 9.326 10.338 1.00 39.73 ATOM 602 NH2 ARG 72 32.291 9.194 8.054 1.00 39.15 ATOM 603 C ARG 72 24.891 6.874 11.643 1.00 27.40 ATOM 604 O ARG 72 25.333 6.367 12.675 1.00 29.05 ATOM 605 N ILE 73 23.618 7.243 11.504 1.00 26.22 ATOM 606 CA ILE 73 22.648 7.015 12.566 1.00 24.04 ATOM 607 CB ILE 73 21.631 8.178 12.705 1.00 22.57 ATOM 608 CG2 ILE 73 20.568 7.810 13.744 1.00 23.16 ATOM 609 CG1 ILE 73 22.352 9.463 13.124 1.00 23.44 ATOM 610 CD1 ILE 73 21.412 10.645 13.411 1.00 23.02 ATOM 611 C ILE 73 21.884 5.747 12.205 1.00 25.40 ATOM 612 O ILE 73 21.067 5.737 11.276 1.00 23.63 ATOM 613 N THR 74 22.155 4.679 12.947 1.00 25.29 ATOM 614 CA THR 74 21.521 3.388 12.712 1.00 27.03 ATOM 615 CB THR 74 21.790 2.433 13.878 1.00 29.63 ATOM 616 OG1 THR 74 23.157 2.555 14.286 1.00 33.21 ATOM 617 CG2 THR 74 21.531 0.998 13.445 1.00 33.49 ATOM 618 C THR 74 20.007 3.466 12.510 1.00 25.59 ATOM 619 O THR 74 19.479 2.985 11.508 1.00 25.68 ATOM 620 N GLY 75 19.315 4.063 13.472 1.00 26.41 ATOM 621 CA GLY 75 17.868 4.181 13.388 1.00 25.95 ATOM 622 C GLY 75 17.382 4.896 12.139 1.00 25.86 ATOM 623 O GLY 75 16.324 4.563 11.603 1.00 25.03 ATOM 624 N PHE 76 18.146 5.877 11.667 1.00 24.84 ATOM 625 CA PHE 76 17.752 6.612 10.466 1.00 25.41 ATOM 626 CB PHE 76 18.643 7.847 10.259 1.00 23.08 ATOM 627 CG PHE 76 18.319 8.634 9.005 1.00 25.15 ATOM 628 CD1 PHE 76 18.889 8.291 7.778 1.00 25.38 ATOM 629 CD2 PHE 76 17.443 9.714 9.050 1.00 23.74 ATOM 630 CE1 PHE 76 18.592 9.015 6.621 1.00 25.08 ATOM 631 CE2 PHE 76 17.140 10.445 7.891 1.00 24.62 ATOM 632 CZ PHE 76 17.717 10.092 6.680 1.00 22.76 ATOM 633 C PHE 76 17.828 5.717 9.240 1.00 24.88 ATOM 634 O PHE 76 16.888 5.665 8.447 1.00 24.05 ATOM 635 N MET 77 18.943 5.007 9.088 1.00 25.71 ATOM 636 CA MET 77 19.123 4.136 7.937 1.00 26.70 ATOM 637 CB MET 77 20.575 3.655 7.852 1.00 28.75 ATOM 638 CG MET 77 21.577 4.773 7.554 1.00 30.31 ATOM 639 SD MET 77 21.118 5.827 6.136 1.00 31.94 ATOM 640 CE MET 77 21.818 4.891 4.717 1.00 35.36 ATOM 641 C MET 77 18.164 2.947 7.920 1.00 28.58 ATOM 642 O MET 77 18.071 2.233 6.919 1.00 28.47 ATOM 643 N GLU 78 17.449 2.737 9.022 1.00 29.72 ATOM 644 CA GLU 78 16.477 1.652 9.091 1.00 30.71 ATOM 645 CB GLU 78 16.312 1.153 10.525 1.00 32.46 ATOM 646 CG GLU 78 17.393 0.187 10.966 1.00 38.31 ATOM 647 CD GLU 78 17.235 −0.231 12.411 1.00 40.71 ATOM 648 OE1 GLU 78 16.118 −0.633 12.794 1.00 43.62 ATOM 649 OE2 GLU 78 18.226 −0.160 13.163 1.00 43.48 ATOM 650 C GLU 78 15.129 2.121 8.558 1.00 31.42 ATOM 651 O GLU 78 14.226 1.315 8.336 1.00 29.99 ATOM 652 N LEU 79 14.984 3.428 8.368 1.00 30.08 ATOM 653 CA LEU 79 13.735 3.958 7.832 1.00 29.88 ATOM 654 CB LEU 79 13.658 5.476 8.044 1.00 25.44 ATOM 655 CG LEU 79 13.653 5.967 9.495 1.00 25.48 ATOM 656 CD1 LEU 79 13.735 7.483 9.516 1.00 23.35 ATOM 657 CD2 LEU 79 12.392 5.480 10.219 1.00 24.40 ATOM 658 C LEU 79 13.745 3.633 6.339 1.00 29.03 ATOM 659 O LEU 79 14.815 3.562 5.735 1.00 26.93 ATOM 660 N CYS 80 12.573 3.419 5.744 1.00 30.41 ATOM 661 CA CYS 80 12.524 3.114 4.314 1.00 32.22 ATOM 662 CB CYS 80 11.081 2.931 3.830 1.00 33.77 ATOM 663 SG CYS 80 10.113 4.443 3.665 1.00 35.11 ATOM 664 C CYS 80 13.182 4.281 3.582 1.00 32.79 ATOM 665 O CYS 80 13.107 5.432 4.032 1.00 31.43 ATOM 666 N GLN 81 13.825 3.986 2.458 1.00 32.81 ATOM 667 CA GLN 81 14.533 5.009 1.694 1.00 33.38 ATOM 668 CB GLN 81 15.144 4.401 0.433 1.00 36.20 ATOM 669 CG GLN 81 15.988 5.382 −0.353 1.00 40.19 ATOM 670 CD GLN 81 16.894 4.693 −1.346 1.00 42.67 ATOM 671 OE1 GLN 81 16.429 4.055 −2.295 1.00 44.22 ATOM 672 NE2 GLN 81 18.201 4.808 −1.128 1.00 42.74 ATOM 673 C GLN 81 13.702 6.225 1.317 1.00 32.60 ATOM 674 O GLN 81 14.218 7.346 1.286 1.00 31.70 ATOM 675 N ASN 82 12.423 6.017 1.019 1.00 30.05 ATOM 676 CA ASN 82 11.571 7.139 0.655 1.00 29.42 ATOM 677 CB ASN 82 10.160 6.665 0.317 1.00 30.85 ATOM 678 CG ASN 82 9.211 7.818 0.086 1.00 33.27 ATOM 679 OD1 ASN 82 8.605 8.345 1.026 1.00 35.99 ATOM 680 ND2 ASN 82 9.091 8.236 −1.168 1.00 34.74 ATOM 681 C ASN 82 11.508 8.175 1.775 1.00 27.40 ATOM 682 O ASN 82 11.635 9.372 1.527 1.00 26.11 ATOM 683 N ASP 83 11.310 7.716 3.008 1.00 26.77 ATOM 684 CA ASP 83 11.236 8.635 4.140 1.00 25.04 ATOM 685 CB ASP 83 10.629 7.921 5.354 1.00 24.28 ATOM 686 CG ASP 83 9.136 7.649 5.175 1.00 25.67 ATOM 687 OD1 ASP 83 8.564 8.116 4.166 1.00 26.27 ATOM 688 OD2 ASP 83 8.531 6.978 6.034 1.00 25.59 ATOM 689 C ASP 83 12.594 9.253 4.471 1.00 23.54 ATOM 690 O ASP 83 12.663 10.407 4.886 1.00 24.66 ATOM 691 N GLN 84 13.672 8.497 4.276 1.00 22.13 ATOM 692 CA GLN 84 15.008 9.029 4.518 1.00 23.18 ATOM 693 CB GLN 84 16.076 8.012 4.118 1.00 22.97 ATOM 694 CG GLN 84 16.201 6.783 5.019 1.00 24.40 ATOM 695 CD GLN 84 17.278 5.826 4.511 1.00 23.49 ATOM 696 OE1 GLN 84 18.170 6.233 3.777 1.00 24.96 ATOM 697 NE2 GLN 84 17.202 4.563 4.916 1.00 22.35 ATOM 698 C GLN 84 15.176 10.290 3.663 1.00 24.86 ATOM 699 O GLN 84 15.624 11.331 4.147 1.00 24.41 ATOM 700 N ILE 85 14.819 10.175 2.384 1.00 24.70 ATOM 701 CA ILE 85 14.908 11.283 1.433 1.00 24.80 ATOM 702 CB ILE 85 14.426 10.838 0.013 1.00 26.48 ATOM 703 CG2 ILE 85 14.299 12.043 −0.917 1.00 23.15 ATOM 704 CG1 ILE 85 15.410 9.827 −0.588 1.00 26.97 ATOM 705 CD1 ILE 85 16.766 10.354 −0.861 1.00 29.45 ATOM 706 C ILE 85 14.067 12.473 1.905 1.00 24.78 ATOM 707 O ILE 85 14.539 13.614 1.914 1.00 25.40 ATOM 708 N LEU 86 12.829 12.203 2.310 1.00 23.18 ATOM 709 CA LEU 86 11.935 13.259 2.784 1.00 22.88 ATOM 710 CB LEU 86 10.554 12.687 3.114 1.00 22.96 ATOM 711 CG LEU 86 9.712 12.313 1.902 1.00 28.74 ATOM 712 CD1 LEU 86 8.410 11.644 2.366 1.00 27.61 ATOM 713 CD2 LEU 86 9.425 13.575 1.084 1.00 29.85 ATOM 714 C LEU 86 12.480 13.973 4.013 1.00 21.25 ATOM 715 O LEU 86 12.448 15.193 4.089 1.00 21.77 ATOM 716 N LEU 87 12.965 13.213 4.986 1.00 22.23 ATOM 717 CA LEU 87 13.510 13.821 6.196 1.00 20.76 ATOM 718 CB LEU 87 13.946 12.736 7.186 1.00 20.64 ATOM 719 CG LEU 87 12.830 11.876 7.789 1.00 20.81 ATOM 720 CD1 LEU 87 13.425 10.787 8.681 1.00 21.55 ATOM 721 CD2 LEU 87 11.901 12.762 8.590 1.00 21.01 ATOM 722 C LEU 87 14.696 14.727 5.860 1.00 21.15 ATOM 723 O LEU 87 14.808 15.842 6.367 1.00 21.87 ATOM 724 N LEU 88 15.585 14.246 5.003 1.00 20.92 ATOM 725 CA LEU 88 16.744 15.039 4.624 1.00 22.07 ATOM 726 CB LEU 88 17.736 14.172 3.837 1.00 20.79 ATOM 727 CG LEU 88 18.572 13.279 4.759 1.00 24.02 ATOM 728 CD1 LEU 88 19.333 12.241 3.956 1.00 21.15 ATOM 729 CD2 LEU 88 19.534 14.159 5.556 1.00 20.95 ATOM 730 C LEU 88 16.380 16.293 3.831 1.00 22.47 ATOM 731 O LEU 88 16.876 17.380 4.121 1.00 22.21 ATOM 732 N LYS 89 15.505 16.153 2.841 1.00 24.00 ATOM 733 CA LYS 89 15.106 17.303 2.028 1.00 25.58 ATOM 734 CB LYS 89 14.174 16.855 0.897 1.00 28.38 ATOM 735 CG LYS 89 13.626 18.006 0.053 1.00 33.25 ATOM 736 CD LYS 89 12.677 17.499 −1.032 1.00 36.96 ATOM 737 CE LYS 89 12.083 18.647 −1.857 1.00 40.68 ATOM 738 NZ LYS 89 13.067 19.285 −2.776 1.00 41.21 ATOM 739 C LYS 89 14.416 18.384 2.861 1.00 23.76 ATOM 740 O LYS 89 14.693 19.572 2.716 1.00 23.44 ATOM 741 N SER 90 13.518 17.972 3.745 1.00 24.58 ATOM 742 CA SER 90 12.806 18.943 4.559 1.00 24.92 ATOM 743 CB SER 90 11.462 18.359 5.011 1.00 25.41 ATOM 744 OG SER 90 11.643 17.177 5.770 1.00 25.27 ATOM 745 C SER 90 13.585 19.418 5.785 1.00 24.40 ATOM 746 O SER 90 13.377 20.536 6.255 1.00 24.10 ATOM 747 N GLY 91 14.493 18.587 6.290 1.00 22.98 ATOM 748 CA GLY 91 15.210 18.966 7.496 1.00 22.61 ATOM 749 C GLY 91 16.696 19.258 7.446 1.00 23.29 ATOM 750 O GLY 91 17.268 19.627 8.473 1.00 22.29 ATOM 751 N CYS 92 17.332 19.116 6.284 1.00 23.33 ATOM 752 CA CYS 92 18.770 19.368 6.205 1.00 23.73 ATOM 753 CB CYS 92 19.291 19.140 4.781 1.00 26.18 ATOM 754 SG CYS 92 18.549 20.198 3.516 1.00 35.39 ATOM 755 C CYS 92 19.151 20.772 6.668 1.00 22.55 ATOM 756 O CYS 92 20.073 20.938 7.467 1.00 20.78 ATOM 757 N LEU 93 18.442 21.782 6.176 1.00 20.74 ATOM 758 CA LEU 93 18.762 23.153 6.549 1.00 20.88 ATOM 759 CB LEU 93 18.001 24.147 5.659 1.00 19.11 ATOM 760 CG LEU 93 18.457 25.615 5.791 1.00 22.77 ATOM 761 CD1 LEU 93 19.968 25.732 5.556 1.00 20.31 ATOM 762 CD2 LEU 93 17.689 26.483 4.787 1.00 21.80 ATOM 763 C LEU 93 18.478 23.427 8.024 1.00 20.09 ATOM 764 O LEU 93 19.190 24.205 8.667 1.00 21.56 ATOM 765 N GLU 94 17.452 22.788 8.568 1.00 18.63 ATOM 766 CA GLU 94 17.125 22.979 9.975 1.00 22.09 ATOM 767 CB GLU 94 15.813 22.273 10.335 1.00 20.52 ATOM 768 CG GLU 94 14.643 22.753 9.497 1.00 23.52 ATOM 769 CD GLU 94 13.303 22.276 10.027 1.00 24.62 ATOM 770 OE1 GLU 94 13.285 21.458 10.972 1.00 25.58 ATOM 771 OE2 GLU 94 12.268 22.724 9.492 1.00 26.18 ATOM 772 C GLU 94 18.267 22.440 10.828 1.00 21.56 ATOM 773 O GLU 94 18.622 23.035 11.840 1.00 23.14 ATOM 774 N VAL 95 18.847 21.315 10.419 1.00 22.47 ATOM 775 CA VAL 95 19.970 20.757 11.167 1.00 21.92 ATOM 776 CB VAL 95 20.358 19.348 10.660 1.00 20.19 ATOM 777 CG1 VAL 95 21.640 18.884 11.347 1.00 17.76 ATOM 778 CG2 VAL 95 19.230 18.359 10.954 1.00 21.38 ATOM 779 C VAL 95 21.179 21.690 11.043 1.00 20.91 ATOM 780 O VAL 95 21.891 21.921 12.022 1.00 23.34 ATOM 781 N VAL 96 21.419 22.219 9.843 1.00 20.72 ATOM 782 CA VAL 96 22.544 23.142 9.640 1.00 20.86 ATOM 783 CB VAL 96 22.632 23.609 8.168 1.00 20.89 ATOM 784 CG1 VAL 96 23.622 24.766 8.034 1.00 21.60 ATOM 795 CG2 VAL 96 23.078 22.435 7.285 1.00 22.01 ATOM 786 C VAL 96 22.384 24.369 10.545 1.00 20.92 ATOM 787 O VAL 96 23.356 24.873 11.119 1.00 20.53 ATOM 788 N LEU 97 21.151 24.847 10.672 1.00 21.56 ATOM 789 CA LEU 97 20.879 26.008 11.507 1.00 22.41 ATOM 790 CB LEU 97 19.414 26.427 11.382 1.00 24.63 ATOM 791 CG LEU 97 19.039 27.746 12.062 1.00 27.57 ATOM 792 CD1 LEU 97 19.785 28.888 11.375 1.00 27.68 ATOM 793 CD2 LEU 97 17.522 27.969 11.984 1.00 27.40 ATOM 794 C LEU 97 21.196 25.687 12.963 1.00 23.37 ATOM 795 O LEU 97 21.774 26.510 13.670 1.00 24.02 ATOM 796 N VAL 98 20.795 24.505 13.424 1.00 22.24 ATOM 797 CA VAL 98 21.083 24.124 14.801 1.00 22.66 ATOM 798 CB VAL 98 20.454 22.753 15.168 1.00 24.14 ATOM 799 CG1 VAL 98 20.950 22.295 16.540 1.00 21.61 ATOM 800 CG2 VAL 98 18.936 22.872 15.184 1.00 22.31 ATOM 801 C VAL 98 22.598 24.041 14.977 1.00 21.26 ATOM 802 O VAL 98 23.147 24.583 15.930 1.00 23.35 ATOM 803 N ARG 99 23.275 23.381 14.043 1.00 21.04 ATOM 804 CA ARG 99 24.728 23.238 14.126 1.00 22.66 ATOM 805 CB ARG 99 25.241 22.338 12.997 1.00 21.34 ATOM 806 CG ARG 99 24.958 20.860 13.204 1.00 19.68 ATOM 807 CD ARG 99 25.493 20.040 12.042 1.00 20.91 ATOM 808 NE ARG 99 25.596 18.628 12.392 1.00 19.97 ATOM 809 CZ ARG 99 26.207 17.710 11.651 1.00 21.46 ATOM 810 NH1 ARG 99 26.774 18.047 10.499 1.00 19.48 ATOM 811 NH2 ARG 99 26.268 16.456 12.077 1.00 19.49 ATOM 812 C ARG 99 25.444 24.586 14.068 1.00 23.66 ATOM 813 O ARG 99 26.496 24.770 14.680 1.00 22.32 ATOM 814 N MET 100 24.873 25.524 13.325 1.00 24.98 ATOM 815 CA MET 100 25.468 26.849 13.200 1.00 26.11 ATOM 816 CB MET 100 24.580 27.732 12.315 1.00 24.69 ATOM 817 CG MET 100 25.125 29.131 12.096 1.00 28.62 ATOM 818 SD MET 100 23.935 30.203 11.266 1.00 30.73 ATOM 819 CE MET 100 22.917 30.695 12.620 1.00 28.23 ATOM 820 C MET 100 25.647 27.500 14.580 1.00 26.32 ATOM 821 O MET 100 26.560 28.303 14.791 1.00 25.50 ATOM 822 N CYS 101 24.782 27.140 15.524 1.00 26.14 ATOM 823 CA CYS 101 24.857 27.716 16.861 1.00 26.26 ATOM 824 CB CYS 101 23.647 27.273 17.686 1.00 26.15 ATOM 825 SG CYS 101 22.070 27.833 16.958 1.00 28.21 ATOM 826 C CYS 101 26.155 27.369 17.579 1.00 26.31 ATOM 827 O CYS 101 26.556 28.064 18.512 1.00 27.18 ATOM 828 N ARG 102 26.810 26.300 17.134 1.00 26.05 ATOM 829 CA ARG 102 28.080 25.863 17.715 1.00 25.81 ATOM 830 CB ARG 102 28.487 24.477 17.194 1.00 24.97 ATOM 831 CG ARG 102 27.477 23.360 17.374 1.00 24.25 ATOM 832 CD ARG 102 27.899 22.131 16.567 1.00 24.77 ATOM 833 NE ARG 102 29.120 21.499 17.075 1.00 24.27 ATOM 834 CZ ARG 102 30.251 21.376 16.384 1.00 25.69 ATOM 835 NH1 ARG 102 30.334 21.847 15.146 1.00 22.95 ATOM 836 NH2 ARG 102 31.300 20.763 16.924 1.00 24.83 ATOM 837 C ARG 102 29.167 26.837 17.290 1.00 25.16 ATOM 838 O ARG 102 30.189 26.965 17.956 1.00 26.46 ATOM 839 N ALA 103 28.949 27.499 16.158 1.00 25.50 ATOM 840 CA ALA 103 29.925 28.438 15.610 1.00 24.73 ATOM 841 CB ALA 103 30.282 28.031 14.191 1.00 24.76 ATOM 842 C ALA 103 29.412 29.869 15.626 1.00 25.49 ATOM 843 O ALA 103 29.663 30.641 14.696 1.00 26.25 ATOM 844 N PHE 104 28.701 30.220 16.693 1.00 24.81 ATOM 845 CA PHE 104 28.138 31.552 16.837 1.00 24.87 ATOM 846 CB PHE 104 26.612 31.463 16.834 1.00 24.62 ATOM 847 CG PHE 104 25.912 32.800 16.868 1.00 27.48 ATOM 848 CD1 PHE 104 25.548 33.383 18.082 1.00 27.30 ATOM 849 CD2 PHE 104 25.599 33.465 15.685 1.00 25.70 ATOM 850 CE1 PHE 104 24.876 34.610 18.115 1.00 27.97 ATOM 851 CE2 PHE 104 24.930 34.693 15.708 1.00 26.67 ATOM 852 CZ PHE 104 24.568 35.263 16.923 1.00 25.05 ATOM 853 C PHE 104 28.637 32.156 18.145 1.00 26.24 ATOM 854 O PHE 104 28.624 31.504 19.188 1.00 25.16 ATOM 855 N ASN 105 29.095 33.398 18.078 1.00 24.14 ATOM 856 CA ASN 105 29.594 34.080 19.259 1.00 25.15 ATOM 857 CB ASN 105 30.833 34.889 18.884 1.00 25.27 ATOM 858 CG ASN 105 31.414 35.640 20.054 1.00 28.22 ATOM 859 OD1 ASN 105 30.811 35.715 21.125 1.00 29.75 ATOM 860 ND2 ASN 105 32.592 36.211 19.853 1.00 28.02 ATOM 861 C ASN 105 28.471 34.999 19.744 1.00 25.46 ATOM 862 O ASN 105 28.218 36.043 19.148 1.00 23.70 ATOM 863 N PRO 106 27.784 34.615 20.835 1.00 26.30 ATOM 864 CD PRO 106 27.965 33.373 21.611 1.00 27.28 ATOM 865 CA PRO 106 26.680 35.414 21.382 1.00 27.94 ATOM 866 CB PRO 106 25.995 34.442 22.339 1.00 27.49 ATOM 867 CG PRO 106 27.150 33.646 22.867 1.00 27.98 ATOM 868 C PRO 106 27.052 36.731 22.059 1.00 28.50 ATOM 869 O PRO 106 26.169 37.481 22.470 1.00 29.76 ATOM 870 N LEU 107 28.344 37.024 22.173 1.00 28.28 ATOM 871 CA LEU 107 28.761 38.277 22.800 1.00 30.25 ATOM 872 CB LEU 107 30.150 38.138 23.444 1.00 28.28 ATOM 873 CG LEU 107 30.176 37.231 24.686 1.00 31.14 ATOM 874 CD1 LEU 107 31.562 37.188 25.277 1.00 29.40 ATOM 875 CD2 LEU 107 29.192 37.746 25.726 1.00 32.31 ATOM 876 C LEU 107 28.758 39.433 21.807 1.00 29.75 ATOM 877 O LEU 107 28.332 40.533 22.142 1.00 31.64 ATOM 878 N ASN 108 29.231 39.193 20.589 1.00 28.78 ATOM 879 CA ASN 108 29.249 40.246 19.580 1.00 28.18 ATOM 880 CB ASN 108 30.681 40.517 19.107 1.00 27.56 ATOM 881 CG ASN 108 31.362 39.279 18.538 1.00 28.12 ATOM 882 OD1 ASN 108 30.733 38.238 18.347 1.00 26.25 ATOM 883 ND2 ASN 108 32.657 39.396 18.257 1.00 24.43 ATOM 884 C ASN 108 28.364 39.894 18.386 1.00 27.75 ATOM 885 O ASN 108 28.432 40.537 17.343 1.00 27.33 ATOM 886 N ASN 109 27.535 38.870 18.556 1.00 27.69 ATOM 887 CA ASN 109 26.627 38.418 17.512 1.00 28.83 ATOM 888 CB ASN 109 25.465 39.395 17.353 1.00 29.93 ATOM 889 CG ASN 109 24.546 39.387 18.543 1.00 32.72 ATOM 890 OD1 ASN 109 24.216 38.324 19.072 1.00 32.17 ATOM 891 ND2 ASN 109 24.116 40.575 18.973 1.00 31.31 ATOM 892 C ASN 109 27.293 38.222 16.164 1.00 27.63 ATOM 893 O ASN 109 26.918 38.861 15.183 1.00 27.80 ATOM 894 N THR 110 28.283 37.342 16.124 1.00 26.91 ATOM 895 CA THR 110 28.990 37.042 14.889 1.00 26.50 ATOM 896 CB THR 110 30.469 37.468 14.967 1.00 25.46 ATOM 897 OG1 THR 110 31.071 36.887 16.130 1.00 24.60 ATOM 898 CG2 THR 110 30.587 38.987 15.050 1.00 26.91 ATOM 899 C THR 110 28.908 35.535 14.668 1.00 26.44 ATOM 900 O THR 110 28.813 34.765 15.625 1.00 26.49 ATOM 901 N VAL 111 28.928 35.124 13.407 1.00 25.62 ATOM 902 CA VAL 111 28.859 33.713 13.058 1.00 25.05 ATOM 903 CB VAL 111 27.550 33.386 12.292 1.00 26.15 ATOM 904 CG1 VAL 111 27.581 34.012 10.893 1.00 25.65 ATOM 905 CG2 VAL 111 27.364 31.875 12.207 1.00 25.76 ATOM 906 C VAL 111 30.056 33.361 12.178 1.00 25.27 ATOM 907 O VAL 111 30.541 34.204 11.415 1.00 24.98 ATOM 908 N LEU 112 30.536 32.126 12.302 1.00 23.55 ATOM 909 CA LEU 112 31.677 31.660 11.520 1.00 24.51 ATOM 910 CB LEU 112 32.171 30.316 12.067 1.00 24.17 ATOM 911 CG LEU 112 33.323 29.570 11.384 1.00 26.81 ATOM 912 CD1 LEU 112 34.579 30.439 11.321 1.00 24.50 ATOM 913 CD2 LEU 112 33.603 28.292 12.176 1.00 26.23 ATOM 914 C LEU 112 31.251 31.512 10.063 1.00 25.07 ATOM 915 O LEU 112 30.347 30.734 9.751 1.00 23.68 ATOM 916 N PHE 113 31.905 32.267 9.183 1.00 25.79 ATOM 917 CA PHE 113 31.595 32.240 7.759 1.00 27.26 ATOM 918 CB PHE 113 30.686 33.415 7.399 1.00 26.26 ATOM 919 CG PHE 113 30.216 33.399 5.975 1.00 26.51 ATOM 920 CD1 PHE 113 29.338 32.412 5.528 1.00 27.75 ATOM 921 CD2 PHE 113 30.661 34.358 5.073 1.00 26.90 ATOM 922 CE1 PHE 113 28.910 32.380 4.199 1.00 27.83 ATOM 923 CE2 PHE 113 30.239 34.336 3.736 1.00 27.68 ATOM 924 CZ PHE 113 29.361 33.344 3.302 1.00 26.77 ATOM 925 C PHE 113 32.885 32.318 6.954 1.00 28.10 ATOM 926 O PHE 113 33.651 33.271 7.079 1.00 29.91 ATOM 927 N GLU 114 33.117 31.310 6.122 1.00 30.65 ATOM 928 CA GLU 114 34.325 31.243 5.312 1.00 31.06 ATOM 929 CB GLU 114 34.296 32.295 4.188 1.00 30.36 ATOM 930 CG GLU 114 33.108 32.146 3.220 1.00 33.61 ATOM 931 CD GLU 114 33.194 33.074 2.006 1.00 36.26 ATOM 932 OE1 GLU 114 33.847 34.137 2.098 1.00 37.14 ATOM 933 OE2 GLU 114 32.596 32.746 0.960 1.00 36.76 ATOM 934 C GLU 114 35.579 31.416 6.169 1.00 31.09 ATOM 935 O GLU 114 36.425 32.267 5.893 1.00 29.44 ATOM 936 N GLY 115 35.678 30.619 7.232 1.00 31.65 ATOM 937 CA GLY 115 36.862 30.653 8.077 1.00 31.02 ATOM 938 C GLY 115 36.987 31.636 9.227 1.00 31.03 ATOM 939 O GLY 115 37.850 31.453 10.081 1.00 31.02 ATOM 940 N LYS 116 36.165 32.678 9.266 1.00 30.47 ATOM 941 CA LYS 116 36.247 33.640 10.364 1.00 29.13 ATOM 942 CB LYS 116 37.081 34.850 9.950 1.00 31.65 ATOM 943 CG LYS 116 38.518 34.542 9.546 1.00 35.17 ATOM 944 CD LYS 116 39.156 35.784 8.933 1.00 39.50 ATOM 945 CE LYS 116 40.598 35.550 8.517 1.00 41.93 ATOM 946 HZ LYS 116 41.482 35.336 9.699 1.00 46.16 ATOM 947 C LYS 116 34.855 34.108 10.773 1.00 28.58 ATOM 948 O LYS 116 33.883 33.914 10.035 1.00 25.63 ATOM 949 N TYR 117 34.773 34.731 11.947 1.00 26.38 ATOM 950 CA TYR 117 33.513 35.241 12.473 1.00 26.28 ATOM 951 CB TYR 117 33.557 35.311 14.006 1.00 27.82 ATOM 952 CG TYR 117 33.470 33.964 14.684 1.00 25.87 ATOM 953 CD1 TYR 117 34.524 33.048 14.605 1.00 27.04 ATOM 954 CE1 TYR 117 34.426 31.782 15.190 1.00 26.50 ATOM 955 CD2 TYR 117 32.316 33.585 15.369 1.00 23.65 ATOM 956 CE2 TYR 117 32.208 32.329 15.953 1.00 26.33 ATOM 957 CZ TYR 117 33.263 31.433 15.858 1.00 26.31 ATOM 958 OH TYR 117 33.136 30.179 16.405 1.00 29.08 ATOM 959 C TYR 117 33.191 36.624 11.922 1.00 27.89 ATOM 960 O TYR 117 34.063 37.491 11.837 1.00 27.82 ATOM 961 N GLY 118 31.932 36.821 11.551 1.00 27.62 ATOM 962 CA GLY 118 31.503 38.104 11.029 1.00 27.35 ATOM 963 C GLY 118 30.086 38.415 11.476 1.00 27.40 ATOM 964 O GLY 118 29.275 37.502 11.644 1.00 26.12 ATOM 965 N GLY 119 29.787 39.698 11.673 1.00 27.51 ATOM 966 CA GLY 119 28.455 40.092 12.104 1.00 28.25 ATOM 967 C GLY 119 27.465 39.994 10.964 1.00 30.48 ATOM 968 O GLY 119 27.845 39.624 9.852 1.00 32.66 ATOM 969 N MET 120 26.203 40.328 11.215 1.00 30.06 ATOM 970 CA MET 120 25.200 40.245 10.159 1.00 33.29 ATOM 971 CB MET 120 23.786 40.417 10.742 1.00 35.95 ATOM 972 CG MET 120 23.464 41.793 11.321 1.00 40.01 ATOM 973 SD MET 120 23.194 43.077 10.066 1.00 44.66 ATOM 974 CE MET 120 21.580 42.608 9.449 1.00 38.51 ATOM 975 C MET 120 25.423 41.233 9.010 1.00 33.96 ATOM 976 O MET 120 24.889 41.036 7.916 1.00 32.84 ATOM 977 N GLN 121 26.218 42.280 9.245 1.00 34.68 ATOM 978 CA GLN 121 26.489 43.281 8.209 1.00 36.23 ATOM 979 CB GLN 121 27.204 44.509 8.794 1.00 37.39 ATOM 980 CG GLN 121 28.683 44.292 9.088 1.00 40.21 ATOM 981 CD GLN 121 28.930 43.759 10.485 1.00 42.57 ATOM 982 OE1 GLN 121 28.035 43.184 11.111 1.00 42.30 ATOM 983 NE2 GLN 121 30.154 43.943 10.982 1.00 43.39 ATOM 984 C GLN 121 27.357 42.670 7.117 1.00 36.52 ATOM 985 O GLN 121 27.577 43.263 6.062 1.00 38.05 ATOM 986 N MET 122 27.852 41.474 7.397 1.00 35.28 ATOM 987 CA MET 122 28.686 40.731 6.474 1.00 32.99 ATOM 988 CB MET 122 29.324 39.562 7.239 1.00 34.32 ATOM 989 CG MET 122 30.068 38.536 6.417 1.00 32.66 ATOM 990 SD MET 122 31.016 37.409 7.491 1.00 32.03 ATOM 991 CE MET 122 29.704 36.572 8.406 1.00 29.49 ATOM 992 C MET 122 27.819 40.225 5.317 1.00 33.06 ATOM 993 O MET 122 28.315 39.986 4.219 1.00 31.80 ATOM 994 N PHE 123 26.519 40.094 5.571 1.00 31.66 ATOM 995 CA PHE 123 25.565 39.596 4.580 1.00 32.27 ATOM 996 CB PHE 123 24.640 38.567 5.235 1.00 29.78 ATOM 997 CG PHE 123 25.366 37.400 5.838 1.00 30.41 ATOM 998 CD1 PHE 123 25.875 36.387 5.030 1.00 28.95 ATOM 999 CD2 PHE 123 25.553 37.318 7.213 1.00 28.84 ATOM 1000 CE1 PHE 123 26.556 35.307 5.586 1.00 28.63 ATOM 1001 CE2 PHE 123 26.234 36.243 7.779 1.00 28.70 ATOM 1002 CZ PHE 123 26.736 35.235 6.965 1.00 29.76 ATOM 1003 C PHE 123 24.709 40.695 3.952 1.00 33.01 ATOM 1004 O PHE 123 23.671 40.410 3.352 1.00 32.84 ATOM 1005 N LYS 124 25.149 41.941 4.082 1.00 33.57 ATOM 1006 CA LYS 124 24.409 43.075 3.542 1.00 35.39 ATOM 1007 CB LYS 124 25.228 44.361 3.737 1.00 38.66 ATOM 1008 CG LYS 124 24.439 45.645 3.501 1.00 43.12 ATOM 1009 CD LYS 124 23.162 45.650 4.341 1.00 46.67 ATOM 1010 CE LYS 124 22.286 46.866 4.040 1.00 49.30 ATOM 1011 NZ LYS 124 20.975 46.787 4.753 1.00 48.16 ATOM 1012 C LYS 124 24.005 42.923 2.071 1.00 33.97 ATOM 1013 O LYS 124 22.858 43.169 1.719 1.00 34.76 ATOM 1014 N ALA 125 24.936 42.497 1.219 1.00 34.80 ATOM 1015 CA ALA 125 24.666 42.347 −0.215 1.00 34.52 ATOM 1016 CB ALA 125 25.955 41.965 −0.953 1.00 33.38 ATOM 1017 C ALA 125 23.548 41.366 −0.583 1.00 35.75 ATOM 1018 O ALA 125 23.125 41.313 −1.738 1.00 35.49 ATOM 1019 N LEU 126 23.071 40.581 0.378 1.00 35.88 ATOM 1020 CA LEU 126 21.993 39.640 0.085 1.00 35.88 ATOM 1021 CB LEU 126 21.877 38.583 1.181 1.00 34.67 ATOM 1022 CG LEU 126 23.019 37.586 1.309 1.00 33.16 ATOM 1023 CD1 LEU 126 22.701 36.629 2.442 1.00 33.20 ATOM 1024 CD2 LEU 126 23.200 36.831 −0.006 1.00 31.66 ATOM 1025 C LEU 126 20.661 40.360 −0.037 1.00 35.66 ATOM 1026 O LEU 126 19.745 39.881 −0.699 1.00 37.30 ATOM 1027 N GLY 127 20.556 41.509 0.618 1.00 36.88 ATOM 1028 CA GLY 127 19.319 42.261 0.577 1.00 37.45 ATOM 1029 C GLY 127 18.231 41.495 1.295 1.00 38.00 ATOM 1030 O GLY 127 17.047 41.645 0.992 1.00 37.47 ATOM 1031 N SER 128 18.637 40.672 2.257 1.00 38.76 ATOM 1032 CA SER 128 17.696 39.862 3.024 1.00 38.85 ATOM 1033 CB SER 128 17.783 38.399 2.575 1.00 39.65 ATOM 1034 OG SER 128 17.675 38.280 1.167 1.00 40.93 ATOM 1035 C SER 128 18.004 39.946 4.518 1.00 38.88 ATOM 1036 O SER 128 18.142 38.916 5.184 1.00 38.92 ATOM 1037 N ASP 129 18.104 41.160 5.050 1.00 38.31 ATOM 1038 CA ASP 129 18.413 41.327 6.469 1.00 37.76 ATOM 1039 CB ASP 129 18.513 42.809 6.837 1.00 38.81 ATOM 1040 CG ASP 129 19.785 43.458 6.322 1.00 37.85 ATOM 1041 OD1 ASP 129 20.698 42.734 5.884 1.00 39.00 ATOM 1042 OD2 ASP 129 19.877 44.700 6.369 1.00 40.89 ATOM 1043 C ASP 129 17.399 40.651 7.382 1.00 37.23 ATOM 1044 O ASP 129 17.734 40.238 8.490 1.00 36.42 ATOM 1045 N ASP 130 16.156 40.542 6.930 1.00 36.72 ATOM 1046 CA ASP 130 15.143 39.901 7.755 1.00 36.80 ATOM 1047 CB ASP 130 13.760 40.044 7.110 1.00 38.13 ATOM 1048 CG ASP 130 13.722 39.535 5.688 1.00 40.50 ATOM 1049 OD1 ASP 130 14.726 39.717 4.969 1.00 40.76 ATOM 1050 OD2 ASP 130 12.680 38.969 5.285 1.00 41.30 ATOM 1051 C ASP 130 15.507 38.430 7.958 1.00 34.04 ATOM 1052 O ASP 130 15.376 37.899 9.058 1.00 32.59 ATOM 1053 N LEU 131 15.974 37.779 6.897 1.00 31.60 ATOM 1054 CA LEU 131 16.368 36.380 6.994 1.00 29.28 ATOM 1055 CB LEU 131 16.735 35.812 5.615 1.00 28.37 ATOM 1056 CG LEU 131 17.529 34.490 5.653 1.00 28.49 ATOM 1057 CD1 LEU 131 16.701 33.410 6.352 1.00 26.24 ATOM 1058 CD2 LEU 131 17.895 34.046 4.249 1.00 25.43 ATOM 1059 C LEU 131 17.569 36.270 7.924 1.00 28.88 ATOM 1060 O LEU 131 17.560 35.495 8.882 1.00 28.78 ATOM 1061 N VAL 132 18.603 37.058 7.646 1.00 28.88 ATOM 1062 CA VAL 132 19.805 37.032 8.473 1.00 28.97 ATOM 1063 CB VAL 132 20.843 38.038 7.953 1.00 28.69 ATOM 1064 CG1 VAL 132 22.086 37.998 8.822 1.00 27.42 ATOM 1065 CG2 VAL 132 21.195 37.706 6.512 1.00 29.10 ATOM 1066 C VAL 132 19.490 37.319 9.943 1.00 29.17 ATOM 1067 O VAL 132 19.912 36.571 10.831 1.00 29.93 ATOM 1068 N ASN 133 18.748 38.395 10.198 1.00 29.09 ATOM 1069 CA ASN 133 18.367 38.759 11.562 1.00 28.91 ATOM 1070 CB ASN 133 17.477 40.004 11.552 1.00 31.79 ATOM 1071 CG ASN 133 18.275 41.297 11.466 1.00 35.19 ATOM 1072 OD1 ASN 133 17.728 42.352 11.149 1.00 36.03 ATOM 1073 ND2 ASN 133 19.569 41.222 11.765 1.00 34.40 ATOM 1074 C ASN 133 17.634 37.620 12.266 1.00 28.71 ATOM 1075 O ASN 133 17.850 37.376 13.453 1.00 28.36 ATOM 1076 N GLU 134 16.758 36.928 11.546 1.00 27.60 ATOM 1077 CA GLU 134 16.033 35.815 12.154 1.00 29.70 ATOM 1078 CB GLU 134 14.904 35.340 11.235 1.00 30.25 ATOM 1079 CG GLU 134 13.612 36.130 11.441 1.00 37.54 ATOM 1080 CD GLU 134 12.429 35.572 10.672 1.00 39.03 ATOM 1081 OE1 GLU 134 12.311 34.333 10.568 1.00 42.45 ATOM 1082 OE2 GLU 134 11.604 36.376 10.186 1.00 43.40 ATOM 1083 C GLU 134 16.978 34.659 12.484 1.00 28.63 ATOM 1084 O GLU 134 16.867 34.040 13.540 1.00 27.53 ATOM 1085 N ALA 135 17.916 34.385 11.583 1.00 28.23 ATOM 1086 CA ALA 135 18.887 33.317 11.791 1.00 27.00 ATOM 1087 CB ALA 135 19.769 33.178 10.571 1.00 26.34 ATOM 1088 C ALA 135 19.734 33.636 13.019 1.00 27.05 ATOM 1089 O ALA 135 19.955 32.774 13.876 1.00 25.93 ATOM 1090 N PHE 136 20.199 34.881 13.104 1.00 27.53 ATOM 1091 CA PHE 136 21.018 35.322 14.229 1.00 28.38 ATOM 1092 CB PHE 136 21.569 36.728 13.963 1.00 29.04 ATOM 1093 CG PHE 136 22.817 36.742 13.123 1.00 27.20 ATOM 1094 CD1 PHE 136 22.858 36.084 11.898 1.00 28.97 ATOM 1095 CD2 PHE 136 23.954 37.422 13.555 1.00 28.84 ATOM 1096 CE1 PHE 136 24.014 36.103 11.114 1.00 28.21 ATOM 1097 CE2 PHE 136 25.117 37.446 12.776 1.00 27.38 ATOM 1098 CZ PHE 136 25.143 36.785 11.555 1.00 27.06 ATOM 1099 C PHE 136 20.278 35.306 15.566 1.00 29.12 ATOM 1100 O PHE 136 20.834 34.876 16.581 1.00 27.78 ATOM 1101 N ASP 137 19.031 35.772 15.573 1.00 30.75 ATOM 1102 CA ASP 137 18.247 35.798 16.808 1.00 31.48 ATOM 1103 CB ASP 137 16.888 36.463 16.570 1.00 34.88 ATOM 1104 CG ASP 137 17.013 37.938 16.197 1.00 39.69 ATOM 1105 OD1 ASP 137 18.118 38.513 16.338 1.00 41.72 ATOM 1106 OD2 ASP 137 15.997 38.524 15.769 1.00 41.77 ATOM 1107 C ASP 137 18.046 34.388 17.361 1.00 30.07 ATOM 1108 O ASP 137 18.094 34.173 18.572 1.00 28.12 ATOM 1109 N PHE 138 17.814 33.430 16.470 1.00 29.22 ATOM 1110 CA PHE 138 17.635 32.043 16.888 1.00 27.56 ATOM 1111 CB PHE 138 17.284 31.156 15.692 1.00 26.66 ATOM 1112 CG PHE 138 17.481 29.693 15.964 1.00 27.08 ATOM 1113 CD1 PHE 138 16.631 29.018 16.833 1.00 27.62 ATOM 1114 CD2 PHE 138 18.562 29.010 15.414 1.00 25.94 ATOM 1115 CE1 PHE 138 16.854 27.679 17.157 1.00 27.42 ATOM 1116 CE2 PHE 138 18.798 27.671 15.731 1.00 26.61 ATOM 1117 CZ PHE 138 17.942 27.005 16.606 1.00 27.10 ATOM 1118 C PHE 138 18.931 31.524 17.520 1.00 26.65 ATOM 1119 O PHE 138 18.932 30.996 18.638 1.00 25.79 ATOM 1120 N ALA 139 20.028 31.673 16.783 1.00 26.86 ATOM 1121 CA ALA 139 21.335 31.228 17.246 1.00 28.26 ATOM 1122 CB ALA 139 22.409 31.620 16.246 1.00 24.42 ATOM 1123 C ALA 139 21.629 31.854 18.598 1.00 29.32 ATOM 1124 O ALA 139 22.062 31.175 19.523 1.00 29.76 ATOM 1125 N LYS 140 21.388 33.154 18.705 1.00 30.35 ATOM 1126 CA LYS 140 21.628 33.857 19.955 1.00 33.43 ATOM 1127 CB LYS 140 21.305 35.345 19.795 1.00 35.05 ATOM 1128 CG LYS 140 21.512 36.156 21.056 1.00 41.64 ATOM 1129 CD LYS 140 21.304 37.645 20.808 1.00 45.36 ATOM 1130 CE LYS 140 21.412 38.426 22.113 1.00 48.64 ATOM 1131 NZ LYS 140 22.648 38.062 22.869 1.00 48.83 ATOM 1132 C LYS 140 20.784 33.250 21.072 1.00 32.60 ATOM 1133 O LYS 140 21.271 33.018 22.173 1.00 33.54 ATOM 1134 N ASN 141 19.520 32.968 20.782 1.00 33.89 ATOM 1135 CA ASN 141 18.645 32.397 21.794 1.00 34.26 ATOM 1136 CB ASN 141 17.187 32.488 21.351 1.00 35.65 ATOM 1137 CG ASN 141 16.714 33.922 21.246 1.00 41.37 ATOM 1138 OD1 ASN 141 17.033 34.759 22.102 1.00 41.73 ATOM 1139 ND2 ASN 141 15.944 34.218 20.203 1.00 43.55 ATOM 1140 C ASN 141 18.993 30.961 22.155 1.00 32.74 ATOM 1141 O ASN 141 18.857 30.565 23.307 1.00 32.51 ATOM 1142 N LEU 142 19.439 30.178 21.180 1.00 31.43 ATOM 1143 CA LEU 142 19.800 28.800 21.475 1.00 29.57 ATOM 1144 CB LEU 142 20.061 28.009 20.190 1.00 31.15 ATOM 1145 CG LEU 142 20.302 26.512 20.415 1.00 30.62 ATOM 1146 CD1 LEU 142 19.000 25.852 20.835 1.00 28.71 ATOM 1147 CD2 LEU 142 20.824 25.870 19.149 1.00 30.61 ATOM 1148 C LEU 142 21.058 28.809 22.329 1.00 28.67 ATOM 1149 O LEU 142 21.188 28.022 23.266 1.00 27.68 ATOM 1150 N CYS 143 21.988 29.706 22.004 1.00 28.64 ATOM 1151 CA CYS 143 23.240 29.805 22.751 1.00 28.53 ATOM 1152 CB CYS 143 24.164 30.857 22.118 1.00 29.40 ATOM 1153 SG CYS 143 25.058 30.297 20.626 1.00 30.27 ATOM 1154 C CYS 143 23.011 30.141 24.225 1.00 28.51 ATOM 1155 O CYS 143 23.811 29.764 25.083 1.00 27.46 ATOM 1156 N SER 144 21.922 30.844 24.524 1.00 27.47 ATOM 1157 CA SER 144 21.631 31.204 25.907 1.00 30.41 ATOM 1158 CB SER 144 20.407 32.123 25.978 1.00 30.97 ATOM 1159 OG SER 144 19.221 31.404 25.687 1.00 32.16 ATOM 1160 C SER 144 21.391 29.963 26.776 1.00 30.53 ATOM 1161 O SER 144 21.527 30.024 27.995 1.00 31.62 ATOM 1162 N LEU 145 21.039 28.841 26.147 1.00 29.38 ATOM 1163 CA LEU 145 20.787 27.600 26.878 1.00 28.47 ATOM 1164 CB LEU 145 19.886 26.664 26.062 1.00 30.06 ATOM 1165 CG LEU 145 18.452 27.120 25.776 1.00 30.81 ATOM 1166 CD1 LEU 145 17.736 26.074 24.929 1.00 31.42 ATOM 1167 CD2 LEU 145 17.711 27.326 27.092 1.00 32.81 ATOM 1168 C LEU 145 22.078 26.869 27.242 1.00 27.00 ATOM 1169 O LEU 145 22.060 25.936 28.041 1.00 26.93 ATOM 1170 N GLN 146 23.192 27.285 26.647 1.00 27.19 ATOM 1171 CA GLN 146 24.481 26.669 26.938 1.00 28.35 ATOM 1172 CB GLN 146 24.912 27.015 28.364 1.00 31.85 ATOM 1173 CG GLN 146 25.051 28.468 28.638 1.00 37.93 ATOM 1174 CD GLN 146 26.153 29.120 27.823 1.00 43.03 ATOM 1175 OE1 GLN 146 27.326 28.736 27.920 1.00 45.91 ATOM 1176 NE2 GLN 146 25.785 30.096 27.005 1.00 46.57 ATOM 1177 C GLN 146 24.451 25.147 26.797 1.00 28.31 ATOM 1178 O GLN 146 24.803 24.425 27.738 1.00 28.78 ATOM 1179 N LEU 147 24.035 24.657 25.634 1.00 24.96 ATOM 1180 CA LEU 147 23.971 23.219 25.405 1.00 25.05 ATOM 1181 CB LEU 147 23.129 22.919 24.166 1.00 24.70 ATOM 1182 CG LEU 147 21.682 23.401 24.168 1.00 25.61 ATOM 1183 CD1 LEU 147 21.020 22.977 22.858 1.00 27.01 ATOM 1184 CD2 LEU 147 20.945 22.817 25.369 1.00 26.03 ATOM 1185 C LEU 147 25.357 22.616 25.206 1.00 25.19 ATOM 1186 O LEU 147 26.253 23.262 24.664 1.00 25.02 ATOM 1187 N THR 148 25.533 21.377 25.650 1.00 25.71 ATOM 1188 CA THR 148 26.809 20.697 25.473 1.00 25.53 ATOM 1189 CB THR 148 27.004 19.561 26.495 1.00 25.85 ATOM 1190 OG1 THR 148 25.986 18.572 26.297 1.00 25.37 ATOM 1191 CG2 THR 148 26.933 20.101 27.937 1.00 25.32 ATOM 1192 C THR 148 26.777 20.078 24.076 1.00 26.33 ATOM 1193 O THR 148 25.741 20.098 23.395 1.00 23.91 ATOM 1194 N GLU 149 27.906 19.528 23.647 1.00 24.54 ATOM 1195 CA GLU 149 27.973 18.898 22.335 1.00 25.20 ATOM 1196 CB GLU 149 29.420 18.498 22.007 1.00 24.58 ATOM 1197 CG GLU 149 30.257 19.657 21.475 1.00 27.87 ATOM 1198 CD GLU 149 29.926 20.009 20.024 1.00 28.51 ATOM 1199 OE1 GLU 149 30.532 19.410 19.113 1.00 28.15 ATOM 1200 OE2 GLU 149 29.053 20.877 19.794 1.00 30.62 ATOM 1201 C GLU 149 27.052 17.684 22.268 1.00 24.09 ATOM 1202 O GLU 149 26.472 17.403 21.225 1.00 26.05 ATOM 1203 N GLU 150 26.904 16.968 23.377 1.00 24.30 ATOM 1204 CA GLU 150 26.034 15.789 23.393 1.00 24.51 ATOM 1205 CB GLU 150 26.163 15.027 24.712 1.00 24.35 ATOM 1206 CG GLU 150 27.526 14.403 24.987 1.00 28.10 ATOM 1207 CD GLU 150 27.522 13.586 26.280 1.00 31.06 ATOM 1208 OE1 GLU 150 26.883 14.030 27.258 1.00 29.36 ATOM 1209 OE2 GLU 150 28.154 12.507 26.322 1.00 31.37 ATOM 1210 C GLU 150 24.571 16.189 23.211 1.00 24.19 ATOM 1211 O GLU 150 23.807 15.500 22.529 1.00 24.28 ATOM 1212 N GLU 151 24.187 17.300 23.833 1.00 23.86 ATOM 1213 CA GLU 151 22.818 17.787 23.757 1.00 23.65 ATOM 1214 CB GLU 151 22.595 18.871 24.816 1.00 23.47 ATOM 1215 CG GLU 151 22.812 18.336 26.238 1.00 23.24 ATOM 1216 CD GLU 151 22.835 19.420 27.300 1.00 25.20 ATOM 1217 OE1 GLU 151 23.196 20.573 26.977 1.00 25.28 ATOM 1218 OE2 GLU 151 22.505 19.111 28.466 1.00 25.81 ATOM 1219 C GLU 151 22.524 18.311 22.358 1.00 24.05 ATOM 1220 O GLU 151 21.432 18.113 21.833 1.00 22.27 ATOM 1221 N ILE 152 23.510 18.968 21.751 1.00 23.11 ATOM 1222 CA ILE 152 23.342 19.487 20.406 1.00 24.39 ATOM 1223 CB ILE 152 24.538 20.358 19.996 1.00 26.20 ATOM 1224 CG2 ILE 152 24.545 20.559 18.484 1.00 27.07 ATOM 1225 CG1 ILE 152 24.461 21.699 20.732 1.00 27.68 ATOM 1226 CD1 ILE 152 25.778 22.469 20.758 1.00 32.87 ATOM 1227 C ILE 152 23.208 18.318 19.440 1.00 24.33 ATOM 1228 O ILE 152 22.394 18.346 16.515 1.00 24.36 ATOM 1229 N ALA 153 24.007 17.282 19.666 1.00 22.40 ATOM 1230 CA ALA 153 23.968 16.097 18.821 1.00 21.95 ATOM 1231 CB ALA 153 25.004 15.076 19.311 1.00 20.15 ATOM 1232 C ALA 153 22.578 15.471 18.836 1.00 19.88 ATOM 1233 O ALA 153 21.965 15.238 17.788 1.00 20.80 ATOM 1234 N LEU 154 22.092 15.199 20.037 1.00 19.09 ATOM 1235 CA LEU 154 20.794 14.573 20.222 1.00 21.33 ATOM 1236 CB LEU 154 20.604 14.206 21.699 1.00 21.40 ATOM 1237 CG LEU 154 21.616 13.184 22.230 1.00 24.62 ATOM 1238 CD1 LEU 154 21.415 12.961 23.728 1.00 25.79 ATOM 1239 CD2 LEU 154 21.448 11.878 21.472 1.00 25.80 ATOM 1240 C LEU 154 19.653 15.456 19.730 1.00 21.75 ATOM 1241 O LEU 154 18.742 14.979 19.044 1.00 20.76 ATOM 1242 N PHE 155 19.706 16.744 20.061 1.00 21.95 ATOM 1243 CA PHE 155 18.662 17.654 19.621 1.00 23.38 ATOM 1244 CB PHE 155 18.826 19.038 20.250 1.00 22.84 ATOM 1245 CG PHE 155 17.755 20.007 19.841 1.00 24.22 ATOM 1246 CD1 PHE 155 16.419 19.737 20.107 1.00 25.61 ATOM 1247 CD2 PHE 155 18.077 21.187 19.186 1.00 24.20 ATOM 1248 CE1 PHE 155 15.415 20.636 19.723 1.00 25.64 ATOM 1249 CE2 PHE 155 17.087 22.088 18.800 1.00 24.91 ATOM 1250 CZ PHE 155 15.753 21.812 19.069 1.00 24.00 ATOM 1251 C PHE 155 18.654 17.792 18.104 1.00 22.70 ATOM 1252 O PHE 155 17.595 17.740 17.481 1.00 23.42 ATOM 1253 N SER 156 19.824 17.967 17.502 1.00 22.39 ATOM 1254 CA SER 156 19.873 18.105 16.053 1.00 21.92 ATOM 1255 CB SER 156 21.308 18.330 15.565 1.00 23.31 ATOM 1256 OG SER 156 22.097 17.163 15.712 1.00 21.35 ATOM 1257 C SER 156 19.290 16.853 15.407 1.00 20.69 ATOM 1258 O SER 156 18.632 16.939 14.378 1.00 21.06 ATOM 1259 N SER 157 19.508 15.692 16.020 1.00 19.99 ATOM 1260 CA SER 157 18.974 14.456 15.462 1.00 20.74 ATOM 1261 CB SER 157 19.609 13.232 16.139 1.00 20.43 ATOM 1262 OG SER 157 19.026 12.965 17.405 1.00 22.34 ATOM 1263 C SER 157 17.443 14.403 15.596 1.00 21.96 ATOM 1264 O SER 157 16.759 13.833 14.739 1.00 20.32 ATOM 1265 N ALA 158 16.907 14.994 16.663 1.00 21.59 ATOM 1266 CA ALA 158 15.453 15.015 16.866 1.00 23.00 ATOM 1267 CB ALA 158 15.111 15.494 18.284 1.00 22.43 ATOM 1268 C ALA 158 14.815 15.939 15.837 1.00 22.79 ATOM 1269 O ALA 158 13.707 15.690 15.366 1.00 24.41 ATOM 1270 N VAL 159 15.519 17.012 15.494 1.00 22.53 ATOM 1271 CA VAL 159 15.037 17.965 14.497 1.00 21.80 ATOM 1272 CB VAL 159 15.997 19.175 14.393 1.00 21.36 ATOM 1273 CG1 VAL 159 15.670 20.003 13.162 1.00 23.95 ATOM 1274 CG2 VAL 159 15.877 20.036 15.649 1.00 19.81 ATOM 1275 C VAL 159 14.945 17.257 13.143 1.00 22.32 ATOM 1276 O VAL 159 13.981 17.434 12.390 1.00 22.54 ATOM 1277 N LEU 160 15.946 16.429 12.861 1.00 20.50 ATOM 1278 CA LEU 160 16.011 15.661 11.622 1.00 21.56 ATOM 1279 CB LEU 160 17.416 15.067 11.443 1.00 18.74 ATOM 1280 CG LEU 160 17.565 14.114 10.252 1.00 20.46 ATOM 1281 CD1 LEU 160 17.342 14.880 8.962 1.00 23.67 ATOM 1282 CD2 LEU 160 18.944 13.466 10.269 1.00 22.07 ATOM 1283 C LEU 160 14.988 14.523 11.574 1.00 22.22 ATOM 1284 O LEU 160 14.305 14.336 10.569 1.00 23.99 ATOM 1285 N ILE 161 14.906 13.753 12.654 1.00 24.28 ATOM 1286 CA ILE 161 13.982 12.622 12.723 1.00 24.95 ATOM 1287 CB ILE 161 14.492 11.534 13.712 1.00 25.36 ATOM 1288 CG2 ILE 161 13.739 10.234 13.494 1.00 24.65 ATOM 1289 CG1 ILE 161 15.993 11.289 13.515 1.00 29.20 ATOM 1290 CD1 ILE 161 16.372 10.830 12.152 1.00 31.88 ATOM 1291 C ILE 161 12.632 13.136 13.203 1.00 23.52 ATOM 1292 O ILE 161 12.214 12.852 14.327 1.00 22.05 ATOM 1293 N SER 162 11.966 13.909 12.347 1.00 23.68 ATOM 1294 CA SER 162 10.671 14.482 12.681 1.00 24.76 ATOM 1295 CB SER 162 10.612 15.946 12.264 1.00 23.48 ATOM 1296 OG SER 162 9.274 16.413 12.349 1.00 27.54 ATOM 1297 C SER 162 9.514 13.742 12.030 1.00 25.92 ATOM 1298 O SER 162 9.393 13.707 10.810 1.00 23.88 ATOM 1299 N PRO 163 8.630 13.154 12.848 1.00 28.81 ATOM 1300 CD PRO 163 8.685 13.100 14.321 1.00 28.18 ATOM 1301 CA PRO 163 7.477 12.411 12.333 1.00 29.09 ATOM 1302 CB PRO 163 7.018 11.612 13.546 1.00 28.39 ATOM 1303 CG PRO 163 7.318 12.553 14.684 1.00 29.92 ATOM 1304 C PRO 163 6.375 13.312 11.786 1.00 30.74 ATOM 1305 O PRO 163 5.354 12.824 11.297 1.00 31.15 ATOM 1306 N ASP 164 6.586 14.624 11.851 1.00 31.09 ATOM 1307 CA ASP 164 5.582 15.563 11.371 1.00 32.86 ATOM 1308 CB ASP 164 5.494 16.768 12.309 1.00 35.68 ATOM 1309 CG ASP 164 5.004 16.383 13.697 1.00 41.26 ATOM 1310 OD1 ASP 164 3.928 15.754 13.790 1.00 42.32 ATOM 1311 OD2 ASP 164 5.691 16.704 14.692 1.00 44.22 ATOM 1312 C ASP 164 5.788 16.038 9.942 1.00 31.89 ATOM 1313 O ASP 164 4.929 16.727 9.394 1.00 31.96 ATOM 1314 N ARG 165 6.910 15.665 9.333 1.00 29.36 ATOM 1315 CA ARG 165 7.184 16.073 7.963 1.00 28.58 ATOM 1316 CB ARG 165 8.525 15.507 7.477 1.00 25.79 ATOM 1317 CG ARG 165 9.732 15.898 8.313 1.00 24.11 ATOM 1318 CD ARG 165 9.861 17.404 8.460 1.00 20.61 ATOM 1319 NE ARG 165 11.169 17.760 8.990 1.00 22.12 ATOM 1320 CZ ARG 165 11.512 18.971 9.415 1.00 22.71 ATOM 1321 NH1 ARG 165 10.641 19.972 9.383 1.00 21.83 ATOM 1322 NH2 ARG 165 12.734 19.177 9.883 1.00 22.67 ATOM 1323 C ARG 165 6.068 15.546 7.076 1.00 30.34 ATOM 1324 O ARG 165 5.655 14.396 7.207 1.00 31.07 ATOM 1325 N ALA 166 5.575 16.381 6.171 1.00 30.71 ATOM 1326 CA ALA 166 4.507 15.945 5.287 1.00 30.26 ATOM 1327 CB ALA 166 3.891 17.146 4.567 1.00 31.74 ATOM 1328 C ALA 166 5.051 14.946 4.276 1.00 28.73 ATOM 1329 O ALA 166 6.240 14.961 3.950 1.00 26.64 ATOM 1330 N TRP 167 4.166 14.070 3.806 1.00 28.10 ATOM 1331 CA TRP 167 4.475 13.046 2.806 1.00 27.46 ATOM 1332 CB TRP 167 5.309 13.631 1.650 1.00 28.13 ATOM 1333 CG TRP 167 4.811 14.960 1.098 1.00 32.39 ATOM 1334 CD2 TRP 167 3.672 15.177 0.245 1.00 31.61 ATOM 1335 CE2 TRP 167 3.616 16.560 −0.035 1.00 32.63 ATOM 1336 CE3 TRP 167 2.697 14.336 −0.307 1.00 31.53 ATOM 1337 CD1 TRP 167 5.378 16.192 1.292 1.00 33.04 ATOM 1338 NE1 TRP 167 4.666 17.155 0.614 1.00 33.34 ATOM 1339 CZ2 TRP 167 2.620 17.123 −0.847 1.00 32.95 ATOM 1340 CZ3 TRP 167 1.702 14.899 −1.121 1.00 31.83 ATOM 1341 CH2 TRP 167 1.675 16.277 −1.379 1.00 32.36 ATOM 1342 C TRP 167 5.172 11.789 3.327 1.00 27.06 ATOM 1343 O TRP 167 5.413 10.863 2.550 1.00 27.23 ATOM 1344 N LEU 168 5.507 11.737 4.617 1.00 26.83 ATOM 1345 CA LEU 168 6.161 10.537 5.145 1.00 26.56 ATOM 1346 CB LEU 168 6.521 10.703 6.633 1.00 27.73 ATOM 1347 CG LEU 168 7.684 11.644 7.009 1.00 26.59 ATOM 1348 CD1 LEU 168 7.798 11.758 8.529 1.00 25.28 ATOM 1349 CD2 LEU 168 8.982 11.124 6.417 1.00 25.28 ATOM 1350 C LEU 168 5.217 9.347 4.973 1.00 28.20 ATOM 1351 O LEU 168 4.022 9.457 5.241 1.00 26.68 ATOM 1352 N LEU 169 5.755 8.219 4.513 1.00 28.02 ATOM 1353 CA LEU 169 4.954 7.016 4.307 1.00 28.10 ATOM 1354 CB LEU 169 5.588 6.132 3.231 1.00 27.55 ATOM 1355 CG LEU 169 5.571 6.687 1.802 1.00 29.51 ATOM 1356 CD1 LEU 169 6.406 5.802 0.879 1.00 26.49 ATOM 1357 CD2 LEU 169 4.130 6.785 1.319 1.00 26.84 ATOM 1358 C LEU 169 4.785 6.216 5.593 1.00 29.45 ATOM 1359 O LEU 169 3.754 5.582 5.800 1.00 30.01 ATOM 1360 N GLU 170 5.801 6.237 6.452 1.00 29.04 ATOM 1361 CA GLU 170 5.736 5.518 7.721 1.00 29.15 ATOM 1362 CB GLU 170 6.684 4.315 7.706 1.00 29.47 ATOM 1363 CG GLU 170 6.321 3.256 6.672 1.00 32.25 ATOM 1364 CD GLU 170 7.296 2.095 6.659 1.00 32.48 ATOM 1365 OE1 GLU 170 6.494 2.323 6.391 1.00 35.86 ATOM 1366 OE2 GLU 170 6.866 0.954 6.918 1.00 33.16 ATOM 1367 C GLU 170 6.106 6.453 8.863 1.00 28.40 ATOM 1368 O GLU 170 7.150 6.297 9.493 1.00 26.92 ATOM 1369 N PRO 171 5.241 7.440 9.148 1.00 29.50 ATOM 1370 CD PRO 171 3.953 7.686 8.474 1.00 28.57 ATOM 1371 CA PRO 171 5.467 8.416 10.217 1.00 29.67 ATOM 1372 CB PRO 171 4.238 9.320 10.125 1.00 30.97 ATOM 1373 CG PRO 171 3.174 8.408 9.536 1.00 29.77 ATOM 1374 C PRO 171 5.652 7.816 11.610 1.00 31.30 ATOM 1375 O PRO 171 6.520 8.259 12.371 1.00 28.88 ATOM 1376 N ARG 172 4.838 6.815 11.940 1.00 31.06 ATOM 1377 CA ARG 172 4.915 6.153 13.240 1.00 32.55 ATOM 1378 CB ARG 172 3.916 4.992 13.299 1.00 36.17 ATOM 1379 CG ARG 172 2.639 5.296 14.065 1.00 42.42 ATOM 1380 CD ARG 172 2.802 4.986 15.561 1.00 49.54 ATOM 1381 ME ARG 172 3.861 5.774 16.202 1.00 53.35 ATOM 1382 CZ ARG 172 4.305 5.573 17.443 1.00 55.25 ATOM 1383 NH1 ARG 172 3.788 4.604 18.192 1.00 56.19 ATOM 1384 NH2 ARG 172 5.268 6.342 17.941 1.00 56.24 ATOM 1385 C ARG 172 6.319 5.637 13.552 1.00 31.45 ATOM 1386 O ARG 172 6.764 5.702 14.702 1.00 30.68 ATOM 1387 N LYS 173 7.010 5.117 12.540 1.00 29.22 ATOM 1388 CA LYS 173 8.363 4.615 12.743 1.00 29.66 ATOM 1389 CB LYS 173 6.861 3.870 11.503 1.00 32.78 ATOM 1390 CG LYS 173 8.200 2.513 11.305 1.00 37.00 ATOM 1391 CD LYS 173 8.782 1.776 10.116 1.00 39.09 ATOM 1392 CE LYS 173 8.072 0.449 9.888 1.00 41.03 ATOM 1393 NZ LYS 173 8.678 −0.294 8.745 1.00 43.13 ATOM 1394 C LYS 173 9.300 5.768 13.076 1.00 28.29 ATOM 1395 O LYS 173 10.207 5.625 13.894 1.00 26.75 ATOM 1396 N VAL 174 9.082 6.913 12.441 1.00 26.90 ATOM 1397 CA VAL 174 9.903 8.085 12.713 1.00 25.57 ATOM 1398 CB VAL 174 9.616 9.215 11.709 1.00 23.33 ATOM 1399 CG1 VAL 174 10.401 10.474 12.096 1.00 20.63 ATOM 1400 CG2 VAL 174 9.999 8.758 10.303 1.00 22.21 ATOM 1401 C VAL 174 9.587 8.575 14.122 1.00 26.24 ATOM 1402 O VAL 174 10.484 8.917 14.889 1.00 24.66 ATOM 1403 N GLN 175 8.303 8.603 14.458 1.00 27.11 ATOM 1404 CA GLN 175 7.869 9.040 15.779 1.00 28.66 ATOM 1405 CB GLN 175 6.339 8.967 15.878 1.00 31.02 ATOM 1406 CG GLN 175 5.779 9.114 17.286 1.00 38.22 ATOM 1407 CD GLN 175 4.257 9.212 17.301 1.00 42.67 ATOM 1408 OE1 GLN 175 3.570 8.514 16.550 1.00 45.50 ATOM 1409 NE2 GLN 175 3.723 10.073 18.164 1.00 43.62 ATOM 1410 C GLN 175 8.500 8.188 16.875 1.00 28.75 ATOM 1411 O GLN 175 8.945 8.712 17.901 1.00 26.15 ATOM 1412 N LYS 176 8.541 6.876 16.654 1.00 28.86 ATOM 1413 CA LYS 176 9.107 5.956 17.636 1.00 28.72 ATOM 1414 CB LYS 176 8.919 4.505 17.183 1.00 31.92 ATOM 1415 CG LYS 176 7.473 4.016 17.228 1.00 34.30 ATOM 1416 CD LYS 176 7.364 2.603 16.658 1.00 37.65 ATOM 1417 CE LYS 176 5.916 2.139 16.565 1.00 40.91 ATOM 1418 HZ LYS 176 5.250 2.029 17.897 1.00 43.69 ATOM 1419 C LYS 176 10.584 6.223 17.897 1.00 28.09 ATOM 1420 O LYS 176 11.030 6.193 19.046 1.00 26.98 ATOM 1421 N LEU 177 11.343 6.483 16.836 1.00 26.02 ATOM 1422 CA LEU 177 12.765 6.759 16.994 1.00 25.81 ATOM 1423 CB LEU 177 13.484 6.723 15.635 1.00 24.35 ATOM 1424 CG LEU 177 14.977 7.090 15.579 1.00 22.01 ATOM 1425 CD1 LEU 177 15.766 6.331 16.644 1.00 22.19 ATOM 1426 CD2 LEU 177 15.518 6.775 14.192 1.00 21.74 ATOM 1427 C LEU 177 12.968 8.114 17.662 1.00 26.28 ATOM 1428 O LEU 177 13.832 8.258 18.531 1.00 25.96 ATOM 1429 N GLN 178 12.173 9.107 17.272 1.00 25.47 ATOM 1430 CA GLN 178 12.321 10.429 17.860 1.00 25.14 ATOM 1431 CB GLN 178 11.416 11.457 17.182 1.00 24.25 ATOM 1432 CG GLN 178 11.846 12.882 17.499 1.00 23.94 ATOM 1433 CD GLN 175 10.909 13.935 17.145 1.00 25.80 ATOM 1434 OE1 GLN 178 11.140 14.977 16.579 1.00 26.74 ATOM 1435 NE2 GLN 178 9.559 13.683 17.498 1.00 22.56 ATOM 1436 C GLN 178 12.018 10.428 19.357 1.00 26.38 ATOM 1437 O GLN 178 12.634 11.181 20.117 1.00 25.08 ATOM 1438 N GLU 179 11.068 9.599 19.785 1.00 26.53 ATOM 1439 CA GLU 179 10.722 9.544 21.205 1.00 28.84 ATOM 1440 CB GLU 179 9.459 8.701 21.434 1.00 31.20 ATOM 1441 CG GLU 179 8.231 9.239 20.723 1.00 36.58 ATOM 1442 CD GLU 179 6.954 8.494 21.087 1.00 41.47 ATOM 1443 OE1 GLU 179 5.955 8.650 20.353 1.00 43.13 ATOM 1444 OE2 GLU 179 6.948 7.763 22.104 1.00 43.96 ATOM 1445 C GLU 179 11.880 8.974 22.015 1.00 26.71 ATOM 1446 O GLU 179 12.134 9.414 23.136 1.00 26.95 ATOM 1447 N LYS 180 12.577 7.993 21.451 1.00 25.60 ATOM 1448 CA LYS 180 13.710 7.394 22.141 1.00 25.20 ATOM 1449 CB LYS 180 14.201 6.153 21.391 1.00 26.31 ATOM 1450 CG LYS 180 13.223 4.981 21.476 1.00 26.70 ATOM 1451 CD LYS 180 13.546 3.909 20.452 1.00 26.50 ATOM 1452 CE LYS 180 12.394 2.906 20.308 1.00 26.04 ATOM 1453 NZ LYS 180 12.689 1.913 19.246 1.00 24.63 ATOM 1454 C LYS 180 14.811 8.434 22.237 1.00 25.02 ATOM 1455 O LYS 180 15.505 8.520 23.244 1.00 23.42 ATOM 1456 N ILE 181 14.955 9.242 21.189 1.00 25.84 ATOM 1457 CA ILE 181 15.969 10.291 21.179 1.00 23.07 ATOM 1458 CB ILE 181 16.073 10.948 19.784 1.00 22.59 ATOM 1459 CG2 ILE 181 16.997 12.160 19.837 1.00 21.40 ATOM 1460 CG1 ILE 181 16.612 9.926 18.773 1.00 22.13 ATOM 1461 CD1 ILE 181 16.648 10.429 17.343 1.00 20.82 ATOM 1462 C ILE 181 15.659 11.359 22.233 1.00 24.68 ATOM 1463 O ILE 181 16.544 11.768 22.988 1.00 24.27 ATOM 1464 N TYR 182 14.406 11.803 22.292 1.00 24.89 ATOM 1465 CA TYR 182 14.010 12.821 23.263 1.00 25.67 ATOM 1466 CB TYR 182 12.563 13.254 23.019 1.00 27.04 ATOM 1467 CG TYR 182 12.440 14.408 22.052 1.00 28.95 ATOM 1468 CD1 TYR 182 11.386 14.474 21.145 1.00 29.65 ATOM 1469 CE1 TYR 182 11.270 15.540 20.250 1.00 28.75 ATOM 1470 CD2 TYR 182 13.376 15.437 22.049 1.00 28.12 ATOM 1471 CE2 TYR 182 13.271 16.506 21.165 1.00 30.56 ATOM 1472 CZ TYR 182 12.216 16.550 20.266 1.00 28.99 ATOM 1473 OH TYR 182 12.119 17.595 19.381 1.00 29.53 ATOM 1474 C TYR 182 14.166 12.328 24.695 1.00 26.66 ATOM 1475 O TYR 182 14.539 13.093 25.586 1.00 26.29 ATOM 1476 N PHE 183 13.879 11.050 24.910 1.00 26.50 ATOM 1477 CA PHE 183 14.008 10.457 26.232 1.00 29.79 ATOM 1478 CB PHE 183 13.388 9.057 26.249 1.00 34.77 ATOM 1479 CG PHE 183 11.913 9.045 26.597 1.00 44.65 ATOM 1480 CD1 PHE 183 11.105 7.963 26.237 1.00 48.06 ATOM 1481 CD2 PHE 183 11.337 10.097 27.321 1.00 47.29 ATOM 1482 CE1 PHE 183 9.739 7.929 26.592 1.00 49.51 ATOM 1483 CE2 PHE 183 9.976 10.071 27.681 1.00 48.55 ATOM 1484 CZ PHE 183 9.179 8.985 27.315 1.00 48.81 ATOM 1485 C PHE 183 15.483 10.397 26.619 1.00 28.13 ATOM 1486 O PHE 183 15.826 10.610 27.771 1.00 27.21 ATOM 1487 N ALA 184 16.351 10.117 25.650 1.00 28.03 ATOM 1488 CA ALA 184 17.785 10.060 25.907 1.00 26.92 ATOM 1489 CB ALA 184 18.519 9.527 24.684 1.00 26.34 ATOM 1490 C ALA 184 18.291 11.460 26.240 1.00 25.39 ATOM 1491 O ALA 184 19.044 11.658 27.196 1.00 25.22 ATOM 1492 N LEU 185 17.862 12.429 25.441 1.00 24.98 ATOM 1493 CA LEU 185 18.268 13.816 25.620 1.00 24.30 ATOM 1494 CB LEU 185 17.704 14.671 24.488 1.00 24.30 ATOM 1495 CG LEU 185 17.940 16.182 24.573 1.00 24.55 ATOM 1496 CD1 LEU 185 19.449 16.479 24.607 1.00 21.33 ATOM 1497 CD2 LEU 185 17.283 16.860 23.367 1.00 22.54 ATOM 1498 C LEU 185 17.821 14.392 26.957 1.00 24.99 ATOM 1499 O LEU 185 18.537 15.178 27.569 1.00 24.67 ATOM 1500 N GLN 186 16.631 14.011 27.400 1.00 25.81 ATOM 1501 CA GLN 186 16.103 14.506 28.660 1.00 26.62 ATOM 1502 CB GLN 186 14.694 13.966 28.876 1.00 30.90 ATOM 1503 CG GLN 186 13.997 14.508 30.094 1.00 36.75 ATOM 1504 CD GLN 186 12.629 13.896 30.263 1.00 43.23 ATOM 1505 OE1 GLN 186 12.491 12.666 30.304 1.00 46.44 ATOM 1506 NE2 GLN 186 11.602 14.744 30.354 1.00 43.40 ATOM 1507 C GLN 186 17.006 14.073 29.807 1.00 27.38 ATOM 1508 O GLN 186 17.212 14.824 30.762 1.00 27.01 ATOM 1509 N HIS 187 17.544 12.860 29.715 1.00 27.90 ATOM 1510 CA HIS 187 18.433 12.356 30.756 1.00 27.79 ATOM 1511 CB HIS 187 18.610 10.846 30.604 1.00 28.15 ATOM 1512 CG HIS 187 17.409 10.064 31.028 1.00 29.94 ATOM 1513 CD2 HIS 187 16.329 9.642 30.330 1.00 31.20 ATOM 1514 ND1 HIS 187 17.185 9.695 32.337 1.00 32.49 ATOM 1515 CE1 HIS 187 16.019 9.083 32.428 1.00 30.69 ATOM 1516 NE2 HIS 187 15.478 9.038 31.225 1.00 32.71 ATOM 1517 C HIS 187 19.785 13.066 30.724 1.00 27.63 ATOM 1518 O HIS 187 20.312 13.450 31.771 1.00 25.57 ATOM 1519 N VAL 188 20.337 13.251 29.526 1.00 27.19 ATOM 1520 CA VAL 188 21.623 13.932 29.371 1.00 26.76 ATOM 1521 CB VAL 188 22.032 14.045 27.876 1.00 27.81 ATOM 1522 CG1 VAL 188 23.281 14.923 27.734 1.00 25.30 ATOM 1523 CG2 VAL 188 22.283 12.657 27.301 1.00 26.52 ATOM 1524 C VAL 188 21.545 15.341 29.954 1.00 27.08 ATOM 1525 O VAL 188 22.460 15.801 30.639 1.00 27.95 ATOM 1526 N ILE 189 20.444 16.023 29.675 1.00 26.81 ATOM 1527 CA ILE 189 20.243 17.382 30.156 1.00 28.56 ATOM 1528 CB ILE 189 18.865 17.902 29.700 1.00 27.38 ATOM 1529 CG2 ILE 189 18.428 19.099 30.549 1.00 27.87 ATOM 1530 CG1 ILE 189 18.940 18.263 28.213 1.00 25.31 ATOM 1531 CD1 ILE 189 17.612 18.583 27.585 1.00 23.03 ATOM 1532 C ILE 189 20.381 17.482 31.675 1.00 29.59 ATOM 1533 O ILE 189 20.810 18.504 32.205 1.00 28.17 ATOM 1534 N GLN 190 20.025 16.413 32.374 1.00 31.73 ATOM 1535 CA GLN 190 20.130 16.401 33.824 1.00 34.66 ATOM 1536 CB GLN 190 19.517 15.115 34.383 1.00 35.71 ATOM 1537 CG GLN 190 18.181 14.749 33.767 1.00 36.32 ATOM 1538 CD GLN 190 17.525 13.575 34.469 1.00 37.87 ATOM 1539 OE1 GLN 190 18.207 12.705 35.008 1.00 37.94 ATOM 1540 NE2 GLN 190 16.195 13.537 34.453 1.00 37.69 ATOM 1541 C GLN 190 21.589 16.522 34.282 1.00 36.42 ATOM 1542 O GLN 190 21.864 17.088 35.341 1.00 37.31 ATOM 1543 N LYS 191 22.522 15.995 33.491 1.00 36.35 ATOM 1544 CA LYS 191 23.944 16.060 33.849 1.00 38.86 ATOM 1545 CB LYS 191 24.816 15.373 32.798 1.00 36.60 ATOM 1546 CG LYS 191 24.892 13.887 32.917 1.00 34.28 ATOM 1547 CD LYS 191 26.075 13.357 32.132 1.00 33.89 ATOM 1548 CE LYS 191 25.937 13.646 30.650 1.00 32.20 ATOM 1549 NZ LYS 191 27.090 13.103 29.891 1.00 33.09 ATOM 1550 C LYS 191 24.424 17.491 33.962 1.00 40.84 ATOM 1551 O LYS 191 25.233 17.835 34.822 1.00 40.86 ATOM 1552 N ASN 192 23.928 18.318 33.056 1.00 43.43 ATOM 1553 CA ASN 192 24.297 19.714 33.003 1.00 45.38 ATOM 1554 CB ASN 192 24.548 20.071 31.541 1.00 44.67 ATOM 1555 CG ASN 192 25.345 18.985 30.817 1.00 44.92 ATOM 1556 OD1 ASN 192 26.513 18.751 31.126 1.00 42.55 ATOM 1557 ND2 ASN 192 24.705 18.301 29.870 1.00 43.86 ATOM 1558 C ASN 192 23.151 20.518 33.607 1.00 47.90 ATOM 1559 O ASN 192 22.728 20.250 34.732 1.00 50.09 ATOM 1560 N HIS 193 22.653 21.490 32.859 1.00 48.81 ATOM 1561 CA HIS 193 21.548 22.351 33.281 1.00 51.29 ATOM 1562 CB HIS 193 20.616 22.551 32.091 1.00 49.68 ATOM 1563 CG HIS 193 21.321 22.468 30.777 1.00 49.19 ATOM 1564 CD2 HIS 193 21.274 21.535 29.798 1.00 47.56 ATOM 1565 ND1 HIS 193 22.270 23.387 30.387 1.00 47.61 ATOM 1566 CE1 HIS 193 22.780 23.022 29.224 1.00 48.67 ATOM 1567 NE2 HIS 193 22.193 21.901 28.846 1.00 47.30 ATOM 1568 C HIS 193 20.730 21.875 34.487 1.00 53.71 ATOM 1569 O HIS 193 19.715 21.195 34.328 1.00 53.57 ATOM 1570 N LEU 194 21.168 22.233 35.692 1.00 57.22 ATOM 1571 CA LEU 194 20.433 21.852 36.897 1.00 60.04 ATOM 1572 CB LEU 194 21.288 22.076 38.151 1.00 60.66 ATOM 1573 CG LEU 194 20.990 21.191 39.372 1.00 61.69 ATOM 1574 CD1 LEU 194 19.593 21.481 39.902 1.00 61.58 ATOM 1575 CD2 LEU 194 21.127 19.716 38.987 1.00 60.81 ATOM 1576 C LEU 194 19.240 22.797 36.874 1.00 61.24 ATOM 1577 O LEU 194 19.397 23.968 36.530 1.00 61.98 ATOM 1578 N ASP 195 18.059 22.304 37.242 1.00 62.55 ATOM 1579 CA ASP 195 16.846 23.119 37.178 1.00 63.43 ATOM 1580 CB ASP 195 17.019 24.440 37.937 1.00 66.10 ATOM 1581 CG ASP 195 16.716 24.303 39.424 1.00 67.60 ATOM 1582 OD1 ASP 195 17.314 23.423 40.082 1.00 67.56 ATOM 1583 OD2 ASP 195 15.875 25.076 39.934 1.00 68.82 ATOM 1584 C ASP 195 16.696 23.351 35.681 1.00 62.91 ATOM 1585 O ASP 195 17.481 24.071 35.062 1.00 62.29 ATOM 1586 N ASP 196 15.680 22.739 35.095 1.00 62.38 ATOM 1587 CA ASP 196 15.525 22.819 33.661 1.00 61.54 ATOM 1588 CB ASP 196 15.581 21.397 33.106 1.00 62.97 ATOM 1589 CG ASP 196 14.499 20.508 33.693 1.00 63.92 ATOM 1590 OD1 ASP 196 13.365 20.512 33.165 1.00 63.95 ATOM 1591 OD2 ASP 196 14.777 19.817 34.697 1.00 64.35 ATOM 1592 C ASP 196 14.350 23.545 33.028 1.00 60.76 ATOM 1593 O ASP 196 14.171 24.758 33.190 1.00 59.34 ATOM 1594 N GLU 197 13.572 22.747 32.298 1.00 58.84 ATOM 1595 CA GLU 197 12.429 23.157 31.434 1.00 57.17 ATOM 1596 CB GLU 197 11.960 24.576 31.830 1.00 59.78 ATOM 1597 CG GLU 197 10.901 25.109 30.876 1.00 63.41 ATOM 1598 CD GLU 197 10.666 26.601 31.023 1.00 66.17 ATOM 1599 OE1 GLU 197 9.831 27.144 30.268 1.00 67.86 ATOM 1600 OE2 GLU 197 11.313 27.231 31.888 1.00 68.19 ATOM 1601 C GLU 197 13.138 23.163 30.147 1.00 53.54 ATOM 1602 O GLU 197 12.537 23.364 29.092 1.00 54.00 ATOM 1603 N THR 198 14.446 22.924 30.229 1.00 48.95 ATOM 1604 CA THR 198 15.345 22.910 29.088 1.00 43.99 ATOM 1605 CB THR 198 16.731 22.376 29.499 1.00 43.60 ATOM 1606 OG1 THR 198 17.251 23.185 30.559 1.00 42.61 ATOM 1607 CG2 THR 198 17.699 22.422 28.318 1.00 43.36 ATOM 1608 C THR 198 14.842 22.125 27.889 1.00 39.98 ATOM 1609 O THR 198 14.772 22.665 26.790 1.00 39.06 ATOM 1610 N LEU 199 14.497 20.857 28.084 1.00 37.03 ATOM 1611 CA LEU 199 14.009 20.057 26.966 1.00 35.00 ATOM 1612 CB LEU 199 13.650 18.639 27.414 1.00 34.87 ATOM 1613 CG LEU 199 13.972 17.518 26.418 1.00 34.97 ATOM 1614 CD1 LEU 199 13.114 16.299 26.728 1.00 34.01 ATOM 1615 CD2 LEU 199 13.729 17.980 25.004 1.00 33.06 ATOM 1616 C LEU 199 12.774 20.725 26.362 1.00 33.27 ATOM 1617 O LEU 199 12.668 20.860 25.148 1.00 31.34 ATOM 1618 N ALA 200 11.849 21.147 27.219 1.00 32.76 ATOM 1619 CA ALA 200 10.625 21.804 26.763 1.00 33.19 ATOM 1620 CB ALA 200 9.706 22.120 27.963 1.00 32.22 ATOM 1621 C ALA 200 10.956 23.084 26.002 1.00 32.43 ATOM 1622 O ALA 200 10.341 23.380 24.977 1.00 31.79 ATOM 1623 N LYS 201 11.931 23.841 26.497 1.00 32.28 ATOM 1624 CA LYS 201 12.327 25.084 25.838 1.00 32.01 ATOM 1625 CB LYS 201 13.342 25.854 26.682 1.00 35.09 ATOM 1626 CG LYS 201 12.853 26.322 28.036 1.00 36.56 ATOM 1627 CD LYS 201 13.903 27.242 28.652 1.00 40.79 ATOM 1628 CE LYS 201 13.616 27.553 30.107 1.00 43.94 ATOM 1629 NZ LYS 201 14.677 28.430 30.671 1.00 47.03 ATOM 1630 C LYS 201 12.946 24.787 24.480 1.00 30.91 ATOM 1631 O LYS 201 12.775 25.552 23.531 1.00 30.11 ATOM 1632 N LEU 202 13.683 23.683 24.391 1.00 30.46 ATOM 1633 CA LEU 202 14.307 23.297 23.129 1.00 29.29 ATOM 1634 CB LEU 202 15.258 22.117 23.331 1.00 28.23 ATOM 1635 CG LEU 202 16.633 22.426 23.923 1.00 29.50 ATOM 1636 CD1 LEU 202 17.429 21.126 24.055 1.00 27.57 ATOM 1637 CD2 LEU 202 17.367 23.417 23.022 1.00 27.80 ATOM 1638 C LEU 202 13.224 22.906 22.138 1.00 28.85 ATOM 1639 O LEU 202 13.181 23.399 21.011 1.00 30.02 ATOM 1640 N ILE 203 12.348 22.011 22.567 1.00 28.20 ATOM 1641 CA ILE 203 11.261 21.552 21.722 1.00 29.72 ATOM 1642 CB ILE 203 10.370 20.553 22.498 1.00 30.66 ATOM 1643 CG2 ILE 203 9.101 20.248 21.709 1.00 31.62 ATOM 1644 CG1 ILE 203 11.165 19.271 22.774 1.00 33.22 ATOM 1645 CD1 ILE 203 10.477 18.296 23.714 1.00 33.21 ATOM 1646 C ILE 203 10.415 22.729 21.217 1.00 28.90 ATOM 1647 O ILE 203 9.962 22.734 20.073 1.00 26.56 ATOM 1648 N ALA 204 10.228 23.733 22.070 1.00 28.33 ATOM 1649 CA ALA 204 9.434 24.904 21.716 1.00 28.52 ATOM 1650 CB ALA 204 9.188 25.761 22.948 1.00 29.61 ATOM 1651 C ALA 204 10.076 25.754 20.629 1.00 29.35 ATOM 1652 O ALA 204 9.423 26.622 20.054 1.00 28.72 ATOM 1653 N LYS 205 11.354 25.520 20.351 1.00 27.27 ATOM 1654 CA LYS 205 12.039 26.293 19.326 1.00 27.82 ATOM 1655 CB LYS 205 13.525 26.443 19.674 1.00 28.06 ATOM 1656 CG LYS 205 13.779 27.246 20.941 1.00 31.35 ATOM 1657 CD LYS 205 15.270 27.343 21.249 1.00 32.78 ATOM 1658 CE LYS 205 15.505 27.938 22.624 1.00 36.42 ATOM 1659 NZ LYS 205 14.840 29.262 22.784 1.00 40.34 ATOM 1660 C LYS 205 11.894 25.657 17.945 1.00 27.11 ATOM 1661 O LYS 205 12.205 26.284 16.938 1.00 28.06 ATOM 1662 N ILE 206 11.417 24.418 17.897 1.00 27.34 ATOM 1663 CA ILE 206 11.256 23.725 16.621 1.00 28.94 ATOM 1664 CB ILE 206 10.453 22.417 16.794 1.00 29.50 ATOM 1665 CG2 ILE 206 10.159 21.801 15.429 1.00 31.00 ATOM 1666 CG1 ILE 206 11.214 21.447 17.703 1.00 28.15 ATOM 1667 CD1 ILE 206 12.423 20.830 17.088 1.00 28.61 ATOM 1668 C ILE 206 10.562 24.590 15.559 1.00 29.28 ATOM 1669 O ILE 206 11.094 24.783 14.462 1.00 30.10 ATOM 1670 N PRO 207 9.366 25.125 15.869 1.00 30.04 ATOM 1671 CD PRO 207 8.554 24.973 17.089 1.00 29.62 ATOM 1672 CA PRO 207 8.673 25.957 14.877 1.00 30.42 ATOM 1673 CB PRO 207 7.365 26.337 15.582 1.00 31.19 ATOM 1674 CG PRO 207 7.695 26.204 17.041 1.00 33.14 ATOM 1675 C PRO 207 9.480 27.165 14.417 1.00 29.62 ATOM 1676 O PRO 207 9.339 27.616 13.281 1.00 29.83 ATOM 1677 N THR 208 10.339 27.675 15.290 1.00 26.85 ATOM 1678 CA THR 208 11.162 28.819 14.935 1.00 28.12 ATOM 1679 CB THR 208 11.856 29.396 16.159 1.00 29.03 ATOM 1680 OG1 THR 208 10.864 29.918 17.052 1.00 31.90 ATOM 1681 CG2 THR 208 12.821 30.506 15.751 1.00 29.68 ATOM 1682 C THR 208 12.216 28.407 13.915 1.00 28.22 ATOM 1683 O THR 208 12.463 29.113 12.944 1.00 28.12 ATOM 1684 N ILE 209 12.830 27.252 14.142 1.00 26.44 ATOM 1685 CA ILE 209 13.850 26.746 13.240 1.00 25.22 ATOM 1686 CB ILE 209 14.375 25.383 13.732 1.00 23.83 ATOM 1687 CG2 ILE 209 15.308 24.776 12.693 1.00 23.71 ATOM 1688 CG1 ILE 209 15.079 25.568 15.081 1.00 21.30 ATOM 1689 CD1 ILE 209 15.644 24.294 15.685 1.00 21.88 ATOM 1690 C ILE 209 13.256 26.602 11.842 1.00 23.64 ATOM 1691 O ILE 209 13.884 26.965 10.847 1.00 24.10 ATOM 1692 N THR 210 12.035 26.083 11.781 1.00 23.76 ATOM 1693 CA THR 210 11.334 25.888 10.520 1.00 21.79 ATOM 1694 CB THR 210 10.047 25.064 10.737 1.00 22.51 ATOM 1695 OG1 THR 210 10.397 23.748 11.173 1.00 21.60 ATOM 1696 CG2 THR 210 9.248 24.958 9.448 1.00 24.33 ATOM 1697 C THR 210 10.974 27.202 9.825 1.00 22.08 ATOM 1698 O THR 210 11.033 27.289 8.603 1.00 22.39 ATOM 1699 N ALA 211 10.604 28.220 10.600 1.00 22.88 ATOM 1700 CA ALA 211 10.239 29.526 10.037 1.00 22.29 ATOM 1701 CB ALA 211 9.678 30.435 11.127 1.00 23.28 ATOM 1702 C ALA 211 11.451 30.186 9.384 1.00 23.47 ATOM 1703 O ALA 211 11.334 30.822 8.335 1.00 23.25 ATOM 1704 N VAL 212 12.617 30.045 10.006 1.00 22.80 ATOM 1705 CA VAL 212 13.824 30.627 9.433 1.00 23.37 ATOM 1706 CB VAL 212 15.049 30.433 10.353 1.00 23.62 ATOM 1707 CG1 VAL 212 16.298 30.998 9.684 1.00 22.67 ATOM 1708 CG2 VAL 212 14.811 31.125 11.682 1.00 24.14 ATOM 1709 C VAL 212 14.115 29.970 8.088 1.00 23.99 ATOM 1710 O VAL 212 14.409 30.649 7.106 1.00 25.86 ATOM 1711 N CYS 213 14.012 28.645 8.041 1.00 23.57 ATOM 1712 CA CYS 213 14.284 27.910 6.814 1.00 25.76 ATOM 1713 CB CYS 213 14.404 26.411 7.123 1.00 25.45 ATOM 1714 SG CYS 213 15.842 26.040 8.202 1.00 29.19 ATOM 1715 C CYS 213 13.259 28.167 5.704 1.00 27.48 ATOM 1716 O CYS 213 13.613 28.194 4.521 1.00 26.56 ATOM 1717 N ASN 214 11.994 28.358 6.063 1.00 28.96 ATOM 1718 CA ASN 214 10.998 28.640 5.031 1.00 30.22 ATOM 1719 CB ASN 214 9.573 28.612 5.592 1.00 32.61 ATOM 1720 CG ASK 214 9.129 27.218 5.987 1.00 34.72 ATOM 1721 OD1 ASN 214 9.481 26.237 5.337 1.00 35.64 ATOM 1722 ND2 ASN 214 8.335 27.128 7.043 1.00 36.05 ATOM 1723 C ASN 214 11.297 30.021 4.473 1.00 29.75 ATOM 1724 O ASN 214 11.165 30.260 3.275 1.00 30.40 ATOM 1725 N LEU 215 11.712 30.930 5.348 1.00 28.89 ATOM 1726 CA LEU 215 12.033 32.278 4.909 1.00 27.73 ATOM 1727 CB LEU 215 12.411 33.151 6.104 1.00 26.66 ATOM 1728 CG LEU 215 12.531 34.649 5.816 1.00 28.15 ATOM 1729 CD1 LEU 215 11.296 35.147 5.064 1.00 29.37 ATOM 1730 CD2 LEU 215 12.699 35.393 7.124 1.00 29.37 ATOM 1731 C LEU 215 13.179 32.197 3.904 1.00 27.61 ATOM 1732 O LEU 215 13.206 32.939 2.918 1.00 27.88 ATOM 1733 N HIS 216 14.119 31.284 4.150 1.00 26.67 ATOM 1734 CA HIS 216 15.246 31.081 3.244 1.00 25.98 ATOM 1735 CB HIS 216 16.177 29.982 3.777 1.00 26.15 ATOM 1736 CG HIS 216 17.116 29.420 2.748 1.00 25.88 ATOM 1737 CD2 HIS 216 18.361 29.799 2.372 1.00 25.25 ATOM 1736 ND1 HIS 216 16.785 28.351 1.942 1.00 27.09 ATOM 1739 CE1 HIS 216 17.784 28.098 1.115 1.00 26.92 ATOM 1740 NE2 HIS 216 18.753 28.964 1.355 1.00 24.89 ATOM 1741 C HIS 216 14.692 30.674 1.884 1.00 26.04 ATOM 1742 O HIS 216 15.052 31.247 0.860 1.00 26.79 ATOM 1743 N GLY 217 13.810 29.681 1.885 1.00 26.73 ATOM 1744 CA GLY 217 13.220 29.223 0.641 1.00 28.62 ATOM 1745 C GLY 217 12.537 30.359 −0.096 1.00 30.50 ATOM 1746 O GLY 217 12.648 30.471 −1.314 1.00 30.23 ATOM 1747 N GLU 218 11.829 31.209 0.644 1.00 33.00 ATOM 1748 CA GLU 218 11.128 32.344 0.050 1.00 34.40 ATOM 1749 CB GLU 218 10.279 33.050 1.110 1.00 37.30 ATOM 1750 CG GLU 218 9.078 32.243 1.568 1.00 43.62 ATOM 1751 CD GLU 218 8.375 32.862 2.765 1.00 48.13 ATOM 1752 OE1 GLU 218 8.082 34.077 2.718 1.00 50.14 ATOM 1753 OE2 GLU 218 8.108 32.131 3.750 1.00 50.72 ATOM 1754 C GLU 218 12.092 33.338 −0.596 1.00 33.43 ATOM 1755 O GLU 218 11.906 33.735 −1.735 1.00 33.17 ATOM 1756 N LYS 219 13.120 33.742 0.151 1.00 33.47 ATOM 1757 CA LYS 219 14.100 34.686 −0.368 1.00 33.64 ATOM 1758 CB LYS 219 15.188 34.972 0.677 1.00 33.37 ATOM 1759 CG LYS 219 14.707 35.722 1.911 1.00 34.09 ATOM 1760 CD LYS 219 14.125 37.076 1.537 1.00 35.69 ATOM 1761 CE LYS 219 13.682 37.852 2.765 1.00 39.13 ATOM 1762 NZ LYS 219 13.047 39.158 2.399 1.00 40.00 ATOM 1763 C LYS 219 14.745 34.118 −1.625 1.00 35.52 ATOM 1764 O LYS 219 15.051 34.847 −2.573 1.00 34.96 ATOM 1765 N LEU 220 14.950 32.807 −1.626 1.00 35.22 ATOM 1766 CA LEU 220 15.566 32.138 −2.759 1.00 36.55 ATOM 1767 CB LEU 220 15.877 30.690 −2.389 1.00 37.39 ATOM 1768 CG LEU 220 16.647 29.830 −3.383 1.00 38.60 ATOM 1769 CD1 LEU 220 17.945 30.519 −3.792 1.00 38.29 ATOM 1770 CD2 LEU 220 16.936 28.489 −2.729 1.00 39.42 ATOM 1771 C LEU 220 14.652 32.166 −3.979 1.00 37.19 ATOM 1772 O LEU 220 15.102 32.465 −5.086 1.00 37.42 ATOM 1773 N GLN 221 13.369 31.916 −3.773 1.00 38.14 ATOM 1774 CA GLN 221 12.409 31.930 −4.870 1.00 39.61 ATOM 1775 CB GLN 221 11.002 31.632 −4.350 1.00 43.16 ATOM 1776 CG GLN 221 10.849 30.214 −3.829 1.00 47.61 ATOM 1777 CD GLN 221 11.363 29.177 −4.820 1.00 51.15 ATOM 1778 OE1 GLN 221 10.772 28.966 −5.881 1.00 52.70 ATOM 1779 NE2 GLN 221 12.480 28.534 −4.479 1.00 51.82 ATOM 1780 C GLN 221 12.420 33.261 −5.607 1.00 38.21 ATOM 1781 O GLN 221 12.365 33.296 −6.835 1.00 37.75 ATOM 1782 N VAL 222 12.497 34.354 −4.857 1.00 36.97 ATOM 1783 CA VAL 222 12.529 35.676 −5.467 1.00 37.21 ATOM 1784 CB VAL 222 12.377 36.795 −4.411 1.00 36.85 ATOM 1785 CG1 VAL 222 12.444 38.154 −5.086 1.00 37.24 ATOM 1786 CG2 VAL 222 11.050 36.645 −3.678 1.00 37.77 ATOM 1787 C VAL 222 13.846 35.867 −6.217 1.00 37.47 ATOM 1788 O VAL 222 13.869 36.424 −7.316 1.00 37.13 ATOM 1789 N PHE 223 14.943 35.400 −5.624 1.00 37.83 ATOM 1790 CA PHE 223 16.248 35.521 −6.268 1.00 39.20 ATOM 1791 CB PHE 223 17.349 34.906 −5.392 1.00 37.95 ATOM 1792 CG PHE 223 18.731 35.023 −5.984 1.00 39.28 ATOM 1793 CD1 PHE 223 19.405 36.238 −5.975 1.00 39.67 ATOM 1794 CD2 PHE 223 19.339 33.927 −6.589 1.00 39.69 ATOM 1795 CE1 PHE 223 20.666 36.362 −6.565 1.00 41.73 ATOM 1796 CE2 PHE 223 20.600 34.042 −7.180 1.00 40.32 ATOM 1797 CZ PHE 223 21.262 35.263 −7.168 1.00 39.45 ATOM 1798 C PHE 223 16.201 34.789 −7.612 1.00 40.64 ATOM 1799 O PHE 223 16.767 35.249 −8.603 1.00 40.48 ATOM 1800 N LYS 224 15.520 33.647 −7.634 1.00 42.33 ATOM 1801 CA LYS 224 15.399 32.857 −8.851 1.00 45.23 ATOM 1802 CB LYS 224 14.629 31.560 −8.571 1.00 47.13 ATOM 1803 CG LYS 224 14.588 30.593 −9.749 1.00 50.45 ATOM 1804 CD LYS 224 13.866 29.303 −9.383 1.00 52.28 ATOM 1805 CE LYS 224 13.785 28.351 −10.572 1.00 54.02 ATOM 1806 NZ LYS 224 13.051 27.088 −10.246 1.00 54.04 ATOM 1807 C LYS 224 14.688 33.677 −9.925 1.00 45.85 ATOM 1808 O LYS 224 14.990 33.545 −11.108 1.00 45.85 ATOM 1809 N GLN 225 13.748 34.525 −9.509 1.00 47.18 ATOM 1810 CA GLN 225 13.020 35.378 −10.448 1.00 48.45 ATOM 1811 CB GLN 225 11.936 36.196 −9.732 1.00 49.96 ATOM 1812 CG GLN 225 10.784 35.397 −9.136 1.00 51.68 ATOM 1813 CD GLN 225 9.678 36.298 −8.600 1.00 53.23 ATOM 1814 OE1 GLN 225 9.911 37.141 −7.732 1.00 52.56 ATOM 1815 NE2 GLN 225 8.470 36.127 −9.123 1.00 53.37 ATOM 1816 C GLN 225 13.990 36.352 −11.106 1.00 47.94 ATOM 1817 O GLN 225 14.094 36.417 −12.331 1.00 48.26 ATOM 1818 N SER 226 14.698 37.107 −10.272 1.00 48.06 ATOM 1819 CA SER 226 15.658 38.104 −10.731 1.00 47.80 ATOM 1820 CB SER 226 16.139 38.940 −9.542 1.00 47.91 ATOM 1821 OG SER 226 15.055 39.594 −8.906 1.00 49.47 ATOM 1822 C SER 226 16.871 37.533 −11.467 1.00 47.59 ATOM 1823 O SER 226 17.314 38.099 −12.464 1.00 46.97 ATOM 1824 N HIS 227 17.414 36.422 −10.979 1.00 47.93 ATOM 1825 CA HIS 227 18.586 35.827 −11.614 1.00 47.70 ATOM 1826 CB HIS 227 19.831 36.103 −10.769 1.00 48.42 ATOM 1827 CG HIS 227 19.920 37.513 −10.273 1.00 48.29 ATOM 1828 CD2 HIS 227 20.711 38.543 −10.651 1.00 48.92 ATOM 1829 ND1 HIS 227 19.120 37.996 −9.260 1.00 48.46 ATOM 1830 CE1 HIS 227 19.418 39.263 −9.033 1.00 49.03 ATOM 1831 NE2 HIS 227 20.381 39.620 −9.864 1.00 50.21 ATOM 1832 C HIS 227 18.439 34.324 −11.826 1.00 48.58 ATOM 1833 O HIS 227 19.133 33.523 −11.189 1.00 47.32 ATOM 1834 N PRO 228 17.543 33.921 −12.741 1.00 48.73 ATOM 1835 CD PRO 228 16.807 34.782 −13.684 1.00 49.28 ATOM 1836 CA PRO 228− 17.303 32.504 −13.039 1.00 50.04 ATOM 1837 CB PRO 228 16.245 32.563 −14.143 1.00 49.26 ATOM 1838 CG PRO 228 16.574 33.846 −14.849 1.00 48.18 ATOM 1839 C PRO 228 16.554 31.735 −13.471 1.00 50.55 ATOM 1840 O PRO 228 18.823 30.641 −12.974 1.00 49.03 ATOM 1841 N ASP 229 19.317 32.315 −14.392 1.00 51.87 ATOM 1842 CA ASP 229 20.525 31.674 −14.901 1.00 53.58 ATOM 1843 CB ASP 229 21.177 32.564 −15.964 1.00 55.87 ATOM 1844 CG ASP 229 22.285 31.852 −16.723 1.00 58.49 ATOM 1845 OD1 ASP 229 22.014 30.790 −17.328 1.00 58.29 ATOM 1846 OD2 ASP 229 23.429 32.356 −16.719 1.00 61.04 ATOM 1847 C ASP 229 21.543 31.343 −13.806 1.00 53.73 ATOM 1848 O ASP 229 22.073 30.232 −13.765 1.00 53.65 ATOM 1849 N ILE 230 21.817 32.304 −12.925 1.00 52.95 ATOM 1850 CA ILE 230 22.776 32.094 −11.838 1.00 52.12 ATOM 1851 CB ILE 230 22.850 33.326 −10.891 1.00 52.89 ATOM 1852 CG2 ILE 230 23.663 32.984 −9.644 1.00 51.95 ATOM 1853 CG1 ILE 230 23.479 34.520 −11.616 1.00 53.24 ATOM 1854 CD1 ILE 230 22.607 35.126 −12.699 1.00 55.39 ATOM 1855 C ILE 230 22.405 30.868 −11.002 1.00 51.37 ATOM 1856 O ILE 230 23.277 30.119 −10.553 1.00 50.26 ATOM 1857 N VAL 231 21.105 30.672 −10.803 1.00 49.90 ATOM 1858 CA VAL 231 20.601 29.554 −10.015 1.00 48.50 ATOM 1859 CB VAL 231 19.103 29.753 −9.683 1.00 48.35 ATOM 1860 CG1 VAL 231 18.587 28.582 −8.857 1.00 47.45 ATOM 1861 CG2 VAL 231 18.908 31.063 −8.933 1.00 48.33 ATOM 1862 C VAL 231 20.769 28.200 −10.701 1.00 48.45 ATOM 1863 O VAL 231 21.269 27.245 −10.105 1.00 46.75 ATOM 1864 N ASN 232 20.353 28.124 −11.959 1.00 48.93 ATOM 1865 CA ASN 232 20.432 26.880 −12.708 1.00 49.80 ATOM 1866 CB ASN 232 19.459 26.920 −13.889 1.00 53.19 ATOM 1867 CG ASN 232 18.019 27.092 −13.448 1.00 56.24 ATOM 1868 OD1 ASN 232 17.513 26.322 −12.630 1.00 57.63 ATOM 1869 ND2 ASN 232 17.347 28.105 −13.991 1.00 57.88 ATOM 1870 C ASN 232 21.816 26.527 −13.222 1.00 48.52 ATOM 1871 O ASN 232 22.077 25.366 −13.534 1.00 48.20 ATOM 1872 N THR 233 22.710 27.508 −13.300 1.00 47.20 ATOM 1873 CA THR 233 24.042 27.241 −13.831 1.00 46.67 ATOM 1874 CB THR 233 24.295 28.057 −15.122 1.00 46.77 ATOM 1875 OG1 THR 233 24.612 29.414 −14.787 1.00 47.29 ATOM 1876 CG2 THR 233 23.055 28.045 −16.001 1.00 46.89 ATOM 1877 C THR 233 25.209 27.492 −12.887 1.00 45.74 ATOM 1878 O THR 233 26.313 26.999 −13.121 1.00 46.15 ATOM 1879 N LEU 234 24.987 28.256 −11.825 1.00 44.27 ATOM 1880 CA LEU 234 26.078 28.536 −10.906 1.00 42.05 ATOM 1881 CB LEU 234 26.278 30.049 −10.789 1.00 43.57 ATOM 1882 CG LEU 234 26.870 30.673 −12.058 1.00 44.97 ATOM 1883 CD1 LEU 234 26.979 32.180 −11.909 1.00 46.57 ATOM 1884 CD2 LEU 234 28.240 30.068 −12.318 1.00 45.46 ATOM 1885 C LEU 234 25.950 27.899 −9.523 1.00 40.08 ATOM 1886 O LEU 234 26.941 27.410 −8.978 1.00 41.11 ATOM 1887 N PHE 235 24.745 27.889 −8.960 1.00 36.54 ATOM 1888 CA PHE 235 24.535 27.295 −7.637 1.00 33.39 ATOM 1889 CB PHE 235 23.080 27.480 −7.190 1.00 33.46 ATOM 1890 CG PHE 235 22.786 28.827 −6.591 1.00 31.78 ATOM 1891 CD1 PHE 235 23.700 29.867 −6.683 1.00 33.45 ATOM 1892 CD2 PHE 235 21.579 29.057 −5.942 1.00 33.88 ATOM 1893 CE1 PHE 235 23.416 31.120 −6.137 1.00 34.74 ATOM 1894 CE2 PHE 235 21.285 30.308 −5.393 1.00 33.31 ATOM 1895 CZ PHE 235 22.205 31.338 −5.492 1.00 33.08 ATOM 1896 C PHE 235 24.856 25.807 −7.651 1.00 30.87 ATOM 1897 O PHE 235 24.744 25.154 −8.687 1.00 29.90 ATOM 1898 N PRO 236 25.259 25.251 −6.498 1.00 29.01 ATOM 1899 CD PRO 236 25.543 25.924 −5.220 1.00 27.51 ATOM 1900 CA PRO 236 25.586 23.825 −6.408 1.00 28.71 ATOM 1901 CB PRO 236 25.967 23.652 −4.941 1.00 27.24 ATOM 1902 CG PRO 236 26.543 24.992 −4.598 1.00 28.61 ATOM 1903 C PRO 236 24.372 22.985 −6.788 1.00 29.15 ATOM 1904 O PRO 236 23.257 23.245 −6.336 1.00 27.23 ATOM 1905 N PRO 237 24.573 21.966 −7.630 1.00 29.03 ATOM 1906 CD PRO 237 25.811 21.603 −8.341 1.00 28.29 ATOM 1907 CA PRO 237 23.460 21.113 −8.047 1.00 29.54 ATOM 1908 CB PRO 237 24.166 19.971 −8.765 1.00 29.15 ATOM 1909 CG PRO 237 25.285 20.697 −9.457 1.00 30.03 ATOM 1910 C PRO 237 22.561 20.642 −6.898 1.00 30.20 ATOM 1911 O PRO 237 21.334 20.703 −7.011 1.00 28.77 ATOM 1912 N LEU 238 23.159 20.193 −5.795 1.00 29.38 ATOM 1913 CA LEU 238 22.371 19.720 −4.652 1.00 29.57 ATOM 1914 CB LEU 238 23.280 19.148 −3.558 1.00 28.08 ATOM 1915 CG LEU 238 22.562 18.712 −2.271 1.00 27.84 ATOM 1916 CD1 LEU 238 21.542 17.633 −2.597 1.00 28.16 ATOM 1917 CD2 LEU 238 23.573 18.196 −1.250 1.00 25.13 ATOM 1918 C LEU 238 21.504 20.828 −4.060 1.00 31.04 ATOM 1919 O LEU 238 20.385 20.579 −3.608 1.00 31.07 ATOM 1920 N TYR 239 22.022 22.051 −4.062 1.00 30.34 ATOM 1921 CA TYR 239 21.290 23.189 −3.524 1.00 31.47 ATOM 1922 CB TYR 239 22.196 24.419 −3.509 1.00 30.35 ATOM 1923 CG TYR 239 21.607 25.640 −2.836 1.00 29.41 ATOM 1924 CD1 TYR 239 20.775 26.513 −3.535 1.00 30.76 ATOM 1925 CE1 TYR 239 20.284 27.672 −2.934 1.00 30.38 ATOM 1926 CD2 TYR 239 21.926 25.950 −1.514 1.00 28.97 ATOM 1927 CE2 TYR 239 21.442 27.101 −0.904 1.00 30.43 ATOM 1928 CZ TYR 239 20.625 27.960 −1.624 1.00 30.74 ATOM 1929 OH TYR 239 20.177 29.117 −1.037 1.00 35.16 ATOM 1930 C TYR 239 20.056 23.442 −4.384 1.00 33.26 ATOM 1931 O TYR 239 18.969 23.714 −3.870 1.00 32.84 ATOM 1932 N LYS 240 20.223 23.348 −5.699 1.00 33.87 ATOM 1933 CA LYS 240 19.100 23.546 −6.605 1.00 35.74 ATOM 1934 CB LYS 240 19.580 23.506 −8.058 1.00 37.63 ATOM 1935 CG LYS 240 18.468 23.659 −9.083 1.00 43.97 ATOM 1936 CD LYS 240 19.026 23.682 −10.503 1.00 47.75 ATOM 1937 CE LYS 240 17.906 23.676 −11.535 1.00 51.07 ATOM 1938 NZ LYS 240 18.426 23.651 −12.941 1.00 52.39 ATOM 1939 C LYS 240 18.059 22.447 −6.370 1.00 35.10 ATOM 1940 O LYS 240 16.862 22.721 −6.270 1.00 35.12 ATOM 1941 N GLU 241 18.529 21.209 −6.259 1.00 33.16 ATOM 1942 CA GLU 241 17.657 20.060 −6.053 1.00 33.21 ATOM 1943 CB GLU 241 18.483 18.767 −6.055 1.00 33.06 ATOM 1944 CG GLU 241 17.684 17.505 −5.711 1.00 33.33 ATOM 1945 CD GLU 241 18.533 16.243 −5.731 1.00 32.45 ATOM 1946 OE1 GLU 241 19.105 15.919 −6.792 1.00 35.20 ATOM 1947 OE2 GLU 241 18.629 15.569 −4.687 1.00 33.93 ATOM 1948 C GLU 241 16.832 20.125 −4.776 1.00 33.04 ATOM 1949 O GLU 241 15.664 19.747 −4.771 1.00 34.27 ATOM 1950 N LEU 242 17.434 20.607 −3.695 1.00 33.22 ATOM 1951 CA LEU 242 16.740 20.682 −2.416 1.00 34.25 ATOM 1952 CB LEU 242 17.754 20.729 −1.271 1.00 32.75 ATOM 1953 CG LEU 242 18.705 19.539 −1.138 1.00 34.23 ATOM 1954 CD1 LEU 242 19.752 19.841 −0.083 1.00 35.05 ATOM 1955 CD2 LEU 242 17.926 18.292 −0.779 1.00 35.31 ATOM 1956 C LEU 242 15.782 21.853 −2.256 1.00 35.37 ATOM 1957 O LEU 242 14.755 21.721 −1.597 1.00 34.72 ATOM 1958 N PHE 243 16.113 22.992 −2.854 1.00 37.53 ATOM 1959 CA PHE 243 15.286 24.182 −2.710 1.00 41.05 ATOM 1960 CB PHE 243 16.129 25.297 −2.090 1.00 38.64 ATOM 1961 CG PHE 243 16.939 24.850 −0.897 1.00 37.15 ATOM 1962 CD1 PHE 243 18.329 24.797 −0.962 1.00 34.33 ATOM 1963 CD2 PHE 243 16.309 24.446 0.277 1.00 34.27 ATOM 1964 CE1 PHE 243 19.082 24.346 0.123 1.00 34.36 ATOM 1965 CE2 PHE 243 17.051 23.992 1.369 1.00 36.44 ATOM 1966 CZ PHE 243 18.442 23.941 1.291 1.00 34.07 ATOM 1967 C PHE 243 14.594 24.690 −3.975 1.00 45.43 ATOM 1968 O PHE 243 14.154 25.842 −4.021 1.00 45.60 ATOM 1969 N ASN 244 14.496 23.835 −4.992 1.00 50.27 ATOM 1970 CA ASN 244 13.627 24.187 −6.248 1.00 54.32 ATOM 1971 CB ASN 244 14.845 24.575 −7.327 1.00 55.30 ATOM 1972 CG ASN 244 15.432 25.954 −7.105 1.00 58.57 ATOM 1973 OD1 ASN 244 14.720 26.961 −7.151 1.00 59.86 ATOM 1974 ND2 ASN 244 16.737 26.010 −6.861 1.00 60.33 ATOM 1975 C ASN 244 12.977 23.028 −6.749 1.00 55.97 ATOM 1976 O ASN 244 11.823 23.215 −7.137 1.00 58.40 ATOM 1977 N HIS 691 15.075 13.032 −6.848 1.00 41.98 ATOM 1978 CA HIS 691 16.238 13.605 −6.167 1.00 42.61 ATOM 1979 CB HIS 691 15.999 13.671 −4.658 1.00 45.30 ATOM 1980 CG HIS 691 14.679 14.268 −4.285 1.00 47.14 ATOM 1981 CD2 HIS 691 14.328 15.542 −3.992 1.00 47.32 ATOM 1982 ND1 HIS 691 13.518 13.527 −4.227 1.00 48.40 ATOM 1983 CE1 HIS 691 12.509 14.318 −3.913 1.00 49.67 ATOM 1984 NE2 HIS 691 12.973 15.547 −3.765 1.00 50.69 ATOM 1985 C HIS 691 17.466 12.756 −6.442 1.00 41.10 ATOM 1986 O HIS 691 17.940 12.027 −5.570 1.00 39.31 ATOM 1987 N LYS 692 17.977 12.862 −7.661 1.00 40.46 ATOM 1988 CA LYS 692 19.136 12.092 −8.079 1.00 40.37 ATOM 1989 CB LYS 692 19.497 12.451 −9.523 1.00 42.93 ATOM 1990 CG LYS 692 20.567 11.554 −10.137 1.00 47.97 ATOM 1991 CD LYS 692 20.901 11.967 −11.569 1.00 51.10 ATOM 1992 CE LYS 692 21.771 10.913 −12.257 1.00 52.83 ATOM 1993 NZ LYS 692 23.026 10.630 −11.497 1.00 54.26 ATOM 1994 C LYS 692 20.354 12.299 −7.177 1.00 38.35 ATOM 1995 O LYS 692 20.951 11.336 −6.697 1.00 37.83 ATOM 1996 N ILE 693 20.714 13.553 −6.941 1.00 35.38 ATOM 1997 CA ILE 693 21.882 13.854 −6.122 1.00 35.12 ATOM 1998 CB ILE 693 22.166 15.363 −6.123 1.00 32.22 ATOM 1999 CG2 ILE 693 23.426 15.656 −5.328 1.00 33.60 ATOM 2000 CG1 ILE 693 22.336 15.844 −7.568 1.00 34.55 ATOM 2001 CD1 ILE 693 22.439 17.342 −7.716 1.00 32.01 ATOM 2002 C ILE 693 21.788 13.355 −4.678 1.00 33.70 ATOM 2003 O ILE 693 22.664 12.636 −4.205 1.00 31.97 ATOM 2004 N LEU 694 20.730 13.742 −3.978 1.00 33.87 ATOM 2005 CA LEU 694 20.560 13.328 −2.592 1.00 35.23 ATOM 2006 CB LEU 694 19.232 13.866 −2.050 1.00 36.03 ATOM 2007 CG LEU 694 18.964 13.754 −0.549 1.00 36.23 ATOM 2008 CD1 LEU 694 20.078 14.436 0.243 1.00 33.63 ATOM 2009 CD2 LEU 694 17.622 14.395 −0.241 1.00 34.69 ATOM 2010 C LEU 694 20.587 11.804 −2.520 1.00 35.61 ATOM 2011 O LEU 694 21.159 11.212 −1.602 1.00 33.23 ATOM 2012 N HIS 695 19.982 11.178 −3.520 1.00 36.63 ATOM 2013 CA HIS 695 19.913 9.729 −3.595 1.00 39.34 ATOM 2014 CB HIS 695 19.071 9.324 −4.805 1.00 43.87 ATOM 2015 CG HIS 695 18.316 8.049 −4.616 1.00 50.18 ATOM 2016 CD2 HIS 695 16.985 7.800 −4.582 1.00 51.51 ATOM 2017 ND1 HIS 695 18.939 6.831 −4.437 1.00 52.83 ATOM 2018 CE1 HIS 695 18.024 5.887 −4.305 1.00 52.75 ATOM 2019 NE2 HIS 695 16.830 6.448 −4.389 1.00 53.18 ATOM 2020 C HIS 695 21.317 9.153 −3.717 1.00 39.12 ATOM 2021 O HIS 695 21.658 8.158 −3.068 1.00 40.09 ATOM 2022 N ARG 696 22.139 9.784 −4.545 1.00 37.19 ATOM 2023 CA ARG 696 23.496 9.307 −4.730 1.00 36.26 ATOM 2024 CB ARG 696 24.199 10.085 −5.835 1.00 37.76 ATOM 2025 CG ARG 696 25.596 9.562 −6.085 1.00 39.24 ATOM 2026 CD ARG 696 26.427 10.510 −6.899 1.00 40.46 ATOM 2027 NE ARG 696 27.767 9.968 −7.097 1.00 43.23 ATOM 2028 CZ ARG 696 28.741 10.610 −7.730 1.00 44.16 ATOM 2029 NH1 ARG 696 28.520 11.823 −8.221 1.00 42.50 ATOM 2030 NH2 ARG 696 29.927 10.033 −7.884 1.00 43.92 ATOM 2031 C ARG 696 24.308 9.431 −3.447 1.00 34.63 ATOM 2032 O ARG 696 25.043 8.517 −3.081 1.00 32.87 ATOM 2033 N LEU 697 24.174 10.567 −2.769 1.00 32.92 ATOM 2034 CA LEU 697 24.918 10.800 −1.538 1.00 32.40 ATOM 2035 CB LEU 697 24.693 12.235 −1.047 1.00 29.94 ATOM 2036 CG LEU 697 25.210 13.332 −1.989 1.00 28.77 ATOM 2037 CD1 LEU 697 24.983 14.716 −1.377 1.00 27.97 ATOM 2038 CD2 LEU 697 26.686 13.116 −2.257 1.00 28.17 ATOM 2039 C LEU 697 24.567 9.793 −0.446 1.00 33.91 ATOM 2040 O LEU 697 25.447 9.321 0.282 1.00 33.09 ATOM 2041 N LEU 698 23.287 9.455 −0.338 1.00 35.43 ATOM 2042 CA LEU 698 22.836 8.494 0.662 1.00 39.05 ATOM 2043 CB LEU 698 21.317 8.332 0.605 1.00 36.77 ATOM 2044 CG LEU 698 20.470 9.189 1.534 1.00 35.45 ATOM 2045 CD1 LEU 698 19.002 8.875 1.295 1.00 33.66 ATOM 2046 CD2 LEU 698 20.857 8.902 2.977 1.00 34.33 ATOM 2047 C LEU 698 23.464 7.119 0.473 1.00 41.14 ATOM 2048 O LEU 698 23.649 6.374 1.434 1.00 41.09 ATOM 2049 N GLN 699 23.790 6.786 −0.769 1.00 44.86 ATOM 2050 CA GLN 699 24.355 5.478 −1.064 1.00 48.97 ATOM 2051 CB GLN 699 23.629 4.895 −2.278 1.00 50.91 ATOM 2052 CG GLN 699 22.142 5.248 −2.281 1.00 54.28 ATOM 2053 CD GLN 699 21.316 4.356 −3.180 1.00 56.50 ATOM 2054 OE1 GLN 699 21.080 3.187 −2.866 1.00 57.96 ATOM 2055 NE2 GLN 699 20.870 4.901 −4.309 1.00 57.46 ATOM 2056 C GLN 699 25.866 5.479 −1.285 1.00 49.73 ATOM 2057 O GLN 699 26.471 4.426 −1.486 1.00 50.77 ATOM 2058 N GLU 700 26.475 6.658 −1.237 1.00 50.70 ATOM 2059 CA GLU 700 27.917 6.773 −1.426 1.00 51.84 ATOM 2060 CB GLU 700 28.326 8.248 −1.470 1.00 52.07 ATOM 2061 CG GLU 700 29.708 8.509 −2.060 1.00 53.82 ATOM 2062 CD GLU 700 29.815 8.077 −3.516 1.00 53.97 ATOM 2063 OE1 GLU 700 28.904 8.404 −4.307 1.00 54.46 ATOM 2064 OE2 GLU 700 30.815 7.419 −3.871 1.00 55.26 ATOM 2065 C GLU 700 28.627 6.070 −0.269 1.00 52.20 ATOM 2066 O GLU 700 29.459 5.175 −0.527 1.00 52.35 ATOM 2067 OXT GLU 700 28.335 6.428 0.891 1.00 52.40 ATOM 2068 OH2 WAT 801 14.711 26.653 2.728 1.00 24.40 ATOM 2069 OH2 WAT 802 26.414 20.512 8.977 1.00 20.53 ATOM 2070 OH2 WAT 803 25.635 40.975 13.967 1.00 28.74 ATOM 2071 OH2 WAT 804 13.552 16.269 8.746 1.00 21.45 ATOM 2072 OH2 WAT 805 21.059 40.743 3.993 1.00 34.61 ATOM 2073 OH2 WAT 806 11.847 19.482 13.154 1.00 27.86 ATOM 2074 OH2 WAT 807 24.620 17.326 14.726 1.00 20.00 ATOM 2075 OH2 WAT 808 25.763 19.395 −5.509 1.00 24.65 ATOM 2076 OH2 WAT 809 27.566 41.817 2.053 1.00 34.09 ATOM 2077 OH2 WAT 810 1.729 8.907 4.075 1.00 31.53 ATOM 2078 OH2 WAT 811 7.205 27.241 11.662 1.00 35.98 ATOM 2079 OH2 WAT 812 23.647 26.541 23.470 1.00 28.06 ATOM 2080 OH2 WAT 613 14.409 33.457 14.799 1.00 33.72 ATOM 2081 OH2 WAT 814 13.065 3.124 16.758 1.00 28.22 ATOM 2082 OH2 WAT 815 30.885 19.043 2.598 1.00 33.40 ATOM 2083 OH2 WAT 816 36.157 39.234 1.950 1.00 43.36 ATOM 2084 OH2 WAT 817 12.139 22.822 7.031 1.00 30.28 ATOM 2085 OH2 WAT 818 3.298 4.825 10.176 1.00 23.53 ATOM 2086 OH2 WAT 819 1.704 13.633 4.812 1.00 22.44 ATOM 2087 OH2 WAT 820 4.214 13.018 8.864 1.00 29.86 ATOM 2088 OH2 WAT 821 0.762 10.736 7.722 1.00 36.08 ATOM 2089 OH2 WAT 822 0.166 11.985 3.762 1.00 37.47 ATOM 2090 OH2 WAT 823 31.803 41.991 11.509 1.00 38.01 ATOM 2091 OH2 WAT 825 29.323 24.136 13.813 1.00 31.41 ATOM 2092 OH2 WAT 832 15.159 19.303 30.516 1.00 39.31 ATOM 2093 OH2 WAT 835 3.146 11.579 6.786 1.00 34.28 ATOM 2094 OH2 WAT 836 8.412 22.351 12.154 1.00 37.30 ATOM 2095 OH2 WAT 837 14.427 24.078 4.226 1.00 33.47 ATOM 2096 OH2 WAT 839 2.395 4.154 7.605 1.00 29.06 ATOM 2097 OH2 WAT 840 26.537 16.496 27.832 1.00 31.09 ATOM 2098 OH2 WAT 841 8.106 20.585 7.958 1.00 33.63 ATOM 2099 OH2 WAT 842 11.326 3.463 14.716 1.00 31.28 ATOM 2100 OH2 WAT 843 14.267 3.376 12.820 1.00 30.09 ATOM 2101 OH2 WAT 844 12.746 22.210 13.480 1.00 53.73 ATOM 2102 OH2 WAT 846 34.204 40.570 11.521 1.00 54.26 ATOM 2103 OH2 WAT 847 9.625 5.990 8.120 1.00 29.28 ATOM 2104 OH2 WAT 848 9.201 31.722 7.032 1.00 45.91 ATOM 2105 OH2 WAT 849 12.004 24.958 5.330 1.00 32.20 ATOM 2106 OH2 WAT 850 37.886 45.476 1.031 1.00 31.54 ATOM 2107 OH2 WAT 851 31.059 28.266 8.430 1.00 44.76 ATOM 2108 OH2 WAT 852 19.435 16.697 −9.090 1.00 46.89 ATOM 2109 OH2 WAT 853 18.131 44.059 3.829 1.00 54.92 ATOM 2110 OH2 WAT 854 26.481 10.672 28.939 1.00 48.07 ATOM 2111 OH2 WAT 855 6.654 19.232 5.941 1.00 41.68 ATOM 2112 OH2 WAT 856 9.668 17.943 18.268 1.00 32.85 ATOM 2113 OH2 WAT 857 10.512 10.846 24.734 1.00 38.33 ATOM 2114 OH2 WAT 858 20.864 44.415 2.676 1.00 50.37 ATOM 2115 OH2 WAT 859 10.258 −0.353 5.697 1.00 56.40 ATOM 2116 OH2 WAT 860 2.560 9.064 21.518 1.00 69.57 ATOM 2117 OH2 WAT 861 33.537 17.935 17.817 1.00 38.63 ATOM 2118 OH2 WAT 862 7.370 24.146 6.448 1.00 36.09 ATOM 2119 OH2 WAT 863 30.158 20.333 25.058 1.00 30.28 ATOM 2120 OH2 WAT 865 30.909 40.546 −7.045 1.00 44.78 ATOM 2121 OH2 WAT 866 15.610 43.031 8.646 1.00 47.88 ATOM 2122 OH2 WAT 867 12.882 25.860 0.818 1.00 36.53 ATOM 2123 OH2 WAT 868 36.979 45.229 −7.650 1.00 75.27 ATOM 2124 OH2 WAT 869 9.261 19.297 12.679 1.00 36.84 ATOM 2125 OH2 WAT 870 15.360 22.134 6.145 1.00 36.08 ATOM 2126 OH2 WAT 871 23.204 42.943 6.553 1.00 55.50 ATOM 2127 OH2 WAT 873 24.254 39.737 21.553 1.00 69.04 ATOM 2128 OH2 WAT 874 20.154 35.236 −14.461 1.00 40.58 ATOM 2129 OH2 WAT 875 5.710 19.528 10.717 1.00 51.87 ATOM 2130 OH2 WAT 876 22.924 24.573 −10.275 1.00 59.21 ATOM 2131 OH2 WAT 877 12.716 26.906 −1.662 1.00 46.87 ATOM 2132 OH2 WAT 878 29.438 8.222 21.664 1.00 31.21 ATOM 2133 OH2 WAT 879 20.109 5.113 16.032 1.00 39.95 ATOM 2134 OH2 WAT 880 24.412 46.283 17.227 1.00 55.64 ATOM 2135 OH2 WAT 881 28.720 9.423 6.651 1.00 32.54 ATOM 2136 OH2 WAT 883 42.162 41.811 5.003 1.00 55.81 ATOM 2137 OH2 WAT 884 7.066 29.019 8.902 1.00 52.17 ATOM 2138 OH2 WAT 885 18.047 2.153 2.538 1.00 50.39 ATOM 2139 OH2 WAT 886 24.362 3.892 9.915 1.00 41.25 ATOM 2140 OH2 WAT 887 15.604 37.471 −2.711 1.00 42.93 ATOM 2141 OH2 WAT 889 4.907 3.035 10.619 1.00 41.58 ATOM 2142 OH2 WAT 890 21.088 8.951 −7.950 1.00 37.07 ATOM 2143 OH2 WAT 891 26.883 7.714 24.992 1.00 38.03 ATOM 2144 OH2 WAT 892 27.672 6.863 14.497 1.00 33.97 ATOM 2145 OH2 WAT 893 32.830 16.371 13.351 1.00 39.04 ATOM 2146 OH2 WAT 894 27.935 24.454 28.849 1.00 58.27 ATOM 2147 OH2 WAT 895 31.271 29.479 18.350 1.00 35.40 ATOM 2148 OH2 WAT 896 20.663 0.959 10.098 1.00 29.75 ATOM 2149 OH2 WAT 898 25.086 4.474 5.856 1.00 58.91 ATOM 2150 OH2 WAT 899 10.823 19.991 1.639 1.00 50.34 ATOM 2151 OH2 WAT 900 36.503 19.016 22.377 1.00 47.47 ATOM 2152 OH2 WAT 901 7.753 18.823 14.805 1.00 63.11 ATOM 2153 OH2 WAT 902 39.898 36.941 0.917 1.00 58.76 ATOM 2154 OH2 WAT 903 9.902 17.486 15.681 1.00 43.86 ATOM 2155 OH2 WAT 904 10.082 39.246 11.235 1.00 61.89 ATOM 2156 OH2 WAT 905 11.163 31.359 −8.260 1.00 56.41 ATOM 2157 OH2 WAT 906 31.409 30.077 0.054 1.00 38.17 ATOM 2158 OH2 WAT 907 −0.262 4.591 11.602 1.00 40.33 ATOM 2159 OH2 WAT 908 31.641 28.926 2.593 1.00 66.15 ATOM 2160 OH2 WAT 909 −1.843 16.272 8.893 1.00 44.52 ATOM 2161 OH2 WAT 910 10.182 38.951 7.471 1.00 67.08 ATOM 2162 OH2 WAT 911 13.297 1.372 1.110 1.00 53.70 ATOM 2163 OH2 WAT 912 15.299 2.429 15.304 1.00 39.81 ATOM 2164 OH2 WAT 913 16.202 17.257 31.878 1.00 39.68 ATOM 2165 OH2 WAT 914 33.600 36.849 17.451 1.00 35.02 ATOM 2166 OH2 WAT 915 −0.283 12.217 10.059 1.00 33.29 ATOM 2167 OH2 WAT 916 20.496 1.221 17.973 1.00 45.64 ATOM 2168 OH2 WAT 917 22.207 39.746 15.987 1.00 51.55 ATOM 2169 OH2 WAT 918 14.385 33.613 17.595 1.00 42.92 ATOM 2170 OH2 WAT 919 26.248 13.606 −7.378 1.00 37.16 ATOM 2171 OH2 WAT 920 25.959 6.408 −4.445 1.00 48.88 ATOM 2172 OH2 WAT 921 17.591 2.898 16.434 1.00 39.25 ATOM 2173 OH2 WAT 922 33.239 45.203 11.047 1.00 49.84 ATOM 2174 OH2 WAT 923 12.608 31.888 −12.406 1.00 50.03 ATOM 2175 OH2 WAT 924 26.381 45.820 0.731 1.00 44.95 ATOM 2176 OH2 WAT 925 7.350 22.130 18.821 1.00 48.55 ATOM 2177 OH2 WAT 926 23.505 34.031 25.189 1.00 52.64 ATOM 2178 OH2 WAT 927 23.404 53.128 −2.298 1.00 76.10 ATOM 2179 OH2 WAT 928 29.823 49.147 1.695 1.00 48.44 ATOM 2180 OH2 WAT 929 21.489 3.727 1.417 1.00 61.20 ATOM 2181 OH2 WAT 930 18.898 35.011 −16.838 1.00 67.70 ATOM 2182 OH2 WAT 931 8.048 22.678 24.638 1.00 35.53 ATOM 2183 OH2 WAT 933 33.982 42.818 −3.037 1.00 40.39 ATOM 2184 OH2 WAT 934 9.979 28.055 25.701 1.00 46.53 ATOM 2185 OH2 WAT 935 13.628 22.137 2.420 1.00 44.85 ATOM 2186 OH2 WAT 936 19.171 1.332 15.385 1.00 37.36 ATOM 2187 OH2 WAT 939 27.207 28.433 −6.434 1.00 68.57 ATOM 2188 OH2 WAT 940 3.857 1.418 8.795 1.00 68.25 ATOM 2189 OH2 WAT 941 16.520 42.036 −2.158 1.00 79.07 ATOM 2190 OH2 WAT 942 17.605 46.558 2.927 1.00 47.55 ATOM 2191 OH2 WAT 943 15.096 42.405 3.989 1.00 53.50 ATOM 2192 OH2 WAT 950 9.314 22.415 6.528 1.00 40.77 ATOM 2193 OH2 WAT 951 5.922 25.754 4.200 1.00 58.05 ATOM 2194 OH2 WAT 952 −0.116 13.000 6.780 1.00 96.22 ATOM 2195 OH2 WAT 954 33.641 28.462 7.707 1.00 38.33 ATOM 2196 OH2 WAT 955 20.020 19.781 −9.186 1.00 46.18 ATOM 2197 OH2 WAT 956 22.350 22.390 −11.831 1.00 44.39 ATOM 2198 C1 REA 500 22.676 32.386 7.585 1.00 44.19 ATOM 2199 C2 REA 500 21.906 33.574 6.875 1.00 44.67 ATOM 2200 C3 REA 500 21.637 33.455 5.374 1.00 44.62 ATOM 2201 C4 REA 500 22.790 32.926 4.506 1.00 44.15 ATOM 2202 C5 REA 500 23.891 32.096 5.255 1.00 43.36 ATOM 2203 C6 REA 500 23.862 31.835 6.638 1.00 42.89 ATOM 2204 C7 REA 500 24.919 31.045 7.334 1.00 41.43 ATOM 2205 C8 REA 500 25.046 29.710 7.573 1.00 38.85 ATOM 2206 C9 REA 500 26.080 29.094 8.397 1.00 39.63 ATOM 2207 C10 REA 500 26.066 27.725 8.531 1.00 37.78 ATOM 2208 C11 REA 500 27.051 27.018 9.329 1.00 37.42 ATOM 2209 C12 REA 500 27.070 25.694 9.440 1.00 37.89 ATOM 2210 C13 REA 500 28.057 24.977 10.242 1.00 38.53 ATOM 2211 C14 REA 500 27.951 23.626 10.224 1.00 36.87 ATOM 2212 C15 REA 500 28.705 22.564 10.870 1.00 35.41 ATOM 2213 C16 REA 500 21.650 31.254 7.888 1.00 44.23 ATOM 2214 C17 REA 500 23.235 32.990 8.910 1.00 45.49 ATOM 2215 C18 REA 500 24.948 31.651 4.234 1.00 43.96 ATOM 2216 C19 REA 500 27.157 29.991 9.084 1.00 37.79 ATOM 2217 C20 REA 500 29.159 25.776 11.043 1.00 39.49 ATOM 2218 01 REA 500 28.377 21.424 10.626 1.00 36.24 ATOM 2219 02 REA 500 29.641 22.779 11.628 1.00 31.52 END

References

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[0275] Brünger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. A47, 110-119, (1998).

[0276] Hirose, T., Smith, R. J., and Jetten, A. M. (1994) RORg: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem. Biophys. Res. Commun. 205, 1976-1983.

[0277] Jones, T. A., Zou, J. Y., Cowan, S. W. et Kjeldgaard, M. (1991) Improved methods for building protein models in electron density maps and the location of errors in theses models. Acta crystallogr. A47, 110-119

[0278] Kurebayashi S, and Hirose T. (1998) Novel orphan receptor: ROR gamma expressed during adipocyte differenciation. Nippon Rinsho, 56, 1729-1733.

[0279] Lau P., Bailey P., Dowhan D. H., Muscat G. E. (1999) Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differenciation: RORalpha1 directly interacts with p300 and myoD. Nucleic Acids Research, 27, 411-420.

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1 46 1 780 DNA Artificial Sequence Description of Artificial Sequence Nucleotide sequence coding for a fragment of rat ROR-beta 1 ggg cag tta gct ccc ggg ata aca atg tct gag atc gat cga att gca 48 Gly Gln Leu Ala Pro Gly Ile Thr Met Ser Glu Ile Asp Arg Ile Ala 1 5 10 15 cag aac atc att aag tcc cat ttg gag acg tgc cag tac aca atg gaa 96 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 gag ctc cat cag ctg gca tgg cag acc cac acc tat gag gaa ata aag 144 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 gca tat caa agc aag tcc agg gag gct ctg tgg cag cag tgt gcc atc 192 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 cag atc acc cac gcc atc caa tat gtg gtg gag ttc gca aag cgg ata 240 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 aca ggc ttc atg gag ctg tgt cag aac gat cag atc tta ctt ctg aag 288 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 tca ggt tgc ttg gaa gtg gtt tta gtg aga atg tgc cgt gcc ttc aac 336 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 cca tta aac aac act gtt ctg ttt gaa gga aaa tat gga gga atg caa 384 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 atg ttc aaa gcc tta ggt tct gat gac cta gtg aat gaa gca ttt gac 432 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 ttt gcg aag aat ctg tgt tcc ttg cag ctg acc gag gaa gag att gct 480 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 ctg ttc tcc tct gct gtt ctg ata tcc cca gac cga gcc tgg ctg tta 528 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Leu 165 170 175 gaa cca aga aaa gtc cag aag ctt cag gaa aaa att tat ttt gca ctt 576 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 caa cat gtg att cag aag aat cac ctg gat gat gag acc ctg gca aag 624 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 tta ata gcc aag ata cca act atc acg gca gtc tgc aac ttg cat ggg 672 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 gag aag cta cag gta ttt aag cag tct cat cca gac ata gtg aat aca 720 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Asp Ile Val Asn Thr 225 230 235 240 ctg ttt cct cca ttg tac aag gag ctc ttt aat cct gac tgt gct gcg 768 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro Asp Cys Ala Ala 245 250 255 gtc tgc aaa tga 780 Val Cys Lys 2 244 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of rat ROR-beta 2 Met Ser Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp Gln 20 25 30 Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg Glu 35 40 45 Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser Asp 115 120 125 Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser Leu 130 135 140 Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu Ile 145 150 155 160 Ser Pro Asp Arg Ala Trp Leu Leu Glu Pro Arg Lys Val Gln Lys Leu 165 170 175 Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn His 180 185 190 Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr Ile 195 200 205 Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys Gln 210 215 220 Ser His Pro Asp Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Asn Pro 3 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-beta 3 Met Thr Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp Gln 20 25 30 Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg Glu 35 40 45 Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser Asp 115 120 125 Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser Leu 130 135 140 Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu Ile 145 150 155 160 Ser Pro Asp Arg Ala Trp Leu Ile Glu Pro Arg Lys Val Gln Lys Leu 165 170 175 Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn His 180 185 190 Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr Ile 195 200 205 Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys Gln 210 215 220 Ser His Pro Glu Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Asn Pro 4 242 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 4 Leu Thr Glu Ile Glu His Leu Val Gln Ser Val Cys Lys Ser Tyr Arg 1 5 10 15 Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Ser Asn 20 25 30 Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln Arg Lys Ser Met Trp 35 40 45 Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala Met Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn Arg Thr Val Phe Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg Ala Leu Gly Cys Ser 115 120 125 Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Ser Leu Ser Ala Leu 130 135 140 His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile 145 150 155 160 Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg Lys Val Glu Gln Leu 165 170 175 Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr His 180 185 190 Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser 195 200 205 Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile Phe Gln His Leu His 210 215 220 Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe 225 230 235 240 Ser Thr 5 242 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 5 Leu Thr Asp Ile Glu Tyr Leu Val Gln Asn Val Cys Lys Ser Phe Arg 1 5 10 15 Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Thr Asn 20 25 30 Leu Phe Ser Arg Glu Glu Val Thr Ser Tyr Gln Arg Lys Ser Met Trp 35 40 45 Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Ile Leu Leu Thr Ala Gly Ala Met Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Tyr Asn Ala Asn Asn His Thr Val Phe Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Val Glu Leu Phe Arg Ala Leu Gly Cys Ser 115 120 125 Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Phe Leu Ser Ala Leu 130 135 140 Cys Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile 145 150 155 160 Asn Ala Asn Arg Pro Gly Leu Gln Glu Lys Arg Arg Val Glu His Leu 165 170 175 Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr His 180 185 190 Arg Gln Gly Leu Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser 195 200 205 Leu Cys Ser Gln His Val Glu Lys Leu Gln Ile Phe Gln His Leu His 210 215 220 Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe 225 230 235 240 Ser Thr 6 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 6 Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp Gln 20 25 30 Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg Glu 35 40 45 Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val Phe 85 90 95 Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr Phe 100 105 110 Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys Glu 115 120 125 Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser Met 130 135 140 His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu Met 145 150 155 160 Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys Leu 165 170 175 Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn His 180 185 190 Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr Leu 195 200 205 Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys Ala 210 215 220 Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Thr Ser 7 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 7 Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp Gln 20 25 30 Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg Glu 35 40 45 Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val Phe 85 90 95 Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr Phe 100 105 110 Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys Glu 115 120 125 Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser Met 130 135 140 His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu Met 145 150 155 160 Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys Leu 165 170 175 Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn His 180 185 190 Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr Leu 195 200 205 Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys Ala 210 215 220 Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Thr Ser 8 245 PRT Artificial Sequence Description of Artificial Sequence Fragment of rat ROR-beta 8 Thr Met Ser Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp 20 25 30 Gln Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg 35 40 45 Glu Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser 115 120 125 Asp Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser 130 135 140 Leu Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu 145 150 155 160 Ile Ser Pro Asp Arg Ala Trp Leu Leu Glu Pro Arg Lys Val Gln Lys 165 170 175 Leu Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn 180 185 190 His Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr 195 200 205 Ile Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys 210 215 220 Gln Ser His Pro Asp Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Asn Pro 9 245 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-beta 9 Thr Met Thr Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp 20 25 30 Gln Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg 35 40 45 Glu Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser 115 120 125 Asp Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser 130 135 140 Leu Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu 145 150 155 160 Ile Ser Pro Asp Arg Ala Trp Leu Ile Glu Pro Arg Lys Val Gln Lys 165 170 175 Leu Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn 180 185 190 His Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr 195 200 205 Ile Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys 210 215 220 Gln Ser His Pro Glu Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Asn Pro 10 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 10 Ser Leu Thr Glu Ile Glu His Leu Val Gln Ser Val Cys Lys Ser Tyr 1 5 10 15 Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Ser 20 25 30 Asn Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln Arg Lys Ser Met 35 40 45 Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala Met Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn Arg Thr Val Phe 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg Ala Leu Gly Cys 115 120 125 Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Ser Leu Ser Ala 130 135 140 Leu His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu 145 150 155 160 Ile Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg Lys Val Glu Gln 165 170 175 Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr 180 185 190 His Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg 195 200 205 Ser Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile Phe Gln His Leu 210 215 220 His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu 225 230 235 240 Phe Ser Thr 11 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 11 Ser Leu Thr Asp Ile Glu Tyr Leu Val Gln Asn Val Cys Lys Ser Phe 1 5 10 15 Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Thr 20 25 30 Asn Leu Phe Ser Arg Glu Glu Val Thr Ser Tyr Gln Arg Lys Ser Met 35 40 45 Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Ile Leu Leu Thr Ala Gly Ala Met Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asn Asn His Thr Val Phe 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Val Glu Leu Phe Arg Ala Leu Gly Cys 115 120 125 Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Phe Leu Ser Ala 130 135 140 Leu Cys Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu 145 150 155 160 Ile Asn Ala Asn Arg Pro Gly Leu Gln Glu Lys Arg Arg Val Glu His 165 170 175 Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr 180 185 190 His Arg Gln Gly Leu Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg 195 200 205 Ser Leu Cys Ser Gln His Val Glu Lys Leu Gln Ile Phe Gln His Leu 210 215 220 His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu 225 230 235 240 Phe Ser Thr 12 245 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 12 Ser Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp 20 25 30 Gln Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg 35 40 45 Glu Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val 85 90 95 Phe Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr 100 105 110 Phe Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys 115 120 125 Glu Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser 130 135 140 Met His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu 145 150 155 160 Met Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys 165 170 175 Leu Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn 180 185 190 His Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr 195 200 205 Leu Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys 210 215 220 Ala Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Thr Ser 13 245 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 13 Ser Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp 20 25 30 Gln Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg 35 40 45 Glu Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val 85 90 95 Phe Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr 100 105 110 Phe Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys 115 120 125 Glu Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser 130 135 140 Met His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu 145 150 155 160 Met Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys 165 170 175 Leu Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn 180 185 190 His Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr 195 200 205 Leu Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys 210 215 220 Ala Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Thr Ser 245 14 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of rat ROR-beta 14 Thr Met Ser Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp 20 25 30 Gln Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg 35 40 45 Glu Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser 115 120 125 Asp Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser 130 135 140 Leu Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu 145 150 155 160 Ile Ser Pro Asp Arg Ala Trp Leu Leu Glu Pro Arg Lys Val Gln Lys 165 170 175 Leu Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn 180 185 190 His Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr 195 200 205 Ile Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys 210 215 220 Gln Ser His Pro Asp Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Asn 15 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-beta 15 Thr Met Thr Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp 20 25 30 Gln Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg 35 40 45 Glu Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser 115 120 125 Asp Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser 130 135 140 Leu Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu 145 150 155 160 Ile Ser Pro Asp Arg Ala Trp Leu Ile Glu Pro Arg Lys Val Gln Lys 165 170 175 Leu Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn 180 185 190 His Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr 195 200 205 Ile Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys 210 215 220 Gln Ser His Pro Glu Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Asn 16 242 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 16 Ser Leu Thr Glu Ile Glu His Leu Val Gln Ser Val Cys Lys Ser Tyr 1 5 10 15 Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Ser 20 25 30 Asn Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln Arg Lys Ser Met 35 40 45 Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala Met Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn Arg Thr Val Phe 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg Ala Leu Gly Cys 115 120 125 Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Ser Leu Ser Ala 130 135 140 Leu His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu 145 150 155 160 Ile Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg Lys Val Glu Gln 165 170 175 Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr 180 185 190 His Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg 195 200 205 Ser Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile Phe Gln His Leu 210 215 220 His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu 225 230 235 240 Phe Ser 17 242 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 17 Ser Leu Thr Asp Ile Glu Tyr Leu Val Gln Asn Val Cys Lys Ser Phe 1 5 10 15 Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Thr 20 25 30 Asn Leu Phe Ser Arg Glu Glu Val Thr Ser Tyr Gln Arg Lys Ser Met 35 40 45 Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Ile Leu Leu Thr Ala Gly Ala Met Glu Val Val 85 90 95 Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asn Asn His Thr Val Phe 100 105 110 Phe Glu Gly Lys Tyr Gly Gly Val Glu Leu Phe Arg Ala Leu Gly Cys 115 120 125 Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Phe Leu Ser Ala 130 135 140 Leu Cys Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu 145 150 155 160 Ile Asn Ala Asn Arg Pro Gly Leu Gln Glu Lys Arg Arg Val Glu His 165 170 175 Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr 180 185 190 His Arg Gln Gly Leu Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg 195 200 205 Ser Leu Cys Ser Gln His Val Glu Lys Leu Gln Ile Phe Gln His Leu 210 215 220 His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu 225 230 235 240 Phe Ser 18 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 18 Ser Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp 20 25 30 Gln Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg 35 40 45 Glu Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val 85 90 95 Phe Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr 100 105 110 Phe Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys 115 120 125 Glu Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser 130 135 140 Met His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu 145 150 155 160 Met Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys 165 170 175 Leu Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn 180 185 190 His Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr 195 200 205 Leu Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys 210 215 220 Ala Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Thr 19 244 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 19 Ser Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His 1 5 10 15 Leu Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp 20 25 30 Gln Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg 35 40 45 Glu Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln 50 55 60 Tyr Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys 65 70 75 80 Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val 85 90 95 Phe Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr 100 105 110 Phe Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys 115 120 125 Glu Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser 130 135 140 Met His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu 145 150 155 160 Met Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys 165 170 175 Leu Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn 180 185 190 His Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr 195 200 205 Leu Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys 210 215 220 Ala Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys 225 230 235 240 Glu Leu Phe Thr 20 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of rat ROR-beta 20 Met Ser Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp Gln 20 25 30 Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg Glu 35 40 45 Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser Asp 115 120 125 Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser Leu 130 135 140 Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu Ile 145 150 155 160 Ser Pro Asp Arg Ala Trp Leu Leu Glu Pro Arg Lys Val Gln Lys Leu 165 170 175 Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn His 180 185 190 Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr Ile 195 200 205 Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys Gln 210 215 220 Ser His Pro Asp Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Asn 21 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-beta 21 Met Thr Glu Ile Asp Arg Ile Ala Gln Asn Ile Ile Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Thr Met Glu Glu Leu His Gln Leu Ala Trp Gln 20 25 30 Thr His Thr Tyr Glu Glu Ile Lys Ala Tyr Gln Ser Lys Ser Arg Glu 35 40 45 Ala Leu Trp Gln Gln Cys Ala Ile Gln Ile Thr His Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Thr Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Leu Leu Leu Lys Ser Gly Cys Leu Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Phe Asn Pro Leu Asn Asn Thr Val Leu Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Gln Met Phe Lys Ala Leu Gly Ser Asp 115 120 125 Asp Leu Val Asn Glu Ala Phe Asp Phe Ala Lys Asn Leu Cys Ser Leu 130 135 140 Gln Leu Thr Glu Glu Glu Ile Ala Leu Phe Ser Ser Ala Val Leu Ile 145 150 155 160 Ser Pro Asp Arg Ala Trp Leu Ile Glu Pro Arg Lys Val Gln Lys Leu 165 170 175 Gln Glu Lys Ile Tyr Phe Ala Leu Gln His Val Ile Gln Lys Asn His 180 185 190 Leu Asp Asp Glu Thr Leu Ala Lys Leu Ile Ala Lys Ile Pro Thr Ile 195 200 205 Thr Ala Val Cys Asn Leu His Gly Glu Lys Leu Gln Val Phe Lys Gln 210 215 220 Ser His Pro Glu Ile Val Asn Thr Leu Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Asn 22 241 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 22 Leu Thr Glu Ile Glu His Leu Val Gln Ser Val Cys Lys Ser Tyr Arg 1 5 10 15 Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Ser Asn 20 25 30 Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln Arg Lys Ser Met Trp 35 40 45 Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala Met Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn Arg Thr Val Phe Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg Ala Leu Gly Cys Ser 115 120 125 Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Ser Leu Ser Ala Leu 130 135 140 His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile 145 150 155 160 Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg Lys Val Glu Gln Leu 165 170 175 Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr His 180 185 190 Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser 195 200 205 Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile Phe Gln His Leu His 210 215 220 Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe 225 230 235 240 Ser 23 241 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 23 Leu Thr Asp Ile Glu Tyr Leu Val Gln Asn Val Cys Lys Ser Phe Arg 1 5 10 15 Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln Arg Thr Asn 20 25 30 Leu Phe Ser Arg Glu Glu Val Thr Ser Tyr Gln Arg Lys Ser Met Trp 35 40 45 Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Ile Leu Leu Thr Ala Gly Ala Met Glu Val Val Leu 85 90 95 Val Arg Met Cys Arg Ala Tyr Asn Ala Asn Asn His Thr Val Phe Phe 100 105 110 Glu Gly Lys Tyr Gly Gly Val Glu Leu Phe Arg Ala Leu Gly Cys Ser 115 120 125 Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Phe Leu Ser Ala Leu 130 135 140 Cys Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile 145 150 155 160 Asn Ala Asn Arg Pro Gly Leu Gln Glu Lys Arg Arg Val Glu His Leu 165 170 175 Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys Lys Thr His 180 185 190 Arg Gln Gly Leu Leu Ala Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser 195 200 205 Leu Cys Ser Gln His Val Glu Lys Leu Gln Ile Phe Gln His Leu His 210 215 220 Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe 225 230 235 240 Ser 24 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 24 Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp Gln 20 25 30 Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg Glu 35 40 45 Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val Phe 85 90 95 Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr Phe 100 105 110 Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys Glu 115 120 125 Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser Met 130 135 140 His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu Met 145 150 155 160 Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys Leu 165 170 175 Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn His 180 185 190 Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr Leu 195 200 205 Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys Ala 210 215 220 Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Thr 25 243 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 25 Met Ala Glu Leu Glu His Leu Ala Gln Asn Ile Ser Lys Ser His Leu 1 5 10 15 Glu Thr Cys Gln Tyr Leu Arg Glu Glu Leu Gln Gln Ile Thr Trp Gln 20 25 30 Thr Phe Leu Gln Glu Glu Ile Glu Asn Tyr Gln Asn Lys Gln Arg Glu 35 40 45 Val Met Trp Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr 50 55 60 Val Val Glu Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln 65 70 75 80 Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ser Leu Glu Val Val Phe 85 90 95 Ile Arg Met Cys Arg Ala Phe Asp Ser Gln Asn Asn Thr Val Tyr Phe 100 105 110 Asp Gly Lys Tyr Ala Ser Pro Asp Val Phe Lys Ser Leu Gly Cys Glu 115 120 125 Asp Phe Ile Ser Phe Val Phe Glu Phe Gly Lys Ser Leu Cys Ser Met 130 135 140 His Leu Thr Glu Asp Glu Ile Ala Leu Phe Ser Ala Phe Val Leu Met 145 150 155 160 Ser Ala Asp Arg Ser Trp Leu Gln Glu Lys Val Lys Ile Glu Lys Leu 165 170 175 Gln Gln Lys Ile Gln Leu Ala Leu Gln His Val Leu Gln Lys Asn His 180 185 190 Arg Glu Asp Gly Ile Leu Thr Lys Leu Ile Cys Lys Val Ser Thr Leu 195 200 205 Arg Ala Leu Cys Gly Arg His Thr Glu Lys Leu Met Ala Phe Lys Ala 210 215 220 Ile Tyr Pro Asp Ile Val Arg Leu His Phe Pro Pro Leu Tyr Lys Glu 225 230 235 240 Leu Phe Thr 26 251 PRT Artificial Sequence Description of Artificial Sequence Fragment of rat ROR-beta 26 Gly Gln Leu Ala Pro Gly Ile Thr Met Ser Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Leu 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Asp Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn 245 250 27 251 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-beta 27 Gly Gln Leu Ala Pro Gly Ile Thr Met Thr Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Ile 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Glu Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn 245 250 28 249 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 28 Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu Val 1 5 10 15 Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val Thr 35 40 45 Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Arg 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser 245 29 249 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 29 Ala Pro Glu Val Pro Tyr Ala Ser Leu Thr Asp Ile Glu Tyr Leu Val 1 5 10 15 Gln Asn Val Cys Lys Ser Phe Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Thr Asn Leu Phe Ser Arg Glu Glu Val Thr 35 40 45 Ser Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Ile Leu Leu Thr 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asn Asn His Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Val Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Phe Leu Ser Ala Leu Cys Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala Asn Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Arg Val Glu His Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Gly Leu Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Lys 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser 245 30 251 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 30 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr 245 250 31 251 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 31 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr 245 250 32 252 PRT Artificial Sequence Description of Artificial Sequence Fragment of rat ROR-beta 32 Gly Gln Leu Ala Pro Gly Ile Thr Met Ser Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Leu 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Asp Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro 245 250 33 252 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 33 Gly Gln Leu Ala Pro Gly Ile Thr Met Thr Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Ile 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Glu Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro 245 250 34 250 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-gamma 34 Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu Val 1 5 10 15 Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val Thr 35 40 45 Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Arg 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr 245 250 35 250 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-gamma 35 Ala Pro Glu Val Pro Tyr Ala Ser Leu Thr Asp Ile Glu Tyr Leu Val 1 5 10 15 Gln Asn Val Cys Lys Ser Phe Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Thr Asn Leu Phe Ser Arg Glu Glu Val Thr 35 40 45 Ser Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Ile Leu Leu Thr 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asn Asn His Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Val Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Phe Leu Ser Ala Leu Cys Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala Asn Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Arg Val Glu His Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Gly Leu Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Lys 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr 245 250 36 252 PRT Artificial Sequence Description of Artificial Sequence Fragment of human ROR-alpha 36 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr Ser 245 250 37 252 PRT Artificial Sequence Description of Artificial Sequence Fragment of murine ROR-alpha 37 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr Ser 245 250 38 259 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of rat ROR-beta 38 Gly Gln Leu Ala Pro Gly Ile Thr Met Ser Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Leu 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Asp Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro Asp Cys Ala Ala 245 250 255 Val Cys Lys 39 276 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of human ROR-gamma 39 Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu Val 1 5 10 15 Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val Thr 35 40 45 Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Arg 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser Pro Val 245 250 255 Gly Cys Pro Ser Asp Leu Glu Glu Gly Leu Leu Ala Ser Pro Tyr Gly 260 265 270 Leu Leu Ala Thr 275 40 260 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of murine ROR-gamma 40 Ala Pro Glu Val Pro Tyr Ala Ser Leu Thr Asp Ile Glu Tyr Leu Val 1 5 10 15 Gln Asn Val Cys Lys Ser Phe Arg Glu Thr Cys Gln Leu Arg Leu Glu 20 25 30 Asp Leu Leu Arg Gln Arg Thr Asn Leu Phe Ser Arg Glu Glu Val Thr 35 40 45 Ser Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His 50 55 60 His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu 65 70 75 80 Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Ile Leu Leu Thr 85 90 95 Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn 100 105 110 Ala Asn Asn His Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Val Glu 115 120 125 Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp 130 135 140 Phe Ser His Phe Leu Ser Ala Leu Cys Phe Ser Glu Asp Glu Ile Ala 145 150 155 160 Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala Asn Arg Pro Gly Leu Gln 165 170 175 Glu Lys Arg Arg Val Glu His Leu Gln Tyr Asn Leu Glu Leu Ala Phe 180 185 190 His His His Leu Cys Lys Thr His Arg Gln Gly Leu Leu Ala Lys Leu 195 200 205 Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Lys 210 215 220 Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe 225 230 235 240 Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Asp Val Glu Ser Pro Glu 245 250 255 Gly Leu Ser Lys 260 41 262 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of human ROR-alpha 41 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr Ser Glu Phe Glu Pro 245 250 255 Ala Met Gln Ile Asp Gly 260 42 262 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of murine ROR-alpha 42 Gly Glu Thr Ser Pro Thr Val Ser Met Ala Glu Leu Glu His Leu Ala 1 5 10 15 Gln Asn Ile Ser Lys Ser His Leu Glu Thr Cys Gln Tyr Leu Arg Glu 20 25 30 Glu Leu Gln Gln Ile Thr Trp Gln Thr Phe Leu Gln Glu Glu Ile Glu 35 40 45 Asn Tyr Gln Asn Lys Gln Arg Glu Val Met Trp Gln Leu Cys Ala Ile 50 55 60 Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Asp Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys 85 90 95 Ala Gly Ser Leu Glu Val Val Phe Ile Arg Met Cys Arg Ala Phe Asp 100 105 110 Ser Gln Asn Asn Thr Val Tyr Phe Asp Gly Lys Tyr Ala Ser Pro Asp 115 120 125 Val Phe Lys Ser Leu Gly Cys Glu Asp Phe Ile Ser Phe Val Phe Glu 130 135 140 Phe Gly Lys Ser Leu Cys Ser Met His Leu Thr Glu Asp Glu Ile Ala 145 150 155 160 Leu Phe Ser Ala Phe Val Leu Met Ser Ala Asp Arg Ser Trp Leu Gln 165 170 175 Glu Lys Val Lys Ile Glu Lys Leu Gln Gln Lys Ile Gln Leu Ala Leu 180 185 190 Gln His Val Leu Gln Lys Asn His Arg Glu Asp Gly Ile Leu Thr Lys 195 200 205 Leu Ile Cys Lys Val Ser Thr Leu Arg Ala Leu Cys Gly Arg His Thr 210 215 220 Glu Lys Leu Met Ala Phe Lys Ala Ile Tyr Pro Asp Ile Val Arg Leu 225 230 235 240 His Phe Pro Pro Leu Tyr Lys Glu Leu Phe Thr Ser Glu Phe Glu Pro 245 250 255 Ala Met Gln Ile Asp Gly 260 43 259 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of human ROR-beta 43 Gly Gln Leu Ala Pro Gly Ile Thr Met Thr Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Ile 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Glu Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro Asp Cys Ala Thr 245 250 255 Ala Cys Lys 44 259 PRT Artificial Sequence Description of Artificial Sequence Amino acid sequence of rat ROR-beta 44 Gly Gln Leu Ala Pro Gly Ile Thr Met Ser Glu Ile Asp Arg Ile Ala 1 5 10 15 Gln Asn Ile Ile Lys Ser His Leu Glu Thr Cys Gln Tyr Thr Met Glu 20 25 30 Glu Leu His Gln Leu Ala Trp Gln Thr His Thr Tyr Glu Glu Ile Lys 35 40 45 Ala Tyr Gln Ser Lys Ser Arg Glu Ala Leu Trp Gln Gln Cys Ala Ile 50 55 60 Gln Ile Thr His Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Ile 65 70 75 80 Thr Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Leu Leu Leu Lys 85 90 95 Ser Gly Cys Leu Glu Val Val Leu Val Arg Met Cys Arg Ala Phe Asn 100 105 110 Pro Leu Asn Asn Thr Val Leu Phe Glu Gly Lys Tyr Gly Gly Met Gln 115 120 125 Met Phe Lys Ala Leu Gly Ser Asp Asp Leu Val Asn Glu Ala Phe Asp 130 135 140 Phe Ala Lys Asn Leu Cys Ser Leu Gln Leu Thr Glu Glu Glu Ile Ala 145 150 155 160 Leu Phe Ser Ser Ala Val Leu Ile Ser Pro Asp Arg Ala Trp Leu Leu 165 170 175 Glu Pro Arg Lys Val Gln Lys Leu Gln Glu Lys Ile Tyr Phe Ala Leu 180 185 190 Gln His Val Ile Gln Lys Asn His Leu Asp Asp Glu Thr Leu Ala Lys 195 200 205 Leu Ile Ala Lys Ile Pro Thr Ile Thr Ala Val Cys Asn Leu His Gly 210 215 220 Glu Lys Leu Gln Val Phe Lys Gln Ser His Pro Asp Ile Val Asn Thr 225 230 235 240 Leu Phe Pro Pro Leu Tyr Lys Glu Leu Phe Asn Pro Asp Cys Ala Ala 245 250 255 Val Cys Lys 45 267 PRT Homo sapiens 45 Asp Ser Tyr Glu Leu Ser Pro Gln Leu Glu Glu Leu Ile Thr Lys Val 1 5 10 15 Ser Lys Ala His Gln Glu Thr Phe Pro Ser Leu Cys Gln Leu Gly Lys 20 25 30 Tyr Thr Thr Asn Ser Ser Ala Asp His Arg Val Gln Leu Asp Leu Gly 35 40 45 Leu Trp Asp Lys Phe Ser Glu Leu Ala Thr Lys Cys Ile Ile Lys Ile 50 55 60 Val Glu Phe Ala Lys Arg Leu Pro Gly Phe Thr Gly Leu Ser Ile Ala 65 70 75 80 Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys Leu Asp Ile Leu Met Leu 85 90 95 Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln Asp Thr Met Thr Phe Ser 100 105 110 Asp Gly Leu Thr Leu Asn Arg Thr Gln Met His Asn Ala Gly Phe Gly 115 120 125 Pro Leu Thr Asp Leu Val Phe Ala Phe Ala Gly Gln Leu Leu Pro Leu 130 135 140 Glu Met Asp Asp Thr Glu Thr Gly Leu Leu Ser Ala Ile Cys Leu Ile 145 150 155 160 Cys Gly Asp Arg Met Asp Leu Glu Glu Pro Glu Lys Val Asp Lys Leu 165 170 175 Gln Glu Pro Leu Leu Glu Ala Leu Arg Leu Tyr Ala Arg Arg Arg Arg 180 185 190 Pro Ser Gln Pro Tyr Met Phe Pro Arg Met Leu Met Lys Ile Thr Asp 195 200 205 Leu Arg Gly Ile Ser Thr Lys Gly Ala Glu Arg Ala Ile Thr Leu Lys 210 215 220 Met Glu Ile Pro Gly Pro Met Pro Pro Leu Ile Arg Glu Met Leu Glu 225 230 235 240 Asn Pro Glu Met Phe Glu Asp Asp Ser Ser Gln Pro Gly Pro His Pro 245 250 255 Asn Ala Ser Ser Glu Asp Glu Val Pro Gly Gly 260 265 46 15 PRT Artificial Sequence Description of Artificial Sequence Synthetic peptide 46 Arg His Lys Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser 1 5 10 15 

1. Polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals.
 2. Polypeptides according to claim 1, characterized in that at least the approximately 100 to 200 first amino-acids of the N-terminal part of the sequence of said receptor is deleted.
 3. Polypeptides according to claim 1, derived from the nuclear receptor ROR, wherein the binding properties of the ligand-binding domain, or LBD, of said receptor, are maintained.
 4. Polypeptides derived from the nuclear receptor RORβ, of mammals, such as human or rat, these derived polypeptides comprising a polypeptide as defined in claim 1, such as the polypeptides delimited by the amino-acids located in positions 201 to 459 of the sequences of rat or human RORβ represented on FIG. 3, said polypeptides being characterized in that at least one of the cysteine in position 454 or in position 458 of the amino-acid sequence of said nuclear receptor RORβ, as represented on FIG. 3, is deleted or substituted by another amino-acid, natural or not, such as alanine or serine.
 5. Polypeptides according to claim 1, characterized in that they correspond to the fragments of mammals ROR, and more particularly of rat, human, or murine RORβ, α, or γ, delimited in their N-terminal extremity by the amino acid located in one of the positions 201 to 209 of the ROR sequences represented on FIG. 3, and in their C-terminal extremity by the amino acid located in one of the positions 451 or 452, of the ROR sequences represented on FIG.
 3. 6. Polypeptides according to claim 1, as defined above, chosen among: the fragment delimited by the amino acids located in positions 209 to 452 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 2, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 3, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 4, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 5, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 6, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 7, the fragment delimited by the amino acids located in positions 208 to 452 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 8, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 9, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 10, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 11, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 12, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 13, the fragment delimited by the amino acids located in positions 208 to 451 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 14, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 15, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 16, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 17, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 18, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 19, the fragment delimited by the amino acids located in positions 209 to 451 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 20, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 21, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 22, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 23, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 24, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 25, the fragment delimited by the amino acids located in positions 201 to 451 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 26, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 27, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 28, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 29, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 30, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO: 31, the fragment delimited by the amino acids located in positions 201 to 452 of: the sequence of the rat RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 32, the sequence of the human RORβ represented on FIG. 3, and corresponding to SEQ ID NO: 33, the sequence of the human RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 34, the sequence of the murine RORγ represented on FIG. 3, and corresponding to SEQ ID NO: 35, the sequence of the human RORα represented on FIG. 3, and corresponding to SEQ ID NO: 36, the sequence of the murine RORα represented on FIG. 3, and corresponding to SEQ ID NO:
 37. 7. Polypeptides according to claim 1, characterized by the following characteristics: they have the properties of binding a ligand and of transactivation of the LBD of the receptor ROR, they are soluble in aqueous solvants, they are crystallisable in aqueous solvents, especially by the hanging drop vapour diffusion method, more particularly at approximately 4° C. or polypeptides or peptide sequences derived of those above mentioned, for example by suppression, addition or substitution of one or several amino acids, these polypeptides or peptide sequences having the characteristics above mentioned.
 8. Molecular complexes comprising a polypeptide according to claim 1, said polypeptide being in association with: a ROR-LBD ligand which is an agonist, such as stearic acid, or an antagonist of the ROR-LBD, such as retinoic acid, and/or with a co-peptide having a sequence of approximately 15-20 amino-acids and comprising the co-activator motif LXXLL or a co-repressor motif (I/L)XX(V/I)I or LXX(H/I)IXXX(I/L) wherein X represents any amino acid, natural or not, such as co-peptides chosen among fragments of co-activators of transcription, especially those of the p160 family, and more particularly among fragments of the co-activators SRC1, such as the fragment 686-700 of SRC1, or among fragments of co-repressors of transcription.
 9. Nucleotide sequence coding for a polypeptide according to claim
 1. 10. Nucleotide sequence according to claim 9, associated to elements necessary for the transcription of this sequence, particularly a promoter and a terminator of transcription.
 11. Vector, particularly plasmid, comprising a nucleotide sequence according to claim 9 or
 11. 12. Host cells, such as E. coli, transformed with a vector according to claim
 11. 13. Process for obtaining a polypeptide according to claim 1 comprises: a step of transforming host cells with a nucleotide sequence coding for a polypeptide, using a vector, a step of cultivating a transformed host cell according to claim 12 thus obtained, in an appropriate culture medium, and the recovery, and if necessary, the purification of the recombinant polypeptide or molecular complex obtained.
 14. A crystal comprising a polypeptide according to claim
 1. 15. A crystal according to claim 14, characterized in that said crystal diffracts to at least 3 angstrom resolution and has a crystal stability within 5% of its unit cell dimensions.
 16. A crystal according to claim 14, wherein the ROR-LBD has the following unit cell dimensions in angstroms: a=52.302 Å, b=58.490 Å and c=106.036 Å, α=β=χ=90°, and an orthorhombic space group P212121.
 17. A crystal obtained by carrying out a process according to claim 13, and comprising a step of crystallisation in aqueous solvents of polypeptides, especially at 4° C. by the hanging drop vapour diffusion method, and wherein said polypeptides are polypeptides derived from the retinoic acid-related orphan receptor (ROR) in mammals, characterized in that they are delimited in their N-terminal extremity by an amino-acid located between positions 1 to 209 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3, or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals, and in their C-terminal extremity by an amino-acid located between positions 450 to 452 of the rat, human, or murine RORβ, α, or γ, as represented on FIG. 3 or by an amino-acid located at corresponding positions in nuclear receptor ROR of other subtypes than α, β and γ, and/or of other mammals.
 18. A method for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor, or for the screening of ligands that perturb the structure of the receptor and having an effect on the recruitment of cofactors (co-activators and co-repressors) and hence on gene regulation, comprising: contacting a polypeptide according to claim 1 with a compound that is a ROR-LBD ligand.
 19. A method for the screening of compounds acting as agonists or antagonists of ROR, comprising: contacting a polypeptide according to claim 1 with a compound that is a ROR-LBD ligand, said compounds being useful in the frame of the treatment of pathologies related to the central nervous system, the retinal organisation, the sensorial signal integration, the motricity, and sterility.
 20. Process for the screening of a ROR-LBD ligand which is an agonist, or an antagonist of said receptor, said process comprising the following steps: contacting a polypeptide according to claim 1, advantageously linked to a solid support, with the particular compound susceptible to be a ROR-LBD ligand, or tested ligand, being labelled, such as with a fluorescent, radioactive or enzymatic label, detection of the possible association between the said polypeptide, and the tested ligand, by measuring the used label, especially after rinsing the support used in the preceding step, or by mass spectrometry under non denaturing conditions.
 21. Process for the analysis of the tridimensional structure of the complexes formed with a polypeptide according to claim 1, and a particular compound susceptible to be a ROR-LBD ligand, said process comprising the following steps: contacting the said polypeptide, with said particular compound, crystallisation of the complex formed between the said polypeptide, and the tested ligand, especially with the vapour diffusion method, and tridimensional analysis of said complex, especially with the molecular replacement method, or tridimensional analysis of said complex in soluble state, by using an appropriate method such as NMR. 